Dissecting transmission to understand parasite evolution

Luís M. Silva, Kayla C. King, Jacob C. Koella

PLOS Pathogens: published March 25, 2025 | https://doi.org/10.1371/journal.ppat.1012964

Sporothrix is neglected among the neglected

Daniel R. Matute, Marcus de Melo Teixeira

PLOS Pathogens: published March 6, 2025 | https://doi.org/10.1371/journal.ppat.1012898

Five things to consider before proposing that a circular RNA is a viroid

Jian Wu, David M. Bisaro

PLOS Pathogens: published March 7, 2025 | https://doi.org/10.1371/journal.ppat.1012958

Virolithopanspermia: Might viruses be transported in rocks through space?

Frederic D. Bushman

PLOS Pathogens: published March 18, 2025 | https://doi.org/10.1371/journal.ppat.1012955

Advances in the dissection of Anopheles–Plasmodium interactions

Sally A. Saab, Victor Cardoso-Jaime, Mary Kefi, George Dimopoulos

PLOS Pathogens: published March 31, 2025 | https://doi.org/10.1371/journal.ppat.1012965

A genome-wide screen in ex vivo gallbladders identifies Listeria monocytogenes factors required for virulence in vivo

Nicole H. Schwardt, Cortney R. Halsey, Madison E. Sanchez, Billy M. Ngo, Michelle L. Reniere

PLOS Pathogens: published March 3, 2025 | https://doi.org/10.1371/journal.ppat.1012491

Repurposing alcohol-abuse drug disulfiram for the treatment of KSHV-infected primary effusion lymphoma by activating antiviral innate immunity

Lijie Wang, Zhenshan Liu, Zeyu Xu, Wenjing Wang, Jinhong Yang, Junjie Zhang, Shanping He, Qiming Liang, Tingting Li

PLOS Pathogens: published March 4, 2025 | https://doi.org/10.1371/journal.ppat.1012957

The CXCR6-CXCL16 axis mediates T cell control of polyomavirus infection in the kidney

Matthew D. Lauver, Zoe E. Katz, Havell Markus, Nicole M. Derosia, Ge Jin, Katelyn N. Ayers, Arrienne B. Butic, Kaitlyn Bushey, Catherine S. Abendroth, Dajiang J. Liu, Aron E. Lukacher

PLOS Pathogens: published March 5, 2025 | https://doi.org/10.1371/journal.ppat.1012969

Molecular evolution and geographic migration of severe fever with thrombocytopenia syndrome virus in Asia

Ruyi Sheng, Tianyu Cheng, Yao Wang, Hongling Wen

PLOS Pathogens: published March 7, 2025 | https://doi.org/10.1371/journal.ppat.1012970

Unidirectional recruitment between MeCP2 and KSHV-encoded LANA revealed by CRISPR/Cas9 recruitment assay

Ido Lavi, Supriya Bhattacharya, Ankita Awase, Ola Orgil, Nir Avital, Guy Journo, Vyacheslav Gurevich, Meir Shamay

PLOS Pathogens: published March 10, 2025 | https://doi.org/10.1371/journal.ppat.1012972

The CLIC/GEEC pathway regulates particle uptake and formation of the virus-containing compartment (VCC) in HIV-1-infected macrophages

Kathleen Candor, Lingmei Ding, Sai Balchand, Jason E. Hammonds, Paul Spearman

PLOS Pathogens: published March 11, 2025 | https://doi.org/10.1371/journal.ppat.1012564

Enhancing MyD88 oligomerization is one important mechanism by which IBDV VP2 induces inflammatory response

Mengmeng Huang, Mengmeng Xu, Jingzhe Han, Erjing Ke, Xinxin Niu, Yulong Zhang, Guodong Wang, Hangbo Yu, Runhang Liu, Suyan Wang, Yongzhen Liu, Yuntong Chen, Jinze Han, Ziwen Wu, Hongyu Cui, Yanping Zhang, Yulu Duan, Yulong Gao, Xiaole Qi

PLOS Pathogens: published March 11, 2025 | https://doi.org/10.1371/journal.ppat.1012985

Lytic coelomocyte death is tuned by cleavage but not phosphorylation of MLKL in echinoderms

