Quorum sensing across bacterial and viral domains

Olivia P. Duddy, Bonnie L. Bassler

PLOS Pathogens: published January 7, 2021 | https://doi.org/10.1371/journal.ppat.1009074

Exploring amino acid and peptide transporters as therapeutic targets to attenuate virulence and antibiotic resistance in Staphylococcus aureus

Merve Suzan Zeden, Órla Burke, Moya Vallely, Claire Fingleton, James P. O’Gara

PLOS Pathogens: published January 14, 2021 | https://doi.org/10.1371/journal.ppat.1009093

Short and sweet: How glycans impact prion conversion, cofactor interactions, and cross-species transmission

Patricia Aguilar-Calvo, Julia A. Callender, Christina J. Sigurdson

PLOS Pathogens: published January 14, 2021 | https://doi.org/10.1371/journal.ppat.1009123

DUSP11 and triphosphate RNA balance during virus infection

Joon H. Choi, Christopher S. Sullivan

PLOS Pathogens: published January 14, 2021 | https://doi.org/10.1371/journal.ppat.1009145

G protein-coupled receptors: The choreographers of innate immunity in Caenorhabditis elegans

Siddharth R. Venkatesh, Varsha Singh

PLOS Pathogens: published January 21, 2021 | https://doi.org/10.1371/journal.ppat.1009151

Mechanisms and therapeutic potential of collateral sensitivity to antibiotics

Roderich Roemhild, Dan I. Andersson

PLOS Pathogens: published January 14, 2021 | https://doi.org/10.1371/journal.ppat.1009172

Etiology of lactic acidosis in malaria

Hendrik Possemiers, Leen Vandermosten, Philippe E. Van den Steen

PLOS Pathogens: published January 7, 2021 | https://doi.org/10.1371/journal.ppat.1009122

The genetic proteome: Using genetics to inform the proteome of mycobacterial pathogens

Kathleen R. Nicholson, C. Bruce Mousseau, Matthew M. Champion, Patricia A. Champion

PLOS Pathogens: published January 7, 2021 | https://doi.org/10.1371/journal.ppat.1009124

The role of Neuropilin-1 in COVID-19

Bindu S. Mayi, Jillian A. Leibowitz, Arden T. Woods, Katherine A. Ammon, Alphonse E. Liu, Aarti Raja

PLOS Pathogens: published January 4, 2021 | https://doi.org/10.1371/journal.ppat.1009153

Bacterial nucleomodulins: A coevolutionary adaptation to the eukaryotic command center

Hannah E. Hanford, Juanita Von Dwingelo, Yousef Abu Kwaik

PLOS Pathogens: published January 21, 2021 | https://doi.org/10.1371/journal.ppat.1009184

Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses

Hui Feng, Yi-Bing Zhang, Jian-Fang Gui, Stanley M. Lemon, Daisuke Yamane

PLOS Pathogens: published January 21, 2021 | https://doi.org/10.1371/journal.ppat.1009220

T-bet-dependent ILC1- and NK cell-derived IFN-γ mediates cDC1-dependent host resistance against Toxoplasma gondii

Américo H. López-Yglesias, Elise Burger, Ellie Camanzo, Andrew T. Martin, Alessandra M. Araujo, Samantha F. Kwok, Felix Yarovinsky

PLOS Pathogens: published January 19, 2021 | https://doi.org/10.1371/journal.ppat.1008299

Bartonella effector protein C mediates actin stress fiber formation via recruitment of GEF-H1 to the plasma membrane

Simon Marlaire, Christoph Dehio

PLOS Pathogens: published January 28, 2021 | https://doi.org/10.1371/journal.ppat.1008548

Related Articles

1. Bartonella type IV secretion effector BepC induces stress fiber formation through activation of GEF-H1

Intra-host changes in Kaposi sarcoma-associated herpesvirus genomes in Ugandan adults with Kaposi sarcoma

