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May 2023

A chitin-rich, hyperbranched microcolony of Aspergillus fumigatus that overexpresses the transcription factor ZfpA. Chitin is represented in cyan and cytoplasmic RFP is shown in magenta. Schoen et al. 2023

Image Credit: Taylor J. Schoen

Pearls

Prions are the greatest protein misfolding problem, and yeast has several solutions

Reed B. Wickner, Herman K. Edskes, Songsong Wu, Kristen Gregg

Advances in the treatment of invasive fungal disease

Zhuan Zhang, Gerald F. Bills, Zhiqiang An

APOBECs: Our fickle friends?

Jaquelin P. Dudley

Induction mechanisms and strategies underlying interprophage competition during polylysogeny

Justin E. Silpe, Olivia P. Duddy, Bonnie L. Bassler

Unmasking a fungal fire

Ivy M. Dambuza, Adilia Warris, Fabián Salazar

Reviews

A bacterial binary toxin system that kills both insects and aquatic crustaceans: Photorhabdus insect-related toxins A and B

Hao-Ching Wang, Shin-Jen Lin, Han-Ching Wang, Ramya Kumar, Phuoc Thien Le, Jiann-Horng Leu

The multifaceted interactions between pathogens and host ESCRT machinery

Yolanda Rivera-Cuevas, Vern B. Carruthers

Roles of long non-coding RNAs in plant immunity

Juan Huang, Wenling Zhou, Xiaoming Zhang, Yi Li

Research Articles

Intracellular bottlenecking permits no more than three tomato yellow leaf curl virus genomes to initiate replication in a single cell

Ruifan Ren, Limin Zheng, Junping Han, Camila Perdoncini Carvalho, Shuhei Miyashita, Deyong Zhang, Feng Qu

Aspergillus fumigatus transcription factor ZfpA regulates hyphal development and alters susceptibility to antifungals and neutrophil killing during infection

Taylor J. Schoen, Dante G. Calise, Jin Woo Bok, Morgan A. Giese, Chibueze D. Nwagwu, Robert Zarnowski, David Andes, Anna Huttenlocher, Nancy P. Keller

Identification of diphenylurea derivatives as novel endocytosis inhibitors that demonstrate broad-spectrum activity against SARS-CoV-2 and influenza A virus both in vitro and in vivo

Nirmal Kumar, Irshad Maajid Taily, Charandeep Singh, Sahil Kumar, Raju S. Rajmani, Debajyoti Chakraborty, Anshul Sharma, Priyanka Singh, Krishan Gopal Thakur, Raghavan Varadarajan, Rajesh P. Ringe, Prabal Banerjee, Indranil Banerjee

Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike

Xiaodi Yu, Jarek Juraszek, Lucy Rutten, Mark J. G. Bakkers, Sven Blokland, Jelle M. Melchers, Niels J. F. van den Broek, Annemiek Y. W. Verwilligen, Pravien Abeywickrema, Johan Vingerhoets, Jean-Marc Neefs, Shah A. Mohamed Bakhash, Pavitra Roychoudhury, Alex Greninger, Sujata Sharma, Johannes P. M. Langedijk

A conserved Y-shaped RNA structure in the 3’UTR of chikungunya virus genome as a host-specialized element that modulates viral replication and evolution

Eugenia Soledad Bardossy, Sebastiano Volpe, Diego Ezequiel Alvarez, Claudia Verónica Filomatori

An Sfi1-like centrin-interacting centriolar plaque protein affects nuclear microtubule homeostasis

Christoph Wenz, Caroline Sophie Simon, Tatiany Patricia Romão, Vanessa Saskia Stürmer, Marta Machado, Natacha Klages, Anja Klemmer, Yannik Voß, Markus Ganter, Mathieu Brochet, Julien Guizetti

An ACAT inhibitor suppresses SARS-CoV-2 replication and boosts antiviral T cell activity

