August 2022

Human Cytomegalovirus uses multivesicular structures to release large amounts of virus products in pulses from infected cells. This route differs from classical mechanisms proposed for herpesvirus secondary envelopment and egress. The characteristics of this process seem to vary between virus strains, suggesting a role in divergent phenotypes in viral spreading. The image shows correlative light- and electron microscopy (CLEM) data of an HCMV infected cell. The virus is a dual-fluorescent variant of the HCMV strain Merlin expressing fluorescent gM-Cherry (membrane glycoprotein/ magenta) and pp150-EGFP (tegument protein/ green). The inserts depict HCMV particles in different stages of the maturation process. Flomm et al

Image Credit: Felix J Flomm and Jens B. Bosse, Hannover Medical School at CSSB Hamburg, Germany.

Pearls

Viruses in neurodegenerative diseases: More than just suspects in crimes

Pascal Leblanc, Ina Maja Vorberg

PLOS Pathogens: published August 4, 2022 | https://doi.org/10.1371/journal.ppat.1010670

Transmission through seeds: The unknown life of plant viruses

Israel Pagán

PLOS Pathogens: published August 11, 2022 | https://doi.org/10.1371/journal.ppat.1010707

Type I interferons during host–fungus interactions: Is antifungal immunity going viral?

Marina Pekmezovic, Axel Dietschmann, Mark S. Gresnigt

PLOS Pathogens: published August 25, 2022 | https://doi.org/10.1371/journal.ppat.1010740

Reviews

C3aR plays both sides in regulating resistance to bacterial infections

Jesse A. Corcoran, Brooke A. Napier

PLOS Pathogens: published August 4, 2022 | https://doi.org/10.1371/journal.ppat.1010657

Bidirectional cytokine-microRNA control: A novel immunoregulatory framework in leishmaniasis

Abdollah Jafarzadeh, Maryam Nemati, Najmeh Aminizadeh, Neelam Bodhale, Arup Sarkar, Sara Jafarzadeh, Iraj Sharifi, Bhaskar Saha

PLOS Pathogens: published August 4, 2022 | https://doi.org/10.1371/journal.ppat.1010696

Molecular architecture of bacterial type IV secretion systems

Michael J. Sheedlo, Melanie D. Ohi, D. Borden Lacy, Timothy L. Cover

PLOS Pathogens: published August 11, 2022 | https://doi.org/10.1371/journal.ppat.1010720

Viral-mediated activation and inhibition of programmed cell death

Shayla Grace Verburg, Rebecca Margaret Lelievre, Michael James Westerveld, Jordon Marcus Inkol, Yi Lin Sun, Samuel Tekeste Workenhe

PLOS Pathogens: published August 11, 2022 | https://doi.org/10.1371/journal.ppat.1010718

Research Articles

Capsule type defines the capability of Klebsiella pneumoniae in evading Kupffer cell capture in the liver

Xueting Huang, Xiuyuan Li, Haoran An, Juanjuan Wang, Ming Ding, Lijun Wang, Lulu Li, Quanjiang Ji, Fen Qu, Hui Wang, Yingchun Xu, Xinxin Lu, Yuan He, Jing-Ren Zhang

PLOS Pathogens: published August 1, 2022 | https://doi.org/10.1371/journal.ppat.1010693

Role of serine/threonine protein phosphatase PrpN in the life cycle of Bacillus anthracis

Aakriti Gangwal, Nitika Sangwan, Neha Dhasmana, Nishant Kumar, Chetkar Chandra Keshavam, Lalit K. Singh, Ankur Bothra, Ajay K. Goel, Andrei P. Pomerantsev, Stephen H. Leppla, Yogendra Singh

PLOS Pathogens: published August 1, 2022 | https://doi.org/10.1371/journal.ppat.1010729

A complete twelve-gene deletion null mutant reveals that cyclic di-GMP is a global regulator of phase-transition and host colonization in Erwinia amylovora

Roshni R. Kharadi, Kayla Selbmann, George W. Sundin

PLOS Pathogens: published August 1, 2022 | https://doi.org/10.1371/journal.ppat.1010737

KSHV RTA antagonizes SMC5/6 complex-induced viral chromatin compaction by hijacking the ubiquitin-proteasome system

Chunyan Han, Dun Zhang, Chenwu Gui, Liang Huang, Sijia Chang, Lianghui Dong, Lei Bai, Shuwen Wu, Ke Lan

PLOS Pathogens: published August 1, 2022 | https://doi.org/10.1371/journal.ppat.1010744