Jan Clement Santiago, Jason D. Goldman, Hong Zhao, Alec P. Pankow, Fred Okuku, Michael W. Schmitt, Lennie H. Chen, C. Alexander Hill, Corey Casper, Warren T. Phipps, James I. Mullins

PLOS Pathogens: published January 19, 2021 | https://doi.org/10.1371/journal.ppat.1008594

Extensive proteomic and transcriptomic changes quench the TCR/CD3 activation signal of latently HIV-1 infected T cells

Eric Carlin, Braxton Greer, Kelsey Lowman, Alexandra Duverger, Frederic Wagner, David Moylan, Alexander Dalecki, Shekwonya Samuel, Mildred Perez, Steffanie Sabbaj, Olaf Kutsch

PLOS Pathogens: published January 19, 2021 | https://doi.org/10.1371/journal.ppat.1008748

Red-light is an environmental effector for mutualism between begomovirus and its vector whitefly

Pingzhi Zhao, Xuan Zhang, Yuqing Gong, Duan Wang, Dongqing Xu, Ning Wang, Yanwei Sun, Lianbo Gao, Shu-Sheng Liu, Xing Wang Deng, Daniel J. Kliebenstein, Xueping Zhou, Rong-Xiang Fang, Jian Ye

PLOS Pathogens: published January 11, 2021 | https://doi.org/10.1371/journal.ppat.1008770

The N-terminus of varicella-zoster virus glycoprotein B has a functional role in fusion

Stefan L. Oliver, Yi Xing, Dong-Hua Chen, Soung Hun Roh, Grigore D. Pintilie, David A. Bushnell, Marvin H. Sommer, Edward Yang, Andrea Carfi, Wah Chiu, Ann M. Arvin

PLOS Pathogens: published January 7, 2021 | https://doi.org/10.1371/journal.ppat.1008961

Novel modulators of p53-signaling encoded by unknown genes of emerging viruses

Dina Alzhanova, Kathleen Corcoran, Aubrey G. Bailey, Kristin Long, Sharon Taft-Benz, Rachel L. Graham, Grant S. Broussard, Mark Heise, Gabriele Neumann, Peter Halfmann, Yoshihiro Kawaoka, Ralph S. Baric, Blossom Damania, Dirk P. Dittmer

PLOS Pathogens: published January 7, 2021 | https://doi.org/10.1371/journal.ppat.1009033

Bartonella type IV secretion effector BepC induces stress fiber formation through activation of GEF-H1

Chunyan Wang, Haoran Zhang, Jiaqi Fu, Meng Wang, Yuhao Cai, Tianyun Ding, Jiezhang Jiang, Jane E. Koehler, Xiaoyun Liu, Congli Yuan

PLOS Pathogens: published January 28, 2021 | https://doi.org/10.1371/journal.ppat.1009065

Related Articles

1. Bartonella effector protein C mediates actin stress fiber formation via recruitment of GEF-H1 to the plasma membrane

T cells in the brain enhance neonatal mortality during peripheral LCMV infection

Laurie L. Kenney, Erik P. Carter, Anna Gil, Liisa K. Selin

PLOS Pathogens: published January 5, 2021 | https://doi.org/10.1371/journal.ppat.1009066

Balancing of the mitotic exit network and cell wall integrity signaling governs the development and pathogenicity in Magnaporthe oryzae

Wanzhen Feng, Ziyi Yin, Haowen Wu, Peng Liu, Xinyu Liu, Muxing Liu, Rui Yu, Chuyun Gao, Haifeng Zhang, Xiaobo Zheng, Ping Wang, Zhengguang Zhang

PLOS Pathogens: published January 7, 2021 | https://doi.org/10.1371/journal.ppat.1009080

Rapid adaptation to human protein kinase R by a unique genomic rearrangement in rhesus cytomegalovirus

Stephanie J. Child, Alexander L. Greninger, Adam P. Geballe

PLOS Pathogens: published January 26, 2021 | https://doi.org/10.1371/journal.ppat.1009088

