Cell death as a defense strategy against pathogens in plants and animals

Jose Salguero-Linares, Nuria S. Coll

PLOS Pathogens: published April 6, 2023 | https://doi.org/10.1371/journal.ppat.1011253

Ribosome heterogeneity and specialization of Plasmodium parasites

James P. McGee, Jean-Paul Armache, Scott E. Lindner

PLOS Pathogens: published April 13, 2023 | https://doi.org/10.1371/journal.ppat.1011267

Small family, big impact: RNL helper NLRs and their importance in plant innate immunity

Svenja C. Saile, Farid El Kasmi

PLOS Pathogens: published April 20, 2023 | https://doi.org/10.1371/journal.ppat.1011315

Scanning barcodes: A way to explore viral populations

Emily A. Fitzmeyer, Emily N. Gallichotte, Gregory D. Ebel

PLOS Pathogens: published April 20, 2023 | https://doi.org/10.1371/journal.ppat.1011291

Redox mechanisms and their pathological role in prion diseases: The road to ruin

Jereme G. Spiers, Hsiao-Jou Cortina Chen, Joern R. Steinert

PLOS Pathogens: published April 27, 2023 | https://doi.org/10.1371/journal.ppat.1011309

Fighting pathogens in two battlefields: Antimicrobial defenses in the African lungfish

Elisa Casadei, Irene Salinas

PLOS Pathogens: published April 27, 2023 | https://doi.org/10.1371/journal.ppat.1011302

Developing an appropriate evolutionary baseline model for the study of SARS-CoV-2 patient samples

John W. Terbot II, Parul Johri, Schuyler W. Liphardt, Vivak Soni, Susanne P. Pfeifer, Brandon S. Cooper, Jeffrey M. Good, Jeffrey D. Jensen

PLOS Pathogens: published April 5, 2023 | https://doi.org/10.1371/journal.ppat.1011265

Environmental reservoirs of the drug-resistant pathogenic yeast Candida auris

Ayorinde B. Akinbobola, Ryan Kean, Syed Manzoor Ahmed Hanifi, Richard S. Quilliam

PLOS Pathogens: published April 13, 2023 | https://doi.org/10.1371/journal.ppat.1011268

MoErv14 mediates the intracellular transport of cell membrane receptors to govern the appressorial formation and pathogenicity of Magnaporthe oryzae

Bin Qian, Xiaotong Su, Ziyuan Ye, Xinyu Liu, Muxing Liu, Haifeng Zhang, Ping Wang, Zhengguang Zhang

PLOS Pathogens: published April 3, 2023 | https://doi.org/10.1371/journal.ppat.1011251

Evolutionary dynamics of dengue virus in India

Suraj Jagtap, Chitra Pattabiraman, Arun Sankaradoss, Sudhir Krishna, Rahul Roy

PLOS Pathogens: published April 3, 2023 | https://doi.org/10.1371/journal.ppat.1010862

Variation in anthelmintic responses are driven by genetic differences among diverse C. elegans wild strains

Amanda O. Shaver, Janneke Wit, Clayton M. Dilks, Timothy A. Crombie, Hanchen Li, Raffi V. Aroian, Erik C. Andersen

PLOS Pathogens: published April 3, 2023 | https://doi.org/10.1371/journal.ppat.1011285

Naturally occurring substitution of an amino acid in a plant virus gene-silencing suppressor enhances viral adaptation to increasing thermal stress

Lina Cai, Mingqing Dang, Yawen Yang, Ruoxin Mei, Fan Li, Xiaorong Tao, Peter Palukaitis, Randy Beckett, W. Allen Miller, Stewart M. Gray, Yi Xu

PLOS Pathogens: published April 3, 2023 | https://doi.org/10.1371/journal.ppat.1011301

Essential role of an ERV-derived Env38 protein in adaptive humoral immunity against an exogenous SVCV infection in a zebrafish model

Yun Hong, Chong-bin Hu, Jun Bai, Dong-dong Fan, Ai-fu Lin, Li-xin Xiang, Jian-zhong Shao