Streptococcal autolysin promotes dysfunction of swine tracheal epithelium by interacting with vimentin

Yu Meng, Qing Wang, Zhe Ma, Weiyi Li, Kai Niu, Ting Zhu, Huixing Lin, Chengping Lu, Hongjie Fan

PLOS Pathogens: published August 3, 2022 | https://doi.org/10.1371/journal.ppat.1010765

Intermittent bulk release of human cytomegalovirus

Felix J. Flomm, Timothy K. Soh, Carola Schneider, Linda Wedemann, Hannah M. Britt, Konstantinos Thalassinos, Søren Pfitzner, Rudolph Reimer, Kay Grünewald, Jens B. Bosse

PLOS Pathogens: published August 4, 2022 | https://doi.org/10.1371/journal.ppat.1010575

Expanding the tolerance of segmented Influenza A Virus genome using a balance compensation strategy

Xiujuan Zhao, Xiaojing Lin, Ping Li, Zinuo Chen, Chengcheng Zhang, Balaji Manicassamy, Lijun Rong, Qinghua Cui, Ruikun Du

PLOS Pathogens: published August 4, 2022 | https://doi.org/10.1371/journal.ppat.1010756

Influenza A virus elicits peri-vascular adipose tissue inflammation and vascular dysfunction of the aorta in pregnant mice

Osezua Oseghale, Stella Liong, Madison Coward-Smith, Eunice E. To, Jonathan R. Erlich, Raymond Luong, Felicia Liong, Mark Miles, Shaghayegh Norouzi, Cara Martin, Sharon O’Toole, Robert D. Brooks, Steven Bozinovski, Ross Vlahos, John J. O’Leary, Doug A. Brooks, Stavros Selemidis

PLOS Pathogens: published August 5, 2022 | https://doi.org/10.1371/journal.ppat.1010703

Deletion of the Plasmodium falciparum exported protein PTP7 leads to Maurer’s clefts vesiculation, host cell remodeling defects, and loss of surface presentation of EMP1

Olivia M. S. Carmo, Gerald J. Shami, Dezerae Cox, Boyin Liu, Adam J. Blanch, Snigdha Tiash, Leann Tilley, Matthew W. A. Dixon

PLOS Pathogens: published August 5, 2022 | https://doi.org/10.1371/journal.ppat.1009882

The TPR domain of PgaA is a multifunctional scaffold that binds PNAG and modulates PgaB-dependent polymer processing

Roland Pfoh, Adithya S. Subramanian, Jingjing Huang, Dustin J. Little, Adam Forman, Benjamin R. DiFrancesco, Negar Balouchestani-Asli, Elena N. Kitova, John S. Klassen, Régis Pomès, Mark Nitz, P. Lynne Howell

PLOS Pathogens: published August 5, 2022 | https://doi.org/10.1371/journal.ppat.1010750

Suppression of annexin A1 and its receptor reduces herpes simplex virus 1 lethality in mice

Li-Chiu Wang, Shang-Rung Wu, Hui-Wen Yao, Pin Ling, Guey-Chuen Perng, Yen-Chi Chiu, Sheng-Min Hsu, Shun-Hua Chen

PLOS Pathogens: published August 8, 2022 | https://doi.org/10.1371/journal.ppat.1010692

The chromatin remodeling protein ATRX positively regulates IRF3-dependent type I interferon production and interferon-induced gene expression

Anne-Charlotte Stilp, Myriam Scherer, Patrick König, Axel Fürstberger, Hans A. Kestler, Thomas Stamminger

PLOS Pathogens: published August 8, 2022 | https://doi.org/10.1371/journal.ppat.1010748

TMEM41B and VMP1 modulate cellular lipid and energy metabolism for facilitating dengue virus infection

Meisam Yousefi, Wai Suet Lee, Biaoguo Yan, Liang Cui, Cythia Lingli Yong, Xin Yap, Kwan Sing Leona Tay, Wenjie Qiao, Dewei Tan, Nur Insyirah Nurazmi, Martin Linster, Gavin J. D. Smith, Yie Hou Lee, Jan E. Carette, Eng Eong Ooi, Kuan Rong Chan, Yaw Shin Ooi

PLOS Pathogens: published August 8, 2022 | https://doi.org/10.1371/journal.ppat.1010763

ZccE is a Novel P-type ATPase That Protects Streptococcus mutans Against Zinc Intoxication