Pomalidomide restores immune recognition of primary effusion lymphoma through upregulation of ICAM-1 and B7-2

Prabha Shrestha, David A. Davis, Hannah K. Jaeger, Alexandra Stream, Ashley I. Aisabor, Robert Yarchoan

PLOS Pathogens: published January 7, 2021 | https://doi.org/10.1371/journal.ppat.1009091

TRK-Fused Gene (TFG), a protein involved in protein secretion pathways, is an essential component of the antiviral innate immune response

Kashif Aziz Khan, Alexandre Marineau, Priscilla Doyon, Mariana Acevedo, Étienne Durette, Anne-Claude Gingras, Marc J. Servant

PLOS Pathogens: published January 7, 2021 | https://doi.org/10.1371/journal.ppat.1009111

Emergency response for evaluating SARS-CoV-2 immune status, seroprevalence and convalescent plasma in Argentina

Diego S. Ojeda, María Mora Gonzalez Lopez Ledesma, Horacio M. Pallarés, Guadalupe S. Costa Navarro, Lautaro Sanchez, Beatriz Perazzi, Sergio M. Villordo, Diego E. Alvarez, BioBanco Working Group, Marcela Echavarria, Kasopefoluwa Y. Oguntuyo, Christian S. Stevens, Benhur Lee, Jorge Carradori, Julio J. Caramelo, Marcelo J. Yanovsky, Andrea V. Gamarnik

PLOS Pathogens: published January 14, 2021 | https://doi.org/10.1371/journal.ppat.1009161

Carbomer-based adjuvant elicits CD8 T-cell immunity by inducing a distinct metabolic state in cross-presenting dendritic cells

Woojong Lee, Brock Kingstad-Bakke, Brett Paulson, Autumn Larsen, Katherine Overmyer, Chandranaik B. Marinaik, Kelly Dulli, Randall Toy, Gabriela Vogel, Katherine P. Mueller, Kelsey Tweed, Alex J. Walsh, Jason Russell, Krishanu Saha, Leticia Reyes, Melissa C. Skala, John-Demian Sauer, Dmitry M. Shayakhmetov, Joshua Coon, Krishnendu Roy, M. Suresh

PLOS Pathogens: published January 14, 2021 | https://doi.org/10.1371/journal.ppat.1009168

Escalation in the host-pathogen arms race: A host resistance response corresponds to a heightened bacterial virulence response

Qi Wang, Nadia Shakoor, Adam Boyher, Kira M. Veley, Jeffrey C. Berry, Todd C. Mockler, Rebecca S. Bart

PLOS Pathogens: published January 11, 2021 | https://doi.org/10.1371/journal.ppat.1009175

Kaposi’s sarcoma-associated herpesvirus latency-associated nuclear antigen dysregulates expression of MCL-1 by targeting FBW7

Yeong Jun Kim, Yuri Kim, Abhishek Kumar, Chan Woo Kim, Zsolt Toth, Nam Hyuk Cho, Hye-Ra Lee

PLOS Pathogens: published January 20, 2021 | https://doi.org/10.1371/journal.ppat.1009179

Host-specific functional compartmentalization within the oligopeptide transporter during the Borrelia burgdorferi enzootic cycle

Ashley M. Groshong, Melissa A. McLain, Justin D. Radolf

PLOS Pathogens: published January 11, 2021 | https://doi.org/10.1371/journal.ppat.1009180

A type VII secretion system of Streptococcus gallolyticus subsp. gallolyticus contributes to gut colonization and the development of colon tumors

John Culver Taylor, Xinsheng Gao, Juan Xu, Michael Holder, Joseph Petrosino, Ritesh Kumar, Wen Liu, Magnus Höök, Chris Mackenzie, Andrew Hillhouse, Wesley Brashear, Maria Patricia Nunez, Yi Xu

PLOS Pathogens: published January 6, 2021 | https://doi.org/10.1371/journal.ppat.1009182

Orthopoxvirus K3 orthologs show virus- and host-specific inhibition of the antiviral protein kinase PKR

Chorong Park, Chen Peng, M. Julhasur Rahman, Sherry L. Haller, Loubna Tazi, Greg Brennan, Stefan Rothenburg

PLOS Pathogens: published January 14, 2021 | https://doi.org/10.1371/journal.ppat.1009183

Inositol phosphates promote HIV-1 assembly and maturation to facilitate viral spread in human CD4⁺ T cells

Gregory A. Sowd, Christopher Aiken

PLOS Pathogens: published January 21, 2021 | https://doi.org/10.1371/journal.ppat.1009190

Related Articles

1. Correction: Inositol phosphates promote HIV-1 assembly and maturation to facilitate viral spread in human CD4⁺ T cells

Immunological design of commensal communities to treat intestinal infection and inflammation

Rebecca L. Brown, Max L. Y. Larkinson, Thomas B. Clarke

PLOS Pathogens: published January 19, 2021 | https://doi.org/10.1371/journal.ppat.1009191

A novel mode of control of nickel uptake by a multifunctional metallochaperone

Milica Denic, Evelyne Turlin, Valérie Michel, Frédéric Fischer, Mozhgan Khorasani-Motlagh, Deborah Zamble, Daniel Vinella, Hilde de Reuse

PLOS Pathogens: published January 14, 2021 | https://doi.org/10.1371/journal.ppat.1009193

Bacterial dormancy: A subpopulation of viable but non-culturable cells demonstrates better fitness for revival

Sariqa Wagley, Helen Morcrette, Andrea Kovacs-Simon, Zheng R. Yang, Ann Power, Richard K. Tennant, John Love, Neil Murray, Richard W. Titball, Clive S. Butler

PLOS Pathogens: published January 13, 2021 | https://doi.org/10.1371/journal.ppat.1009194

K18-hACE2 mice develop respiratory disease resembling severe COVID-19

Claude Kwe Yinda, Julia R. Port, Trenton Bushmaker, Irene Offei Owusu, Jyothi N. Purushotham, Victoria A. Avanzato, Robert J. Fischer, Jonathan E. Schulz, Myndi G. Holbrook, Madison J. Hebner, Rebecca Rosenke, Tina Thomas, Andrea Marzi, Sonja M. Best, Emmie de Wit, Carl Shaia, Neeltje van Doremalen, Vincent J. Munster

PLOS Pathogens: published January 19, 2021 | https://doi.org/10.1371/journal.ppat.1009195

Dissecting genetic and sex-specific sources of host heterogeneity in pathogen shedding and spread

Jonathon A. Siva-Jothy, Pedro F. Vale

PLOS Pathogens: published January 19, 2021 | https://doi.org/10.1371/journal.ppat.1009196

Related Articles

1. Correction: Dissecting genetic and sex-specific sources of host heterogeneity in pathogen shedding and spread

Functional analyses of epidemic Clostridioides difficile toxin B variants reveal their divergence in utilizing receptors and inducing pathology

Zhenrui Pan, Yuanyuan Zhang, Jianhua Luo, Danyang Li, Yao Zhou, Liuqing He, Qi Yang, Min Dong, Liang Tao

PLOS Pathogens: published January 28, 2021 | https://doi.org/10.1371/journal.ppat.1009197

Metabolic reprogramming of the myeloid lineage by Schistosoma mansoni infection persists independently of antigen exposure

Diana Cortes-Selva, Lisa Gibbs, J. Alan Maschek, Marcia Nascimento, Tyler Van Ry, James E. Cox, Eyal Amiel, Keke C. Fairfax

PLOS Pathogens: published January 8, 2021 | https://doi.org/10.1371/journal.ppat.1009198

In vivo nanoscale analysis of the dynamic synergistic interaction of Bacillus thuringiensis Cry11Aa and Cyt1Aa toxins in Aedes aegypti

Samira López-Molina, Nathaly Alexandre do Nascimento, Maria Helena Neves Lobo Silva-Filha, Adán Guerrero, Jorge Sánchez, Sabino Pacheco, Sarjeet S. Gill, Mario Soberón, Alejandra Bravo

