It’s uncomplicated: Prevention of urinary tract infections in an era of increasing antibiotic resistance

Lori L. Burrows

PLOS Pathogens: published February 1, 2024 | https://doi.org/10.1371/journal.ppat.1011930

The “basics” of HIV-1 assembly

Christopher Sumner, Akira Ono

PLOS Pathogens: published February 1, 2024 | https://doi.org/10.1371/journal.ppat.1011937

Dolosigranulum pigrum: A promising nasal probiotic candidate

Reed M. Stubbendieck, Jillian H. Hurst, Matthew S. Kelly

PLOS Pathogens: published February 1, 2024 | https://doi.org/10.1371/journal.ppat.1011955

Fights on the surface prior to fungal invasion of insects

Junmei Shang, Song Hong, Chengshu Wang

PLOS Pathogens: published February 22, 2024 | https://doi.org/10.1371/journal.ppat.1011994

Epstein-Barr virus lytic gene BNRF1 promotes B-cell lymphomagenesis via IFI27 upregulation

Ken Sagou, Yoshitaka Sato, Yusuke Okuno, Takahiro Watanabe, Tomoki Inagaki, Yashiro Motooka, Shinya Toyokuni, Takayuki Murata, Hitoshi Kiyoi, Hiroshi Kimura

PLOS Pathogens: published February 1, 2024 | https://doi.org/10.1371/journal.ppat.1011954

Neutralizing monoclonal antibodies against the Gc fusion loop region of Crimean–Congo hemorrhagic fever virus

Liushuai Li, Tingting Chong, Lu Peng, Yajie Liu, Guibo Rao, Yan Fu, Yanni Shu, Jiamei Shen, Qinghong Xiao, Jia Liu, Jiang Li, Fei Deng, Bing Yan, Zhihong Hu, Sheng Cao, Manli Wang

PLOS Pathogens: published February 1, 2024 | https://doi.org/10.1371/journal.ppat.1011948

Influenza A virus resistance to 4’-fluorouridine coincides with viral attenuation in vitro and in vivo

Carolin M. Lieber, Hae-Ji Kang, Megha Aggarwal, Nicole A. Lieberman, Elizabeth B. Sobolik, Jeong-Joong Yoon, Michael G. Natchus, Robert M. Cox, Alexander L. Greninger, Richard K. Plemper

PLOS Pathogens: published February 1, 2024 | https://doi.org/10.1371/journal.ppat.1011993

A kinesin-13 family kinesin in Trypanosoma brucei regulates cytokinesis and cytoskeleton morphogenesis by promoting microtubule bundling

Huiqing Hu, Yasuhiro Kurasawa, Qing Zhou, Ziyin Li

PLOS Pathogens: published February 1, 2024 | https://doi.org/10.1371/journal.ppat.1012000

Hepatitis B virus RNAs co-opt ELAVL1 for stabilization and CRM1-dependent nuclear export

Yingcheng Zheng, Mengfei Wang, Jiatong Yin, Yurong Duan, Chuanjian Wu, Zaichao Xu, Yanan Bu, Jingjing Wang, Quan Chen, Guoguo Zhu, Kaitao Zhao, Lu Zhang, Rong Hua, Yanping Xu, Xiyu Hu, Xiaoming Cheng, Yuchen Xia

PLOS Pathogens: published February 2, 2024 | https://doi.org/10.1371/journal.ppat.1011999

Structural basis of the recognition of adeno-associated virus by the neurological system-related receptor carbonic anhydrase IV

Ran Zhang, Yixiao Liu, Fengxi Yu, Guangxue Xu, Lili Li, Baobin Li, Zhiyong Lou

PLOS Pathogens: published February 5, 2024 | https://doi.org/10.1371/journal.ppat.1011953

Guanylate-binding protein 1 acts as a pro-viral factor for the life cycle of hepatitis C virus

Daniela Bender, Alexandra Koulouri, Xingjian Wen, Mirco Glitscher, Anja Schollmeier, Liliana Fernandes da Costa, Robin Oliver Murra, Gert Paul Carra, Vanessa Haberger, Gerrit J. K. Praefcke, Eberhard Hildt

PLOS Pathogens: published February 5, 2024 | https://doi.org/10.1371/journal.ppat.1011976

Distinct roles for type I and type III interferons in virulent human metapneumovirus pathogenesis

Yu Zhang, Jiuyang Xu, Margot Miranda-Katz, Jorna Sojati, Sharon J. Tollefson, Michelle L. Manni, John F. Alcorn, Saumendra N. Sarkar, John V. Williams