Tridib Ganguly, Alexandra M. Peterson, Marissa Burkholder, Jessica K. Kajfasz, Jacqueline Abranches, José A. Lemos

PLOS Pathogens: published August 8, 2022 | https://doi.org/10.1371/journal.ppat.1010477

Genomic evidence of contemporary hybridization between Schistosoma species

Duncan J. Berger, Elsa Léger, Geetha Sankaranarayanan, Mariama Sène, Nicolas D. Diouf, Muriel Rabone, Aidan Emery, Fiona Allan, James A. Cotton, Matthew Berriman, Joanne P. Webster

PLOS Pathogens: published August 8, 2022 | https://doi.org/10.1371/journal.ppat.1010706

Identification of a novel AP2 transcription factor in zygotes with an essential role in Plasmodium ookinete development

Tsubasa Nishi, Izumi Kaneko, Shiroh Iwanaga, Masao Yuda

PLOS Pathogens: published August 10, 2022 | https://doi.org/10.1371/journal.ppat.1010510

Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles

Ashwanth C. Francis, Anna Cereseto, Parmit K. Singh, Jiong Shi, Eric Poeschla, Alan N. Engelman, Christopher Aiken, Gregory B. Melikyan

PLOS Pathogens: published August 11, 2022 | https://doi.org/10.1371/journal.ppat.1010754

Malnutrition and maternal vaccination against typhoid toxin

Durga P. Neupane, Changhwan Ahn, Yi-An Yang, Gi Young Lee, Jeongmin Song

PLOS Pathogens: published August 12, 2022 | https://doi.org/10.1371/journal.ppat.1010731

Distinct translatome changes in specific neural populations precede electroencephalographic changes in prion-infected mice

Lech Kaczmarczyk, Melvin Schleif, Lars Dittrich, Rhiannan H. Williams, Maruša Koderman, Vikas Bansal, Ashish Rajput, Theresa Schulte, Maria Jonson, Clemens Krost, Fabio J. Testaquadra, Stefan Bonn, Walker S. Jackson

PLOS Pathogens: published August 12, 2022 | https://doi.org/10.1371/journal.ppat.1010747

The ESX-4 substrates, EsxU and EsxT, modulate Mycobacterium abscessus fitness

Marion Lagune, Vincent Le Moigne, Matt D. Johansen, Flor Vásquez Sotomayor, Wassim Daher, Cécile Petit, Gina Cosentino, Laura Paulowski, Thomas Gutsmann, Matthias Wilmanns, Florian P. Maurer, Jean-Louis Herrmann, Fabienne Girard-Misguich, Laurent Kremer

PLOS Pathogens: published August 12, 2022 | https://doi.org/10.1371/journal.ppat.1010771

Early and mid-gestation Zika virus (ZIKV) infection in the olive baboon (Papio anubis) leads to fetal CNS pathology by term gestation

Sunam Gurung, Darlene Reuter, Abby Norris, Molly Dubois, Marta Maxted, Krista Singleton, Marisol Castillo-Castrejon, James F. Papin, Dean A. Myers

PLOS Pathogens: published August 15, 2022 | https://doi.org/10.1371/journal.ppat.1010386

Bps polysaccharide of Bordetella pertussis resists antimicrobial peptides by functioning as a dual surface shield and decoy and converts Escherichia coli into a respiratory pathogen

Audra R. Fullen, Jessica L. Gutierrez-Ferman, Kacy S. Yount, Cheraton F. Love, Hyun G. Choi, Mario A. Vargas, Deepa Raju, Kara N. Corps, P. Lynne Howell, Purnima Dubey, Rajendar Deora

PLOS Pathogens: published August 15, 2022 | https://doi.org/10.1371/journal.ppat.1010764

Human LAMP1 accelerates Lassa virus fusion and potently promotes fusion pore dilation upon forcing viral fusion with non-endosomal membrane

You Zhang, Juan Carlos de la Torre, Gregory B. Melikyan

PLOS Pathogens: published August 15, 2022 | https://doi.org/10.1371/journal.ppat.1010625

An in vitro method for inducing titan cells reveals novel features of yeast-to-titan switching in the human fungal pathogen Cryptococcus gattii

Lamin Saidykhan, Joao Correia, Andrey Romanyuk, Anna F. A. Peacock, Guillaume E. Desanti, Leanne Taylor-Smith, Maria Makarova, Elizabeth R. Ballou, Robin C. May

PLOS Pathogens: published August 15, 2022 | https://doi.org/10.1371/journal.ppat.1010321