PLOS Pathogens: published January 19, 2021 | https://doi.org/10.1371/journal.ppat.1009199

A multi-omics approach to Epstein-Barr virus immortalization of B-cells reveals EBNA1 chromatin pioneering activities targeting nucleotide metabolism

R. Jason Lamontagne, Samantha S. Soldan, Chenhe Su, Andreas Wiedmer, Kyoung Jae Won, Fang Lu, Aaron R. Goldman, Jayamanna Wickramasinghe, Hsin-Yao Tang, David W. Speicher, Louise Showe, Andrew V. Kossenkov, Paul M. Lieberman

PLOS Pathogens: published January 26, 2021 | https://doi.org/10.1371/journal.ppat.1009208

Enhanced biofilm and extracellular matrix production by chronic carriage versus acute isolates of Salmonella Typhi

Aishwarya Devaraj, Juan F. González, Bradley Eichar, Gatan Thilliez, Robert A. Kingsley, Stephen Baker, Marc W. Allard, Lauren O. Bakaletz, John S. Gunn, Steven D. Goodman

PLOS Pathogens: published January 19, 2021 | https://doi.org/10.1371/journal.ppat.1009209

Related Articles

1. Correction: Enhanced biofilm and extracellular matrix production by chronic carriage versus acute isolates of Salmonella Typhi

Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2

Tianling Ou, Huihui Mou, Lizhou Zhang, Amrita Ojha, Hyeryun Choe, Michael Farzan

PLOS Pathogens: published January 19, 2021 | https://doi.org/10.1371/journal.ppat.1009212

Naturally occurring substitution in one amino acid in VHSV phosphoprotein enhances viral virulence in flounder

Jee Youn Hwang, Unn Hwa Lee, Min Jin Heo, Min Sun Kim, Ji Min Jeong, So Yeon Kim, Mun Gyeong Kwon, Bo Young Jee, Ki Hong Kim, Chan-Il Park, Jeong Woo Park

PLOS Pathogens: published January 19, 2021 | https://doi.org/10.1371/journal.ppat.1009213

Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART

Charline Bacchus-Souffan, Mark Fitch, Jori Symons, Mohamed Abdel-Mohsen, Daniel B. Reeves, Rebecca Hoh, Mars Stone, Joseph Hiatt, Peggy Kim, Abha Chopra, Haelee Ahn, Vanessa A. York, Daniel L. Cameron, Frederick M. Hecht, Jeffrey N. Martin, Steven A. Yukl, Simon Mallal, Paul U. Cameron, Steven G. Deeks, Joshua T. Schiffer, Sharon R. Lewin, Marc K. Hellerstein, Joseph M. McCune, Peter W. Hunt

PLOS Pathogens: published January 19, 2021 | https://doi.org/10.1371/journal.ppat.1009214

Injection site vaccinology of a recombinant vaccinia-based vector reveals diverse innate immune signatures

Jessamine E. Hazlewood, Troy Dumenil, Thuy T. Le, Andrii Slonchak, Stephen H. Kazakoff, Ann-Marie Patch, Lesley-Ann Gray, Paul M. Howley, Liang Liu, John D. Hayball, Kexin Yan, Daniel J. Rawle, Natalie A. Prow, Andreas Suhrbier

PLOS Pathogens: published January 13, 2021 | https://doi.org/10.1371/journal.ppat.1009215

MEK/ERK signaling is a critical regulator of high-risk human papillomavirus oncogene expression revealing therapeutic targets for HPV-induced tumors

Adrian J. Luna, Rosa T. Sterk, Anastacia M. Griego-Fisher, Joon-Yong Chung, Kiersten L. Berggren, Virginie Bondu, Pamela Barraza-Flores, Andrew T. Cowan, Gregory N. Gan, Emrullah Yilmaz, Hanbyoul Cho, Jae-Hoon Kim, Stephen M. Hewitt, Julie E. Bauman, Michelle A. Ozbun

PLOS Pathogens: published January 22, 2021 | https://doi.org/10.1371/journal.ppat.1009216

In vivo antagonistic role of the Human T-Cell Leukemia Virus Type 1 regulatory proteins Tax and HBZ

Abdou Akkouche, Sara Moodad, Rita Hleihel, Hala Skayneh, Séverine Chambeyron, Hiba El Hajj, Ali Bazarbachi

PLOS Pathogens: published January 20, 2021 | https://doi.org/10.1371/journal.ppat.1009219

Activation of EphA2-EGFR signaling in oral epithelial cells by Candida albicans virulence factors

Marc Swidergall, Norma V. Solis, Nicolas Millet, Manning Y. Huang, Jianfeng Lin, Quynh T. Phan, Michael D. Lazarus, Zeping Wang, Michael R. Yeaman, Aaron P. Mitchell, Scott G. Filler

PLOS Pathogens: published January 20, 2021 | https://doi.org/10.1371/journal.ppat.1009221

A novel sialic acid-binding adhesin present in multiple species contributes to the pathogenesis of Infective endocarditis

Meztlli O. Gaytán, Anirudh K. Singh, Shireen A. Woodiga, Surina A. Patel, Seon-Sook An, Arturo Vera-Ponce de León, Sean McGrath, Anthony R. Miller, Jocelyn M. Bush, Mark van der Linden, Vincent Magrini, Richard K. Wilson, Todd Kitten, Samantha J. King

PLOS Pathogens: published January 19, 2021 | https://doi.org/10.1371/journal.ppat.1009222

Reliable, scalable functional genetics in bloodstream-form Trypanosoma congolense in vitro and in vivo

Georgina Awuah-Mensah, Jennifer McDonald, Pieter C. Steketee, Delphine Autheman, Sarah Whipple, Simon D'Archivio, Cordelia Brandt, Simon Clare, Katherine Harcourt, Gavin J. Wright, Liam J. Morrison, Catarina Gadelha, Bill Wickstead

PLOS Pathogens: published January 22, 2021 | https://doi.org/10.1371/journal.ppat.1009224

The coronavirus proofreading exoribonuclease mediates extensive viral recombination

Jennifer Gribble, Laura J. Stevens, Maria L. Agostini, Jordan Anderson-Daniels, James D. Chappell, Xiaotao Lu, Andrea J. Pruijssers, Andrew L. Routh, Mark R. Denison

PLOS Pathogens: published January 19, 2021 | https://doi.org/10.1371/journal.ppat.1009226

Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes

Dani A. C. Heesterbeek, Remy M. Muts, Vincent P. van Hensbergen, Pieter de Saint Aulaire, Tom Wennekes, Bart W. Bardoel, Nina M. van Sorge, Suzan H. M. Rooijakkers

PLOS Pathogens: published January 22, 2021 | https://doi.org/10.1371/journal.ppat.1009227

Multiple roles of PP2A binding motif in hepatitis B virus core linker and PP2A in regulating core phosphorylation state and viral replication

Ji Xi, Laura Luckenbaugh, Jianming Hu

PLOS Pathogens: published January 25, 2021 | https://doi.org/10.1371/journal.ppat.1009230

Phase separation and DAXX redistribution contribute to LANA nuclear body and KSHV genome dynamics during latency and reactivation

Olga Vladimirova, Alessandra De Leo, Zhong Deng, Andreas Wiedmer, James Hayden, Paul M. Lieberman

PLOS Pathogens: published January 20, 2021 | https://doi.org/10.1371/journal.ppat.1009231

SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells

Michihito Sasaki, Kentaro Uemura, Akihiko Sato, Shinsuke Toba, Takao Sanaki, Katsumi Maenaka, William W. Hall, Yasuko Orba, Hirofumi Sawa

PLOS Pathogens: published January 21, 2021 | https://doi.org/10.1371/journal.ppat.1009233

Infection of porcine small intestinal enteroids with human and pig rotavirus A strains reveals contrasting roles for histo-blood group antigens and terminal sialic acids

Yusheng Guo, Rosario Adriana Candelero-Rueda, Linda Jean Saif, Anastasia Nickolaevna Vlasova

PLOS Pathogens: published January 29, 2021 | https://doi.org/10.1371/journal.ppat.1009237

An Alba-domain protein required for proteome remodelling during trypanosome differentiation and host transition

Shubha Bevkal, Arunasalam Naguleswaran, Ruth Rehmann, Marcel Kaiser, Manfred Heller, Isabel Roditi

PLOS Pathogens: published January 25, 2021 | https://doi.org/10.1371/journal.ppat.1009239

Temporally integrated single cell RNA sequencing analysis of PBMC from experimental and natural primary human DENV-1 infections

Adam T. Waickman, Heather Friberg, Gregory D. Gromowski, Wiriya Rutvisuttinunt, Tao Li, Hayden Siegfried, Kaitlin Victor, Michael K. McCracken, Stefan Fernandez, Anon Srikiatkhachorn, Damon Ellison, Richard G. Jarman, Stephen J. Thomas, Alan L. Rothman, Timothy Endy, Jeffrey R. Currier

PLOS Pathogens: published January 29, 2021 | https://doi.org/10.1371/journal.ppat.1009240

A host cell long noncoding RNA NR_033736 regulates type I interferon-mediated gene transcription and modulates intestinal epithelial anti-Cryptosporidium defense

Juan Li, Kehua Jin, Min Li, Nicholas W. Mathy, Ai-Yu Gong, Silu Deng, Gislaine A. Martins, Mingfei Sun, Juliane K. Strauss-Soukup, Xian-Ming Chen

PLOS Pathogens: published January 22, 2021 | https://doi.org/10.1371/journal.ppat.1009241

Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion

Guido Papa, Donna L. Mallery, Anna Albecka, Lawrence G. Welch, Jérôme Cattin-Ortolá, Jakub Luptak, David Paul, Harvey T. McMahon, Ian G. Goodfellow, Andrew Carter, Sean Munro, Leo C. James

PLOS Pathogens: published January 25, 2021 | https://doi.org/10.1371/journal.ppat.1009246

High genetic variability of Schmallenberg virus M-segment leads to efficient immune escape from neutralizing antibodies

Kerstin Wernike, Ilona Reimann, Ashley C. Banyard, Franziska Kraatz, S. Anna La Rocca, Bernd Hoffmann, Sarah McGowan, Silke Hechinger, Bhudipa Choudhury, Andrea Aebischer, Falko Steinbach, Martin Beer

PLOS Pathogens: published January 26, 2021 | https://doi.org/10.1371/journal.ppat.1009247

The NF-κB regulator Bcl-3 restricts terminal differentiation and promotes memory cell formation of CD8⁺ T cells during viral infection

Hemant Jaiswal, Thomas Ciucci, Hongshan Wang, Wanhu Tang, Estefania Claudio, Philip M. Murphy, Rémy Bosselut, Ulrich Siebenlist

PLOS Pathogens: published January 28, 2021 | https://doi.org/10.1371/journal.ppat.1009249

Human FcRn expression and Type I Interferon signaling control Echovirus 11 pathogenesis in mice

Alexandra I. Wells, Kalena A. Grimes, Kenneth Kim, Emilie Branche, Christopher J. Bakkenist, William H. DePas, Sujan Shresta, Carolyn B. Coyne

PLOS Pathogens: published January 29, 2021 | https://doi.org/10.1371/journal.ppat.1009252

Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease

Wei Wang, Duo Peng, Rodrigo P. Baptista, Yiran Li, Jessica C. Kissinger, Rick L. Tarleton

PLOS Pathogens: published January 28, 2021 | https://doi.org/10.1371/journal.ppat.1009254

