April 2021

Trypanosoma cruzi, the etiologic agent of Chagas' disease, causes massive oxidative stress during infection leading to host cell DNA damage. This fluorescence microscopy image shows intracellular parasites, expressing GFP, multiplying in host cell cytosol. The red foci presented in infected HeLa cell nuclei (stained with DAPI, blue) reveals the phosphorylation of Histone H2Ax, an important signal of genotoxic stress and DNA lesions, caused by the parasite. Florentino et al.

Image Credit: Florentino PTV, Mortara, RA, 2021

Opinions

Individuals cannot rely on COVID-19 herd immunity: Durable immunity to viral disease is limited to viruses with obligate viremic spread

Jonathan W. Yewdell

PLOS Pathogens: published April 26, 2021 | https://doi.org/10.1371/journal.ppat.1009509

Two courses of deconstructed coronavirus please

Connor G. G. Bamford

PLOS Pathogens: published April 29, 2021 | https://doi.org/10.1371/journal.ppat.1009547

Pearls

Now for something completely different: Prototheca, pathogenic algae

Christopher D. Shave, Linda Millyard, Robin C. May

PLOS Pathogens: published April 1, 2021 | https://doi.org/10.1371/journal.ppat.1009362

Microbes and pain

Liwen Deng, Isaac M. Chiu

PLOS Pathogens: published April 1, 2021 | https://doi.org/10.1371/journal.ppat.1009398

The role of antimicrobial peptides in the evolution of endosymbiotic protein import

Oliver D. Caspari, Ingrid Lafontaine

PLOS Pathogens: published April 15, 2021 | https://doi.org/10.1371/journal.ppat.1009466

Fungal cell wall: An underexploited target for antifungal therapies

Chibuike Ibe, Carol A. Munro

PLOS Pathogens: published April 22, 2021 | https://doi.org/10.1371/journal.ppat.1009470

Toward understanding microbiota homeostasis in the plant kingdom

Bradley C. Paasch, Sheng Yang He

PLOS Pathogens: published April 22, 2021 | https://doi.org/10.1371/journal.ppat.1009472

Climate change and the emergence of fungal pathogens

Nnaemeka Emmanuel Nnadi, Dee A. Carter

PLOS Pathogens: published April 29, 2021 | https://doi.org/10.1371/journal.ppat.1009503

RhoGTPases and inflammasomes: Guardians of effector-triggered immunity

Océane Dufies, Laurent Boyer

PLOS Pathogens: published April 29, 2021 | https://doi.org/10.1371/journal.ppat.1009504

Reviews

Microbiome-immune interactions in tuberculosis

Giorgia Mori, Mark Morrison, Antje Blumenthal

PLOS Pathogens: published April 15, 2021 | https://doi.org/10.1371/journal.ppat.1009377

Actives from MMV Open Access Boxes? A suggested way forward

Kirandeep Samby, Paul A. Willis, Jeremy N. Burrows, Benoît Laleu, Peter J. H. Webborn

PLOS Pathogens: published April 22, 2021 | https://doi.org/10.1371/journal.ppat.1009384

Transport mechanisms at the malaria parasite-host cell interface

Josh R. Beck, Chi-Min Ho

PLOS Pathogens: published April 1, 2021 | https://doi.org/10.1371/journal.ppat.1009394

Some conditions apply: Systems for studying Plasmodium falciparum protein function

Heather M. Kudyba, David W. Cobb, Joel Vega-Rodríguez, Vasant Muralidharan

PLOS Pathogens: published April 22, 2021 | https://doi.org/10.1371/journal.ppat.1009442

Research Articles

Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

Rajesh Kumar, Suprit Deshpande, Leigh M. Sewall, Gabriel Ozorowski, Christopher A. Cottrell, Wen-Hsin Lee, Lauren G. Holden, Sara T. Richey, Antra Singh Chandrawacar, Kanika Dhiman, Ashish, Vivek Kumar, Shubbir Ahmed, Nitin Hingankar, Naresh Kumar, Kailapuri G. Murugavel, Aylur K. Srikrishnan, Devin Sok, Andrew B. Ward, Jayanta Bhattacharya