PLOS Pathogens: published April 4, 2023 | https://doi.org/10.1371/journal.ppat.1011222

Syrian hamster convalescence from prototype SARS-CoV-2 confers measurable protection against the attenuated disease caused by the Omicron variant

Kathryn A. Ryan, Kevin R. Bewley, Robert J. Watson, Christopher Burton, Oliver Carnell, Breeze E. Cavell, Amy Challis, Naomi S. Coombes, Elizabeth R. Davies, Jack Edun-Huges, Kirsty Emery, Rachel Fell, Susan A. Fotheringham, Karen E. Gooch, Kathryn Gowan, Alastair Handley, Debbie J. Harris, Richard Hesp, Laura Hunter, Richard Humphreys, Rachel Johnson, Chelsea Kennard, Daniel Knott, Sian Lister, Daniel Morley, Didier Ngabo, Karen L. Osman, Jemma Paterson, Elizabeth J. Penn, Steven T. Pullan, Kevin S. Richards, Sian Summers, Stephen R. Thomas, Thomas Weldon, Nathan R. Wiblin, Emma L. Rayner, Richard T. Vipond, Bassam Hallis, Francisco J. Salguero, Simon G. P. Funnell, Yper Hall

PLOS Pathogens: published April 4, 2023 | https://doi.org/10.1371/journal.ppat.1011293

Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania

Michaela Zwyer, Liliana K. Rutaihwa, Etthel Windels, Jerry Hella, Fabrizio Menardo, Mohamed Sasamalo, Gregor Sommer, Lena Schmülling, Sonia Borrell, Miriam Reinhard, Anna Dötsch, Hellen Hiza, Christoph Stritt, George Sikalengo, Lukas Fenner, Bouke C. De Jong, Midori Kato-Maeda, Levan Jugheli, Joel D. Ernst, Stefan Niemann, Leila Jeljeli, Marie Ballif, Matthias Egger, Niaina Rakotosamimanana, Dorothy Yeboah-Manu, Prince Asare, Bijaya Malla, Horng Yunn Dou, Nicolas Zetola, Robert J. Wilkinson, Helen Cox, E Jane Carter, Joachim Gnokoro, Marcel Yotebieng, Eduardo Gotuzzo, Alash’le Abimiku, Anchalee Avihingsanon, Zhi Ming Xu, Jacques Fellay, Damien Portevin, Klaus Reither, Tanja Stadler, Sebastien Gagneux, Daniela Brites

PLOS Pathogens: published April 4, 2023 | https://doi.org/10.1371/journal.ppat.1010893

Th2-dependent STAT6-regulated genes in intestinal epithelial cells mediate larval trapping during secondary Heligmosomoides polygyrus bakeri infection

Stefanie Westermann, Christoph Schubart, Axel Dietschmann, Kirstin Castiglione, Daniel Radtke, David Voehringer

PLOS Pathogens: published April 5, 2023 | https://doi.org/10.1371/journal.ppat.1011296

The E2 glycoprotein holds key residues for Mayaro virus adaptation to the urban Aedes aegypti mosquito

Chelsea Cereghino, Ferdinand Roesch, Lucía Carrau, Alexandra Hardy, Helder V. Ribeiro-Filho, Annabelle Henrion-Lacritick, Cassandra Koh, Jeffrey M. Marano, Tyler A. Bates, Pallavi Rai, Christina Chuong, Shamima Akter, Thomas Vallet, Hervé Blanc, Truitt J. Elliott, Anne M. Brown, Pawel Michalak, Tanya LeRoith, Jesse D. Bloom, Rafael Elias Marques, Maria-Carla Saleh, Marco Vignuzzi, James Weger-Lucarelli

PLOS Pathogens: published April 5, 2023 | https://doi.org/10.1371/journal.ppat.1010491

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

Dongchun Ni, Priscilla Turelli, Bertrand Beckert, Sergey Nazarov, Emiko Uchikawa, Alexander Myasnikov, Florence Pojer, Didier Trono, Henning Stahlberg, Kelvin Lau

PLOS Pathogens: published April 5, 2023 | https://doi.org/10.1371/journal.ppat.1011206

