Anti-prion drugs do not improve survival in novel knock-in models of inherited prion disease

Daniel J. Walsh, Judy R. Rees, Surabhi Mehra, Matthew E. C. Bourkas, Lech Kaczmarczyk, Erica Stuart, Walker S. Jackson, Joel C. Watts, Surachai Supattapone

PLOS Pathogens: published April 1, 2024 | https://doi.org/10.1371/journal.ppat.1012087

Characterization and genomic analysis of the Lyme disease spirochete bacteriophage ϕBB-1

Dominick R. Faith, Margie Kinnersley, Diane M. Brooks, Dan Drecktrah, Laura S. Hall, Eric Luo, Andrew Santiago-Frangos, Jenny Wachter, D. Scott Samuels, Patrick R. Secor

PLOS Pathogens: published April 1, 2024 | https://doi.org/10.1371/journal.ppat.1012122

Broad-spectrum Delta-BA.2 tandem-fused heterodimer mRNA vaccine delivered by lipopolyplex

Pei Du, Lei Huang, Yi Fang, Fanfan Zhao, Qianyun Li, Xuehui Ma, Ruiqi Li, Qian Chen, Haifa Shen, Qihui Wang, Hangwen Li, George Fu Gao

PLOS Pathogens: published April 1, 2024 | https://doi.org/10.1371/journal.ppat.1012116

Investigating the dose-dependency of the midgut escape barrier using a mechanistic model of within-mosquito dengue virus population dynamics

Rebecca M. Johnson, Isaac J. Stopard, Helen M. Byrne, Philip M. Armstrong, Douglas E. Brackney, Ben Lambert

PLOS Pathogens: published April 1, 2024 | https://doi.org/10.1371/journal.ppat.1011975

Dynamic changes of Bacterial Microbiomes in Oropharynx during Infection and Recovery of COVID-19 Omicron Variant

Guangying Cui, Ying Sun, Yawen Zou, Ranran Sun, Yanxia Gao, Xiaorui Liu, Yongjian Zhou, Donghua Zhang, Xueqing Wang, Yonghong Li, Liwen Liu, Guizhen Zhang, Benchen Rao, Zujiang Yu, Zhigang Ren

PLOS Pathogens: published April 3, 2024 | https://doi.org/10.1371/journal.ppat.1012075

The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca²⁺

Marilina de Sautu, Tobias Herrmann, Gustavo Scanavachi, Simon Jenni, Stephen C. Harrison

PLOS Pathogens: published April 4, 2024 | https://doi.org/10.1371/journal.ppat.1011750

RNA three-dimensional structure drives the sequence organization of potato spindle tuber viroid quasispecies

Jian Wu, Yuhong Zhang, Yuxin Nie, Fei Yan, Craig L. Zirbel, David M. Bisaro

PLOS Pathogens: published April 4, 2024 | https://doi.org/10.1371/journal.ppat.1012142

In vivo single-cell high-dimensional mass cytometry analysis to track the interactions between Klebsiella pneumoniae and myeloid cells

Ricardo Calderon-Gonzalez, Amy Dumigan, Joana Sá-Pessoa, Adrien Kissenpfennig, José A. Bengoechea

PLOS Pathogens: published April 5, 2024 | https://doi.org/10.1371/journal.ppat.1011900

Alpha herpesvirus exocytosis from neuron cell bodies uses constitutive secretory mechanisms, and egress and spread from axons is independent of neuronal firing activity

Anthony E. Ambrosini, Kayla M. Borg, Nikhil Deshmukh, Michael J. Berry II, Lynn W. Enquist, Ian B. Hogue

PLOS Pathogens: published April 5, 2024 | https://doi.org/10.1371/journal.ppat.1012139

Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir

Brandon F. Keele, Afam A. Okoye, Christine M. Fennessey, Benjamin Varco-Merth, Taina T. Immonen, Emek Kose, Andrew Conchas, Mykola Pinkevych, Leslie Lipkey, Laura Newman, Agatha Macairan, Marjorie Bosche, William J. Bosche, Brian Berkemeier, Randy Fast, Mike Hull, Kelli Oswald, Rebecca Shoemaker, Lorna Silipino, Robert J. Gorelick, Derick Duell, Alejandra Marenco, William Brantley, Jeremy Smedley, Michael Axthelm, Miles P. Davenport, Jeffrey D. Lifson, Louis J. Picker

PLOS Pathogens: published April 9, 2024 | https://doi.org/10.1371/journal.ppat.1012135

Pyrrole-based inhibitors of RND-type efflux pumps reverse antibiotic resistance and display anti-virulence potential

Nisha Mahey, Rushikesh Tambat, Ritu Kalia, Rajnita Ingavale, Akriti Kodesia, Nishtha Chandal, Srajan Kapoor, Dipesh Kumar Verma, Krishan Gopal Thakur, Sanjay Jachak, Hemraj Nandanwar

PLOS Pathogens: published April 9, 2024 | https://doi.org/10.1371/journal.ppat.1012121

Mathematical models of drug-resistant tuberculosis lack bacterial heterogeneity: A systematic review

Naomi M. Fuller, Christopher F. McQuaid, Martin J. Harker, Chathika K. Weerasuriya, Timothy D. McHugh, Gwenan M. Knight

PLOS Pathogens: published April 10, 2024 | https://doi.org/10.1371/journal.ppat.1011574

Wolbachia infection-responsive immune genes suppress Plasmodium falciparum infection in Anopheles stephensi

Vandana Vandana, Shengzhang Dong, Tanaya Sheth, Qiang Sun, Han Wen, Amanda Maldonado, Zhiyong Xi, George Dimopoulos

PLOS Pathogens: published April 10, 2024 | https://doi.org/10.1371/journal.ppat.1012145

Sja-let-7 suppresses the development of liver fibrosis via Schistosoma japonicum extracellular vesicles

Haoran Zhong, Bowen Dong, Danlin Zhu, Zhiqiang Fu, Jinming Liu, Yamei Jin

PLOS Pathogens: published April 10, 2024 | https://doi.org/10.1371/journal.ppat.1012153

High-resolution comparative atomic structures of two Giardiavirus prototypes infecting G. duodenalis parasite

Han Wang, Gianluca Marucci, Anna Munke, Mohammad Maruf Hassan, Marco Lalle, Kenta Okamoto

PLOS Pathogens: published April 10, 2024 | https://doi.org/10.1371/journal.ppat.1012140

SARS-CoV-2 infects cells lining the blood-retinal barrier and induces a hyperinflammatory immune response in the retina via systemic exposure

Monu Monu, Faraz Ahmad, Rachel M. Olson, Vaishnavi Balendiran, Pawan Kumar Singh

PLOS Pathogens: published April 10, 2024 | https://doi.org/10.1371/journal.ppat.1012156

A protective role for type I interferon signaling following infection with Mycobacterium tuberculosis carrying the rifampicin drug resistance-conferring RpoB mutation H445Y

Suhas Bobba, Kuldeep S. Chauhan, Sadia Akter, Shibali Das, Ekansh Mittal, Barun Mathema, Jennifer A. Philips, Shabaana A. Khader

PLOS Pathogens: published April 11, 2024 | https://doi.org/10.1371/journal.ppat.1012137

A gain-of-function mutation in zinc cluster transcription factor Rob1 drives Candida albicans adaptive growth in the cystic fibrosis lung environment

Mayssa Gnaien, Corinne Maufrais, Yasmine Rebai, Aicha Kallel, Laurence Ma, Samia Hamouda, Fatma Khalsi, Khaoula Meftah, Hanen Smaoui, Monia Khemiri, Sondes Hadj Fredj, Sophie Bachellier-Bassi, Imène Najjar, Taieb Messaoud, Khadija Boussetta, Kalthoum Kallel, Helmi Mardassi, Christophe d’Enfert, Marie-Elisabeth Bougnoux, Sadri Znaidi

