December 2021

T. gondii resides in a parasitophorous vacuole featuring vesicles that bud with a topology that is consistent with the involvement of host Endosomal Sorting Complexes Required for Transport (ESCRT) machinery. Accordingly, this super-resolution Structured Illumination Microscopy (SIM) image shows accumulation of a dominant negative mutant of the ESCRT-IV protein VPS4A fused to mCherry Red (shown in magenta) together with the ESCRT-III protein CHMP4B (green, stained with anti-CHMP4B) around the parasitophorous vacuole (cyan, stained with anti-TgGRA7) of T. gondii. The image is a maximum projection of 3D SIM images. Rivera-Cuevas et al.

Image Credit: Rivera-Cuevas Y, 2021

Pearls

From canines to humans: Clinical importance of Staphylococcus pseudintermedius

Karen C. Carroll, Carey-Ann D. Burnham, Lars F. Westblade

PLOS Pathogens: published December 2, 2021 | https://doi.org/10.1371/journal.ppat.1009961

Glycerol, a possible new player in the biology of trypanosomes

Frédéric Bringaud, Nicolas Plazolles, Erika Pineda, Corinne Asencio, Oriana Villafraz, Yoann Millerioux, Loïc Rivière, Emmanuel Tetaud

PLOS Pathogens: published December 2, 2021 | https://doi.org/10.1371/journal.ppat.1010035

Insights into potential causes of vascular hyperpermeability in dengue

Andrew Teo, Caroline Lin Lin Chua, Po Ying Chia, Tsin Wen Yeo

PLOS Pathogens: published December 9, 2021 | https://doi.org/10.1371/journal.ppat.1010065

Current state of Ebola virus vaccines: A snapshot

Courtney Woolsey, Thomas W. Geisbert

PLOS Pathogens: published December 9, 2021 | https://doi.org/10.1371/journal.ppat.1010078

Streptococcal superantigens and the return of scarlet fever

Jacklyn R. Hurst, Stephan Brouwer, Mark J. Walker, John K. McCormick

PLOS Pathogens: published December 30, 2021 | https://doi.org/10.1371/journal.ppat.1010097

HIV-1 capsid is the key orchestrator of early viral replication

Vojtech Zila, Thorsten G. Müller, Barbara Müller, Hans-Georg Kräusslich

PLOS Pathogens: published December 30, 2021 | https://doi.org/10.1371/journal.ppat.1010109

Reviews

“Reading” a new chapter in protozoan parasite transcriptional regulation

Krista Fleck, Malorie Nitz, Victoria Jeffers

PLOS Pathogens: published December 2, 2021 | https://doi.org/10.1371/journal.ppat.1010056

Microbial proteasomes as drug targets

Hao Zhang, Gang Lin

PLOS Pathogens: published December 9, 2021 | https://doi.org/10.1371/journal.ppat.1010058

Understanding the interaction between cytomegalovirus and tuberculosis in children: The way forward

Laura Olbrich, Lisa Stockdale, Robindra Basu Roy, Rinn Song, Luka Cicin-Sain, Elizabeth Whittaker, Andrew J. Prendergast, Helen Fletcher, James A. Seddon

PLOS Pathogens: published December 9, 2021 | https://doi.org/10.1371/journal.ppat.1010061

Molecular signatures between citrus and Candidatus Liberibacter asiaticus

Bin Hu, Muhammad Junaid Rao, Xiuxin Deng, Sheo Shankar Pandey, Connor Hendrich, Fang Ding, Nian Wang, Qiang Xu

PLOS Pathogens: published December 9, 2021 | https://doi.org/10.1371/journal.ppat.1010071

Untangling the roles of RNA helicases in antiviral innate immunity

Morgane Baldaccini, Sébastien Pfeffer

PLOS Pathogens: published December 9, 2021 | https://doi.org/10.1371/journal.ppat.1010072

Fungicide effects on human fungal pathogens: Cross-resistance to medical drugs and beyond

Rafael W. Bastos, Luana Rossato, Gustavo H. Goldman, Daniel A. Santos

PLOS Pathogens: published December 9, 2021 | https://doi.org/10.1371/journal.ppat.1010073

Mammalian antiviral systems directed by small RNA

Tomoko Takahashi, Steven M. Heaton, Nicholas F. Parrish

PLOS Pathogens: published December 16, 2021 | https://doi.org/10.1371/journal.ppat.1010091

Schistosome immunomodulators

Sreemoyee Acharya, Akram A. Da’dara, Patrick J. Skelly

PLOS Pathogens: published December 30, 2021 | https://doi.org/10.1371/journal.ppat.1010064

Influenza viruses and coronaviruses: Knowns, unknowns, and common research challenges

Olivier Terrier, Mustapha Si-Tahar, Mariette Ducatez, Christophe Chevalier, Andrés Pizzorno, Ronan Le Goffic, Thibaut Crépin, Gaëlle Simon, Nadia Naffakh

PLOS Pathogens: published December 30, 2021 | https://doi.org/10.1371/journal.ppat.1010106

Pantothenate and CoA biosynthesis in Apicomplexa and their promise as antiparasitic drug targets

Laura E. de Vries, Matteo Lunghi, Aarti Krishnan, Taco W. A. Kooij, Dominique Soldati-Favre

PLOS Pathogens: published December 30, 2021 | https://doi.org/10.1371/journal.ppat.1010124

Research Articles

Gonococcal invasion into epithelial cells depends on both cell polarity and ezrin

Qian Yu, Liang-Chun Wang, Sofia Di Benigno, Daniel C. Stein, Wenxia Song

PLOS Pathogens: published December 1, 2021 | https://doi.org/10.1371/journal.ppat.1009592

Turnip mosaic virus P1 suppresses JA biosynthesis by degrading cpSRP54 that delivers AOCs onto the thylakoid membrane to facilitate viral infection

Mengfei Ji, Jinping Zhao, Kelei Han, Weijun Cui, Xinyang Wu, Binghua Chen, Yuwen Lu, Jiejun Peng, Hongying Zheng, Shaofei Rao, Guanwei Wu, Jianping Chen, Fei Yan

PLOS Pathogens: published December 1, 2021 | https://doi.org/10.1371/journal.ppat.1010108

VgrG-dependent effectors and chaperones modulate the assembly of the type VI secretion system

Xiaoye Liang, Tong-Tong Pei, Hao Li, Hao-Yu Zheng, Han Luo, Yang Cui, Ming-Xuan Tang, Ya-Jie Zhao, Ping Xu, Tao Dong

PLOS Pathogens: published December 1, 2021 | https://doi.org/10.1371/journal.ppat.1010116

The FUR-like regulators PerRA and PerRB integrate a complex regulatory network that promotes mammalian host-adaptation and virulence of Leptospira interrogans

André A. Grassmann, Crispin Zavala-Alvarado, Everton B. Bettin, Mathieu Picardeau, Nadia Benaroudj, Melissa J. Caimano

PLOS Pathogens: published December 2, 2021 | https://doi.org/10.1371/journal.ppat.1009078

The oxidative stress response of pathogenic Leptospira is controlled by two peroxide stress regulators which putatively cooperate in controlling virulence

Crispin Zavala-Alvarado, Samuel G. Huete, Antony T. Vincent, Odile Sismeiro, Rachel Legendre, Hugo Varet, Giovanni Bussotti, Céline Lorioux, Pierre Lechat, Jean-Yves Coppée, Frédéric J. Veyrier, Mathieu Picardeau, Nadia Benaroudj

PLOS Pathogens: published December 2, 2021 | https://doi.org/10.1371/journal.ppat.1009087

A pigtailed macaque model of Kyasanur Forest disease virus and Alkhurma hemorrhagic disease virus pathogenesis

Rebecca M. Broeckel, Friederike Feldmann, Kristin L. McNally, Abhilash I. Chiramel, Gail L. Sturdevant, Jacqueline M. Leung, Patrick W. Hanley, Jamie Lovaglio, Rebecca Rosenke, Dana P. Scott, Greg Saturday, Fadila Bouamr, Angela L. Rasmussen, Shelly J. Robertson, Sonja M. Best

PLOS Pathogens: published December 2, 2021 | https://doi.org/10.1371/journal.ppat.1009678

Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination

Chris Davis, Nicola Logan, Grace Tyson, Richard Orton, William T. Harvey, Jonathan S. Perkins, Guy Mollett, Rachel M. Blacow, The COVID-19 Genomics UK (COG-UK) Consortium, Thomas P. Peacock, Wendy S. Barclay, Peter Cherepanov, Massimo Palmarini, Pablo R. Murcia, Arvind H. Patel, David L. Robertson, John Haughney, Emma C. Thomson, Brian J. Willett, on behalf of the COVID-19 DeplOyed VaccinE (DOVE) Cohort Study investigators

PLOS Pathogens: published December 2, 2021 | https://doi.org/10.1371/journal.ppat.1010022

H9N2 virus-derived M1 protein promotes H5N6 virus release in mammalian cells: Mechanism of avian influenza virus inter-species infection in humans

Fangtao Li, Jiyu Liu, Jizhe Yang, Haoran Sun, Zhimin Jiang, Chenxi Wang, Xin Zhang, Yinghui Yu, Chuankuo Zhao, Juan Pu, Yipeng Sun, Kin-Chow Chang, Jinhua Liu, Honglei Sun

PLOS Pathogens: published December 3, 2021 | https://doi.org/10.1371/journal.ppat.1010098

Anti-prothrombin autoantibodies enriched after infection with SARS-CoV-2 and influenced by strength of antibody response against SARS-CoV-2 proteins

Marc Emmenegger, Sreedhar Saseendran Kumar, Vishalini Emmenegger, Tomas Malinauskas, Thomas Buettner, Laura Rose, Peter Schierack, Martin F. Sprinzl, Clemens J. Sommer, Karl J. Lackner, Adriano Aguzzi, Dirk Roggenbuck, Katrin B. M. Frauenknecht

PLOS Pathogens: published December 3, 2021 | https://doi.org/10.1371/journal.ppat.1010118

Antiviral RNA interference in disease vector (Asian longhorned) ticks

Yan Xu, Zhengwei Zhong, Yanxin Ren, Liting Ma, Zhi Ye, Chuang Gao, Jingwen Wang, Yang Li

PLOS Pathogens: published December 3, 2021 | https://doi.org/10.1371/journal.ppat.1010119

Acetylation of glucosyltransferases regulates Streptococcus mutans biofilm formation and virulence

Qizhao Ma, Yangyang Pan, Yang Chen, Shuxing Yu, Jun Huang, Yaqi Liu, Tao Gong, Jing Zou, Yuqing Li

PLOS Pathogens: published December 3, 2021 | https://doi.org/10.1371/journal.ppat.1010134

Genetic mapping reveals Nfkbid as a central regulator of humoral immunity to Toxoplasma gondii

Scott P. Souza, Samantha D. Splitt, Juan C. Sànchez-Arcila, Julia A. Alvarez, Jessica N. Wilson, Safuwra Wizzard, Zheng Luo, Nicole Baumgarth, Kirk D. C. Jensen

PLOS Pathogens: published December 6, 2021 | https://doi.org/10.1371/journal.ppat.1010081

γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans

Timothy H. Chu, Camille Khairallah, Jason Shieh, Rhea Cho, Zhijuan Qiu, Yue Zhang, Onur Eskiocak, David G. Thanassi, Mark H. Kaplan, Semir Beyaz, Vincent W. Yang, James B. Bliska, Brian S. Sheridan

PLOS Pathogens: published December 6, 2021 | https://doi.org/10.1371/journal.ppat.1010103

Genome-scale CRISPR screen identifies TMEM41B as a multi-function host factor required for coronavirus replication

Limeng Sun, Changzhi Zhao, Zhen Fu, Yanan Fu, Zhelin Su, Yangyang Li, Yuan Zhou, Yubei Tan, Jingjin Li, Yixin Xiang, Xiongwei Nie, Jinfu Zhang, Fei Liu, Shuhong Zhao, Shengsong Xie, Guiqing Peng

PLOS Pathogens: published December 6, 2021 | https://doi.org/10.1371/journal.ppat.1010113

A type VII secretion system in Group B Streptococcus mediates cytotoxicity and virulence

Brady L. Spencer, Uday Tak, Jéssica C. Mendonça, Prescilla E. Nagao, Michael Niederweis, Kelly S. Doran

PLOS Pathogens: published December 6, 2021 | https://doi.org/10.1371/journal.ppat.1010121

RSK1 SUMOylation is required for KSHV lytic replication

Zhenshan Liu, Chengrong Liu, Xin Wang, Wenwei Li, Jingfan Zhou, Peixian Dong, Maggie Z. X. Xiao, Chunxia Wang, Yucai Zhang, Joyce Fu, Fanxiu Zhu, Qiming Liang

PLOS Pathogens: published December 6, 2021 | https://doi.org/10.1371/journal.ppat.1010123

Protective effects of combining monoclonal antibodies and vaccines against the Plasmodium falciparum circumsporozoite protein

Lawrence T. Wang, Lais S. Pereira, Patience K. Kiyuka, Arne Schön, Neville K. Kisalu, Rachel Vistein, Marlon Dillon, Brian G. Bonilla, Alvaro Molina-Cruz, Carolina Barillas-Mury, Joshua Tan, Azza H. Idris, Joseph R. Francica, Robert A. Seder

PLOS Pathogens: published December 6, 2021 | https://doi.org/10.1371/journal.ppat.1010133

A genome-wide CRISPR/Cas9 gene knockout screen identifies immunoglobulin superfamily DCC subclass member 4 as a key host factor that promotes influenza virus endocytosis

Yangming Song, Haixiang Huang, Yuzhen Hu, Jiwen Zhang, Fang Li, Xin Yin, Jianzhong Shi, Yanbing Li, Chengjun Li, Dongming Zhao, Hualan Chen

PLOS Pathogens: published December 6, 2021 | https://doi.org/10.1371/journal.ppat.1010141

Cerebrospinal fluid CD4+ T cell infection in humans and macaques during acute HIV-1 and SHIV infection

Vishakha Sharma, Matthew Creegan, Andrey Tokarev, Denise Hsu, Bonnie M. Slike, Carlo Sacdalan, Phillip Chan, Serena Spudich, Jintanat Ananworanich, Michael A. Eller, Shelly J. Krebs, Sandhya Vasan, Diane L. Bolton, the RV254/SEARCH010 and RV304/SEARCH013 Study Teams

PLOS Pathogens: published December 7, 2021 | https://doi.org/10.1371/journal.ppat.1010105

A double deletion prevents replication of the pestivirus bovine viral diarrhea virus in the placenta of pregnant heifers

Jolene Carlson, Robert Kammerer, Jens Peter Teifke, Julia Sehl-Ewert, Christiane Pfarrer, Gregor Meyers

PLOS Pathogens: published December 8, 2021 | https://doi.org/10.1371/journal.ppat.1010107

Foxp3⁺ CD4⁺ regulatory T cells control dendritic cells in inducing antigen-specific immunity to emerging SARS-CoV-2 antigens

Ryuta Uraki, Masaki Imai, Mutsumi Ito, Hiroaki Shime, Mizuyu Odanaka, Moe Okuda, Yoshihiro Kawaoka, Sayuri Yamazaki

PLOS Pathogens: published December 9, 2021 | https://doi.org/10.1371/journal.ppat.1010085

Library-based analysis reveals segment and length dependent characteristics of defective influenza genomes

Marisa Mendes, Alistair B. Russell

PLOS Pathogens: published December 9, 2021 | https://doi.org/10.1371/journal.ppat.1010125

Cytotoxic CD4+ T-cells specific for EBV capsid antigen BORF1 are maintained in long-term latently infected healthy donors

Alexander C. Dowell, Tracey A. Haigh, Gordon B. Ryan, James E. Turner, Heather M. Long, Graham S. Taylor

PLOS Pathogens: published December 9, 2021 | https://doi.org/10.1371/journal.ppat.1010137

Persister control by leveraging dormancy associated reduction of antibiotic efflux

Sweta Roy, Ali Adem Bahar, Huan Gu, Shikha Nangia, Karin Sauer, Dacheng Ren

PLOS Pathogens: published December 10, 2021 | https://doi.org/10.1371/journal.ppat.1010144

CD40L protects against mouse hepatitis virus-induced neuroinflammatory demyelination

Fareeha Saadi, Debanjana Chakravarty, Saurav Kumar, Mithila Kamble, Bhaskar Saha, Kenneth S. Shindler, Jayasri Das Sarma

PLOS Pathogens: published December 13, 2021 | https://doi.org/10.1371/journal.ppat.1010059

Toxoplasma gondii exploits the host ESCRT machinery for parasite uptake of host cytosolic proteins

Yolanda Rivera-Cuevas, Joshua Mayoral, Manlio Di Cristina, Anna-Lisa E. Lawrence, Einar B. Olafsson, Romir K. Patel, Dishari Thornhill, Benjamin S. Waldman, Akira Ono, Jonathan Z. Sexton, Sebastian Lourido, Louis M. Weiss, Vern B. Carruthers

PLOS Pathogens: published December 13, 2021 | https://doi.org/10.1371/journal.ppat.1010138

A unique NLRC4 receptor from echinoderms mediates Vibrio phagocytosis via rearrangement of the cytoskeleton and polymerization of F-actin

Kaiyu Chen, Siyuan Zhang, Yina Shao, Ming Guo, Weiwei Zhang, Chenghua Li

PLOS Pathogens: published December 13, 2021 | https://doi.org/10.1371/journal.ppat.1010145

The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection

Manuela Bieri, Rodinde Hendrickx, Michael Bauer, Bin Yu, Tania Jetzer, Birgit Dreier, Peer R. E. Mittl, Jens Sobek, Andreas Plückthun, Urs F. Greber, Silvio Hemmi

PLOS Pathogens: published December 15, 2021 | https://doi.org/10.1371/journal.ppat.1010083

Infection-induced chromatin modifications facilitate translocation of herpes simplex virus capsids to the inner nuclear membrane

Vesa Aho, Sami Salminen, Salla Mattola, Alka Gupta, Felix Flomm, Beate Sodeik, Jens B. Bosse, Maija Vihinen-Ranta

PLOS Pathogens: published December 15, 2021 | https://doi.org/10.1371/journal.ppat.1010132

The Schistosoma mansoni nuclear receptor FTZ-F1 maintains esophageal gland function via transcriptional regulation of meg-8.3

Aracely A. Romero, Sarah A. Cobb, Julie N. R. Collins, Steven A. Kliewer, David J. Mangelsdorf, James J. Collins III

PLOS Pathogens: published December 15, 2021 | https://doi.org/10.1371/journal.ppat.1010140

A vesicular stomatitis virus-based prime-boost vaccination strategy induces potent and protective neutralizing antibodies against SARS-CoV-2

Gyoung Nyoun Kim, Jung-ah Choi, Kunyu Wu, Nasrin Saeedian, Eunji Yang, Hayan Park, Sun-Je Woo, Gippeum Lim, Seong-Gyu Kim, Su-Kyeong Eo, Hoe Won Jeong, Taewoo Kim, Jae-Hyung Chang, Sang Hwan Seo, Na Hyung Kim, Eunsil Choi, Seungho Choo, Sangkyun Lee, Andrew Winterborn, Yue Li, Kate Parham, Justin M. Donovan, Brock Fenton, Jimmy D. Dikeakos, Gregory A. Dekaban, S. M. Mansour Haeryfar, Ryan M. Troyer, Eric J. Arts, Stephen D. Barr, Manki Song, C. Yong Kang

PLOS Pathogens: published December 16, 2021 | https://doi.org/10.1371/journal.ppat.1010092

Comparison of RNA synthesis initiation properties of non-segmented negative strand RNA virus polymerases

Afzaal M. Shareef, Barbara Ludeke, Paul Jordan, Jerome Deval, Rachel Fearns

PLOS Pathogens: published December 16, 2021 | https://doi.org/10.1371/journal.ppat.1010151

Quantification of T-cell dynamics during latent cytomegalovirus infection in humans

Sara P. H. van den Berg, Lyanne Y. Derksen, Julia Drylewicz, Nening M. Nanlohy, Lisa Beckers, Josien Lanfermeijer, Stephanie N. Gessel, Martijn Vos, Sigrid A. Otto, Rob J. de Boer, Kiki Tesselaar, José A. M. Borghans, Debbie van Baarle

PLOS Pathogens: published December 16, 2021 | https://doi.org/10.1371/journal.ppat.1010152

Long-term adaptation following influenza A virus host shifts results in increased within-host viral fitness due to higher replication rates, broader dissemination within the respiratory epithelium and reduced tissue damage

Julien A. R. Amat, Veronica Patton, Caroline Chauché, Daniel Goldfarb, Joanna Crispell, Quan Gu, Alice M. Coburn, Gaelle Gonzalez, Daniel Mair, Lily Tong, Luis Martinez-Sobrido, John F. Marshall, Francesco Marchesi, Pablo R. Murcia

PLOS Pathogens: published December 17, 2021 | https://doi.org/10.1371/journal.ppat.1010174

Viral RNA N⁶-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus

Miaoge Xue, Yuexiu Zhang, Haitao Wang, Elizabeth L. Kairis, Mijia Lu, Sadeem Ahmad, Zayed Attia, Olivia Harder, Zijie Zhang, Jiangbo Wei, Phylip Chen, Youling Gao, Mark E. Peeples, Amit Sharma, Prosper Boyaka, Chuan He, Sun Hur, Stefan Niewiesk, Jianrong Li

PLOS Pathogens: published December 20, 2021 | https://doi.org/10.1371/journal.ppat.1010142

The pigtail macaque (Macaca nemestrina) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease

Alexandra Melton, Lara A. Doyle-Meyers, Robert V. Blair, Cecily Midkiff, Hunter J. Melton, Kasi Russell-Lodrigue, Pyone P. Aye, Faith Schiro, Marissa Fahlberg, Dawn Szeltner, Skye Spencer, Brandon J. Beddingfield, Kelly Goff, Nadia Golden, Toni Penney, Breanna Picou, Krystle Hensley, Kristin E. Chandler, Jessica A. Plante, Kenneth S. Plante, Scott C. Weaver, Chad J. Roy, James A. Hoxie, Hongmei Gao, David C. Montefiori, Joseph L. Mankowski, Rudolf P. Bohm, Jay Rappaport, Nicholas J. Maness

PLOS Pathogens: published December 20, 2021 | https://doi.org/10.1371/journal.ppat.1010162

Dynamics of latent HIV under clonal expansion

John M. Murray

PLOS Pathogens: published December 20, 2021 | https://doi.org/10.1371/journal.ppat.1010165

Histone H3 deacetylation promotes host cell viability for efficient infection by Listeria monocytogenes

Matthew J. G. Eldridge, Mélanie A. Hamon

PLOS Pathogens: published December 20, 2021 | https://doi.org/10.1371/journal.ppat.1010173

SARS-CoV-2 receptor binding domain fusion protein efficiently neutralizes virus infection

Abigael Eva Chaouat, Hagit Achdout, Inbal Kol, Orit Berhani, Gil Roi, Einat B. Vitner, Sharon Melamed, Boaz Politi, Eran Zahavy, Ilija Brizic, Tihana Lenac Rovis, Or Alfi, Dana Wolf, Stipan Jonjic, Tomer Israely, Ofer Mandelboim

PLOS Pathogens: published December 20, 2021 | https://doi.org/10.1371/journal.ppat.1010175

Kaposi’s sarcoma-associated herpesvirus vFLIP promotes MEndT to generate hybrid M/E state for tumorigenesis

Weikang Chen, Yao Ding, Dawei Liu, Zhengzhou Lu, Yan Wang, Yan Yuan

PLOS Pathogens: published December 22, 2021 | https://doi.org/10.1371/journal.ppat.1009600

Evolution of protection after maternal immunization for respiratory syncytial virus in cotton rats

Jorge C. G. Blanco, Lori M. Cullen, Arash Kamali, Fatoumata Y. D. Sylla, Marina S. Boukhvalova, Trudy G. Morrison

PLOS Pathogens: published December 23, 2021 | https://doi.org/10.1371/journal.ppat.1009856

Modulation of sensory perception by hydrogen peroxide enables Caenorhabditis elegans to find a niche that provides both food and protection from hydrogen peroxide

Jodie A. Schiffer, Stephanie V. Stumbur, Maedeh Seyedolmohadesin, Yuyan Xu, William T. Serkin, Natalie G. McGowan, Oluwatosin Banjo, Mahdi Torkashvand, Albert Lin, Ciara N. Hosea, Adrien Assié, Buck S. Samuel, Michael P. O’Donnell, Vivek Venkatachalam, Javier Apfeld

PLOS Pathogens: published December 23, 2021 | https://doi.org/10.1371/journal.ppat.1010112

Curcumin activation of a bacterial mechanosensitive channel underlies its membrane permeability and adjuvant properties

Robin Wray, Irene Iscla, Paul Blount

PLOS Pathogens: published December 23, 2021 | https://doi.org/10.1371/journal.ppat.1010198

A novel class of Candida glabrata cell wall proteins with β-helix fold mediates adhesion in clinical isolates

Viktoria Reithofer, Jordan Fernández-Pereira, María Alvarado, Piet de Groot, Lars-Oliver Essen

PLOS Pathogens: published December 28, 2021 | https://doi.org/10.1371/journal.ppat.1009980

Intragenic proviral elements support transcription of defective HIV-1 proviruses

Jeffrey Kuniholm, Elise Armstrong, Brandy Bernabe, Carolyn Coote, Anna Berenson, Samantha D. Patalano, Alex Olson, Xianbao He, Nina H. Lin, Juan I. Fuxman Bass, Andrew J. Henderson

PLOS Pathogens: published December 28, 2021 | https://doi.org/10.1371/journal.ppat.1009982

An increase in glycoprotein concentration on extracellular virions dramatically alters vaccinia virus infectivity and pathogenesis without impacting immunogenicity

Stephanie R. Monticelli, Peter Bryk, Matthew G. Brewer, Hector C. Aguilar, Christopher C. Norbury, Brian M. Ward

PLOS Pathogens: published December 28, 2021 | https://doi.org/10.1371/journal.ppat.1010177

Neisseria gonorrhoeae subverts formin-dependent actin polymerization to colonize human macrophages

Stanimir S. Ivanov, Reneau Castore, Maria Dolores Juarez Rodriguez, Magdalena Circu, Ana-Maria Dragoi

PLOS Pathogens: published December 28, 2021 | https://doi.org/10.1371/journal.ppat.1010184

Longitudinal dynamics of SARS-CoV-2-specific cellular and humoral immunity after natural infection or BNT162b2 vaccination

Patricia Almendro-Vázquez, Rocio Laguna-Goya, Maria Ruiz-Ruigomez, Alberto Utrero-Rico, Antonio Lalueza, Guillermo Maestro de la Calle, Pilar Delgado, Luis Perez-Ordoño, Eva Muro, Juan Vila, Isabel Zamarron, Miguel Moreno-Batanero, Marta Chivite-Lacaba, Francisco Javier Gil-Etayo, Carmen Martín-Higuera, María Ángeles Meléndez-Carmona, Carlos Lumbreras, Irene Arellano, Balbino Alarcon, Luis Miguel Allende, Jose Maria Aguado, Estela Paz-Artal

PLOS Pathogens: published December 28, 2021 | https://doi.org/10.1371/journal.ppat.1010211

Reversion mutations in phosphoprotein P of a codon-pair-deoptimized human respiratory syncytial virus confer increased transcription, immunogenicity, and genetic stability without loss of attenuation

Jessica W. Chen, Lijuan Yang, Celia Santos, Sergio A. Hassan, Peter L. Collins, Ursula J. Buchholz, Cyril Le Nouën

PLOS Pathogens: published December 29, 2021 | https://doi.org/10.1371/journal.ppat.1010191

Cross-reactive and mono-reactive SARS-CoV-2 CD4+ T cells in prepandemic and COVID-19 convalescent individuals

Alexandra M. Johansson, Uma Malhotra, Yeseul G. Kim, Rebecca Gomez, Maxwell P. Krist, Anna Wald, David M. Koelle, William W. Kwok

PLOS Pathogens: published December 29, 2021 | https://doi.org/10.1371/journal.ppat.1010203

Corrections

Correction: SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon

Maya Shemesh, Turgut E. Aktepe, Joshua M. Deerain, Julie L. McAuley, Michelle D. Audsley, Cassandra T. David, Damian F. J. Purcell, Victoria Urin, Rune Hartmann, Gregory W. Moseley, Jason M. Mackenzie, Gideon Schreiber, Daniel Harari

PLOS Pathogens: published December 10, 2021 | https://doi.org/10.1371/journal.ppat.1010146

Correction: Breadth and function of antibody response to acute SARS-CoV-2 infection in humans

Kuan-Ying A. Huang, Tiong Kit Tan, Ting-Hua Chen, Chung-Guei Huang, Ruth Harvey, Saira Hussain, Cheng-Pin Chen, Adam Harding, Javier Gilbert-Jaramillo, Xu Liu, Michael Knight, Lisa Schimanski, Shin-Ru Shih, Yi-Chun Lin, Chien-Yu Cheng, Shu-Hsing Cheng, Yhu-Chering Huang, Tzou-Yien Lin, Jia-Tsrong Jan, Che Ma, William James, Rodney S. Daniels, John W. McCauley, Pramila Rijal, Alain R. Townsend

PLOS Pathogens: published December 10, 2021 | https://doi.org/10.1371/journal.ppat.1010148

Correction: CRISPR-based antimicrobials to obstruct antibiotic-resistant and pathogenic bacteria

Dennise Palacios Araya, Kelli L. Palmer, Breck A. Duerkop

PLOS Pathogens: published December 13, 2021 | https://doi.org/10.1371/journal.ppat.1010153

Expression of Concern

Expression of Concern: Nuclear Localization and Cleavage of STAT6 Is Induced by Kaposi’s Sarcoma-Associated Herpesvirus for Viral Latency

The PLOS Pathogens Editors

PLOS Pathogens: published December 15, 2021 | https://doi.org/10.1371/journal.ppat.1010047

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