Chitinase A, a tightly regulated virulence factor of Salmonella enterica serovar Typhimurium, is actively secreted by a Type 10 Secretion System

Lena Krone, Larissa Faass, Martina Hauke, Christine Josenhans, Tobias Geiger

PLOS Pathogens: published April 5, 2023 | https://doi.org/10.1371/journal.ppat.1011306

Porphyromonas gingivalis induction of TLR2 association with Vinculin enables PI3K activation and immune evasion

Karthikeyan Pandi, Sarah Angabo, Jeba Gnanasekaran, Hasnaa Makkawi, Luba Eli-Berchoer, Fabian Glaser, Gabriel Nussbaum

PLOS Pathogens: published April 6, 2023 | https://doi.org/10.1371/journal.ppat.1011284

Immune evasion strategy involving propionylation by the KSHV interferon regulatory factor 1 (vIRF1)

Jiale Shi, Xuemei Jia, Yujia He, Xinyue Ma, Xiaoyu Qi, Wan Li, Shou-Jiang Gao, Qin Yan, Chun Lu

PLOS Pathogens: published April 6, 2023 | https://doi.org/10.1371/journal.ppat.1011324

Selenoprotein K enhances STING oligomerization to facilitate antiviral response

Lin Lv, Li Chai, Jie Wang, Mengge Wang, Danhui Qin, Hui Song, Yue Fu, Chunyuan Zhao, Jihui Jia, Wei Zhao, Mutian Jia

PLOS Pathogens: published April 6, 2023 | https://doi.org/10.1371/journal.ppat.1011314

A compensatory RNase E variation increases Iron Piracy and Virulence in multidrug-resistant Pseudomonas aeruginosa during Macrophage infection

Mylene Vaillancourt, Anna Clara Milesi Galdino, Sam P. Limsuwannarot, Diana Celedonio, Elizabeth Dimitrova, Matthew Broerman, Catherine Bresee, Yohei Doi, Janet S. Lee, William C. Parks, Peter Jorth

PLOS Pathogens: published April 7, 2023 | https://doi.org/10.1371/journal.ppat.1010942

WRKY1 represses the WHIRLY1 transcription factor to positively regulate plant defense against geminivirus infection

Shaoshuang Sun, Shupeng Li, Xueping Zhou, Xiuling Yang

PLOS Pathogens: published April 7, 2023 | https://doi.org/10.1371/journal.ppat.1011319

MmuPV1 E7’s interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease

James C. Romero-Masters, Miranda Grace, Denis Lee, Joshua Lei, Melanie DePamphilis, Darya Buehler, Rong Hu, Ella Ward-Shaw, Simon Blaine-Sauer, Nathalie Lavoie, Elizabeth A. White, Karl Munger, Paul F. Lambert

PLOS Pathogens: published April 10, 2023 | https://doi.org/10.1371/journal.ppat.1011215

Dengue and chikungunya virus loads in the mosquito Aedes aegypti are determined by distinct genetic architectures

Mario Novelo, Heverton LC Dutra, Hillery C. Metz, Matthew J. Jones, Leah T. Sigle, Francesca D. Frentiu, Scott L. Allen, Stephen F. Chenoweth, Elizabeth A. McGraw

PLOS Pathogens: published April 12, 2023 | https://doi.org/10.1371/journal.ppat.1011307

N⁶-methyladenosine reader protein YTHDC1 regulates influenza A virus NS segment splicing and replication

Yinxing Zhu, Ruifang Wang, Jiahui Zou, Shan Tian, Luyao Yu, Yuanbao Zhou, Ying Ran, Meilin Jin, Huanchun Chen, Hongbo Zhou

PLOS Pathogens: published April 13, 2023 | https://doi.org/10.1371/journal.ppat.1011305

SOX2 downregulation of PML increases HCMV gene expression and growth of glioma cells

Le Wen, Xian-Zhang Wang, Yong Qiu, Yue-Peng Zhou, Qing-Yang Zhang, Shuang Cheng, Jin-Yan Sun, Xing-Jun Jiang, Simon Rayner, William J. Britt, Jian Chen, Fei Hu, Fang-Cheng Li, Min-Hua Luo, Han Cheng