Salmonella Typhimurium outer membrane protein A (OmpA) renders protection from nitrosative stress of macrophages by maintaining the stability of bacterial outer membrane

Atish Roy Chowdhury, Shivjee Sah, Umesh Varshney, Dipshikha Chakravortty

PLOS Pathogens: published August 15, 2022 | https://doi.org/10.1371/journal.ppat.1010708

Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX

Takayoshi Shirasaki, Hui Feng, Helen M. E. Duyvesteyn, William G. Fusco, Kevin L. McKnight, Ling Xie, Mark Boyce, Sathish Kumar, Rina Barouch-Bentov, Olga González-López, Ryan McNamara, Li Wang, Adriana Hertel-Wulff, Xian Chen, Shirit Einav, Joseph A. Duncan, Maryna Kapustina, Elizabeth E. Fry, David I. Stuart, Stanley M. Lemon

PLOS Pathogens: published August 15, 2022 | https://doi.org/10.1371/journal.ppat.1010543

Healthy dynamics of CD4 T cells may drive HIV resurgence in perinatally-infected infants on antiretroviral therapy

Sinead E. Morris, Renate Strehlau, Stephanie Shiau, Elaine J. Abrams, Caroline T. Tiemessen, Louise Kuhn, Andrew J. Yates, on behalf of the EPIICAL Consortium and the LEOPARD study team

PLOS Pathogens: published August 15, 2022 | https://doi.org/10.1371/journal.ppat.1010751

Assembly of ordered DNA-curli fibril complexes during Salmonella biofilm formation correlates with strengths of the type I interferon and autoimmune responses

Lauren K. Nicastro, Jaime de Anda, Neha Jain, Kaitlyn C. M. Grando, Amanda L. Miller, Shingo Bessho, Stefania Gallucci, Gerard C. L. Wong, Çagla Tükel

PLOS Pathogens: published August 16, 2022 | https://doi.org/10.1371/journal.ppat.1010742

Single-cell analysis of Kaposi’s sarcoma-associated herpesvirus infection in three-dimensional air-liquid interface culture model

Kyle L. Jung, Un Yung Choi, Angela Park, Suan-Sin Foo, Stephanie Kim, Shin-Ae Lee, Jae U. Jung

PLOS Pathogens: published August 17, 2022 | https://doi.org/10.1371/journal.ppat.1010775

Analysis of non-human primate models for evaluating prion disease therapeutic efficacy

Meredith A. Mortberg, Eric Vallabh Minikel, Sonia M. Vallabh

PLOS Pathogens: published August 22, 2022 | https://doi.org/10.1371/journal.ppat.1010728

An apical protein, Pcr2, is required for persistent movement by the human parasite Toxoplasma gondii

Jonathan Munera Lopez, Isadonna F. Tengganu, Jun Liu, John M. Murray, Luisa F. Arias Padilla, Ying Zhang, Peter T. Brown, Laurence Florens, Ke Hu

PLOS Pathogens: published August 22, 2022 | https://doi.org/10.1371/journal.ppat.1010776

Divergent Plasmodium actin residues are essential for filament localization, mosquito salivary gland invasion and malaria transmission

Michelle Yee, Tobias Walther, Friedrich Frischknecht, Ross G. Douglas

PLOS Pathogens: published August 23, 2022 | https://doi.org/10.1371/journal.ppat.1010779

Human coronaviruses disassemble processing bodies

Mariel Kleer, Rory P. Mulloy, Carolyn-Ann Robinson, Danyel Evseev, Maxwell P. Bui-Marinos, Elizabeth L. Castle, Arinjay Banerjee, Samira Mubareka, Karen Mossman, Jennifer A. Corcoran

PLOS Pathogens: published August 23, 2022 | https://doi.org/10.1371/journal.ppat.1010724

Universal protection against influenza viruses by multi-subtype neuraminidase and M2 ectodomain virus-like particle

Ki-Hye Kim, Zhuo Li, Noopur Bhatnagar, Jeeva Subbiah, Bo Ryoung Park, Chong Hyun Shin, Peter Pushko, Bao-Zhong Wang, Sang-Moo Kang

PLOS Pathogens: published August 25, 2022 | https://doi.org/10.1371/journal.ppat.1010755

The baseline immunological and hygienic status of pigs impact disease severity of African swine fever

Emilia Radulovic, Kemal Mehinagic, Tsering Wüthrich, Markus Hilty, Horst Posthaus, Artur Summerfield, Nicolas Ruggli, Charaf Benarafa

PLOS Pathogens: published August 25, 2022 | https://doi.org/10.1371/journal.ppat.1010522

SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export

Ross Hall, Anabel Guedán, Melvyn W. Yap, George R. Young, Ruth Harvey, Jonathan P. Stoye, Kate N. Bishop

PLOS Pathogens: published August 25, 2022 | https://doi.org/10.1371/journal.ppat.1010349

An Arginine-Rich Motif in the ORF2 capsid protein regulates the hepatitis E virus lifecycle and interactions with the host cell

Kévin Hervouet, Martin Ferrié, Maliki Ankavay, Claire Montpellier, Charline Camuzet, Virginie Alexandre, Aïcha Dembélé, Cécile Lecoeur, Arnold Thomas Foe, Peggy Bouquet, David Hot, Thibaut Vausselin, Jean-Michel Saliou, Sophie Salomé-Desnoulez, Alexandre Vandeputte, Laurent Marsollier, Priscille Brodin, Marlène Dreux, Yves Rouillé, Jean Dubuisson, Cécile-Marie Aliouat-Denis, Laurence Cocquerel

PLOS Pathogens: published August 25, 2022 | https://doi.org/10.1371/journal.ppat.1010798

Echovirus 11 infection induces pyroptotic cell death by facilitating NLRP3 inflammasome activation

Chong Wang, Ruyi Yang, Fengxia Yang, Yang Han, Yujie Ren, Xiaobei Xiong, Xingyun Wang, Yidan Bi, Lijun Li, Yang Qiu, Yi Xu, Xi Zhou

PLOS Pathogens: published August 26, 2022 | https://doi.org/10.1371/journal.ppat.1010787

PRC1-independent binding and activity of RYBP on the KSHV genome during de novo infection

See-Chi Lee, Zsolt Toth

PLOS Pathogens: published August 26, 2022 | https://doi.org/10.1371/journal.ppat.1010801

Succinate and inosine coordinate innate immune response to bacterial infection

Ming Jiang, Zhuang-gui Chen, Hui Li, Tian-tuo Zhang, Man-jun Yang, Xuan-xian Peng, Bo Peng

PLOS Pathogens: published August 26, 2022 | https://doi.org/10.1371/journal.ppat.1010796

In vivo imaging reveals novel replication sites of a highly oncogenic avian herpesvirus in chickens

Isabelle Lantier, Corentin Mallet, Laurent Souci, Thibaut Larcher, Andele M. Conradie, Katia Courvoisier, Sascha Trapp, David Pasdeloup, Benedikt B. Kaufer, Caroline Denesvre

PLOS Pathogens: published August 29, 2022 | https://doi.org/10.1371/journal.ppat.1010745

HIV infected CD4+ T cell clones are more stable than uninfected clones during long-term antiretroviral therapy

Shuang Guo, Brian T. Luke, Amy R. Henry, Samuel Darko, Leah D. Brandt, Ling Su, David Sun, Daria Wells, Kevin W. Joseph, Dimiter Demirov, Elias K. Halvas, Daniel C. Douek, Xiaolin Wu, John W. Mellors, Stephen H. Hughes

PLOS Pathogens: published August 31, 2022 | https://doi.org/10.1371/journal.ppat.1010726

TBK1 and GABARAP family members suppress Coxsackievirus B infection by limiting viral production and promoting autophagic degradation of viral extracellular vesicles

Savannah Sawaged, Thomas Mota, Honit Piplani, Reetu Thakur, Deepti Lall, Elizabeth McCabe, Soojung Seo, Fayyaz S. Sutterwala, Ralph Feuer, Roberta A. Gottlieb, Jon Sin

PLOS Pathogens: published August 31, 2022 | https://doi.org/10.1371/journal.ppat.1010350

Corrections

Correction: A revised mechanism for how Plasmodium falciparum recruits and exports proteins into its erythrocytic host cell

The PLOS Pathogens Staff

PLOS Pathogens: published August 5, 2022 | https://doi.org/10.1371/journal.ppat.1010757

Correction: Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores

Dennis J. Doorduijn, Dani A. C. Heesterbeek, Maartje Ruyken, Carla J. C. de Haas, Daphne A. C. Stapels, Piet C. Aerts, Suzan H. M. Rooijakkers, Bart W. Bardoel

PLOS Pathogens: published August 8, 2022 | https://doi.org/10.1371/journal.ppat.1010758

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Intermittent bulk release of Human Cytomegalovirus

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