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May 2022

Rice gall dwarf virus (RGDV), an important rice reovirus, hijacks autophagosomes to traverse multiple insect membrane barriers in the midgut and salivary gland of leafhopper vector to enhance viral spread. In virus-infected midgut epithelial cells, ATG8 redistributed into discrete puncta, which were co-localized with viral antigens. Such virus-containing double-membraned autophagosomes are prevented from degradation, resulting in increased viral propagation. Jia et al.

Image Credit: Dongsheng Jia

Opinion

Sexual reproduction is the null hypothesis for life cycles of rust fungi

Alistair R. McTaggart, Timothy Y. James, Alexander Idnurm, Robert F. Park, Louise S. Shuey, Michelle N. K. Demers, M. Catherine Aime

Pearls

Innate immunity in fungi: Is regulated cell death involved?

Maria Laura Gaspar, Teresa E. Pawlowska

Overcoming pH defenses on the skin to establish infections

Flavia G. Costa, Alexander R. Horswill

Reviews

Innate immune surveillance of the circulation: A review on the removal of circulating virions from the bloodstream

Stephanie E. Ander, Frances S. Li, Kathryn S. Carpentier, Thomas E. Morrison

Preclinical and clinical developments for combination treatment of influenza

Paulina Koszalka, Kanta Subbarao, Mariana Baz

Tuberculosis caused by Mycobacterium africanum: Knowns and unknowns

Marta L. Silva, Baltazar Cá, Nuno S. Osório, Pedro N. S. Rodrigues, Ana Raquel Maceiras, Margarida Saraiva

Research Articles

Making genomic surveillance deliver: A lineage classification and nomenclature system to inform rabies elimination

Kathryn Campbell, Robert J. Gifford, Joshua Singer, Verity Hill, Aine O’Toole, Andrew Rambaut, Katie Hampson, Kirstyn Brunker

PTEN differentially regulates endocytosis, migration, and proliferation in the enteric protozoan parasite Entamoeba histolytica

Samia Kadri, Kumiko Nakada-Tsukui, Natsuki Watanabe, Ghulam Jeelani, Tomoyoshi Nozaki

The endoplasmic reticulum membrane protein complex localizes to the mitochondrial - endoplasmic reticulum interface and its subunits modulate phospholipid biosynthesis in Trypanosoma brucei

Advaitha Iyer, Moritz Niemann, Mauro Serricchio, Caroline E. Dewar, Silke Oeljeklaus, Luce Farine, Bettina Warscheid, André Schneider, Peter Bütikofer

Beneath the surface: Amino acid variation underlying two decades of dengue virus antigenic dynamics in Bangkok, Thailand

Angkana T. Huang, Henrik Salje, Ana Coello Escoto, Nayeem Chowdhury, Christian Chávez, Bernardo Garcia-Carreras, Wiriya Rutvisuttinunt, Irina Maljkovic Berry, Gregory D. Gromowski, Lin Wang, Chonticha Klungthong, Butsaya Thaisomboonsuk, Ananda Nisalak, Luke M. Trimmer-Smith, Isabel Rodriguez-Barraquer, Damon W. Ellison, Anthony R. Jones, Stefan Fernandez, Stephen J. Thomas, Derek J. Smith, Richard Jarman, Stephen S. Whitehead, Derek A. T. Cummings, Leah C. Katzelnick

Influenza A virus NS1 protein hijacks YAP/TAZ to suppress TLR3-mediated innate immune response

Qiong Zhang, Xujun Zhang, Xiaobo Lei, Hai Wang, Jingjing Jiang, Yuchong Wang, Kefan Bi, Hongyan Diao

A neutralizing antibody target in early HIV-1 infection was recapitulated in rhesus macaques immunized with the transmitted/founder envelope sequence

Sarah Welbourn, Srirupa Chakraborty, Jie E. Yang, Anne S. Gleinich, Sailaja Gangadhara, Salar Khan, Courtney Ferrebee, Bhrugu Yagnik, Samantha Burton, Tysheena Charles, S. Abigail Smith, Danielle Williams, Rohini Mopuri, Amit A. Upadhyay, Justin Thompson, Matt A. Price, Shiyu Wang, Zhaohui Qin, Xiaoying Shen, LaTonya D. Williams, Nathan Eisel, Tiffany Peters, Lu Zhang, William Kilembe, Etienne Karita, Georgia D. Tomaras, Steven E. Bosinger, Rama R. Amara, Parastoo Azadi, Elizabeth R. Wright, Sandrasegaram Gnanakaran, Cynthia A. Derdeyn

Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection

Amanda J. Lee, Emily Feng, Marianne V. Chew, Elizabeth Balint, Sophie M. Poznanski, Elizabeth Giles, Ali Zhang, Art Marzok, Spencer D. Revill, Fatemeh Vahedi, Anisha Dubey, Ehab Ayaub, Rodrigo Jimenez-Saiz, Joshua J. C. McGrath, Tyrah M. Ritchie, Manel Jordana, Danny D. Jonigk, Maximilian Ackermann, Kjetil Ask, Matthew Miller, Carl D. Richards, Ali A. Ashkar

Multi-omics analysis of the cervical epithelial integrity of women using depot medroxyprogesterone acetate

Frideborg Bradley, Mathias Franzén Boger, Vilde Kaldhusdal, Alexandra Åhlberg, Gabriella Edfeldt, Julie Lajoie, Sofia Bergström, Kenneth Omollo, Anastasios Damdimopoulos, Paulo Czarnewski, Anna Månberg, Julius Oyugi, Joshua Kimani, Peter Nilsson, Keith Fowke, Annelie Tjernlund, Kristina Broliden

TRIM25 and ZAP target the Ebola virus ribonucleoprotein complex to mediate interferon-induced restriction

Rui Pedro Galão, Harry Wilson, Kristina L. Schierhorn, Franka Debeljak, Bianca S. Bodmer, Daniel Goldhill, Thomas Hoenen, Sam J. Wilson, Chad M. Swanson, Stuart J. D. Neil

A nonstructural protein encoded by a rice reovirus induces an incomplete autophagy to promote viral spread in insect vectors

Dongsheng Jia, Qifu Liang, Huan Liu, Guangjun Li, Xiaofeng Zhang, Qian Chen, Aiming Wang, Taiyun Wei

Ubiquitination of Ebola virus VP35 at lysine 309 regulates viral transcription and assembly

Sarah van Tol, Birte Kalveram, Philipp A. Ilinykh, Adam Ronk, Kai Huang, Leopoldo Aguilera-Aguirre, Preeti Bharaj, Adam Hage, Colm Atkins, Maria I. Giraldo, Maki Wakamiya, Maria Gonzalez-Orozco, Abbey N. Warren, Alexander Bukreyev, Alexander N. Freiberg, Ricardo Rajsbaum

Australia as a global sink for the genetic diversity of avian influenza A virus

Michelle Wille, Victoria Grillo, Silvia Ban de Gouvea Pedroso, Graham W. Burgess, Allison Crawley, Celia Dickason, Philip M. Hansbro, Md. Ahasanul Hoque, Paul F. Horwood, Peter D. Kirkland, Nina Yu-Hsin Kung, Stacey E. Lynch, Sue Martin, Michaela McArthur, Kim O’Riley, Andrew J. Read, Simone Warner, Bethany J. Hoye, Simeon Lisovski, Trent Leen, Aeron C. Hurt, Jeff Butler, Ivano Broz, Kelly R. Davies, Patrick Mileto, Matthew J. Neave, Vicky Stevens, Andrew C. Breed, Tommy T. Y. Lam, Edward C. Holmes, Marcel Klaassen, Frank Y. K. Wong

Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development

Megan E. Spurgeon, Jingwei Cheng, Ella Ward-Shaw, Frederick A. Dick, James A. DeCaprio, Paul F. Lambert

NF-YA transcription factors suppress jasmonic acid-mediated antiviral defense and facilitate viral infection in rice

Xiaoxiang Tan, Hehong Zhang, Zihang Yang, Zhongyan Wei, Yanjun Li, Jianping Chen, Zongtao Sun

Metaeffector interactions modulate the type III effector-triggered immunity load of Pseudomonas syringae

Alexandre Martel, Bradley Laflamme, Clare Breit-McNally, Pauline Wang, Fabien Lonjon, Darrell Desveaux, David S. Guttman

Deactivation of the antiviral state by rabies virus through targeting and accumulation of persistently phosphorylated STAT1

Gayathri Manokaran, Michelle D. Audsley, Haruka Funakoda, Cassandra T. David, Katherine A. Garnham, Stephen M. Rawlinson, Celine Deffrasnes, Naoto Ito, Gregory W. Moseley

Targeted mutagenesis in Anaplasma marginale to define virulence and vaccine development against bovine anaplasmosis

Paidashe Hove, Swetha Madesh, Arathy Nair, Deborah Jaworski, Huitao Liu, Jonathan Ferm, Michael D. Kleinhenz, Margaret A. Highland, Andrew K. Curtis, Johann F. Coetzee, Susan M. Noh, Ying Wang, Dominica Genda, Roman R. Ganta

Yersinia pseudotuberculosis doxycycline tolerance strategies include modulating expression of genes involved in cell permeability and tRNA modifications

Hector S. Alvarez-Manzo, Robert K. Davidson, Jasper Van Cauwelaert de Wyels, Katherine L. Cotten, Benjamin H. Nguyen, Melody Xiao, Zeyu Zhu, Jon Anthony, Tim van Opijnen, Kimberly Michele Davis

Time-course of host cell transcription during the HTLV-1 transcriptional burst

Helen Kiik, Saumya Ramanayake, Michi Miura, Yuetsu Tanaka, Anat Melamed, Charles R. M. Bangham

Ehrlichia SLiM ligand mimetic activates Hedgehog signaling to engage a BCL-2 anti-apoptotic cellular program

Caitlan D. Byerly, Shubhajit Mitra, LaNisha L. Patterson, Nicholas A. Pittner, Thangam S. Velayutham, Slobodan Paessler, Veljko Veljkovic, Jere W. McBride

Adaptive immune defense prevents Bartonella persistence upon trans-placental transmission

Lena K. Siewert, Christoph Dehio, Daniel D. Pinschewer

Neisseria genes required for persistence identified via in vivo screening of a transposon mutant library

Katherine A. Rhodes, Man Cheong Ma, María A. Rendón, Magdalene So

A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition

Alexis R. Gibson, Adam Sateriale, Jennifer E. Dumaine, Julie B. Engiles, Ryan D. Pardy, Jodi A. Gullicksrud, Keenan M. O’Dea, John G. Doench, Daniel P. Beiting, Christopher A. Hunter, Boris Striepen

MAVS mediates a protective immune response in the brain to Rift Valley fever virus

Nicholas R. Hum, Feliza A. Bourguet, Aimy Sebastian, Doris Lam, Ashlee M. Phillips, Kristina R. Sanchez, Amy Rasley, Gabriela G. Loots, Dina R. Weilhammer

Regulation of epitope exposure in the gp41 membrane-proximal external region through interactions at the apex of HIV-1 Env

Hannah M. Schapiro, Mukta D. Khasnis, Koree Ahn, Alexandra Karagiaridi, Stephanie Hayden, Maria E. Cilento, Michael J. Root

Pseudorabies virus tegument protein UL13 recruits RNF5 to inhibit STING-mediated antiviral immunity

Zhengjie Kong, Hongyan Yin, Fan Wang, Zhen Liu, Xiaohan Luan, Lei Sun, Wenjun Liu, Yingli Shang

Epitope-focused immunogen design based on the ebolavirus glycoprotein HR2-MPER region

Clara T. Schoeder, Pavlo Gilchuk, Amandeep K. Sangha, Kaitlyn V. Ledwitch, Delphine C. Malherbe, Xuan Zhang, Elad Binshtein, Lauren E. Williamson, Cristina E. Martina, Jinhui Dong, Erica Armstrong, Rachel Sutton, Rachel Nargi, Jessica Rodriguez, Natalia Kuzmina, Brooke Fiala, Neil P. King, Alexander Bukreyev, James E. Crowe Jr., Jens Meiler

The host inflammatory response contributes to disease severity in Crimean-Congo hemorrhagic fever virus infected mice

Joseph W. Golden, Xiankun Zeng, Curtis R. Cline, Jeffrey M. Smith, Sharon P. Daye, Brian D. Carey, Candace D. Blancett, Charles J. Shoemaker, Jun Liu, Collin J. Fitzpatrick, Christopher P. Stefan, Aura R. Garrison

Koala retrovirus load and non-A subtypes are associated with secondary disease among wild northern koalas

Michaela D. J. Blyton, Michael Pyne, Paul Young, Keith Chappell

Comparison of herpes simplex virus 1 genomic diversity between adult sexual transmission partners with genital infection

Molly M. Rathbun, Mackenzie M. Shipley, Christopher D. Bowen, Stacy Selke, Anna Wald, Christine Johnston, Moriah L. Szpara

Ecological divergence of wild birds drives avian influenza spillover and global spread

Nichola J. Hill, Mary Anne Bishop, Nídia S. Trovão, Katherine M. Ineson, Anne L. Schaefer, Wendy B. Puryear, Katherine Zhou, Alexa D. Foss, Daniel E. Clark, Kenneth G. MacKenzie, Jonathon D. Gass Jr., Laura K. Borkenhagen, Jeffrey S. Hall, Jonathan A. Runstadler

Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice

Sandrine Belouzard, Arnaud Machelart, Valentin Sencio, Thibaut Vausselin, Eik Hoffmann, Nathalie Deboosere, Yves Rouillé, Lowiese Desmarets, Karin Séron, Adeline Danneels, Cyril Robil, Loic Belloy, Camille Moreau, Catherine Piveteau, Alexandre Biela, Alexandre Vandeputte, Séverine Heumel, Lucie Deruyter, Julie Dumont, Florence Leroux, Ilka Engelmann, Enagnon Kazali Alidjinou, Didier Hober, Priscille Brodin, Terence Beghyn, François Trottein, Benoit Deprez, Jean Dubuisson

PI Kinase-EhGEF2-EhRho5 axis contributes to LPA stimulated macropinocytosis in Entamoeba histolytica

Achala Apte, Maria Manich, Elisabeth Labruyère, Sunando Datta

CD4 T-cell depletion prevents Lassa fever associated hearing loss in the mouse model

Junki Maruyama, Rachel A. Reyna, Megumi Kishimoto-Urata, Shinji Urata, John T. Manning, Nantian Harsell, Rebecca Cook, Cheng Huang, Janko Nikolich-Zugich, Tomoko Makishima, Slobodan Paessler

Live imaging of Yersinia translocon formation and immune recognition in host cells

Maren Rudolph, Alexander Carsten, Susanne Kulnik, Martin Aepfelbacher, Manuel Wolters

Plasma antibodies from humans infected with zoonotic simian foamy virus do not inhibit cell-to-cell transmission of the virus despite binding to the surface of infected cells

Mathilde Couteaudier, Thomas Montange, Richard Njouom, Chanceline Bilounga-Ndongo, Antoine Gessain, Florence Buseyne

VlsE, the nexus for antigenic variation of the Lyme disease spirochete, also mediates early bacterial attachment to the host microvasculature under shear force

Xi Tan, Yi-Pin Lin, Michael J. Pereira, Mildred Castellanos, Beth L. Hahn, Phillip Anderson, Jenifer Coburn, John M. Leong, George Chaconas

Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD

Tim Krischuns, Catherine Isel, Petra Drncova, Maria Lukarska, Alexander Pflug, Sylvain Paisant, Vincent Navratil, Stephen Cusack, Nadia Naffakh

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The Salmonella transmembrane effector SteD hijacks AP1-mediated vesicular trafficking for delivery to antigen-loading MHCII compartments

Camilla Godlee, Ondrej Cerny, Mei Liu, Samkeliso Blundell, Alanna E. Gallagher, Meriam Shahin, David W. Holden

HIV-1 cell-to-cell spread overcomes the virus entry block of non-macrophage-tropic strains in macrophages

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Corrections

Correction: The arginine deaminase system plays distinct roles in Borrelia burgdorferi and Borrelia hermsii

Crystal L. Richards, Sandra J. Raffel, Sébastien Bontemps-Gallo, Daniel P. Dulebohn, Tessa C. Herbert, Frank C. Gherardini

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Correction: γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans

Timothy H. Chu, Camille Khairallah, Jason Shieh, Rhea Cho, Zhijuan Qiu, Yue Zhang, Onur Eskiocak, David G. Thanassi, Mark H. Kaplan, Semir Beyaz, Vincent W. Yang, James B. Bliska, Brian S. Sheridan

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