PLOS Pathogens: published April 11, 2024 | https://doi.org/10.1371/journal.ppat.1012154

Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies

Ariel S. Wirchnianski, Elisabeth K. Nyakatura, Andrew S. Herbert, Ana I. Kuehne, Shawn A. Abbasi, Catalina Florez, Nadia Storm, Lindsay G. A. McKay, Leandrew Dailey, Erin Kuang, Dafna M. Abelson, Anna Z. Wec, Srinjoy Chakraborti, Frederick W. Holtsberg, Sergey Shulenin, Zachary A. Bornholdt, M. Javad Aman, Anna N. Honko, Anthony Griffiths, John M. Dye, Kartik Chandran, Jonathan R. Lai

PLOS Pathogens: published April 11, 2024 | https://doi.org/10.1371/journal.ppat.1012134

Porcine reproductive and respiratory syndrome virus 2 hijacks CMA-mediated lipolysis through upregulation of small GTPase RAB18

Guo-Li Li, Ying-Qian Han, Bing-Qian Su, Hai-Shen Yu, Shuang Zhang, Guo-Yu Yang, Jiang Wang, Fang Liu, Sheng-Li Ming, Bei-Bei Chu

PLOS Pathogens: published April 12, 2024 | https://doi.org/10.1371/journal.ppat.1012123

African swine fever virus pB318L, a trans-geranylgeranyl-diphosphate synthase, negatively regulates cGAS-STING and IFNAR-JAK-STAT signaling pathways

Xiaohong Liu, Hefeng Chen, Guangqiang Ye, Hongyang Liu, Chunying Feng, Weiye Chen, Liang Hu, Qiongqiong Zhou, Zhaoxia Zhang, Jiangnan Li, Xianfeng Zhang, Xijun He, Yuntao Guan, Zhengshuang Wu, Dongming Zhao, Zhigao Bu, Changjiang Weng, Li Huang

PLOS Pathogens: published April 15, 2024 | https://doi.org/10.1371/journal.ppat.1012136

Small RNA SmsR1 modulates acidogenicity and cariogenic virulence by affecting protein acetylation in Streptococcus mutans

Jing Li, Qizhao Ma, Jun Huang, Yaqi Liu, Jing Zhou, Shuxing Yu, Qiong Zhang, Yongwang Lin, Lingyun Wang, Jing Zou, Yuqing Li

PLOS Pathogens: published April 15, 2024 | https://doi.org/10.1371/journal.ppat.1012147

Lineage frequency time series reveal elevated levels of genetic drift in SARS-CoV-2 transmission in England

QinQin Yu, Joao A. Ascensao, Takashi Okada, The COVID-19 Genomics UK (COG-UK) Consortium, Olivia Boyd, Erik Volz, Oskar Hallatschek

PLOS Pathogens: published April 15, 2024 | https://doi.org/10.1371/journal.ppat.1012090

Progression of herpesvirus infection remodels mitochondrial organization and metabolism

Simon Leclerc, Alka Gupta, Visa Ruokolainen, Jian-Hua Chen, Kari Kunnas, Axel A. Ekman, Henri Niskanen, Ilya Belevich, Helena Vihinen, Paula Turkki, Ana J. Perez-Berna, Sergey Kapishnikov, Elina Mäntylä, Maria Harkiolaki, Eric Dufour, Vesa Hytönen, Eva Pereiro, Tony McEnroe, Kenneth Fahy, Minna U. Kaikkonen, Eija Jokitalo, Carolyn A. Larabell, Venera Weinhardt, Salla Mattola, Vesa Aho, Maija Vihinen-Ranta

PLOS Pathogens: published April 15, 2024 | https://doi.org/10.1371/journal.ppat.1011829

Latent Epstein-Barr virus infection collaborates with Myc over-expression in normal human B cells to induce Burkitt-like Lymphomas in mice

