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March 2022

Tsetse flies are blood feeding insects that live in sub-Saharan Africa. When feeding on a trypanosome-infected host, the ingested protozoan parasites enter the tsetse midgut which is the starting point of a complex developmental cycle along the fly's alimentary tract and mouthparts, ending in the salivary glands where the final metacyclic parasitic stage is formed, ready to infect a new host. The tsetse fly harbors a facultative bacterial symbiont, Sodalis glossinidius, that can be genetically modified to express trypanosome-interacting proteins that are able to modulate the tsetse fly's ability to transmit the parasite.

Image Credit: Luc Verhelst

Reviews

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