Hematopoietic cell-mediated dissemination of murine cytomegalovirus is regulated by NK cells and immune evasion

Shunchuan Zhang, Lauren E. Springer, Han-Zhi Rao, Renee G. Espinosa Trethewy, Lindsey M. Bishop, Meaghan H. Hancock, Finn Grey, Christopher M. Snyder

PLOS Pathogens: published January 28, 2021 | https://doi.org/10.1371/journal.ppat.1009255

Kaposi’s sarcoma-associated herpesvirus processivity factor (PF-8) recruits cellular E3 ubiquitin ligase CHFR to promote PARP1 degradation and lytic replication

Woo-Chang Chung, Seungrae Lee, Yejin Kim, Jong Bok Seo, Moon Jung Song

PLOS Pathogens: published January 28, 2021 | https://doi.org/10.1371/journal.ppat.1009261

Nucleosome landscape reflects phenotypic differences in Trypanosoma cruzi life forms

Alex R. J. Lima, Christiane B. de Araujo, Saloe Bispo, José Patané, Ariel M. Silber, M. Carolina Elias, Julia P. C. da Cunha

PLOS Pathogens: published January 26, 2021 | https://doi.org/10.1371/journal.ppat.1009272

Ebola virus triggers receptor tyrosine kinase-dependent signaling to promote the delivery of viral particles to entry-conducive intracellular compartments

Corina M. Stewart, Alexandra Phan, Yuxia Bo, Nicholas D. LeBlond, Tyler K. T. Smith, Geneviève Laroche, Patrick M. Giguère, Morgan D. Fullerton, Martin Pelchat, Darwyn Kobasa, Marceline Côté

PLOS Pathogens: published January 29, 2021 | https://doi.org/10.1371/journal.ppat.1009275

Lentiviral transduction facilitates RNA interference in the nematode parasite Nippostrongylus brasiliensis

Jana Hagen, Peter Sarkies, Murray E. Selkirk

PLOS Pathogens: published January 26, 2021 | https://doi.org/10.1371/journal.ppat.1009286

Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice

Jessica B. Graham, Jessica L. Swarts, Sarah R. Leist, Alexandra Schäfer, Vineet D. Menachery, Lisa E. Gralinski, Sophia Jeng, Darla R. Miller, Michael A. Mooney, Shannon K. McWeeney, Martin T. Ferris, Fernando Pardo-Manuel de Villena, Mark T. Heise, Ralph S. Baric, Jennifer M. Lund

PLOS Pathogens: published January 29, 2021 | https://doi.org/10.1371/journal.ppat.1009287

Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium

Jessica K. Fiege, Joshua M. Thiede, Hezkiel Arya Nanda, William E. Matchett, Patrick J. Moore, Noe Rico Montanari, Beth K. Thielen, Jerry Daniel, Emma Stanley, Ryan C. Hunter, Vineet D. Menachery, Steven S. Shen, Tyler D. Bold, Ryan A. Langlois

PLOS Pathogens: published January 28, 2021 | https://doi.org/10.1371/journal.ppat.1009292

Gnotobiotic rainbow trout (Oncorhynchus mykiss) model reveals endogenous bacteria that protect against Flavobacterium columnare infection

David Pérez-Pascual, Sol Vendrell-Fernández, Bianca Audrain, Joaquín Bernal-Bayard, Rafael Patiño-Navarrete, Vincent Petit, Dimitri Rigaudeau, Jean-Marc Ghigo

PLOS Pathogens: published January 29, 2021 | https://doi.org/10.1371/journal.ppat.1009302

A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis

Lisa K. McLellan, Michael R. McAllaster, Arthur S. Kim, Ľubomíra Tóthová, Patrick D. Olson, Jerome S. Pinkner, Allyssa L. Daugherty, Teri N. Hreha, James W. Janetka, Daved H. Fremont, Scott J. Hultgren, Herbert W. Virgin, David A. Hunstad

PLOS Pathogens: published January 29, 2021 | https://doi.org/10.1371/journal.ppat.1009314