Kaiyu Chen, Sikou Shen, Zhimeng Lv, Ming Guo, Yina Shao, Chenghua Li

PLOS Pathogens: published March 14, 2025 | https://doi.org/10.1371/journal.ppat.1012991

Leishmania major Dihydrolipoyl dehydrogenase (DLD) is a key metabolic enzyme that drives parasite proliferation, pathology and host immune response

Somtochukwu S. Onwah, Zhirong Mou, Gaurav Gupta, Patience Obi, Nnamdi Ikeogu, Ping Jia, Wen-Wei Zhang, Saeid Ghavami, Ayesha Saleem, Jude Uzonna

PLOS Pathogens: published March 17, 2025 | https://doi.org/10.1371/journal.ppat.1012978

The elevated expression of ORF75, a KSHV lytic gene, in Kaposi sarcoma lesions is driven by a GC-rich DNA cis element in its promoter region

Ashwin Nair, David A. Davis, Andrew Warner, Baktiar Karim, Ramya Ramaswami, Robert Yarchoan

PLOS Pathogens: published March 17, 2025 | https://doi.org/10.1371/journal.ppat.1012984

Eating the brain - A multidisciplinary study provides new insights into the mechanisms underlying the cytopathogenicity of Naegleria fowleri

Ronald Malych, Filipe Folgosa, Jana Pilátová, Libor Mikeš, Vít Dohnálek, Jan Mach, Magdaléna Matějková, Vladimír Kopecký, Pavel Doležal, Robert Sutak

PLOS Pathogens: published March 17, 2025 | https://doi.org/10.1371/journal.ppat.1012995

Coronavirus endoribonuclease nsp15 suppresses host protein synthesis and evades PKR-eIF2α-mediated translation shutoff to ensure viral protein synthesis

Xiaoqian Gong, Shanhuan Feng, Jiehuang Wang, Bo Gao, Wenxiang Xue, Hongyan Chu, Shouguo Fang, Yanmei Yuan, Yuqiang Cheng, Min Liao, Yingjie Sun, Lei Tan, Cuiping Song, Xusheng Qiu, Chan Ding, Edwin Tijhaar, Maria Forlenza, Ying Liao

PLOS Pathogens: published March 17, 2025 | https://doi.org/10.1371/journal.ppat.1012987

Adiponectin pathway activation dampens inflammation and enhances alveolar macrophage fungal killing via LC3-associated phagocytosis

Sri Harshini Goli, Joo-Yeon Lim, Nese Basaran-Akgul, Steven P. Templeton

PLOS Pathogens: published March 17, 2025 | https://doi.org/10.1371/journal.ppat.1012363

Modeling natural coinfection in a bat reservoir shows modulation of Marburg virus shedding and spillover potential

Amy J. Schuh, Brian R. Amman, Jonathan C. Guito, James C. Graziano, Tara K. Sealy, Jonathan S. Towner

PLOS Pathogens: published March 17, 2025 | https://doi.org/10.1371/journal.ppat.1012901

A poxvirus ankyrin protein LSDV012 inhibits IFIT1 in a host-species-specific manner by compromising its RNA binding ability

Shijie Xie, Yongxiang Fang, Zhiyi Liao, Lianxin Cui, Kang Niu, Shuning Ren, Junda Zhu, Wenxue Wu, Zhizhong Jing, Chen Peng

PLOS Pathogens: published March 17, 2025 | https://doi.org/10.1371/journal.ppat.1012994

Myeloid-derived suppressor cell inhibits T-cell-based defense against Klebsiella pneumoniae infection via IDO1 production

Qi Xu, Xiaoxuan Liu, Heng Heng, Han Wang, Kaichao Chen, Edward Wai-Chi Chan, Guan Yang, Sheng Chen

PLOS Pathogens: published March 17, 2025 | https://doi.org/10.1371/journal.ppat.1012979

A genomic and phenotypic investigation of pigeon-adaptive Salmonella

Zining Wang, Zenghai Jiang, Qianzhe Cao, Chenghao Jia, Haiyang Zhou, Chenghu Huang, Linlin Huang, Yingying Huang, Yan Li, Min Yue

PLOS Pathogens: published March 17, 2025 | https://doi.org/10.1371/journal.ppat.1012992

The efflux pump SugE2 involved in protection of Salmonella 4,[5],12:i:- against quaternary ammonium salts and inhibition of virulence

Yuqi Tian, Yaya Wen, Xueying Wang, Youkun Zhang, Xilong Kang, Chuang Meng, Zhiming Pan, Xinan Jiao, Dan Gu

PLOS Pathogens: published March 18, 2025 | https://doi.org/10.1371/journal.ppat.1012951

Discovery of a novel Betacoronavirus 1, cpCoV, in goats in China: The new risk of cross-species transmission

Li Mao, Xuhang Cai, Jizong Li, Xia Li, Siyuan Li, Wenliang Li, Honghui Lu, Yichun Dong, Junjun Zhai, Xingang Xu, Bin Li

PLOS Pathogens: published March 18, 2025 | https://doi.org/10.1371/journal.ppat.1012974

NLRP3 and AIM2 inflammasomes exacerbate the pathogenic Th17 cell response to eggs of the helminth Schistosoma mansoni

Madhusoodhanan Suresh Kumar Meena Kumari, Pengyu Liu, Megan S. Nitchman, Santoshi Chaudhary, Kaile Jump, Yoelkys Morales, Emily A. Miller, Ilana Shecter, Miguel J. Stadecker, Parisa Kalantari

PLOS Pathogens: published March 18, 2025 | https://doi.org/10.1371/journal.ppat.1012108

Gene deletion as a possible strategy adopted by New World Leishmania infantum to maximize geographic dispersion

Monique Florêncio, Marne Coimbra Batalha Chagas, Anderson Guimarães-Costa, Jullyanna Oliveira, Ingrid Waclawiak, Thamara K. F. Oliveira, Elvira Maria Saraiva, Anita Leocadio Freitas-Mesquita, José Roberto Meyer-Fernandes, Laura Aragão-Farias, Camilly Enes Trindade, Patricia Cuervo, Renata Azevedo do Nascimento, Otacilio C. Moreira, Flávia Lima Ribeiro-Gomes, Yara M. Traub-Csekö, Erich Loza Telleria, Slavica Vaselek, Tereza Leštinová, Petr Volf, Gerald F. Späth, Elisa Cupolillo, Mariana Côrtes Boité

PLOS Pathogens: published March 20, 2025 | https://doi.org/10.1371/journal.ppat.1012938

Systemic infection by Candida albicans requires FASN-α subunit induced cell wall remodeling to perturb immune response

Yajing Zhao, Zhishan Zhou, Guiyue Cai, Dandan Zhang, Xiaoting Yu, Dongmei Li, Shuixiu Li, Zhanpeng Zhang, Dongli Zhang, Jiyao Luo, Yunfeng Hu, Aili Gao, Hong Zhang

PLOS Pathogens: published March 26, 2025 | https://doi.org/10.1371/journal.ppat.1012865

A Krüppel-like factor establishes cellular heterogeneity during schistosome tegumental maintenance

Lu Zhao, George R. Wendt, James. J. Collins III

PLOS Pathogens: published March 28, 2025 | https://doi.org/10.1371/journal.ppat.1013002

RNAi screening of uncharacterized genes identifies promising druggable targets in Schistosoma japonicum

Yuxiang Xie, Xiaoling Wang, Shaoyun Cheng, Wanling Liu, Cun Yi, Yanmin You, Wei Zhang, Yuepeng Wang, Enlu Tang, Jipeng Wang, Wei Hu

PLOS Pathogens: published March 28, 2025 | https://doi.org/10.1371/journal.ppat.1013014

The “DDVF” motif used by viral and bacterial proteins to hijack RSK kinases mimics a short linear motif (SLiM) found in proteins related to the RAS-ERK MAP kinase pathway

Martin Veinstein, Vincent Stroobant, Fanny Wavreil, Thomas Michiels, Frédéric Sorgeloos

PLOS Pathogens: published March 28, 2025 | https://doi.org/10.1371/journal.ppat.1013016

Selection and characterization of a broadly neutralizing class of HCV anti-E2 V_H1-69 antibodies

Andreas Soerensen, Filip Popovic, Christina Holmboe Olesen, Blanca Lopez Mendez, Brian Lohse, Zhaochun Chen, Patrizia Farci, Robert H. Purcell, Harvey J. Alter, Lea Klingenberg Barfod, Jens Bukh, Jannick Prentoe

PLOS Pathogens: published March 28, 2025 | https://doi.org/10.1371/journal.ppat.1012428

Ecotin protects Salmonella Typhimurium against the microbicidal activity of host proteases

Lucas Saposnik, Lorena M. Coria, Laura Bruno, Francisco F. Guaimas, Julieta Pandolfi, Melina Pol, Maria Eugenia Urga, Florencia Sabbione, Michael McClelland, Analia Trevani, Karina A. Pasquevich, Juliana Cassataro

PLOS Pathogens: published March 28, 2025 | https://doi.org/10.1371/journal.ppat.1013013

Dynamics of the adhesion complex of the human pathogens Mycoplasma pneumoniae and Mycoplasma genitalium

David Vizarraga, Akihiro Kawamoto, Marina Marcos-Silva, Jesús Martín, Fumiaki Makino, Tomoko Miyata, Jorge Roel-Touris, Enrique Marcos, Oscar Q. Pich, David Aparicio, Ignacio Fita, Makoto Miyata, Jaume Piñol, Keiichi Namba, Tsuyoshi Kenri

PLOS Pathogens: published March 28, 2025 | https://doi.org/10.1371/journal.ppat.1012973

Diversification, loss, and virulence gains of the major effector AvrStb6 during continental spread of the wheat pathogen Zymoseptoria tritici

Ana Margarida Sampaio, Sabina Moser Tralamazza, Faharidine Mohamadi, Yannick De Oliveira, Jérôme Enjalbert, Cyrille Saintenac, Daniel Croll

PLOS Pathogens: published March 31, 2025 | https://doi.org/10.1371/journal.ppat.1012983

Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6

Taha Y. Taha, Shahrzad Ezzatpour, Jennifer M. Hayashi, Chengjin Ye, Francisco J. Zapatero-Belinchón, Julia A. Rosecrans, Gabriella R. Kimmerly, Irene P. Chen, Keith Walcott, Anna Kurianowicz, Danielle M. Jorgens, Natalie R. Chaplin, Annette Choi, David W. Buchholz, Julie Sahler, Zachary T. Hilt, Brian Imbiakha, Cecilia Vagi-Szmola, Mauricio Montano, Erica Stevenson, Martin Gordon, Danielle L. Swaney, Nevan J. Krogan, Gary R. Whittaker, Luis Martinez-Sobrido, Hector C. Aguilar, Melanie Ott

PLOS Pathogens: published March 31, 2025 | https://doi.org/10.1371/journal.ppat.1013020

VAPA mediates lipid exchange between Leishmania amazonensis and host macrophages

Ilona Gdovinova, Albert Descoteaux

PLOS Pathogens: published March 31, 2025 | https://doi.org/10.1371/journal.ppat.1012636

Severe malaria enforces short-lived effector cell differentiation but does not prevent effective secondary responses by memory CD8 T cells

Jacob A. Hildebrand, Noah R. Daniels, Emma M. Dehm, Benjamin D. Fisher, Joseph K. Guter, Chris J. Janse, Erin D. Lucas, Jules A. Sangala, Trevor N. Tankersley, Geoffrey T. Hart, Sara E. Hamilton

PLOS Pathogens: published March 31, 2025 | https://doi.org/10.1371/journal.ppat.1012993

Alternaria alternata effector AaAlta1 targets CmWD40 and participates in regulating disease resistance in Chrysanthemum morifolium

Shuhuan Zhang, Lina Liu, Wenjie Li, Mengru Yin, Qian Hu, Sumei Chen, Fadi Chen, Ye Liu, Zhiyong Guan, Jiafu Jiang

PLOS Pathogens: published March 31, 2025 | https://doi.org/10.1371/journal.ppat.1012942

Correction: Use of the Puccinia sorghi haustorial transcriptome to identify and characterize AvrRp1-D recognized by the maize Rp1-D resistance protein

The PLOS Pathogens Staff

PLOS Pathogens: published March 27, 2025 | https://doi.org/10.1371/journal.ppat.1013022

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1. Use of the Puccinia sorghi haustorial transcriptome to identify and characterize AvrRp1-D recognized by the maize Rp1-D resistance protein