PLOS Pathogens: published April 14, 2023 | https://doi.org/10.1371/journal.ppat.1011316

Architecture of the biofilm-associated archaic Chaperone-Usher pilus CupE from Pseudomonas aeruginosa

Jan Böhning, Adrian W. Dobbelstein, Nina Sulkowski, Kira Eilers, Andriko von Kügelgen, Abul K. Tarafder, Sew-Yeu Peak-Chew, Mark Skehel, Vikram Alva, Alain Filloux, Tanmay A. M. Bharat

PLOS Pathogens: published April 14, 2023 | https://doi.org/10.1371/journal.ppat.1011177

Tim-3 regulates the immunosuppressive function of decidual MDSCs via the Fyn-STAT3-C/EBPβ pathway during Toxoplasma gondii infection

Houbao Qi, Yuantao Li, Xianbing Liu, Yuzhu Jiang, Zhidan Li, Xiaoyan Xu, Haixia Zhang, Xuemei Hu

PLOS Pathogens: published April 14, 2023 | https://doi.org/10.1371/journal.ppat.1011329

4’-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

Carolin M. Lieber, Megha Aggarwal, Jeong-Joong Yoon, Robert M. Cox, Hae-Ji Kang, Julien Sourimant, Mart Toots, Scott K. Johnson, Cheryl A. Jones, Zachary M. Sticher, Alexander A. Kolykhalov, Manohar T. Saindane, Stephen M. Tompkins, Oliver Planz, George R. Painter, Michael G. Natchus, Kaori Sakamoto, Richard K. Plemper

PLOS Pathogens: published April 17, 2023 | https://doi.org/10.1371/journal.ppat.1011342

Constitutive secretion of pro-IL-18 allows keratinocytes to initiate inflammation during bacterial infection

Anders F. Johnson, Jenna S. Sands, Keya M. Trivedi, Raedeen Russell, Doris L. LaRock, Christopher N. LaRock

PLOS Pathogens: published April 17, 2023 | https://doi.org/10.1371/journal.ppat.1011321

Maximal interferon induction by influenza lacking NS1 is infrequent owing to requirements for replication and export

Alison C. Vicary, Marisa Mendes, Sharmada Swaminath, Asama Lekbua, Jack Reddan, Zaida K. Rodriguez, Alistair B. Russell

PLOS Pathogens: published April 17, 2023 | https://doi.org/10.1371/journal.ppat.1010943

ROP16-mediated activation of STAT6 enhances cyst development of type III Toxoplasma gondii in neurons

Joshua A. Kochanowsky, Sambamurthy Chandrasekaran, Jacqueline R. Sanchez, Kaitlin K. Thomas, Anita A. Koshy

PLOS Pathogens: published April 17, 2023 | https://doi.org/10.1371/journal.ppat.1011347

The viral packaging motor potentiates Kaposi’s sarcoma-associated herpesvirus gene expression late in infection

Chloe O. McCollum, Allison L. Didychuk, Dawei Liu, Laura A. Murray-Nerger, Ileana M. Cristea, Britt A. Glaunsinger

PLOS Pathogens: published April 17, 2023 | https://doi.org/10.1371/journal.ppat.1011163

Polyamines and eIF5A hypusination facilitate SREBP2 synthesis and cholesterol production leading to enhanced enterovirus attachment and infection

Mason R. Firpo, Natalie J. LoMascolo, Marine J. Petit, Priya S. Shah, Bryan C. Mounce

PLOS Pathogens: published April 18, 2023 | https://doi.org/10.1371/journal.ppat.1011317

Variant-specific introduction and dispersal dynamics of SARS-CoV-2 in New York City – from Alpha to Omicron

Simon Dellicour, Samuel L. Hong, Verity Hill, Dacia Dimartino, Christian Marier, Paul Zappile, Gordon W. Harkins, Philippe Lemey, Guy Baele, Ralf Duerr, Adriana Heguy

PLOS Pathogens: published April 18, 2023 | https://doi.org/10.1371/journal.ppat.1011348

A replicon RNA vaccine can induce durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned

Megan A. O’Connor, David W. Hawman, Kimberly Meade-White, Shanna Leventhal, Wenjun Song, Samantha Randall, Jacob Archer, Thomas B. Lewis, Brieann Brown, Megan N. Fredericks, Kaitlin R. Sprouse, Hillary C. Tunggal, Mara Maughan, Naoto Iwayama, Chul Ahrens, William Garrison, Solomon Wangari, Kathryn A. Guerriero, Patrick Hanley, Jamie Lovaglio, Greg Saturday, David Veesler, Paul T. Edlefsen, Amit P. Khandhar, Heinz Feldmann, Deborah Heydenburg Fuller, Jesse H. Erasmus

PLOS Pathogens: published April 19, 2023 | https://doi.org/10.1371/journal.ppat.1011298

CMPK2 restricts Zika virus replication by inhibiting viral translation

Joanna B. Pawlak, Jack Chun-Chieh Hsu, Hongjie Xia, Patrick Han, Hee-Won Suh, Tyler L. Grove, Juliet Morrison, Pei-Yong Shi, Peter Cresswell, Maudry Laurent-Rolle

PLOS Pathogens: published April 19, 2023 | https://doi.org/10.1371/journal.ppat.1011286

The proteasome regulator Rpn4 controls antifungal drug tolerance by coupling protein homeostasis with metabolic responses to drug stress

Ka Pui Sharon Yau, Harshini Weerasinghe, Francios A. B. Olivier, Tricia L. Lo, David R. Powell, Barbara Koch, Traude H. Beilharz, Ana Traven

PLOS Pathogens: published April 19, 2023 | https://doi.org/10.1371/journal.ppat.1011338

Ability of the ash dieback pathogen to reproduce and to induce damage on its host are controlled by different environmental parameters

Benoit Marçais, Arnaud Giraudel, Claude Husson

PLOS Pathogens: published April 20, 2023 | https://doi.org/10.1371/journal.ppat.1010558

Toward a pan-SARS-CoV-2 vaccine targeting conserved epitopes on spike and non-spike proteins for potent, broad and durable immune responses

Chang Yi Wang, Wen-Jiun Peng, Be-Sheng Kuo, Yu-Hsin Ho, Min-Sheng Wang, Ya-Ting Yang, Po-Yen Chang, Yea-Huei Shen, Kao-Pin Hwang

PLOS Pathogens: published April 20, 2023 | https://doi.org/10.1371/journal.ppat.1010870

A modified Agrobacterium-mediated transformation for two oomycete pathogens

Luyao Wang, Fei Zhao, Haohao Liu, Han Chen, Fan Zhang, Suhua Li, Tongjun Sun, Vladimir Nekrasov, Sanwen Huang, Suomeng Dong

PLOS Pathogens: published April 21, 2023 | https://doi.org/10.1371/journal.ppat.1011346

The structure of a 12-segmented dsRNA reovirus: New insights into capsid stabilization and organization

Qinfen Zhang, Yuanzhu Gao, Matthew L. Baker, Shanshan Liu, Xudong Jia, Haidong Xu, Jianguo He, Jason T. Kaelber, Shaoping Weng, Wen Jiang

PLOS Pathogens: published April 21, 2023 | https://doi.org/10.1371/journal.ppat.1011341

Neutralization of zoonotic retroviruses by human antibodies: Genotype-specific epitopes within the receptor-binding domain from simian foamy virus

Lasse Toftdal Dynesen, Ignacio Fernandez, Youna Coquin, Manon Delaplace, Thomas Montange, Richard Njouom, Chanceline Bilounga-Ndongo, Félix A. Rey, Antoine Gessain, Marija Backovic, Florence Buseyne

PLOS Pathogens: published April 24, 2023 | https://doi.org/10.1371/journal.ppat.1011339

An aquatic virus exploits the IL6-STAT3-HSP90 signaling axis to promote viral entry