Peter A. C. Wing, Nathalie M. Schmidt, Rory Peters, Maximilian Erdmann, Rachel Brown, Hao Wang, Leo Swadling, COVIDsortium Investigators, Joseph Newman, Nazia Thakur, Kaho Shionoya, Sophie B. Morgan, Timothy SC Hinks, Koichi Watashi, Dalan Bailey, Scott B. Hansen, Andrew D. Davidson, Mala K. Maini, Jane A. McKeating

Trophozoite fitness dictates the intestinal epithelial cell response to Giardia intestinalis infection

Jana Grüttner, Jorik M. van Rijn, Petra Geiser, Alexandra Florbrant, Dominic-Luc Webb, Per M. Hellström, Magnus Sundbom, Mikael E. Sellin, Staffan G. Svärd

EphA2 is a functional entry receptor for HCMV infection of glioblastoma cells

Xiao-Dong Dong, Yan Li, Ying Li, Cong Sun, Shang-Xin Liu, Hao Duan, Run Cui, Qian Zhong, Yong-Gao Mou, Le Wen, Bo Yang, Mu-Sheng Zeng, Min-Hua Luo, Hua Zhang

Aal-circRNA-407 regulates ovarian development of Aedes albopictus, a major arbovirus vector, via the miR-9a-5p/Foxl axis

Yonghui Gao, Lu Yang, Yulan Chen, Peiwen Liu, Ying Zhou, Xiaoguang Chen, Jinbao Gu

Capsular polysaccharide inhibits vaccine-induced O-antigen antibody binding and function across both classical and hypervirulent K2:O1 strains of Klebsiella pneumoniae

Paeton L. Wantuch, Cory J. Knoot, Lloyd S. Robinson, Evgeny Vinogradov, Nichollas E. Scott, Christian M. Harding, David A. Rosen

Long non-coding RNAs are essential for Schistosoma mansoni pairing-dependent adult worm homeostasis and fertility

Gilbert O. Silveira, Helena S. Coelho, Adriana S. A. Pereira, Patrícia A. Miyasato, Daisy W. Santos, Lucas F. Maciel, Giovanna G. G. Olberg, Ana C. Tahira, Eliana Nakano, Maria Leonor S. Oliveira, Murilo S. Amaral, Sergio Verjovski-Almeida

CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy

Colin P. Sharp, Beth H. Thompson, Tessa J. Nash, Ola Diebold, Rute M. Pinto, Luke Thorley, Yao-Tang Lin, Samantha Sives, Helen Wise, Sara Clohisey Hendry, Finn Grey, Lonneke Vervelde, Peter Simmonds, Paul Digard, Eleanor R. Gaunt

Hiding in the yolk: A unique feature of Legionella pneumophila infection of zebrafish

Flávia Viana, Laurent Boucontet, Valerio Laghi, Daniel Schator, Marine Ibranosyan, Sophie Jarraud, Emma Colucci-Guyon, Carmen Buchrieser

Salmonella Enteritidis T1SS protein SiiD inhibits NLRP3 inflammasome activation via repressing the mtROS-ASC dependent pathway

Yaxin Guo, Dan Gu, Tingting Huang, Ang Li, Yi Zhou, Xilong Kang, Chuang Meng, Dan Xiong, Li Song, Xinan Jiao, Zhiming Pan

Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system

Marine Blanc, Clara Lettl, Jérémy Guérin, Anaïs Vieille, Sven Furler, Sylvie Briand-Schumacher, Birgit Dreier, Célia Bergé, Andreas Plückthun, Sandrine Vadon-Le Goff, Rémi Fronzes, Patricia Rousselle, Wolfgang Fischer, Laurent Terradot

Chemosensory protein regulates the behavioural response of Frankliniella intonsa and Frankliniella occidentalis to tomato zonate spot virus–Infected pepper (Capsicum annuum)

Heng Li, Yixin Chen, Chengcong Lu, Houjun Tian, Shuo Lin, Liang Wang, Tingting Linghu, Xue Zheng, Hui Wei, Xiaojing Fan, Yong Chen

Bcl-xL is required to protect endothelial cells latently infected with KSHV from virus induced intrinsic apoptosis

Lyndsey N. Moore, Daniel L. Holmes, Anjali Sharma, Joselyn Landazuri Vinueza, Michael Lagunoff

α-Hemolysin promotes uropathogenic E. coli persistence in bladder epithelial cells via abrogating bacteria-harboring lysosome acidification

Manisha Naskar, Viraj P. Parekh, Mathew A. Abraham, Zehra Alibasic, Min Jung Kim, Gyeongseo Suk, Joo Hwan Noh, Kwan Young Ko, Joonha Lee, Chungho Kim, Hana Yoon, Soman N. Abraham, Hae Woong Choi

Decoding murine cytomegalovirus

Manivel Lodha, Ihsan Muchsin, Christopher Jürges, Vanda Juranic Lisnic, Anne L’Hernault, Andrzej J. Rutkowski, Bhupesh K. Prusty, Arnhild Grothey, Andrea Milic, Thomas Hennig, Stipan Jonjic, Caroline C. Friedel, Florian Erhard, Lars Dölken

A secreted protease-like protein in Zymoseptoria tritici is responsible for avirulence on Stb9 resistance gene in wheat

Reda Amezrou, Colette Audéon, Jérôme Compain, Sandrine Gélisse, Aurélie Ducasse, Cyrille Saintenac, Nicolas Lapalu, Clémentine Louet, Simon Orford, Daniel Croll, Joëlle Amselem, Sabine Fillinger, Thierry C. Marcel

Upregulation of LAG3 modulates the immune imbalance of CD4+ T-cell subsets and exacerbates disease progression in patients with alveolar echinococcosis and a mouse model

Dewei Li, Abidan Ainiwaer, Xuran Zheng, Maolin Wang, Yang Shi, Zibigu Rousu, Xinling Hou, Xuejiao Kang, Muesier Maimaiti, Hui Wang, Jing Li, Chuanshan Zhang

Intervention reducing malaria parasite load in vector mosquitoes: No impact on Plasmodium falciparum extrinsic incubation period and the survival of Anopheles gambiae

Edwige Guissou, Dari Frédéric Da, Domombabele François de Sales Hien, Koudraogo Bienvenue Yameogo, Serge Rakiswende Yerbanga, Georges Anicet Ouédraogo, Kounbobr Roch Dabiré, Thierry Lefèvre, Anna Cohuet

Identification of CDRH3 loops in the B cell receptor repertoire that can be engaged by candidate immunogens

Olivia Swanson, Joshua S. Martin Beem, Brianna Rhodes, Avivah Wang, Maggie Barr, Haiyan Chen, Robert Parks, Kevin O. Saunders, Barton F. Haynes, Kevin Wiehe, Mihai L. Azoitei

Pathogenicity, tissue tropism and potential vertical transmission of SARSr-CoV-2 in Malayan pangolins

Xianghui Liang, Xiaoyuan Chen, Junqiong Zhai, Xiaobing Li, Xu Zhang, Zhipeng Zhang, Ping Zhang, Xiao Wang, Xinyuan Cui, Hai Wang, Niu Zhou, Zu-Jin Chen, Renwei Su, Fuqing Zhou, Edward C. Holmes, David M. Irwin, Rui-Ai Chen, Qian He, Ya-Jiang Wu, Chen Wang, Xue-Qing Du, Shi-Ming Peng, Wei-Jun Xie, Fen Shan, Wan-Ping Li, Jun-Wei Dai, Xuejuan Shen, Yaoyu Feng, Lihua Xiao, Wu Chen, Yongyi Shen

Distinct immune responses associated with vaccination status and protection outcomes after malaria challenge

Damian A. Oyong, Fergal J. Duffy, Maxwell L. Neal, Ying Du, Jason Carnes, Katharine V. Schwedhelm, Nina Hertoghs, Seong-Hwan Jun, Helen Miller, John D. Aitchison, Stephen C. De Rosa, Evan W. Newell, M Juliana McElrath, Suzanne M. McDermott, Kenneth D. Stuart

Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2

Yong Ma, Pengbin Li, Yunqi Hu, Tianyi Qiu, Lixiang Wang, Hongjie Lu, Kexin Lv, Mengxin Xu, Jiaxin Zhuang, Xue Liu, Suhua He, Bing He, Shuning Liu, Lin Liu, Yuanyuan Wang, Xinyu Yue, Yanmei Zhai, Wanyu Luo, Haoting Mai, Yu Kuang, Shifeng Chen, Feng Ye, Na Zhou, Wenjing Zhao, Jun Chen, Shoudeng Chen, Xiaoli Xiong, Mang Shi, Ji-An Pan, Yao-Qing Chen

Integrated post-genomic cell wall analysis reveals floating biofilm formation associated with high expression of flocculins in the pathogen Pichia kudriavzevii

María Alvarado, Jesús Alberto Gómez-Navajas, María Teresa Blázquez-Muñoz, Emilia Gómez-Molero, Carmen Berbegal, Elena Eraso, Gertjan Kramer, Piet W. J. De Groot

The host-directed therapeutic imatinib mesylate accelerates immune responses to Mycobacterium marinum infection and limits pathology associated with granulomas

Tesia L. Cleverley, Siri Peddineni, Jeannette Guarner, Francesca Cingolani, Pamela K. Garcia, Heather Koehler, Edward S. Mocarski, Daniel Kalman

In vitro evidence against productive SARS-CoV-2 infection of human testicular cells: Bystander effects of infection mediate testicular injury

Stefanos Giannakopoulos, Daniel P. Strange, Boonyanudh Jiyarom, Omar Abdelaal, Aaron W. Bradshaw, Vivek R. Nerurkar, Monika A. Ward, Jackson Bakse, Jonathan Yap, Selena Vanapruks, William A. Boisvert, Michelle D. Tallquist, Cecilia Shikuma, Hooman Sadri-Ardekani, Philip Clapp, Sean V. Murphy, Saguna Verma

Enhanced stability of the SARS CoV-2 spike glycoprotein following modification of an alanine cavity in the protein core

Pantelis Poumbourios, Christine Langer, Irene Boo, Tasnim Zakir, Rob J. Center, Anouschka Akerman, Vanessa Milogiannakis, Anupriya Aggarwal, Bronte A. Johnstone, Jungmin Ha, Fasséli Coulibaly, Stuart G. Turville, Heidi E. Drummer

Melatonin alleviates lung injury in H1N1-infected mice by mast cell inactivation and cytokine storm suppression

Caiyun Huo, Yuling Tang, Xinsen Li, Deping Han, Qingyue Gu, Ruijing Su, Yunjie Liu, Russel J. Reiter, Guoshi Liu, Yanxin Hu, Hanchun Yang

The Rvv two-component regulatory system regulates biofilm formation and colonization in Vibrio cholerae

Giordan Kitts, Andrew Rogers, Jennifer K. Teschler, Jin Hwan Park, Michael A. Trebino, Issac Chaudry, Ivan Erill, Fitnat H. Yildiz

A genome-wide screen in macrophages identifies PTEN as required for myeloid restriction of Listeria monocytogenes infection

Rochelle C. Glover, Nicole H. Schwardt, Shania-Kate E. Leano, Madison E. Sanchez, Maureen K. Thomason, Andrew J. Olive, Michelle L. Reniere

Investigating the outcomes of virus coinfection within and across host species

Ryan M. Imrie, Sarah K. Walsh, Katherine E. Roberts, Joanne Lello, Ben Longdon

Functional characterization of the gonococcal polyphosphate pseudo-capsule

Benedetta Manca, Giada Buffi, Greta Magri, Mariangela Del Vecchio, Anna Rita Taddei, Alfredo Pezzicoli, Maria Giuliani

A novel partitivirus orchestrates conidiation, stress response, pathogenicity, and secondary metabolism of the entomopathogenic fungus Metarhizium majus

Ping Wang, Guogen Yang, Najie Shi, Cheng Zhao, Fenglin Hu, Robert H. A. Coutts, Ioly Kotta-Loizou, Bo Huang

Globoside and the mucosal pH mediate parvovirus B19 entry through the epithelial barrier