Jillian A. Bristol, Scott E. Nelson, Makoto Ohashi, Alejandro Casco, Mitchell Hayes, Erik A. Ranheim, Abigail S. Pawelski, Deo R. Singh, Daniel J. Hodson, Eric C. Johannsen, Shannon C. Kenney

PLOS Pathogens: published April 15, 2024 | https://doi.org/10.1371/journal.ppat.1012132

Genetic drift and purifying selection shape within-host influenza A virus populations during natural swine infections

David VanInsberghe, Dillon S. McBride, Juliana DaSilva, Thomas J. Stark, Max S. Y. Lau, Samuel S. Shepard, John R. Barnes, Andrew S. Bowman, Anice C. Lowen, Katia Koelle

PLOS Pathogens: published April 16, 2024 | https://doi.org/10.1371/journal.ppat.1012131

The adaptive immune response to Trichuris in wild versus laboratory mice: An established model system in context

Iris Mair, Jonathan Fenn, Andrew Wolfenden, Ann E. Lowe, Alex Bennett, Andrew Muir, Jacob Thompson, Olive Dieumerci, Larisa Logunova, Susanne Shultz, Janette E. Bradley, Kathryn J. Else

PLOS Pathogens: published April 16, 2024 | https://doi.org/10.1371/journal.ppat.1012119

Evidence for vagal sensory neural involvement in influenza pathogenesis and disease

Nathalie A. J. Verzele, Brendon Y. Chua, Kirsty R. Short, Aung Aung Kywe Moe, Isaac N. Edwards, Helle Bielefeldt-Ohmann, Katina D. Hulme, Ellesandra C. Noye, Marcus Z. W. Tong, Patrick C. Reading, Matthew W. Trewella, Stuart B. Mazzone, Alice E. McGovern

PLOS Pathogens: published April 16, 2024 | https://doi.org/10.1371/journal.ppat.1011635

Palmitoylation of KSHV pORF55 is required for Golgi localization and efficient progeny virion production

Yaru Zhou, Xuezhang Tian, Shaowei Wang, Ming Gao, Chuchu Zhang, Jiali Ma, Xi Cheng, Lei Bai, Hai-Bin Qin, Min-Hua Luo, Qingsong Qin, Baishan Jiang, Ke Lan, Junjie Zhang

PLOS Pathogens: published April 16, 2024 | https://doi.org/10.1371/journal.ppat.1012141

The non-template functions of helper virus RNAs create optimal replication conditions to enhance the proliferation of satellite RNAs

Zimu Qiao, Jin Wang, Kaiyun Huang, Honghao Hu, Zhouhang Gu, Qiansheng Liao, Zhiyou Du

PLOS Pathogens: published April 17, 2024 | https://doi.org/10.1371/journal.ppat.1012174

Depolymerization of SUMO chains induces slender to stumpy differentiation in T. brucei bloodstream parasites

Paula Ana Iribarren, Lucía Ayelén Di Marzio, María Agustina Berazategui, Andreu Saura, Lorena Coria, Juliana Cassataro, Federico Rojas, Miguel Navarro, Vanina Eder Alvarez

PLOS Pathogens: published April 18, 2024 | https://doi.org/10.1371/journal.ppat.1012166

Adaptation of the Mycobacterium tuberculosis transcriptome to biofilm growth

Madison A. Youngblom, Tracy M. Smith, Holly J. Murray, Caitlin S. Pepperell

PLOS Pathogens: published April 18, 2024 | https://doi.org/10.1371/journal.ppat.1012124

Modeling the emergence of viral resistance for SARS-CoV-2 during treatment with an anti-spike monoclonal antibody

Tin Phan, Carolin Zitzmann, Kara W. Chew, Davey M. Smith, Eric S. Daar, David A. Wohl, Joseph J. Eron, Judith S. Currier, Michael D. Hughes, Manish C. Choudhary, Rinki Deo, Jonathan Z. Li, Ruy M. Ribeiro, Ruian Ke, Alan S. Perelson, for the ACTIV-2/A5401 Study Team

PLOS Pathogens: published April 18, 2024 | https://doi.org/10.1371/journal.ppat.1011680

Sensitive detection of pathological seeds of α-synuclein, tau and prion protein on solid surfaces

Christina D. Orrú, Bradley R. Groveman, Andrew G. Hughson, Tomás Barrio, Kachi Isiofia, Brent Race, Natalia C. Ferreira, Pierluigi Gambetti, David A. Schneider, Kentaro Masujin, Kohtaro Miyazawa, Bernardino Ghetti, Gianluigi Zanusso, Byron Caughey

PLOS Pathogens: published April 19, 2024 | https://doi.org/10.1371/journal.ppat.1012175

A novel and ubiquitous miRNA-involved regulatory module ensures precise phosphorylation of RNA polymerase II and proper transcription

Zhiwen Wang, Shan Zhong, Sicong Zhang, Borui Zhang, Yang Zheng, Ye Sun, Qinghua Zhang, Xili Liu

PLOS Pathogens: published April 19, 2024 | https://doi.org/10.1371/journal.ppat.1012138

Type II and IV toxin-antitoxin systems coordinately stabilize the integrative and conjugative element of the ICESa2603 family conferring multiple drug resistance in Streptococcus suis

Qibing Gu, Xiayu Zhu, Yong Yu, Tao Jiang, Zihao Pan, Jiale Ma, Huochun Yao

PLOS Pathogens: published April 19, 2024 | https://doi.org/10.1371/journal.ppat.1012169

Deep mining of the Sequence Read Archive reveals major genetic innovations in coronaviruses and other nidoviruses of aquatic vertebrates

Chris Lauber, Xiaoyu Zhang, Josef Vaas, Franziska Klingler, Pascal Mutz, Arseny Dubin, Thomas Pietschmann, Olivia Roth, Benjamin W. Neuman, Alexander E. Gorbalenya, Ralf Bartenschlager, Stefan Seitz

PLOS Pathogens: published April 22, 2024 | https://doi.org/10.1371/journal.ppat.1012163

Beyond the VSG layer: Exploring the role of intrinsic disorder in the invariant surface glycoproteins of African trypanosomes

Hagen Sülzen, Alexander N. Volkov, Rob Geens, Farnaz Zahedifard, Benoit Stijlemans, Martin Zoltner, Stefan Magez, Yann G.-J. Sterckx, Sebastian Zoll

PLOS Pathogens: published April 22, 2024 | https://doi.org/10.1371/journal.ppat.1012186

Long-term hematopoietic stem cells trigger quiescence in Leishmania parasites

Laura Dirkx, Sara I. Van Acker, Yasmine Nicolaes, João Luís Reis Cunha, Rokaya Ahmad, Rik Hendrickx, Ben Caljon, Hideo Imamura, Didier G. Ebo, Daniel C. Jeffares, Yann G.-J. Sterckx, Louis Maes, Sarah Hendrickx, Guy Caljon

PLOS Pathogens: published April 24, 2024 | https://doi.org/10.1371/journal.ppat.1012181

Enterovirus virus-like-particle and inactivated poliovirus vaccines do not elicit substantive cross-reactive antibody responses

Daniel L. Moss, Alden C. Paine, Peter W. Krug, Masaru Kanekiyo, Tracy J. Ruckwardt

PLOS Pathogens: published April 25, 2024 | https://doi.org/10.1371/journal.ppat.1012159

The inflammasome pathway is activated by dengue virus non-structural protein 1 and is protective during dengue virus infection

Marcus P. Wong, Evan Y. W. Juan, Felix Pahmeier, Sai S. Chelluri, Phoebe Wang, Bryan Castillo-Rojas, Sophie F. Blanc, Scott B. Biering, Russell E. Vance, Eva Harris

PLOS Pathogens: published April 25, 2024 | https://doi.org/10.1371/journal.ppat.1012167

Picornavirus security proteins promote the release of extracellular vesicle enclosed viruses via the modulation of host kinases