Guoli Hou, Zhao Lv, Wenzhi Liu, Shuting Xiong, Qiushi Zhang, Chun Li, Xiaodong Wang, Liang Hu, Chunhua Ding, Rui Song, Hongquan Wang, Yong-An Zhang, Tiaoyi Xiao, Junhua Li

PLOS Pathogens: published April 26, 2023 | https://doi.org/10.1371/journal.ppat.1011320

Related Articles

1. Correction: An aquatic virus exploits the IL6-STAT3-HSP90 signaling axis to promote viral entry

A fungal lytic polysaccharide monooxygenase is required for cell wall integrity, thermotolerance, and virulence of the fungal human pathogen Cryptococcus neoformans

Corinna Probst, Magnus Hallas-Møller, Johan Ø. Ipsen, Jacob T. Brooks, Karsten Andersen, Mireille Haon, Jean-Guy Berrin, Helle J. Martens, Connie B. Nichols, Katja S. Johansen, J. Andrew Alspaugh

PLOS Pathogens: published April 26, 2023 | https://doi.org/10.1371/journal.ppat.1010946

Glucuronoxylomannan intranasal challenge prior to Cryptococcus neoformans pulmonary infection enhances cerebral cryptococcosis in rodents

Hiu Ham Lee, Dylan J. Carmichael, Victoria Ríbeiro, Dana N. Parisi, Melissa E. Munzen, Claudia L. Charles-Niño, Mohamed F. Hamed, Ettiman Kaur, Ayush Mishra, Jiya Patel, Rikki B. Rooklin, Amina Sher, Maria A. Carrillo-Sepulveda, Eliseo A. Eugenin, Michael R. Dores, Luis R. Martinez

PLOS Pathogens: published April 28, 2023 | https://doi.org/10.1371/journal.ppat.1010941

Genomic analysis unveils genome degradation events and gene flux in the emergence and persistence of S. Paratyphi A lineages

Jobin John Jacob, Agila K Pragasam, Karthick Vasudevan, Aravind Velmurugan, Monisha Priya Teekaraman, Tharani Priya Thirumoorthy, Pallab Ray, Madhu Gupta, Arti Kapil, Sulochana Putil Bai, Savitha Nagaraj, Karnika Saigal, Temsunaro Rongsen Chandola, Maria Thomas, Ashish Bavdekar, Sheena Evelyn Ebenezer, Jayanthi Shastri, Anuradha De, Shantha Dutta, Anna P. Alexander, Roshine Mary Koshy, Dasaratha R. Jinka, Ashita Singh, Sunil Kumar Srivastava, Shalini Anandan, Gordon Dougan, Jacob John, Gagandeep Kang, Balaji Veeraraghavan, Ankur Mutreja

PLOS Pathogens: published April 28, 2023 | https://doi.org/10.1371/journal.ppat.1010650

Correction: Genome Dynamics of Campylobacter jejuni in Response to Bacteriophage Predation

Andrew E. Scott, Andrew R. Timms, Phillippa L. Connerton, Catherine Loc Carrillo, Khairul Adzfa Radzun, Ian F. Connerton

PLOS Pathogens: published April 12, 2023 | https://doi.org/10.1371/journal.ppat.1011332

Related Articles

1. Genome Dynamics of Campylobacter jejuni in Response to Bacteriophage Predation

Correction: Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques

Rachele M. Bochart, Kathleen Busman-Sahay, Stephen Bondoc, David W. Morrow, Alexandra M. Ortiz, Christine M. Fennessey, Miranda B. Fischer, Oriene Shiel, Tonya Swanson, Christine M. Shriver-Munsch, Hugh B. Crank, Kimberly M. Armantrout, Aaron M. Barber-Axthelm, Charlotte Langner, Cassandra R. Moats, Caralyn S. Labriola, Rhonda MacAllister, Michael K. Axthelm, Jason M. Brenchley, Brandon F. Keele, Jacob D. Estes, Scott G. Hansen, Jeremy V. Smedley

PLOS Pathogens: published April 19, 2023 | https://doi.org/10.1371/journal.ppat.1011343

Related Articles

1. Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques