Tsetse flies are blood feeding insects that live in sub-Saharan Africa. When feeding on a trypanosome-infected host, the ingested protozoan parasites enter the tsetse midgut which is the starting point of a complex developmental cycle along the fly's alimentary tract and mouthparts, ending in the salivary glands where the final metacyclic parasitic stage is formed, ready to infect a new host. The tsetse fly harbors a facultative bacterial symbiont, Sodalis glossinidius, that can be genetically modified to express trypanosome-interacting proteins that are able to modulate the tsetse fly's ability to transmit the parasite.
Image Credit: Luc Verhelst
Pearls
Lessons from protozoans: Phosphate sensing and polyphosphate storage in fungi
PLOS Pathogens: published March 3, 2022 | https://doi.org/10.1371/journal.ppat.1010298
Scrambled or flipped: 5 facts about how cellular phosphatidylserine localization can mediate viral replication
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PLOS Pathogens: published March 29, 2022 | https://doi.org/10.1371/journal.ppat.1010432
Reviews
Tuft cells are key mediators of interkingdom interactions at mucosal barrier surfaces
PLOS Pathogens: published March 10, 2022 | https://doi.org/10.1371/journal.ppat.1010318
The flexibility of Apicomplexa parasites in lipid metabolism
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Age-associated B cells in viral infection
PLOS Pathogens: published March 17, 2022 | https://doi.org/10.1371/journal.ppat.1010297
Research Articles
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Kynurenine-3-monooxygenase (KMO) broadly inhibits viral infections via triggering NMDAR/Ca2+ influx and CaMKII/ IRF3-mediated IFN-β production
PLOS Pathogens: published March 2, 2022 | https://doi.org/10.1371/journal.ppat.1010366
Multiple knockout mutants reveal a high redundancy of phytotoxic compounds contributing to necrotrophic pathogenesis of Botrytis cinerea
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Differences in neuroinvasion and protective innate immune pathways between encephalitic California Serogroup orthobunyaviruses
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PLOS Pathogens: published March 7, 2022 | https://doi.org/10.1371/journal.ppat.1010346
The glycerol-3-phosphate dehydrogenases GpsA and GlpD constitute the oxidoreductive metabolic linchpin for Lyme disease spirochete host infectivity and persistence in the tick
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Distinct spatial arrangements of ACE2 and TMPRSS2 expression in Syrian hamster lung lobes dictates SARS-CoV-2 infection patterns
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HLA-A*11:01-restricted CD8+ T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people
PLOS Pathogens: published March 7, 2022 | https://doi.org/10.1371/journal.ppat.1010337
SUMOylation of Jun fine-tunes the Drosophila gut immune response
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β-catenin regulates HIV latency and modulates HIV reactivation
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Relaxing the restricted structural dynamics in the human hepatitis B virus RNA encapsidation signal enables replication initiation in vitro
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Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis
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PLOS Pathogens: published March 10, 2022 | https://doi.org/10.1371/journal.ppat.1010376
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Essential role of hyperacetylated microtubules in innate immunity escape orchestrated by the EBV-encoded BHRF1 protein
PLOS Pathogens: published March 11, 2022 | https://doi.org/10.1371/journal.ppat.1010371
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A novel group of negative-sense RNA viruses associated with epizootics in managed and free-ranging freshwater turtles in Florida, USA
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Cyclooxygenase production of PGE2 promotes phagocyte control of A. fumigatus hyphal growth in larval zebrafish
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Disc and Actin Associated Protein 1 influences attachment in the intestinal parasite Giardia lamblia
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Corrections
Correction: Autoacetylation of the Ralstonia solanacearum Effector PopP2 Targets a Lysine Residue Essential for RRS1-R-Mediated Immunity in Arabidopsis
PLOS Pathogens: published March 2, 2022 | https://doi.org/10.1371/journal.ppat.1010368
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