PLOS Pathogens: published February 5, 2024 | https://doi.org/10.1371/journal.ppat.1011840

Basigin mediation of Plasmodium falciparum red blood cell invasion does not require its transmembrane domain or interaction with monocarboxylate transporter 1

Nadine R. King, Catarina Martins Freire, Jawida Touhami, Marc Sitbon, Ashley M. Toye, Timothy J. Satchwell

PLOS Pathogens: published February 5, 2024 | https://doi.org/10.1371/journal.ppat.1011989

SRPK2 Mediates HBV Core Protein Phosphorylation and Capsid Assembly via Docking Interaction

Ryan Pak Hong YIP, Doris Ching Ying Kwok, Louis Tung Faat Lai, Siu-Ming Ho, Ivan Chun Kit Wong, Chi-Ping Chan, Wilson Chun Yu Lau, Jacky Chi Ki Ngo

PLOS Pathogens: published February 7, 2024 | https://doi.org/10.1371/journal.ppat.1011978

N123I mutation in the ALV-J receptor-binding domain region enhances viral replication ability by increasing the binding affinity with chNHE1

Mengmeng Yu, Yao Zhang, Li Zhang, Suyan Wang, Yongzhen Liu, Zhuangzhuang Xu, Peng Liu, Yuntong Chen, Ru Guo, Lingzhai Meng, Tao Zhang, Wenrui Fan, Xiaole Qi, Li Gao, Yanping Zhang, Hongyu Cui, Yulong Gao

PLOS Pathogens: published February 7, 2024 | https://doi.org/10.1371/journal.ppat.1011928

Maternal SARS-CoV-2 infection in pregnancy disrupts gene expression in Hofbauer cells with limited impact on cytotrophoblasts

Elizabeth Ann L. Enninga, Huy Quang Quach, Jin Sung Jang, Maria Cristina Miranda de Araujo Correia, Yaroslav Fedyshyn, Bohdana Fedyshyn, Maureen Lemens, Dawn Littlefield, Supriya Behl, Elise Sintim-Aboagye, Maria C. Mejia Plazas, Maria C. Cardenas, Shree Chakraborty, Satoko Yamaoka, Hideki Ebihara, Akhilesh Pandey, Hu Li, Andrew D. Badley, Erica L. Johnson, Jie Sun, Andrew P. Norgan, Regan N. Theiler, Rana Chakraborty

PLOS Pathogens: published February 7, 2024 | https://doi.org/10.1371/journal.ppat.1011990

The multiplicity of thioredoxin systems meets the specific lifestyles of Clostridia

Cyril Anjou, Aurélie Lotoux, Anna Zhukova, Marie Royer, Léo C. Caulat, Elena Capuzzo, Claire Morvan, Isabelle Martin-Verstraete

PLOS Pathogens: published February 8, 2024 | https://doi.org/10.1371/journal.ppat.1012001

SARS-CoV-2 Nsp1 cooperates with initiation factors EIF1 and 1A to selectively enhance translation of viral RNA

Ranen Aviner, Peter V. Lidsky, Yinghong Xiao, Michel Tassetto, Damian Kim, Lichao Zhang, Patrick L. McAlpine, Joshua Elias, Judith Frydman, Raul Andino

PLOS Pathogens: published February 9, 2024 | https://doi.org/10.1371/journal.ppat.1011535

NFAT signaling is indispensable for persistent memory responses of MCMV-specific CD8⁺ T cells

M. Zeeshan Chaudhry, Lisa Borkner, Upasana Kulkarni, Friederike Berberich-Siebelt, Luka Cicin-Sain

PLOS Pathogens: published February 12, 2024 | https://doi.org/10.1371/journal.ppat.1012025

The HN protein of Newcastle disease virus induces cell apoptosis through the induction of lysosomal membrane permeabilization

Yu Chen, Shanshan Zhu, Tianxing Liao, Chunxuan Wang, Jiajun Han, Zhenyu Yang, Xiaolong Lu, Zenglei Hu, Jiao Hu, Xiaoquan Wang, Min Gu, Ruyi Gao, Kaituo Liu, Xiaowen Liu, Chan Ding, Shunlin Hu, Xiufan Liu

PLOS Pathogens: published February 14, 2024 | https://doi.org/10.1371/journal.ppat.1011981

The Anopheles leucine-rich repeat protein APL1C is a pathogen binding factor recognizing Plasmodium ookinetes and sporozoites

Natalia Marta Zmarlak, Catherine Lavazec, Emma Brito-Fravallo, Corinne Genève, Eduardo Aliprandini, Manuela Camille Aguirre-Botero, Kenneth D. Vernick, Christian Mitri

PLOS Pathogens: published February 14, 2024 | https://doi.org/10.1371/journal.ppat.1012008

Testing the intrinsic mechanisms driving the dynamics of Ross River Virus across Australia

Iain S. Koolhof, Nicholas Beeton, Silvana Bettiol, Michael Charleston, Simon M. Firestone, Katherine Gibney, Peter Neville, Andrew Jardine, Peter Markey, Nina Kurucz, Allan Warchot, Vicki Krause, Michael Onn, Stacey Rowe, Lucinda Franklin, Stephen Fricker, Craig Williams, Scott Carver

PLOS Pathogens: published February 15, 2024 | https://doi.org/10.1371/journal.ppat.1011944

Enterovirus A71 does not meet the uncoating receptor SCARB2 at the cell surface

Yorihiro Nishimura, Kei Sato, Yoshio Koyanagi, Takaji Wakita, Masamichi Muramatsu, Hiroyuki Shimizu, Jeffrey M. Bergelson, Minetaro Arita

PLOS Pathogens: published February 15, 2024 | https://doi.org/10.1371/journal.ppat.1012022

Amino acid 138 in the HA of a H3N2 subtype influenza A virus increases affinity for the lower respiratory tract and alveolar macrophages in pigs

Matias Cardenas, Brittany Seibert, Brianna Cowan, Ana Luiza S. Fraiha, Silvia Carnaccini, L. Claire Gay, Flavio Cargnin Faccin, C. Joaquin Caceres, Tavis K. Anderson, Amy L. Vincent Baker, Daniel R. Perez, Daniela S. Rajao

PLOS Pathogens: published February 20, 2024 | https://doi.org/10.1371/journal.ppat.1012026

Cellular receptors for mammalian viruses

Ana Valero-Rello, Carlos Baeza-Delgado, Iván Andreu-Moreno, Rafael Sanjuán

PLOS Pathogens: published February 20, 2024 | https://doi.org/10.1371/journal.ppat.1012021

Parasite-induced IFN-γ regulates host defense via CD115 and mTOR-dependent mechanism of tissue-resident macrophage death

Andrew T. Martin, Shilpi Giri, Alexandra Safronova, Sophia I. Eliseeva, Samantha F. Kwok, Felix Yarovinsky

PLOS Pathogens: published February 20, 2024 | https://doi.org/10.1371/journal.ppat.1011502

The NP protein of Newcastle disease virus dictates its oncolytic activity by regulating viral mRNA translation efficiency

Tianxing Liao, Yu Chen, Lili Guo, Shanshan Zhu, Tiansong Zhan, Xiaolong Lu, Haixu Xu, Zenglei Hu, Jiao Hu, Min Gu, Xiaowen Liu, Xiaoquan Wang, Shunlin Hu, Xiufan Liu

PLOS Pathogens: published February 20, 2024 | https://doi.org/10.1371/journal.ppat.1012027

Antibody profiling and predictive modeling discriminate between Kaposi sarcoma and asymptomatic KSHV infection

Sydney J. Bennett, Dicle Yalcin, Sara R. Privatt, Owen Ngalamika, Salum J. Lidenge, John T. West, Charles Wood

PLOS Pathogens: published February 21, 2024 | https://doi.org/10.1371/journal.ppat.1012023

Legionella pneumophila usurps host cell lipids for vacuole expansion and bacterial growth

Soma Ghosh, Saumya Bandyopadhyay, Danielle M. Smith, Sangeeta Adak, Clay F. Semenkovich, Laszlo Nagy, Michael J. Wolfgang, Tamara J. O’Connor

PLOS Pathogens: published February 22, 2024 | https://doi.org/10.1371/journal.ppat.1011996

Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods

Todd M. Bell, Paul Facemire, Jeremy J. Bearss, Jo Lynne Raymond, Jennifer Chapman, Xiankun Zeng, Joshua D. Shamblin, Janice A. Williams, Douglas W. Grosenbach, Dennis E. Hruby, Inger K. Damon, Arthur J. Goff, Eric M. Mucker

PLOS Pathogens: published February 22, 2024 | https://doi.org/10.1371/journal.ppat.1012007

Sequences at gene segment termini inclusive of untranslated regions and partial open reading frames play a critical role in mammalian orthoreovirus S gene packaging

Debarpan Dhar, Samir Mehanovic, Walter Moss, Cathy L. Miller

PLOS Pathogens: published February 23, 2024 | https://doi.org/10.1371/journal.ppat.1012037

Porcine circovirus type 2 infection promotes the SUMOylation of nucleophosmin-1 to facilitate the viral circular single-stranded DNA replication

Qian Du, Lei Zhu, Jianhui Zhong, Xueqi Wei, Qi Zhang, Tengfei Shi, Cong Han, Xinhuan Yin, Xingqi Chen, Dewen Tong, Yong Huang

PLOS Pathogens: published February 23, 2024 | https://doi.org/10.1371/journal.ppat.1012014

A tick saliva serpin, IxsS17 inhibits host innate immune system proteases and enhances host colonization by Lyme disease agent

Thu-Thuy Nguyen, Tae Heung Kim, Emily Bencosme-Cuevas, Jacquie Berry, Alex Samuel Kiarie Gaithuma, Moiz Ashraf Ansari, Tae Kwon Kim, Lucas Tirloni, Zeljko Radulovic, James J. Moresco, John R. Yates III, Albert Mulenga

PLOS Pathogens: published February 23, 2024 | https://doi.org/10.1371/journal.ppat.1012032

Species-specific emergence of H7 highly pathogenic avian influenza virus is driven by intrahost selection differences between chickens and ducks

Anja C. M. de Bruin, Monique I. Spronken, Adinda Kok, Miruna E. Rosu, Dennis de Meulder, Stefan van Nieuwkoop, Pascal Lexmond, Mathis Funk, Lonneke M. Leijten, Theo M. Bestebroer, Sander Herfst, Debby van Riel, Ron A. M. Fouchier, Mathilde Richard

PLOS Pathogens: published February 26, 2024 | https://doi.org/10.1371/journal.ppat.1011942

TRIM72 restricts lyssavirus infection by inducing K48-linked ubiquitination and proteasome degradation of the matrix protein

Baokun Sui, Jiaxin Zheng, Zhenfang Fu, Ling Zhao, Ming Zhou

PLOS Pathogens: published February 26, 2024 | https://doi.org/10.1371/journal.ppat.1011718

Mapping the functional form of the trade-off between infection resistance and reproductive fitness under dysregulated immune signaling

Justin T. Critchlow, Arun Prakash, Katherine Y. Zhong, Ann T. Tate

PLOS Pathogens: published February 26, 2024 | https://doi.org/10.1371/journal.ppat.1012049

Microtubule disruption synergizes with STING signaling to show potent and broad-spectrum antiviral activity

Jing Han, Zhimeng Wang, Fangping Han, Bo Peng, Juanjuan Du, Conggang Zhang

PLOS Pathogens: published February 26, 2024 | https://doi.org/10.1371/journal.ppat.1012048

A conserved trypanosomatid differentiation regulator controls substrate attachment and morphological development in Trypanosoma congolense

Eleanor Silvester, Balazs Szoor, Alasdair Ivens, Georgina Awuah-Mensah, Catarina Gadelha, Bill Wickstead, Keith R. Matthews

PLOS Pathogens: published February 26, 2024 | https://doi.org/10.1371/journal.ppat.1011889

Leishmania highjack host lipid body for its proliferation in macrophages by overexpressing host Rab18 and TRAPPC9 by downregulating miR-1914-3p expression

Chandni Sood, Jitender Kumar Verma, Rituparna Basak, Anjali Kapoor, Swarnima Gupta, Amitabha Mukhopadhyay

PLOS Pathogens: published February 27, 2024 | https://doi.org/10.1371/journal.ppat.1012024

Extreme infectious titer variability in individual Aedes aegypti mosquitoes infected with Sindbis virus is associated with both differences in virus population structure and dramatic disparities in specific infectivity

Peter Hodoameda, Gregory D. Ebel, Suchetana Mukhopadhyay, Rollie J. Clem

PLOS Pathogens: published February 27, 2024 | https://doi.org/10.1371/journal.ppat.1012047

Plasmodium falciparum contains functional SCF and CRL4 ubiquitin E3 ligases, and CRL4 is critical for cell division and membrane integrity

Zeba Rizvi, G. Srinivas Reddy, Somesh M. Gorde, Priyanka Pundir, Divya Das, Puran Singh Sijwali

PLOS Pathogens: published February 28, 2024 | https://doi.org/10.1371/journal.ppat.1012045

Downregulation of CPSF6 leads to global mRNA 3’ UTR shortening and enhanced antiviral immune responses

Yong Ge, Jingrong Huang, Rong Chen, Yonggui Fu, Tao Ling, Xin Ou, Xiaohui Rong, Youxiang Cheng, Yi Lin, Fengyi Zhou, Chuanjian Lu, Shaochun Yuan, Anlong Xu

PLOS Pathogens: published February 28, 2024 | https://doi.org/10.1371/journal.ppat.1012061

Genomic and virulence analysis of in vitro cultured Cryptosporidium parvum

Nigel Yarlett, Mary Morada, Deborah A. Schaefer, Kevin Ackman, Elizabeth Carranza, Rodrigo de Paula Baptista, Michael W. Riggs, Jessica C. Kissinger

PLOS Pathogens: published February 28, 2024 | https://doi.org/10.1371/journal.ppat.1011992

Structure and antigenicity of the divergent human astrovirus VA1 capsid spike

Anisa Ghosh, Kevin Delgado-Cunningham, Tomás López, Kassidy Green, Carlos F. Arias, Rebecca M. DuBois

PLOS Pathogens: published February 28, 2024 | https://doi.org/10.1371/journal.ppat.1012028

Whole cell reconstructions of Leishmania mexicana through the cell cycle

Molly Hair, Ryuji Yanase, Flávia Moreira-Leite, Richard John Wheeler, Jovana Sádlová, Petr Volf, Sue Vaughan, Jack Daniel Sunter

PLOS Pathogens: published February 28, 2024 | https://doi.org/10.1371/journal.ppat.1012054

Intoxication of antibiotic persisters by host RNS inactivates their efflux machinery during infection

Séverin Ronneau, Charlotte Michaux, Rachel T. Giorgio, Sophie Helaine

PLOS Pathogens: published February 29, 2024 | https://doi.org/10.1371/journal.ppat.1012033

The timing of HIV-1 infection of cells that persist on therapy is not strongly influenced by replication competency or cellular tropism of the provirus

Sarah B. Joseph, Melissa-Rose Abrahams, Matthew Moeser, Lynn Tyers, Nancie M. Archin, Olivia D. Council, Amy Sondgeroth, Ean Spielvogel, Ann Emery, Shuntai Zhou, Deelan Doolabh, Sherazaan D. Ismail, Salim Abdool Karim, David M. Margolis, Sergei Kosakovsky Pond, Nigel Garrett, Ronald Swanstrom, Carolyn Williamson

PLOS Pathogens: published February 29, 2024 | https://doi.org/10.1371/journal.ppat.1011974

Ongoing evolution of the Mycobacterium tuberculosis lactate dehydrogenase reveals the pleiotropic effects of bacterial adaption to host pressure

Sydney Stanley, Xin Wang, Qingyun Liu, Young Yon Kwon, Abigail M. Frey, Nathan D. Hicks, Andrew J. Vickers, Sheng Hui, Sarah M. Fortune

PLOS Pathogens: published February 29, 2024 | https://doi.org/10.1371/journal.ppat.1012050

Correction: A screen of drug-like molecules identifies chemically diverse electron transport chain inhibitors in apicomplexan parasites

Jenni A. Hayward, F. Victor Makota, Daniela Cihalova, Rachel A. Leonard, Esther Rajendran, Soraya M. Zwahlen, Laura Shuttleworth, Ursula Wiedemann, Christina Spry, Kevin J. Saliba, Alexander G. Maier, Giel G. van Dooren

PLOS Pathogens: published February 1, 2024 | https://doi.org/10.1371/journal.ppat.1011987

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Correction: The replication initiator protein of a geminivirus interacts with host monoubiquitination machinery and stimulates transcription of the viral genome

Nirbhay Kumar Kushwaha, Mansi Bhardwaj, Supriya Chakraborty

PLOS Pathogens: published February 22, 2024 | https://doi.org/10.1371/journal.ppat.1012030

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Correction: Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication

Weiyu Luo, Jie Zhang, Libin Liang, Guangwen Wang, Qibing Li, Pengyang Zhu, Yuan Zhou, Junping Li, Yuhui Zhao, Nan Sun, Shanyu Huang, Chenchen Zhou, Yu Chang, Pengfei Cui, Pucheng Chen, Yongping Jiang, Guohua Deng, Zhigao Bu, Chengjun Li, Li Jiang, Hualan Chen

PLOS Pathogens: published February 23, 2024 | https://doi.org/10.1371/journal.ppat.1012035

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