Corinne Suter, Minela Colakovic, Jan Bieri, Mitra Gultom, Ronald Dijkman, Carlos Ros

Hepatitis B virus hijacks TSG101 to facilitate egress via multiple vesicle bodies

Yingcheng Zheng, Mengfei Wang, Sitong Li, Yanan Bu, Zaichao Xu, Guoguo Zhu, Chuanjian Wu, Kaitao Zhao, Aixin Li, Quan Chen, Jingjing Wang, Rong Hua, Yan Teng, Li Zhao, Xiaoming Cheng, Yuchen Xia

Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like expression in Schistosoma haematobium and Schistosoma mansoni infection

Rebecca C. Oettle, Harriet A. Dickinson, Colin M. Fitzsimmons, Moussa Sacko, Edridah M. Tukahebwa, Iain W. Chalmers, Shona Wilson

Coccidioides undetected in soils from agricultural land and uncorrelated with time or the greater soil fungal community on undeveloped land

Robert Wagner, Liliam Montoya, Jennifer R. Head, Simon Campo, Justin Remais, John W. Taylor

Copper ions inhibit pentose phosphate pathway function in Staphylococcus aureus

Javiera Norambuena, Hassan Al-Tameemi, Hannah Bovermann, Jisun Kim, William N. Beavers, Eric P. Skaar, Dane Parker, Jeffrey M. Boyd

Genomes of the autonomous parvovirus minute virus of mice induce replication stress through RPA exhaustion

MegAnn K. Haubold, Jessica N. Pita Aquino, Sarah R. Rubin, Isabella K. Jones, Clairine I. S. Larsen, Edward Pham, Kinjal Majumder

HIV, asymptomatic STI, and the rectal mucosal immune environment among young men who have sex with men

Vanessa E. Van Doren, S. Abigail Smith, Yi-Juan Hu, Gregory Tharp, Steven Bosinger, Cassie G. Ackerley, Phillip M. Murray, Rama R. Amara, Praveen K. Amancha, Robert A. Arthur, H. Richard Johnston, Colleen F. Kelley

Allosteric regulation of Senecavirus A 3Cpro proteolytic activity by an endogenous phospholipid

Hai-Fan Zhao, Liang Meng, Zhi Geng, Zeng-Qiang Gao, Yu-Hui Dong, Hai-Wei Wang, Heng Zhang

An unbroken network of interactions connecting flagellin domains is required for motility in viscous environments

Marko Nedeljković, Mark A. B. Kreutzberger, Sandra Postel, Daniel Bonsor, Yingying Xing, Neil Jacob, William J. Schuler, Edward H. Egelman, Eric J. Sundberg

Antibody-dependent cellular cytotoxicity, infected cell binding and neutralization by antibodies to the SIV envelope glycoprotein

Michael W. Grunst, Ruby A. Ladd, Natasha M. Clark, Hwi Min Gil, Vadim A. Klenchin, Rosemarie Mason, Genoveffa Franchini, Mario Roederer, David T. Evans

Airway proteolytic control of pneumococcal competence

Haley Echlin, Amy Iverson, Ugo Sardo, Jason W. Rosch

Viral vector delivered immunogen focuses HIV-1 antibody specificity and increases durability of the circulating antibody recall response

LaTonya D. Williams, Xiaoying Shen, Sheetal S. Sawant, Siriwat Akapirat, Lindsay C. Dahora, Matthew Zirui Tay, Sherry Stanfield-Oakley, Saintedym Wills, Derrick Goodman, DeAnna Tenney, Rachel L. Spreng, Lu Zhang, Nicole L. Yates, David C. Montefiori, Michael A. Eller, David Easterhoff, Thomas J. Hope, Supachai Rerks-Ngarm, Punnee Pittisuttithum, Sorachai Nitayaphan, Jean-Louis Excler, Jerome H. Kim, Nelson L. Michael, Merlin L. Robb, Robert J. O’Connell, Nicos Karasavvas, Sandhya Vasan, Guido Ferrari, Georgia D. Tomaras, RV305 study team