PLOS Pathogens: published April 7, 2021 | https://doi.org/10.1371/journal.ppat.1008977

A primary nasopharyngeal three-dimensional air-liquid interface cell culture model of the pseudostratified epithelium reveals differential donor- and cell type-specific susceptibility to Epstein-Barr virus infection

Phillip Ziegler, Yarong Tian, Yulong Bai, Sanna Abrahamsson, Alan Bäckerholm, Alex S. Reznik, Anthony Green, John A. Moore, Stella E. Lee, Michael M. Myerburg, Hyun Jung Park, Ka-Wei Tang, Kathy Ho Yen Shair

PLOS Pathogens: published April 29, 2021 | https://doi.org/10.1371/journal.ppat.1009041

Safe and effective two-in-one replicon-and-VLP minispike vaccine for COVID-19: Protection of mice after a single immunization

Alexandru A. Hennrich, Bevan Sawatsky, Rosalía Santos-Mandujano, Dominic H. Banda, Martina Oberhuber, Anika Schopf, Verena Pfaffinger, Kevin Wittwer, Christiane Riedel, Christian K. Pfaller, Karl-Klaus Conzelmann

PLOS Pathogens: published April 21, 2021 | https://doi.org/10.1371/journal.ppat.1009064

Prophages integrating into prophages: A mechanism to accumulate type III secretion effector genes and duplicate Shiga toxin-encoding prophages in Escherichia coli

Keiji Nakamura, Yoshitoshi Ogura, Yasuhiro Gotoh, Tetsuya Hayashi

PLOS Pathogens: published April 29, 2021 | https://doi.org/10.1371/journal.ppat.1009073

Highly efficient CRISPR-Cas9-mediated gene knockout in primary human B cells for functional genetic studies of Epstein-Barr virus infection

Ezgi Akidil, Manuel Albanese, Alexander Buschle, Adrian Ruhle, Dagmar Pich, Oliver T. Keppler, Wolfgang Hammerschmidt

PLOS Pathogens: published April 15, 2021 | https://doi.org/10.1371/journal.ppat.1009117

Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy

John M. Coffin, Michael J. Bale, Daria Wells, Shuang Guo, Brian Luke, Jennifer M. Zerbato, Michele D. Sobolewski, Twan Sia, Wei Shao, Xiaolin Wu, Frank Maldarelli, Mary F. Kearney, John W. Mellors, Stephen H. Hughes

PLOS Pathogens: published April 7, 2021 | https://doi.org/10.1371/journal.ppat.1009141

Predicting the animal hosts of coronaviruses from compositional biases of spike protein and whole genome sequences through machine learning

Liam Brierley, Anna Fowler

PLOS Pathogens: published April 20, 2021 | https://doi.org/10.1371/journal.ppat.1009149

Neuraminidase B controls neuraminidase A-dependent mucus production and evasion

Alexandria J. Hammond, Ulrike Binsker, Surya D. Aggarwal, Mila Brum Ortigoza, Cynthia Loomis, Jeffrey N. Weiser

PLOS Pathogens: published April 5, 2021 | https://doi.org/10.1371/journal.ppat.1009158

Balancing the influenza neuraminidase and hemagglutinin responses by exchanging the vaccine virus backbone

Jin Gao, Hongquan Wan, Xing Li, Mira Rakic Martinez, Laura Klenow, Yamei Gao, Zhiping Ye, Robert Daniels

PLOS Pathogens: published April 19, 2021 | https://doi.org/10.1371/journal.ppat.1009171

Mycobacterial infection-induced miR-206 inhibits protective neutrophil recruitment via the CXCL12/CXCR4 signalling axis

Kathryn Wright, Kumudika de Silva, Karren M. Plain, Auriol C. Purdie, Tamika A. Blair, Iain G. Duggin, Warwick J. Britton, Stefan H. Oehlers

PLOS Pathogens: published April 7, 2021 | https://doi.org/10.1371/journal.ppat.1009186

The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans

Eillen Tecle, Crystal B. Chhan, Latisha Franklin, Ryan S. Underwood, Wendy Hanna-Rose, Emily R. Troemel

PLOS Pathogens: published April 20, 2021 | https://doi.org/10.1371/journal.ppat.1009350

Robust CAR-T memory formation and function via hematopoietic stem cell delivery

Anjie Zhen, Mayra A. Carrillo, Wenli Mu, Valerie Rezek, Heather Martin, Philip Hamid, Irvin S. Y. Chen, Otto O. Yang, Jerome A. Zack, Scott G. Kitchen

PLOS Pathogens: published April 1, 2021 | https://doi.org/10.1371/journal.ppat.1009404

Differential recognition of HIV-stimulated IL-1β and IL-18 secretion through NLR and NAIP signalling in monocyte-derived macrophages

Kathy Triantafilou, Christopher J. K. Ward, Magdalena Czubala, Robert G. Ferris, Emma Koppe, Curt Haffner, Vincent Piguet, Vipulkumar K. Patel, Heather Amrine-Madsen, Louise K. Modis, Seth L. Masters, Martha Triantafilou

PLOS Pathogens: published April 16, 2021 | https://doi.org/10.1371/journal.ppat.1009417

Plasmodium falciparum malaria drives epigenetic reprogramming of human monocytes toward a regulatory phenotype

Rajan Guha, Anna Mathioudaki, Safiatou Doumbo, Didier Doumtabe, Jeff Skinner, Gunjan Arora, Shafiuddin Siddiqui, Shanping Li, Kassoum Kayentao, Aissata Ongoiba, Judith Zaugg, Boubacar Traore, Peter D. Crompton

PLOS Pathogens: published April 6, 2021 | https://doi.org/10.1371/journal.ppat.1009430

High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19

Sung Hee Ko, Elham Bayat Mokhtari, Prakriti Mudvari, Sydney Stein, Christopher D. Stringham, Danielle Wagner, Sabrina Ramelli, Marcos J. Ramos-Benitez, Jeffrey R. Strich, Richard T. Davey Jr., Tongqing Zhou, John Misasi, Peter D. Kwong, Daniel S. Chertow, Nancy J. Sullivan, Eli A. Boritz

PLOS Pathogens: published April 8, 2021 | https://doi.org/10.1371/journal.ppat.1009431

Human parvovirus B19 interacts with globoside under acidic conditions as an essential step in endocytic trafficking

Jan Bieri, Remo Leisi, Cornelia Bircher, Carlos Ros

PLOS Pathogens: published April 20, 2021 | https://doi.org/10.1371/journal.ppat.1009434

Toggle switch residues control allosteric transitions in bacterial adhesins by participating in a concerted repacking of the protein core

Dagmara I. Kisiela, Pearl Magala, Gianluca Interlandi, Laura A. Carlucci, Angelo Ramos, Veronika Tchesnokova, Benjamin Basanta, Vladimir Yarov-Yarovoy, Hovhannes Avagyan, Anahit Hovhannisyan, Wendy E. Thomas, Ronald E. Stenkamp, Rachel E. Klevit, Evgeni V. Sokurenko

PLOS Pathogens: published April 7, 2021 | https://doi.org/10.1371/journal.ppat.1009440

Extensive activation, tissue trafficking, turnover and functional impairment of NK cells in COVID-19 patients at disease onset associates with subsequent disease severity

Federica Bozzano, Chiara Dentone, Carola Perrone, Antonio Di Biagio, Daniela Fenoglio, Alessia Parodi, Malgorzata Mikulska, Bianca Bruzzone, Daniele Roberto Giacobbe, Antonio Vena, Lucia Taramasso, Laura Nicolini, Nicolò Patroniti, Paolo Pelosi, Angelo Gratarola, Raffaele De Palma, Gilberto Filaci, Matteo Bassetti, Andrea De Maria, on behalf of GECOVID study group

PLOS Pathogens: published April 16, 2021 | https://doi.org/10.1371/journal.ppat.1009448

A human coronavirus evolves antigenically to escape antibody immunity

Rachel T. Eguia, Katharine H. D. Crawford, Terry Stevens-Ayers, Laurel Kelnhofer-Millevolte, Alexander L. Greninger, Janet A. Englund, Michael J. Boeckh, Jesse D. Bloom

PLOS Pathogens: published April 8, 2021 | https://doi.org/10.1371/journal.ppat.1009453

Effector and regulator: Diverse functions of C. elegans C-type lectin-like domain proteins

Barbara Pees, Wentao Yang, Anke Kloock, Carola Petersen, Lena Peters, Li Fan, Meike Friedrichsen, Sabrina Butze, Alejandra Zárate-Potes, Hinrich Schulenburg, Katja Dierking

PLOS Pathogens: published April 1, 2021 | https://doi.org/10.1371/journal.ppat.1009454

The ESCRT-III machinery participates in the production of extracellular vesicles and protein export during Plasmodium falciparum infection

Yunuen Avalos-Padilla, Vasil N. Georgiev, Elena Lantero, Silvia Pujals, René Verhoef, Livia N. Borgheti-Cardoso, Lorenzo Albertazzi, Rumiana Dimova, Xavier Fernàndez-Busquets

PLOS Pathogens: published April 2, 2021 | https://doi.org/10.1371/journal.ppat.1009455

The larger attachment glycoprotein of respiratory syncytial virus produced in primary human bronchial epithelial cultures reduces infectivity for cell lines

Tiffany King, Asuncion Mejias, Octavio Ramilo, Mark E. Peeples

PLOS Pathogens: published April 8, 2021 | https://doi.org/10.1371/journal.ppat.1009469

Nep1-like proteins as a target for plant pathogen control

Katja Pirc, Vesna Hodnik, Tina Snoj, Tea Lenarčič, Simon Caserman, Marjetka Podobnik, Hannah Böhm, Isabell Albert, Anita Kotar, Janez Plavec, Jure Borišek, Martina Damuzzo, Alessandra Magistrato, Boris Brus, Izidor Sosič, Stanislav Gobec, Thorsten Nürnberger, Gregor Anderluh

PLOS Pathogens: published April 15, 2021 | https://doi.org/10.1371/journal.ppat.1009477

Mutations that confer resistance to broadly-neutralizing antibodies define HIV-1 variants of transmitting mothers from that of non-transmitting mothers

Amit Kumar, Elena E. Giorgi, Joshua J. Tu, David R. Martinez, Joshua Eudailey, Michael Mengual, Manukumar Honnayakanahalli Marichannegowda, Russell Van Dyke, Feng Gao, Sallie R. Permar

PLOS Pathogens: published April 2, 2021 | https://doi.org/10.1371/journal.ppat.1009478

FOXO regulates the expression of antimicrobial peptides and promotes phagocytosis of hemocytes in shrimp antibacterial immunity

Cang Li, Pan-Pan Hong, Ming-Chong Yang, Xiao-Fan Zhao, Jin-Xing Wang

PLOS Pathogens: published April 2, 2021 | https://doi.org/10.1371/journal.ppat.1009479

Lipocalin 2 modulates dendritic cell activity and shapes immunity to influenza in a microbiome dependent manner

Martin L. Watzenboeck, Barbara Drobits, Sophie Zahalka, Anna-Dorothea Gorki, Asma Farhat, Federica Quattrone, Anastasiya Hladik, Karin Lakovits, Gabriel M. Richard, Therese Lederer, Birgit Strobl, Gijs A. Versteeg, Louis Boon, Philipp Starkl, Sylvia Knapp

PLOS Pathogens: published April 27, 2021 | https://doi.org/10.1371/journal.ppat.1009487

Neuraminidase-associated plasminogen recruitment enables systemic spread of natural avian Influenza viruses H3N1

Jacob Schön, Angele Breithaupt, Dirk Höper, Jacqueline King, Anne Pohlmann, Rokshana Parvin, Klaus-Peter Behr, Bernd-Andreas Schwarz, Martin Beer, Jürgen Stech, Timm Harder, Christian Grund

PLOS Pathogens: published April 23, 2021 | https://doi.org/10.1371/journal.ppat.1009490

Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection

Wanhai Qin, Xanthe Brands, Cornelis van’t Veer, Alex F. de Vos, Jean-Claude Sirard, Joris J. T. H. Roelofs, Brendon P. Scicluna, Tom van der Poll

PLOS Pathogens: published April 1, 2021 | https://doi.org/10.1371/journal.ppat.1009491

Fatty acid oxidation participates in resistance to nutrient-depleted environments in the insect stages of Trypanosoma cruzi

Rodolpho Ornitz Oliveira Souza, Flávia Silva Damasceno, Sabrina Marsiccobetre, Marc Biran, Gilson Murata, Rui Curi, Frédéric Bringaud, Ariel Mariano Silber

PLOS Pathogens: published April 5, 2021 | https://doi.org/10.1371/journal.ppat.1009495

Hepatitis C virus infection restricts human LINE-1 retrotransposition in hepatoma cells

Anja Schöbel, Van Nguyen-Dinh, Gerald G. Schumann, Eva Herker

PLOS Pathogens: published April 19, 2021 | https://doi.org/10.1371/journal.ppat.1009496

Western-style diet impedes colonization and clearance of Citrobacter rodentium

Junqing An, Xu Zhao, Yanling Wang, Juan Noriega, Andrew T. Gewirtz, Jun Zou

PLOS Pathogens: published April 5, 2021 | https://doi.org/10.1371/journal.ppat.1009497

Temporal dynamics of SARS-CoV-2 mutation accumulation within and across infected hosts

Andrew L. Valesano, Kalee E. Rumfelt, Derek E. Dimcheff, Christopher N. Blair, William J. Fitzsimmons, Joshua G. Petrie, Emily T. Martin, Adam S. Lauring

PLOS Pathogens: published April 7, 2021 | https://doi.org/10.1371/journal.ppat.1009499

The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airways

Manon Laporte, Valerie Raeymaekers, Ria Van Berwaer, Julie Vandeput, Isabel Marchand-Casas, Hendrik-Jan Thibaut, Dominique Van Looveren, Katleen Martens, Markus Hoffmann, Piet Maes, Stefan Pöhlmann, Lieve Naesens, Annelies Stevaert

PLOS Pathogens: published April 22, 2021 | https://doi.org/10.1371/journal.ppat.1009500

Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2

Huihui Mou, Brian D. Quinlan, Haiyong Peng, Guanqun Liu, Yan Guo, Shoujiao Peng, Lizhou Zhang, Meredith E. Davis-Gardner, Matthew R. Gardner, Gogce Crynen, Lindsey B. DeVaux, Zhi Xiang Voo, Charles C. Bailey, Michael D. Alpert, Christoph Rader, Michaela U. Gack, Hyeryun Choe, Michael Farzan

PLOS Pathogens: published April 9, 2021 | https://doi.org/10.1371/journal.ppat.1009501

DNA damage and oxidative stress in human cells infected by Trypanosoma cruzi

Pilar T. V. Florentino, Davi Mendes, Francisca Nathalia L. Vitorino, Davi J. Martins, Julia P. C. Cunha, Renato A. Mortara, Carlos F. M. Menck

PLOS Pathogens: published April 7, 2021 | https://doi.org/10.1371/journal.ppat.1009502

Human plasmacytoid dendritic cells at the crossroad of type I interferon-regulated B cell differentiation and antiviral response to tick-borne encephalitis virus

Marilena P. Etna, Aurora Signorazzi, Daniela Ricci, Martina Severa, Fabiana Rizzo, Elena Giacomini, Andrea Gaggioli, Isabelle Bekeredjian-Ding, Anke Huckriede, Eliana M. Coccia

PLOS Pathogens: published April 15, 2021 | https://doi.org/10.1371/journal.ppat.1009505

The antiviral sirtuin 3 bridges protein acetylation to mitochondrial integrity and metabolism during human cytomegalovirus infection

Xinlei Sheng, Ileana M. Cristea

PLOS Pathogens: published April 15, 2021 | https://doi.org/10.1371/journal.ppat.1009506

Structures of Foot-and-mouth Disease Virus with neutralizing antibodies derived from recovered natural host reveal a mechanism for cross-serotype neutralization

Yong He, Kun Li, Yimei Cao, Zixian Sun, Pinghua Li, Huifang Bao, Sheng Wang, Guoqiang Zhu, Xingwen Bai, Pu Sun, Xuerong Liu, Cheng Yang, Zaixin Liu, Zengjun Lu, Zihe Rao, Zhiyong Lou

PLOS Pathogens: published April 28, 2021 | https://doi.org/10.1371/journal.ppat.1009507

RNA thermosensors facilitate Streptococcus pneumoniae and Haemophilus influenzae immune evasion

Hannes Eichner, Jens Karlsson, Laura Spelmink, Anuj Pathak, Lok-To Sham, Birgitta Henriques-Normark, Edmund Loh

PLOS Pathogens: published April 29, 2021 | https://doi.org/10.1371/journal.ppat.1009513

Plasmacytoid dendritic cells have divergent effects on HIV infection of initial target cells and induce a pro-retention phenotype

Orion Tong, Gabriel Duette, Thomas R. O’Neil, Caroline M. Royle, Hafsa Rana, Blake Johnson, Nicole Popovic, Suat Dervish, Michelle A. E. Brouwer, Heeva Baharlou, Ellis Patrick, Grahame Ctercteko, Sarah Palmer, Eunok Lee, Eric Hunter, Andrew N. Harman, Anthony L. Cunningham, Najla Nasr

PLOS Pathogens: published April 19, 2021 | https://doi.org/10.1371/journal.ppat.1009522

Mechanisms of HIV-1 evasion to the antiviral activity of chemokine CXCL12 indicate potential links with pathogenesis

Marie Armani-Tourret, Zhicheng Zhou, Romain Gasser, Isabelle Staropoli, Vincent Cantaloube-Ferrieu, Yann Benureau, Javier Garcia-Perez, Mayte Pérez-Olmeda, Valérie Lorin, Bénédicte Puissant-Lubrano, Lambert Assoumou, Constance Delaugerre, Jean-Daniel Lelièvre, Yves Lévy, Hugo Mouquet, Guillaume Martin-Blondel, Jose Alcami, Fernando Arenzana-Seisdedos, Jacques Izopet, Philippe Colin, Bernard Lagane

PLOS Pathogens: published April 19, 2021 | https://doi.org/10.1371/journal.ppat.1009526

The specific features of the developing T cell compartment of the neonatal lung are a determinant of respiratory syncytial virus immunopathogenesis

Thomas Démoulins, Melanie Brügger, Beatrice Zumkehr, Blandina I. Oliveira Esteves, Kemal Mehinagic, Amal Fahmi, Loïc Borcard, Adriano Taddeo, Damian Jandrasits, Horst Posthaus, Charaf Benarafa, Nicolas Ruggli, Marco P. Alves

PLOS Pathogens: published April 28, 2021 | https://doi.org/10.1371/journal.ppat.1009529

The RNA helicase DDX5 promotes viral infection via regulating N⁶-methyladenosine levels on the DHX58 and NFκB transcripts to dampen antiviral innate immunity

Jian Xu, Yunhong Cai, ZhenBang Ma, Bo Jiang, Wenxiao Liu, Jing Cheng, Nannan Guo, Zishu Wang, Joshua E. Sealy, Cuiping Song, Xiaojia Wang, Yongqing Li

PLOS Pathogens: published April 28, 2021 | https://doi.org/10.1371/journal.ppat.1009530

Pulmonary insults exacerbate susceptibility to oral Listeria monocytogenes infection through the production of IL-10 by NK cells

Nikki Bortell, Elizabeth R. Aguilera, Laurel L. Lenz

PLOS Pathogens: published April 20, 2021 | https://doi.org/10.1371/journal.ppat.1009531

T cell immune discriminants of HIV reservoir size in a pediatric cohort of perinatally infected individuals

Stefano Rinaldi, Lesley de Armas, Sara Dominguez-Rodríguez, Suresh Pallikkuth, Vinh Dinh, Li Pan, Kathleen Gӓrtner, Rajendra Pahwa, Nicola Cotugno, Pablo Rojo, Eleni Nastouli, Nigel Klein, Caroline Foster, Anita De Rossi, Carlo Giaquinto, Paolo Rossi, Paolo Palma, Savita Pahwa, on behalf of EPIICAL consortium

PLOS Pathogens: published April 26, 2021 | https://doi.org/10.1371/journal.ppat.1009533

Dual transcriptional analysis reveals adaptation of host and pathogen to intracellular survival of Pseudomonas aeruginosa associated with urinary tract infection

Cristina Penaranda, Nicole M. Chumbler, Deborah T. Hung

PLOS Pathogens: published April 26, 2021 | https://doi.org/10.1371/journal.ppat.1009534

Borrelia peptidoglycan interacting Protein (BpiP) contributes to the fitness of Borrelia burgdorferi against host-derived factors and influences virulence in mouse models of Lyme disease

Yue Chen, Sean M. Vargas, Trever C. Smith II, Sai Lakshmi Rajasekhar Karna, Taylor MacMackin Ingle, Karen L. Wozniak, Floyd L. Wormley Jr., Janakiram Seshu

PLOS Pathogens: published April 21, 2021 | https://doi.org/10.1371/journal.ppat.1009535

Herpes Simplex Virus type 1 infects Langerhans cells and the novel epidermal dendritic cell, Epi-cDC2s, via different entry pathways

Kirstie M. Bertram, Naomi R. Truong, Jacinta B. Smith, Min Kim, Kerrie J. Sandgren, Konrad L. Feng, Jason J. Herbert, Hafsa Rana, Kevin Danastas, Monica Miranda-Saksena, Jake W. Rhodes, Ellis Patrick, Ralph C. Cohen, Jake Lim, Steven L. Merten, Andrew N. Harman, Anthony L. Cunningham

PLOS Pathogens: published April 27, 2021 | https://doi.org/10.1371/journal.ppat.1009536

A plasmid locus associated with Klebsiella clinical infections encodes a microbiome-dependent gut fitness factor

Jay Vornhagen, Christine M. Bassis, Srividya Ramakrishnan, Robert Hein, Sophia Mason, Yehudit Bergman, Nicole Sunshine, Yunfan Fan, Caitlyn L. Holmes, Winston Timp, Michael C. Schatz, Vincent B. Young, Patricia J. Simner, Michael A. Bachman

PLOS Pathogens: published April 30, 2021 | https://doi.org/10.1371/journal.ppat.1009537

Origin and evolution of the zinc finger antiviral protein

Daniel Gonçalves-Carneiro, Matthew A. Takata, Heley Ong, Amanda Shilton, Paul D. Bieniasz

PLOS Pathogens: published April 26, 2021 | https://doi.org/10.1371/journal.ppat.1009545

Salmonella enters a dormant state within human epithelial cells for persistent infection

Chak Hon Luk, Camila Valenzuela, Magdalena Gil, Léa Swistak, Perrine Bomme, Yuen-Yan Chang, Adeline Mallet, Jost Enninga

PLOS Pathogens: published April 30, 2021 | https://doi.org/10.1371/journal.ppat.1009550

Two StAR-related lipid transfer proteins play specific roles in endocytosis, exocytosis, and motility in the parasitic protist Entamoeba histolytica

Koushik Das, Natsuki Watanabe, Tomoyoshi Nozaki

PLOS Pathogens: published April 28, 2021 | https://doi.org/10.1371/journal.ppat.1009551

Intraspecific variation in immune gene expression and heritable symbiont density

Holly L. Nichols, Elliott B. Goldstein, Omid Saleh Ziabari, Benjamin J. Parker

PLOS Pathogens: published April 26, 2021 | https://doi.org/10.1371/journal.ppat.1009552

Palmitoylation of the envelope membrane proteins GP5 and M of porcine reproductive and respiratory syndrome virus is essential for virus growth

Minze Zhang, Xiaoliang Han, Klaus Osterrieder, Michael Veit

PLOS Pathogens: published April 23, 2021 | https://doi.org/10.1371/journal.ppat.1009554

Mutational pressure by host APOBEC3s more strongly affects genes expressed early in the lytic phase of herpes simplex virus-1 (HSV-1) and human polyomavirus (HPyV) infection

Maxwell Shapiro, Laurie T. Krug, Thomas MacCarthy

PLOS Pathogens: published April 30, 2021 | https://doi.org/10.1371/journal.ppat.1009560

Genetic and biological properties of H7N9 avian influenza viruses detected after application of the H7N9 poultry vaccine in China

Xin Yin, Guohua Deng, Xianying Zeng, Pengfei Cui, Yujie Hou, Yanjing Liu, Jingzhen Fang, Shuxin Pan, Dongxue Wang, Xiaohan Chen, Yaping Zhang, Xiurong Wang, Guobin Tian, Yanbing Li, Yan Chen, Liling Liu, Yasuo Suzuki, Yuntao Guan, Chengjun Li, Jianzhong Shi, Hualan Chen

PLOS Pathogens: published April 27, 2021 | https://doi.org/10.1371/journal.ppat.1009561

ATRX limits the accessibility of histone H3-occupied HSV genomes during lytic infection

Joseph M. Cabral, Camille H. Cushman, Catherine N. Sodroski, David M. Knipe

PLOS Pathogens: published April 28, 2021 | https://doi.org/10.1371/journal.ppat.1009567

Corrections

Correction: Site-specific analysis of N-glycans from different sheep prion strains

Natali Nakić, Thanh Hoa Tran, Mislav Novokmet, Olivier Andreoletti, Gordan Lauc, Giuseppe Legname

PLOS Pathogens: published April 12, 2021 | https://doi.org/10.1371/journal.ppat.1009511

Correction: Enhanced biofilm and extracellular matrix production by chronic carriage versus acute isolates of Salmonella Typhi

The PLOS Pathogens Staff

PLOS Pathogens: published April 12, 2021 | https://doi.org/10.1371/journal.ppat.1009512

Retraction

Retraction: Epstein-Barr Virus Nuclear Antigen 3C Stabilizes Gemin3 to Block p53-mediated Apoptosis

The PLOS Pathogens Editors

PLOS Pathogens: published April 30, 2021 | https://doi.org/10.1371/journal.ppat.1009556

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Trypanosoma cruzi induces genotoxic stress in HeLa cells

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