Kyra A. Y. Defourny, Xinyi Pei, Frank J. M. van Kuppeveld, Esther N. M. Nolte-´t Hoen

PLOS Pathogens: published April 25, 2024 | https://doi.org/10.1371/journal.ppat.1012133

Direct and indirect effects of CYTOR lncRNA regulate HIV gene expression

Alona Kuzmina, Lopamudra Sadhu, Md Hasanuzzaman, Koh Fujinaga, Jacob C. Schwartz, Oliver T. Fackler, Ran Taube

PLOS Pathogens: published April 25, 2024 | https://doi.org/10.1371/journal.ppat.1012172

Identification of a viral gene essential for the genome replication of a domesticated endogenous virus in ichneumonid parasitoid wasps

Ange Lorenzi, Fabrice Legeai, Véronique Jouan, Pierre-Alain Girard, Michael R. Strand, Marc Ravallec, Magali Eychenne, Anthony Bretaudeau, Stéphanie Robin, Jeanne Rochefort, Mathilde Villegas, Gaelen R. Burke, Rita Rebollo, Nicolas Nègre, Anne-Nathalie Volkoff

PLOS Pathogens: published April 25, 2024 | https://doi.org/10.1371/journal.ppat.1011980

Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity

Qiongqiong Zhou, Deshi Shi, Yan-Dong Tang, Longfeng Zhang, Boli Hu, Chunfu Zheng, Li Huang, Changjiang Weng

PLOS Pathogens: published April 26, 2024 | https://doi.org/10.1371/journal.ppat.1012146

Cryptosporidium life cycle small molecule probing implicates translational repression and an Apetala 2 transcription factor in macrogamont differentiation

Muhammad M. Hasan, Ethan B. Mattice, José E. Teixeira, Rajiv S. Jumani, Erin E. Stebbins, Connor E. Klopfer, Sebastian E. Franco, Melissa S. Love, Case W. McNamara, Christopher D. Huston

PLOS Pathogens: published April 26, 2024 | https://doi.org/10.1371/journal.ppat.1011906

Predicting the presence of infectious virus from PCR data: A meta-analysis of SARS-CoV-2 in non-human primates

Celine E. Snedden, James O. Lloyd-Smith

PLOS Pathogens: published April 29, 2024 | https://doi.org/10.1371/journal.ppat.1012171

Germinal center cytokine driven epigenetic control of Epstein-Barr virus latency gene expression

Yifei Liao, Jinjie Yan, Nina R. Beri, Lisa Giulino-Roth, Ethel Cesarman, Benjamin E. Gewurz

PLOS Pathogens: published April 29, 2024 | https://doi.org/10.1371/journal.ppat.1011939

Immune signaling of Litopenaeus vannamei c-type lysozyme and its role during microsporidian Enterocytozoon hepatopenaei (EHP) infection

Nutthapon Sangklai, Premruethai Supungul, Pattana Jaroenlak, Anchalee Tassanakajon

PLOS Pathogens: published April 29, 2024 | https://doi.org/10.1371/journal.ppat.1012199

CD39 expression by regulatory T cells participates in CD8+ T cell suppression during experimental Trypanosoma cruzi infection

Cintia L. Araujo Furlan, Santiago Boccardo, Constanza Rodriguez, Verónica S. Mary, Camila M. S. Gimenez, Simon C. Robson, Adriana Gruppi, Carolina L. Montes, Eva V. Acosta Rodríguez

PLOS Pathogens: published April 29, 2024 | https://doi.org/10.1371/journal.ppat.1012191

Correction: An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing

Raymond W. Wong, Ahalya Balachandran, Peter K. Cheung, Ran Cheng, Qun Pan, Peter Stoilov, P. Richard Harrigan, Benjamin J. Blencowe, Donald R. Branch, Alan Cochrane

PLOS Pathogens: published April 9, 2024 | https://doi.org/10.1371/journal.ppat.1012155

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1. An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing