August 2021

The image is a compressed, full-thickness z-stack of the colonic musclar wall from a mouse chronically infected with Trypanosoma cruzi. It shows a rare nest of amastigote parasites expressing a luciferase-mNeonGreen dual reporter protein (green). Neurons of the enteric nervous system, damage to which underlies the development of the digestive form of Chagas disease, are shown in magenta (neuron-specific beta-tubulin III, TuJ1⁺). DNA was labelled with Hoechst 33342 (white). Khan et al.

Image Credit: Lewis M, Khan A, 2021

Editorial

Editorial overview of Pearls Microbiome Series: E pluribus unum

Deborah A. Hogan, Joseph Heitman, Mary Ann Jabra-Rizk, Laura J. Knoll, John M. Leong, Neal Silverman

PLOS Pathogens: published August 31, 2021 | https://doi.org/10.1371/journal.ppat.1009912

Pearls

Binding and entering: COVID finds a new home

Michelle N. Vu, Vineet D. Menachery

PLOS Pathogens: published August 30, 2021 | https://doi.org/10.1371/journal.ppat.1009857

Reviews

The long-lasting enigma of polycytidine (polyC) tract

Velia Penza, Stephen J. Russell, Autumn J. Schulze

PLOS Pathogens: published August 4, 2021 | https://doi.org/10.1371/journal.ppat.1009739

Aspergillus fumigatus biofilms: Toward understanding how growth as a multicellular network increases antifungal resistance and disease progression

Kaesi A. Morelli, Joshua D. Kerkaert, Robert A. Cramer

PLOS Pathogens: published August 26, 2021 | https://doi.org/10.1371/journal.ppat.1009794

Research Articles

Intracellular niche-specific profiling reveals transcriptional adaptations required for the cytosolic lifestyle of Salmonella enterica

TuShun R. Powers, Amanda L. Haeberle, Alexander V. Predeus, Disa L. Hammarlöf, Jennifer A. Cundiff, Zeus Saldaña-Ahuactzi, Karsten Hokamp, Jay C. D. Hinton, Leigh A. Knodler

PLOS Pathogens: published August 30, 2021 | https://doi.org/10.1371/journal.ppat.1009280

The pentose phosphate pathway constitutes a major metabolic hub in pathogenic Francisella

Héloise Rytter, Anne Jamet, Jason Ziveri, Elodie Ramond, Mathieu Coureuil, Pauline Lagouge-Roussey, Daniel Euphrasie, Fabiola Tros, Nicolas Goudin, Cerina Chhuon, Ivan Nemazanyy, Fabricio Edgar de Moraes, Carlos Labate, Ida Chiara Guerrera, Alain Charbit

PLOS Pathogens: published August 2, 2021 | https://doi.org/10.1371/journal.ppat.1009326

Structural and functional studies of the first tripartite protein complex at the Trypanosoma brucei flagellar pocket collar

Charlotte Isch, Paul Majneri, Nicolas Landrein, Yulia Pivovarova, Johannes Lesigang, Florian Lauruol, Derrick R. Robinson, Gang Dong, Mélanie Bonhivers

PLOS Pathogens: published August 2, 2021 | https://doi.org/10.1371/journal.ppat.1009329

A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion and virulence in the malaria parasite Plasmodium falciparum

Jun Miao, Chengqi Wang, Amuza Byaruhanga Lucky, Xiaoying Liang, Hui Min, Swamy Rakesh Adapa, Rays Jiang, Kami Kim, Liwang Cui

PLOS Pathogens: published August 17, 2021 | https://doi.org/10.1371/journal.ppat.1009351

The redox-responsive transcriptional regulator Rex represses fermentative metabolism and is required for Listeria monocytogenes pathogenesis

Cortney R. Halsey, Rochelle C. Glover, Maureen K. Thomason, Michelle L. Reniere

PLOS Pathogens: published August 16, 2021 | https://doi.org/10.1371/journal.ppat.1009379

Human cytomegalovirus blocks canonical TGFβ signaling during lytic infection to limit induction of type I interferons

Andrew H. Pham, Jennifer Mitchell, Sara Botto, Kara M. Pryke, Victor R. DeFilippis, Meaghan H. Hancock

PLOS Pathogens: published August 19, 2021 | https://doi.org/10.1371/journal.ppat.1009380

Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through lack of the Rieske cytochrome bc₁ sub-unit

Eliza Ye-Chen Soh, Frances Smith, Maxime Rémi Gimenez, Liang Yang, Rebecca Munk Vejborg, Matthew Fletcher, Nigel Halliday, Sophie Bleves, Stephan Heeb, Miguel Cámara, Michael Givskov, Kim R. Hardie, Tim Tolker-Nielsen, Bérengère Ize, Paul Williams

PLOS Pathogens: published August 30, 2021 | https://doi.org/10.1371/journal.ppat.1009425

Intranasal type I interferon treatment is beneficial only when administered before clinical signs onset in the SARS-CoV-2 hamster model

Pierre Bessière, Marine Wasniewski, Evelyne Picard-Meyer, Alexandre Servat, Thomas Figueroa, Charlotte Foret-Lucas, Amelia Coggon, Sandrine Lesellier, Frank Boué, Nathan Cebron, Blandine Gausserès, Catherine Trumel, Gilles Foucras, Francisco J. Salguero, Elodie Monchatre-Leroy, Romain Volmer

PLOS Pathogens: published August 9, 2021 | https://doi.org/10.1371/journal.ppat.1009427

Measles virus exits human airway epithelia within dislodged metabolically active infectious centers

Camilla E. Hippee, Brajesh K. Singh, Andrew L. Thurman, Ashley L. Cooney, Alejandro A. Pezzulo, Roberto Cattaneo, Patrick L. Sinn

PLOS Pathogens: published August 12, 2021 | https://doi.org/10.1371/journal.ppat.1009458

Herpes simplex virus 2 (HSV-2) evolves faster in cell culture than HSV-1 by generating greater genetic diversity

Alberto Domingo López-Muñoz, Alberto Rastrojo, Rocío Martín, Antonio Alcamí

PLOS Pathogens: published August 26, 2021 | https://doi.org/10.1371/journal.ppat.1009541

Imprecise recombinant viruses evolve via a fitness-driven, iterative process of polymerase template-switching events

Kirsten Bentley, Fadi Ghassan Alnaji, Luke Woodford, Siân Jones, Andrew Woodman, David J. Evans

PLOS Pathogens: published August 20, 2021 | https://doi.org/10.1371/journal.ppat.1009676

pUL21 regulation of pUs3 kinase activity influences the nature of nuclear envelope deformation by the HSV-2 nuclear egress complex

Jamil H. Muradov, Renée L. Finnen, Michael A. Gulak, Thomas J. M. Hay, Bruce W. Banfield

PLOS Pathogens: published August 23, 2021 | https://doi.org/10.1371/journal.ppat.1009679

Fasting increases microbiome-based colonization resistance and reduces host inflammatory responses during an enteric bacterial infection

Franziska A. Graef, Larissa S. Celiberto, Joannie M. Allaire, Mimi T. Y. Kuan, Else S. Bosman, Shauna M. Crowley, Hyungjun Yang, Justin H. Chan, Martin Stahl, Hongbing Yu, Candice Quin, Deanna L. Gibson, Elena F. Verdu, Kevan Jacobson, Bruce A. Vallance

PLOS Pathogens: published August 5, 2021 | https://doi.org/10.1371/journal.ppat.1009719

A non-neutralizing antibody broadly protects against influenza virus infection by engaging effector cells

Yi-An Ko, Yueh-Hsiang Yu, Yen-Fei Wu, Yung-Chieh Tseng, Chia-Lin Chen, King-Siang Goh, Hsin-Yu Liao, Ting-Hua Chen, Ting-Jen Rachel Cheng, An-Suei Yang, Chi-Huey Wong, Che Ma, Kuo-I Lin

PLOS Pathogens: published August 5, 2021 | https://doi.org/10.1371/journal.ppat.1009724

Pertactin contributes to shedding and transmission of Bordetella bronchiseptica

Longhuan Ma, Kalyan K. Dewan, Dawn L. Taylor-Mulneix, Shannon M. Wagner, Bodo Linz, Israel Rivera, Yang Su, Amanda D. Caulfield, Uriel Blas-Machado, Eric T. Harvill

PLOS Pathogens: published August 4, 2021 | https://doi.org/10.1371/journal.ppat.1009735

Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates

Jelle van Schooten, Marlies M. van Haaren, Hui Li, Laura E. McCoy, Colin Havenar-Daughton, Christopher A. Cottrell, Judith A. Burger, Patricia van der Woude, Leanne C. Helgers, Ilhan Tomris, Celia C. Labranche, David C. Montefiori, Andrew B. Ward, Dennis R. Burton, John P. Moore, Rogier W. Sanders, Shane Crotty, George M. Shaw, Marit J. van Gils

PLOS Pathogens: published August 25, 2021 | https://doi.org/10.1371/journal.ppat.1009736

Rapid generation of mouse model for emerging infectious disease with the case of severe COVID-19

Cheng-Pu Sun, Jia-Tsrong Jan, I-Hsuan Wang, Hsiu-Hua Ma, Hui-Ying Ko, Ping-Yi Wu, Tzu-Jiun Kuo, Hsin-Ni Liao, Yu-Hua Lan, Zong-Lin Sie, Yen-Hui Chen, Yi-An Ko, Chun-Che Liao, Liang-Yu Chen, I-Jung Lee, Szu-I Tsung, Yun-Ju Lai, Ming-Tsai Chiang, Jian-Jong Liang, Wen-Chun Liu, Jing-Rong Wang, Joyce Pei-Yi Yuan, Yin-Shiou Lin, Yi-Ching Tsai, Shie-Liang Hsieh, Chia-Wei Li, Han-Chung Wu, Tai-Ming Ko, Yi-Ling Lin, Mi-Hua Tao

PLOS Pathogens: published August 11, 2021 | https://doi.org/10.1371/journal.ppat.1009758

Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies

Marta Alenquer, Filipe Ferreira, Diana Lousa, Mariana Valério, Mónica Medina-Lopes, Marie-Louise Bergman, Juliana Gonçalves, Jocelyne Demengeot, Ricardo B. Leite, Jingtao Lilue, Zemin Ning, Carlos Penha-Gonçalves, Helena Soares, Cláudio M. Soares, Maria João Amorim

PLOS Pathogens: published August 5, 2021 | https://doi.org/10.1371/journal.ppat.1009772

CXCL1: A new diagnostic biomarker for human tuberculosis discovered using Diversity Outbred mice

Deniz Koyuncu, Muhammad Khalid Khan Niazi, Thomas Tavolara, Claudia Abeijon, Melanie L. Ginese, Yanghui Liao, Carolyn Mark, Aubrey Specht, Adam C. Gower, Blanca I. Restrepo, Daniel M. Gatti, Igor Kramnik, Metin Gurcan, Bülent Yener, Gillian Beamer

PLOS Pathogens: published August 17, 2021 | https://doi.org/10.1371/journal.ppat.1009773

Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses

Sofia Banchenko, Ferdinand Krupp, Christine Gotthold, Jörg Bürger, Andrea Graziadei, Francis J. O’Reilly, Ludwig Sinn, Olga Ruda, Juri Rappsilber, Christian M. T. Spahn, Thorsten Mielke, Ian A. Taylor, David Schwefel

PLOS Pathogens: published August 2, 2021 | https://doi.org/10.1371/journal.ppat.1009775

Transovarial transmission of a core virome in the Chagas disease vector Rhodnius prolixus

Tarcísio Fontenele de Brito, Vitor Lima Coelho, Maira Arruda Cardoso, Ingrid Alexandre de Abreu Brito, Mateus Antonio Berni, Fides Lea Zenk, Nicola Iovino, Attilio Pane

PLOS Pathogens: published August 18, 2021 | https://doi.org/10.1371/journal.ppat.1009780

Hippo signaling effectors YAP and TAZ induce Epstein-Barr Virus (EBV) lytic reactivation through TEADs in epithelial cells

Nicholas Van Sciver, Makoto Ohashi, Nicholas P. Pauly, Jillian A. Bristol, Scott E. Nelson, Eric C. Johannsen, Shannon C. Kenney

PLOS Pathogens: published August 2, 2021 | https://doi.org/10.1371/journal.ppat.1009783

Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ART

Michael J. Corley, Carlo Sacdalan, Alina P. S. Pang, Nitiya Chomchey, Nisakorn Ratnaratorn, Victor Valcour, Eugene Kroon, Kyu S. Cho, Andrew C. Belden, Donn Colby, Merlin Robb, Denise Hsu, Serena Spudich, Robert Paul, Sandhya Vasan, Lishomwa C. Ndhlovu, the SEARCH010/RV254 and SEARCH013/RV304 study groups

PLOS Pathogens: published August 13, 2021 | https://doi.org/10.1371/journal.ppat.1009785

Cuban history of CRF19 recombinant subtype of HIV-1

Anna Zhukova, Jakub Voznica, Miraine Dávila Felipe, Thu-Hien To, Lissette Pérez, Yenisleidys Martínez, Yanet Pintos, Melissa Méndez, Olivier Gascuel, Vivian Kouri

PLOS Pathogens: published August 9, 2021 | https://doi.org/10.1371/journal.ppat.1009786

The ALPK1 pathway drives the inflammatory response to Campylobacter jejuni in human intestinal epithelial cells

Jiannan Cui, Coco Duizer, Lieneke I. Bouwman, Kristel S. van Rooijen, Carlos G. P. Voogdt, Jos P. M. van Putten, Marcel R. de Zoete

PLOS Pathogens: published August 2, 2021 | https://doi.org/10.1371/journal.ppat.1009787

Efficient Dicer processing of virus-derived double-stranded RNAs and its modulation by RIG-I-like receptor LGP2

Yuqiang Zhang, Yan Xu, Yunpeng Dai, Zhe Li, Jiaxing Wang, Zhi Ye, Yanxin Ren, Hua Wang, Wan-xiang Li, Jinfeng Lu, Shou-Wei Ding, Yang Li

PLOS Pathogens: published August 3, 2021 | https://doi.org/10.1371/journal.ppat.1009790

NAD⁺ pool depletion as a signal for the Rex regulon involved in Streptococcus agalactiae virulence

Thierry Franza, Annika Rogstam, Saravanamuthu Thiyagarajan, Matthew J. Sullivan, Aurelie Derré-Bobillot, Mikael C. Bauer, Kelvin G. K. Goh, Violette Da Cunha, Philippe Glaser, Derek T. Logan, Glen C. Ulett, Claes von Wachenfeldt, Philippe Gaudu

PLOS Pathogens: published August 9, 2021 | https://doi.org/10.1371/journal.ppat.1009791

Cytomegalovirus late transcription factor target sequence diversity orchestrates viral early to late transcription

Ming Li, Qiaolin Hu, Geoffrey Collins, Mrutyunjaya Parida, Christopher B. Ball, David H. Price, Jeffery L. Meier

PLOS Pathogens: published August 2, 2021 | https://doi.org/10.1371/journal.ppat.1009796

Single-cell transcriptomic analyses of T cells in chronic HCV-infected patients dominated by DAA-induced interferon signaling changes

Matthew A. Burchill, Matthew P. Salomon, Lucy Golden-Mason, Amanda Wieland, Ana C. Maretti-Mira, Michael Gale Jr, Hugo R. Rosen

PLOS Pathogens: published August 9, 2021 | https://doi.org/10.1371/journal.ppat.1009799

SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon

Maya Shemesh, Turgut E. Aktepe, Joshua M. Deerain, Julie L. McAuley, Michelle D. Audsley, Cassandra T. David, Damian F. J. Purcell, Victoria Urin, Rune Hartmann, Gregory W. Moseley, Jason M. Mackenzie, Gideon Schreiber, Daniel Harari

PLOS Pathogens: published August 26, 2021 | https://doi.org/10.1371/journal.ppat.1009800

Modern Acinetobacter baumannii clinical isolates replicate inside spacious vacuoles and egress from macrophages

Gabriela Sycz, Gisela Di Venanzio, Jesus S. Distel, Mariana G. Sartorio, Nguyen-Hung Le, Nichollas E. Scott, Wandy L. Beatty, Mario F. Feldman

PLOS Pathogens: published August 9, 2021 | https://doi.org/10.1371/journal.ppat.1009802

The degree of polymerization and sulfation patterns in heparan sulfate are critical determinants of cytomegalovirus entry into host cells

Dipanwita Mitra, Mohammad H. Hasan, John T. Bates, Michael A. Bierdeman, Dallas R. Ederer, Rinkuben C. Parmar, Lauren A. Fassero, Quntao Liang, Hong Qiu, Vaibhav Tiwari, Fuming Zhang, Robert J. Linhardt, Joshua S. Sharp, Lianchun Wang, Ritesh Tandon

PLOS Pathogens: published August 5, 2021 | https://doi.org/10.1371/journal.ppat.1009803

Luteolin as a potential host-directed immunotherapy adjunct to isoniazid treatment of tuberculosis

Dhiraj Kumar Singh, Sultan Tousif, Ashima Bhaskar, Annu Devi, Kriti Negi, Barnani Moitra, Anand Ranganathan, Ved Prakash Dwivedi, Gobardhan Das

PLOS Pathogens: published August 20, 2021 | https://doi.org/10.1371/journal.ppat.1009805

Loss of Septation Initiation Network (SIN) kinases blocks tissue invasion and unlocks echinocandin cidal activity against Aspergillus fumigatus

Ana Camila Oliveira Souza, Adela Martin-Vicente, Ashley V. Nywening, Wenbo Ge, David J. Lowes, Brian M. Peters, Jarrod R. Fortwendel

PLOS Pathogens: published August 9, 2021 | https://doi.org/10.1371/journal.ppat.1009806

The PilB-PilZ-FimX regulatory complex of the Type IV pilus from Xanthomonas citri

Edgar E. Llontop, William Cenens, Denize C. Favaro, Germán G. Sgro, Roberto K. Salinas, Cristiane R. Guzzo, Chuck S. Farah

PLOS Pathogens: published August 16, 2021 | https://doi.org/10.1371/journal.ppat.1009808

Mouse papillomavirus type 1 (MmuPV1) DNA is frequently integrated in benign tumors by microhomology-mediated end-joining

Lulu Yu, Vladimir Majerciak, Xiang-Yang Xue, Aayushi Uberoi, Alexei Lobanov, Xiongfong Chen, Maggie Cam, Stephen H. Hughes, Paul F. Lambert, Zhi-Ming Zheng

PLOS Pathogens: published August 3, 2021 | https://doi.org/10.1371/journal.ppat.1009812

Substrate-mediated regulation of the arginine transporter of Toxoplasma gondii

Esther Rajendran, Morgan Clark, Cibelly Goulart, Birte Steinhöfel, Erick T. Tjhin, Simon Gross, Nicholas C. Smith, Kiaran Kirk, Giel G. van Dooren

PLOS Pathogens: published August 5, 2021 | https://doi.org/10.1371/journal.ppat.1009816

Detoxification of methylglyoxal by the glyoxalase system is required for glutathione availability and virulence activation in Listeria monocytogenes

Andrea Anaya-Sanchez, Ying Feng, John C. Berude, Daniel A. Portnoy

PLOS Pathogens: published August 18, 2021 | https://doi.org/10.1371/journal.ppat.1009819

Nine viruses from eight lineages exhibiting new evolutionary modes that co-infect a hypovirulent phytopathogenic fungus

Fan Mu, Bo Li, Shufen Cheng, Jichun Jia, Daohong Jiang, Yanping Fu, Jiasen Cheng, Yang Lin, Tao Chen, Jiatao Xie

PLOS Pathogens: published August 24, 2021 | https://doi.org/10.1371/journal.ppat.1009823

pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread

Tomasz H. Benedyk, Julia Muenzner, Viv Connor, Yue Han, Katherine Brown, Kaveesha J. Wijesinghe, Yunhui Zhuang, Susanna Colaco, Guido A. Stoll, Owen S. Tutt, Stanislava Svobodova, Dmitri I. Svergun, Neil A. Bryant, Janet E. Deane, Andrew E. Firth, Cy M. Jeffries, Colin M. Crump, Stephen C. Graham

PLOS Pathogens: published August 16, 2021 | https://doi.org/10.1371/journal.ppat.1009824

Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART

Maria Pino, Susan Pereira Ribeiro, Amélie Pagliuzza, Khader Ghneim, Anum Khan, Emily Ryan, Justin L. Harper, Colin T. King, Sarah Welbourn, Luca Micci, Sol Aldrete, Keith A. Delman, Theron Stuart, Michael Lowe, Jason M. Brenchley, Cynthia A. Derdeyn, Kirk Easley, Rafick P. Sekaly, Nicolas Chomont, Mirko Paiardini, Vincent C. Marconi

PLOS Pathogens: published August 27, 2021 | https://doi.org/10.1371/journal.ppat.1009825

EBNA2 driven enhancer switching at the CIITA-DEXI locus suppresses HLA class II gene expression during EBV infection of B-lymphocytes

Chenhe Su, Fang Lu, Samantha S. Soldan, R. Jason Lamontagne, Hsin-Yao Tang, Giorgia Napoletani, Paul J. Farrell, Italo Tempera, Andrew V. Kossenkov, Paul M. Lieberman

PLOS Pathogens: published August 5, 2021 | https://doi.org/10.1371/journal.ppat.1009834

Coordinated action of multiple transporters in the acquisition of essential cationic amino acids by the intracellular parasite Toxoplasma gondii

Stephen J. Fairweather, Esther Rajendran, Martin Blume, Kiran Javed, Birte Steinhöfel, Malcolm J. McConville, Kiaran Kirk, Stefan Bröer, Giel G. van Dooren

PLOS Pathogens: published August 25, 2021 | https://doi.org/10.1371/journal.ppat.1009835

Exosomal miR-224 contributes to hemolymph microbiota homeostasis during bacterial infection in crustacean

Yi Gong, Xiaoyuan Wei, Wanwei Sun, Xin Ren, Jiao Chen, Jude Juventus Aweya, Hongyu Ma, Kok-Gan Chan, Yueling Zhang, Shengkang Li

PLOS Pathogens: published August 11, 2021 | https://doi.org/10.1371/journal.ppat.1009837

Probing the spatiotemporal patterns of HBV multiplication reveals novel features of its subcellular processes

Lei Yue, Chang Li, Mingzhu Xu, Min Wu, Jiahui Ding, Jiangxia Liu, Xiaonan Zhang, Zhenghong Yuan

PLOS Pathogens: published August 9, 2021 | https://doi.org/10.1371/journal.ppat.1009838

Activation of Cph1 causes ß(1,3)-glucan unmasking in Candida albicans and attenuates virulence in mice in a neutrophil-dependent manner

Andrew S. Wagner, Trevor J. Hancock, Stephen W. Lumsdaine, Sarah J. Kauffman, Mikayla M. Mangrum, Elise K. Phillips, Timothy E. Sparer, Todd B. Reynolds

PLOS Pathogens: published August 25, 2021 | https://doi.org/10.1371/journal.ppat.1009839

Hantavirus infection-induced B cell activation elevates free light chains levels in circulation

Jussi Hepojoki, Luz E. Cabrera, Satu Hepojoki, Carla Bellomo, Lauri Kareinen, Leif C. Andersson, Antti Vaheri, Satu Mäkelä, Jukka Mustonen, Olli Vapalahti, Valeria Martinez, Tomas Strandin

PLOS Pathogens: published August 11, 2021 | https://doi.org/10.1371/journal.ppat.1009843

Host GRXC6 restricts Tomato yellow leaf curl virus infection by inhibiting the nuclear export of the V2 protein

Wenhao Zhao, Yijun Zhou, Xueping Zhou, Xiaofeng Wang, Yinghua Ji

PLOS Pathogens: published August 16, 2021 | https://doi.org/10.1371/journal.ppat.1009844

The Drosophila Baramicin polypeptide gene protects against fungal infection

Mark Austin Hanson, Lianne B. Cohen, Alice Marra, Igor Iatsenko, Steven A. Wasserman, Bruno Lemaitre

PLOS Pathogens: published August 25, 2021 | https://doi.org/10.1371/journal.ppat.1009846

Blocking HSV-1 glycoprotein K binding to signal peptide peptidase reduces virus infectivity in vitro and in vivo

Shaohui Wang, Ujjaldeep Jaggi, Jack Yu, Homayon Ghiasi

PLOS Pathogens: published August 5, 2021 | https://doi.org/10.1371/journal.ppat.1009848

Acute SARS-CoV-2 infections harbor limited within-host diversity and transmit via tight transmission bottlenecks

Katarina M. Braun, Gage K. Moreno, Cassia Wagner, Molly A. Accola, William M. Rehrauer, David A. Baker, Katia Koelle, David H. O’Connor, Trevor Bedford, Thomas C. Friedrich, Louise H. Moncla

PLOS Pathogens: published August 23, 2021 | https://doi.org/10.1371/journal.ppat.1009849

Metabolomics provide new insights into mechanisms of Wolbachia-induced paternal defects in Drosophila melanogaster

Hua-Bao Zhang, Zheng Cao, Jun-Xue Qiao, Zi-Qian Zhong, Chen-Chen Pan, Chen Liu, Li-Min Zhang, Yu-Feng Wang

PLOS Pathogens: published August 12, 2021 | https://doi.org/10.1371/journal.ppat.1009859

Robust innate immune responses at the placenta during early gestation may limit in utero HIV transmission

Erica L. Johnson, Dominika Swieboda, Amanda Olivier, Elizabeth Ann L. Enninga, Rana Chakraborty

PLOS Pathogens: published August 25, 2021 | https://doi.org/10.1371/journal.ppat.1009860

Integrative multi-omics profiling reveals cAMP-independent mechanisms regulating hyphal morphogenesis in Candida albicans

Kyunghun Min, Thomas F. Jannace, Haoyu Si, Krishna R. Veeramah, John D. Haley, James B. Konopka

PLOS Pathogens: published August 16, 2021 | https://doi.org/10.1371/journal.ppat.1009861

Cytomegalovirus immediate-early 1 proteins form a structurally distinct protein class with adaptations determining cross-species barriers

Johannes Schweininger, Myriam Scherer, Franziska Rothemund, Eva-Maria Schilling, Sonja Wörz, Thomas Stamminger, Yves A. Muller

PLOS Pathogens: published August 9, 2021 | https://doi.org/10.1371/journal.ppat.1009863

Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale

Archie A. Khan, Harry C. Langston, Fernanda C. Costa, Francisco Olmo, Martin C. Taylor, Conor J. McCann, John M. Kelly, Michael D. Lewis

PLOS Pathogens: published August 23, 2021 | https://doi.org/10.1371/journal.ppat.1009864

Seroconversion and fever are dose-dependent in a nonhuman primate model of inhalational COVID-19

Paul A. Dabisch, Jennifer Biryukov, Katie Beck, Jeremy A. Boydston, Jaleal S. Sanjak, Artemas Herzog, Brian Green, Gregory Williams, John Yeager, Jordan K. Bohannon, Brian Holland, David Miller, Amy L. Reese, Denise Freeburger, Susan Miller, Tammy Jenkins, Sherry Rippeon, James Miller, David Clarke, Emmanuel Manan, Ashley Patty, Kim Rhodes, Tina Sweeney, Michael Winpigler, Owen Price, Jason Rodriguez, Louis A. Altamura, Heather Zimmerman, Alec S. Hail, Victoria Wahl, Michael Hevey

PLOS Pathogens: published August 23, 2021 | https://doi.org/10.1371/journal.ppat.1009865

NK cells eliminate Epstein-Barr virus bound to B cells through a specific antibody-mediated uptake

Elisenda Alari-Pahissa, Michelle Ataya, Ilias Moraitis, Miriam Campos-Ruiz, Mireia Altadill, Aura Muntasell, Anna Moles, Miguel López-Botet

PLOS Pathogens: published August 20, 2021 | https://doi.org/10.1371/journal.ppat.1009868

BB0562 is a nutritional virulence determinant with lipase activity important for Borrelia burgdorferi infection and survival in fatty acid deficient environments

Hunter W. Kuhn, Amanda G. Lasseter, Philip P. Adams, Carlos Flores Avile, Brandee L. Stone, Darrin R. Akins, Travis J. Jewett, Mollie W. Jewett

PLOS Pathogens: published August 20, 2021 | https://doi.org/10.1371/journal.ppat.1009869

EBV latent membrane proteins promote hybrid epithelial-mesenchymal and extreme mesenchymal states of nasopharyngeal carcinoma cells for tumorigenicity

Nannan Zhu, Xiaoting Xu, Yan Wang, Mu-Sheng Zeng, Yan Yuan

PLOS Pathogens: published August 18, 2021 | https://doi.org/10.1371/journal.ppat.1009873

Short- and long-range cis interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical carcinogenesis

Ian J. Groves, Emma L. A. Drane, Marco Michalski, Jack M. Monahan, Cinzia G. Scarpini, Stephen P. Smith, Giovanni Bussotti, Csilla Várnai, Stefan Schoenfelder, Peter Fraser, Anton J. Enright, Nicholas Coleman

PLOS Pathogens: published August 25, 2021 | https://doi.org/10.1371/journal.ppat.1009875

Avian influenza A virus susceptibility, infection, transmission, and antibody kinetics in European starlings

Jeremy W. Ellis, J. Jeffrey Root, Loredana M. McCurdy, Kevin T. Bentler, Nicole L. Barrett, Kaci K. VanDalen, Katherine L. Dirsmith, Susan A. Shriner

PLOS Pathogens: published August 30, 2021 | https://doi.org/10.1371/journal.ppat.1009879

Nasal alum-adjuvanted vaccine promotes IL-33 release from alveolar epithelial cells that elicits IgA production via type 2 immune responses

Eita Sasaki, Hideki Asanuma, Haruka Momose, Keiko Furuhata, Takuo Mizukami, Isao Hamaguchi

PLOS Pathogens: published August 30, 2021 | https://doi.org/10.1371/journal.ppat.1009890

Lung eosinophils elicited during allergic and acute aspergillosis express RORγt and IL-23R but do not require IL-23 for IL-17 production

Bhawna Yadav, Charles A. Specht, Chrono K. Lee, Maria Pokrovskii, Jun R. Huh, Dan R. Littman, Stuart M. Levitz

PLOS Pathogens: published August 31, 2021 | https://doi.org/10.1371/journal.ppat.1009891

A kinase-independent function of PAK is crucial for pathogen-mediated actin remodelling

Anthony Davidson, Joe Tyler, Peter Hume, Vikash Singh, Vassilis Koronakis

PLOS Pathogens: published August 30, 2021 | https://doi.org/10.1371/journal.ppat.1009902

Critical role of IL-25-ILC2-IL-5 axis in the production of anti-Francisella LPS IgM by B1 B cells

Carlos Henrique D. Barbosa, Louis Lantier, Joseph Reynolds, Jinyong Wang, Fabio Re

PLOS Pathogens: published August 27, 2021 | https://doi.org/10.1371/journal.ppat.1009905

Corrections

Correction: Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans

Barbara Holzer, Pramila Rijal, Adam McNee, Basudev Paudyal, Veronica Martini, Becky Clark, Tanuja Manjegowda, Francisco J. Salguero, Emily Bessell, John C. Schwartz, Katy Moffat, Miriam Pedrera, Simon P. Graham, Alistair Noble, Marie Bonnet-Di Placido, Roberto M. La Ragione, William Mwangi, Peter Beverley, John W. McCauley, Rodney S. Daniels, John A. Hammond, Alain R. Townsend, Elma Tchilian

PLOS Pathogens: published August 4, 2021 | https://doi.org/10.1371/journal.ppat.1009815

Correction: Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol

Michael G. Dorrington, Clinton J. Bradfield, Justin B. Lack, Bin Lin, Sinu P. John, Jonathan J. Liang, Tregei Starr, Orna Ernst, Julia L. Gross, Jing Sun, Alexandra H. Miller, Olivia Steele-Mortimer, Iain D. C. Fraser

PLOS Pathogens: published August 4, 2021 | https://doi.org/10.1371/journal.ppat.1009821

Correction: Monocyte subset redistribution from blood to kidneys in patients with Puumala virus caused hemorrhagic fever with renal syndrome

Sindhu Vangeti, Tomas Strandin, Sang Liu, Johanna Tauriainen, Anne Räisänen-Sokolowski, Luz E. Cabrera, Antti Hassinen, Satu Mäkelä, Jukka Mustonen, Antti Vaheri, Olli Vapalahti, Jonas Klingström, Anna Smed-Sörensen

PLOS Pathogens: published August 25, 2021 | https://doi.org/10.1371/journal.ppat.1009876

Correction: Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of Candida albicans

Fitz Gerald S. Silao, Kicki Ryman, Tong Jiang, Meliza Ward, Nicolas Hansmann, Chris Molenaar, Ning-Ning Liu, Changbin Chen, Per O. Ljungdahl

PLOS Pathogens: published August 30, 2021 | https://doi.org/10.1371/journal.ppat.1009877

Correction: Robust CAR-T memory formation and function via hematopoietic stem cell delivery

Anjie Zhen, Mayra A Carrillo, Wenli Mu, Valerie Rezek, Heather Martin, Philip Hamid, Irvin S. Y. Chen, Otto O. Yang, Jerome A. Zack, Scott G. Kitchen

PLOS Pathogens: published August 30, 2021 | https://doi.org/10.1371/journal.ppat.1009895

Correction: Luteolin-mediated Kv1.3 K⁺ channel inhibition augments BCG vaccine efficacy against tuberculosis by promoting central memory T cell responses in mice

Dhiraj Kumar Singh, Ved Prakash Dwivedi, Shashi Prakash Singh, Anjna Kumari, Saurabh Kumar Sharma, Anand Ranganathan, Luc Van Kaer, Gobardhan Das

PLOS Pathogens: published August 30, 2021 | https://doi.org/10.1371/journal.ppat.1009896

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Focus of chronic Trypanosoma cruzi infection in the muscular layer of the colon wall

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**Focus of chronic Trypanosoma cruzi infection in the muscular layer of the colon wall**