Rice gall dwarf virus (RGDV), an important rice reovirus, hijacks autophagosomes to traverse multiple insect membrane barriers in the midgut and salivary gland of leafhopper vector to enhance viral spread. In virus-infected midgut epithelial cells, ATG8 redistributed into discrete puncta, which were co-localized with viral antigens. Such virus-containing double-membraned autophagosomes are prevented from degradation, resulting in increased viral propagation. Jia et al.
Image Credit: Dongsheng Jia
Opinion
Sexual reproduction is the null hypothesis for life cycles of rust fungi
PLOS Pathogens: published May 26, 2022 | https://doi.org/10.1371/journal.ppat.1010439
Pearls
Innate immunity in fungi: Is regulated cell death involved?
PLOS Pathogens: published May 19, 2022 | https://doi.org/10.1371/journal.ppat.1010460
Overcoming pH defenses on the skin to establish infections
PLOS Pathogens: published May 26, 2022 | https://doi.org/10.1371/journal.ppat.1010512
Reviews
Innate immune surveillance of the circulation: A review on the removal of circulating virions from the bloodstream
PLOS Pathogens: published May 5, 2022 | https://doi.org/10.1371/journal.ppat.1010474
Preclinical and clinical developments for combination treatment of influenza
PLOS Pathogens: published May 12, 2022 | https://doi.org/10.1371/journal.ppat.1010481
Tuberculosis caused by Mycobacterium africanum: Knowns and unknowns
PLOS Pathogens: published May 26, 2022 | https://doi.org/10.1371/journal.ppat.1010490
Research Articles
Making genomic surveillance deliver: A lineage classification and nomenclature system to inform rabies elimination
PLOS Pathogens: published May 2, 2022 | https://doi.org/10.1371/journal.ppat.1010023
PTEN differentially regulates endocytosis, migration, and proliferation in the enteric protozoan parasite Entamoeba histolytica
PLOS Pathogens: published May 2, 2022 | https://doi.org/10.1371/journal.ppat.1010147
The endoplasmic reticulum membrane protein complex localizes to the mitochondrial - endoplasmic reticulum interface and its subunits modulate phospholipid biosynthesis in Trypanosoma brucei
PLOS Pathogens: published May 2, 2022 | https://doi.org/10.1371/journal.ppat.1009717
Beneath the surface: Amino acid variation underlying two decades of dengue virus antigenic dynamics in Bangkok, Thailand
PLOS Pathogens: published May 2, 2022 | https://doi.org/10.1371/journal.ppat.1010500
Vibrio cholerae requires oxidative respiration through the bd-I and cbb3 oxidases for intestinal proliferation
PLOS Pathogens: published May 2, 2022 | https://doi.org/10.1371/journal.ppat.1010102
Influenza A virus NS1 protein hijacks YAP/TAZ to suppress TLR3-mediated innate immune response
PLOS Pathogens: published May 3, 2022 | https://doi.org/10.1371/journal.ppat.1010505
A neutralizing antibody target in early HIV-1 infection was recapitulated in rhesus macaques immunized with the transmitted/founder envelope sequence
PLOS Pathogens: published May 3, 2022 | https://doi.org/10.1371/journal.ppat.1010488
Toxoplasma gondii excretion of glycolytic products is associated with acidification of the parasitophorous vacuole during parasite egress
PLOS Pathogens: published May 5, 2022 | https://doi.org/10.1371/journal.ppat.1010139
FoQDE2-dependent milRNA promotes Fusarium oxysporum f. sp. cubense virulence by silencing a glycosyl hydrolase coding gene expression
PLOS Pathogens: published May 5, 2022 | https://doi.org/10.1371/journal.ppat.1010157
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Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection
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Multi-omics analysis of the cervical epithelial integrity of women using depot medroxyprogesterone acetate
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A nonstructural protein encoded by a rice reovirus induces an incomplete autophagy to promote viral spread in insect vectors
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Ubiquitination of Ebola virus VP35 at lysine 309 regulates viral transcription and assembly
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Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development
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NF-YA transcription factors suppress jasmonic acid-mediated antiviral defense and facilitate viral infection in rice
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Metaeffector interactions modulate the type III effector-triggered immunity load of Pseudomonas syringae
PLOS Pathogens: published May 16, 2022 | https://doi.org/10.1371/journal.ppat.1010541
Deactivation of the antiviral state by rabies virus through targeting and accumulation of persistently phosphorylated STAT1
PLOS Pathogens: published May 16, 2022 | https://doi.org/10.1371/journal.ppat.1010533
Targeted mutagenesis in Anaplasma marginale to define virulence and vaccine development against bovine anaplasmosis
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Yersinia pseudotuberculosis doxycycline tolerance strategies include modulating expression of genes involved in cell permeability and tRNA modifications
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Time-course of host cell transcription during the HTLV-1 transcriptional burst
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Ehrlichia SLiM ligand mimetic activates Hedgehog signaling to engage a BCL-2 anti-apoptotic cellular program
PLOS Pathogens: published May 16, 2022 | https://doi.org/10.1371/journal.ppat.1010345
Adaptive immune defense prevents Bartonella persistence upon trans-placental transmission
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Neisseria genes required for persistence identified via in vivo screening of a transposon mutant library
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A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition
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MAVS mediates a protective immune response in the brain to Rift Valley fever virus
PLOS Pathogens: published May 18, 2022 | https://doi.org/10.1371/journal.ppat.1010231
Regulation of epitope exposure in the gp41 membrane-proximal external region through interactions at the apex of HIV-1 Env
PLOS Pathogens: published May 18, 2022 | https://doi.org/10.1371/journal.ppat.1010531
Pseudorabies virus tegument protein UL13 recruits RNF5 to inhibit STING-mediated antiviral immunity
PLOS Pathogens: published May 18, 2022 | https://doi.org/10.1371/journal.ppat.1010544
Epitope-focused immunogen design based on the ebolavirus glycoprotein HR2-MPER region
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The host inflammatory response contributes to disease severity in Crimean-Congo hemorrhagic fever virus infected mice
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Koala retrovirus load and non-A subtypes are associated with secondary disease among wild northern koalas
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Comparison of herpes simplex virus 1 genomic diversity between adult sexual transmission partners with genital infection
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Ecological divergence of wild birds drives avian influenza spillover and global spread
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Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice
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PI Kinase-EhGEF2-EhRho5 axis contributes to LPA stimulated macropinocytosis in Entamoeba histolytica
PLOS Pathogens: published May 20, 2022 | https://doi.org/10.1371/journal.ppat.1010550
CD4 T-cell depletion prevents Lassa fever associated hearing loss in the mouse model
PLOS Pathogens: published May 23, 2022 | https://doi.org/10.1371/journal.ppat.1010557
Live imaging of Yersinia translocon formation and immune recognition in host cells
PLOS Pathogens: published May 23, 2022 | https://doi.org/10.1371/journal.ppat.1010251
Plasma antibodies from humans infected with zoonotic simian foamy virus do not inhibit cell-to-cell transmission of the virus despite binding to the surface of infected cells
PLOS Pathogens: published May 23, 2022 | https://doi.org/10.1371/journal.ppat.1010470
VlsE, the nexus for antigenic variation of the Lyme disease spirochete, also mediates early bacterial attachment to the host microvasculature under shear force
PLOS Pathogens: published May 23, 2022 | https://doi.org/10.1371/journal.ppat.1010511
Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD
PLOS Pathogens: published May 23, 2022 | https://doi.org/10.1371/journal.ppat.1010328
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The Salmonella transmembrane effector SteD hijacks AP1-mediated vesicular trafficking for delivery to antigen-loading MHCII compartments
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HIV-1 cell-to-cell spread overcomes the virus entry block of non-macrophage-tropic strains in macrophages
PLOS Pathogens: published May 27, 2022 | https://doi.org/10.1371/journal.ppat.1010335
Haemagglutinin substitutions N125D, D127E, D222G and R223Q improve replicative fitness and vaccine effectiveness of an A/H1N1pdm09 live attenuated influenza vaccine virus by enhancing α-2,6 receptor binding
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Effector loss drives adaptation of Pseudomonas syringae pv. actinidiae biovar 3 to Actinidia arguta
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Corrections
Correction: The arginine deaminase system plays distinct roles in Borrelia burgdorferi and Borrelia hermsii
PLOS Pathogens: published May 10, 2022 | https://doi.org/10.1371/journal.ppat.1010549
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PLOS Pathogens: published May 25, 2022 | https://doi.org/10.1371/journal.ppat.1010586