Burkholderia thailandensis (green) infected BMDMs lacking GBPs fail to control bacterial-mediated actin (red) polymerization and intercellular spread and fusion with neighboring cells. Structured illumination microscopy image collected in collaboration with the St. Jude Children's Research Hospital Light Microscopy core facility. Place et al.
Image Credit: D Place and St. Jude Children's Research Hospital Light Microscopy Core Facility
Pearls
Pathogenic Nocardia: A diverse genus of emerging pathogens or just poorly recognized?
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Let’s shine a light on fungal infections: A noninvasive imaging toolbox
PLOS Pathogens: published March 5, 2020 | https://doi.org/10.1371/journal.ppat.1008257
When Pigs Fly: Pandemic influenza enters the 21st century
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5 challenges in understanding the role of the virome in health and disease
PLOS Pathogens: published March 26, 2020 | https://doi.org/10.1371/journal.ppat.1008318
Maternal gatekeepers: How maternal antibody Fc characteristics influence passive transfer and infant protection
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African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity
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Antibiotic interactions shape short-term evolution of resistance in E. faecalis
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RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation
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Host-glycan metabolism is regulated by a species-conserved two-component system in Streptococcus pneumoniae
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JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor
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Resolution of herpes simplex virus reactivation in vivo results in neuronal destruction
PLOS Pathogens: published March 5, 2020 | https://doi.org/10.1371/journal.ppat.1008296
Pathogen to commensal? Longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection
PLOS Pathogens: published March 5, 2020 | https://doi.org/10.1371/journal.ppat.1008298
High crossreactivity of human T cell responses between Lassa virus lineages
PLOS Pathogens: published March 6, 2020 | https://doi.org/10.1371/journal.ppat.1008352
Monocyte metabolic reprogramming promotes pro-inflammatory activity and Staphylococcus aureus biofilm clearance
PLOS Pathogens: published March 6, 2020 | https://doi.org/10.1371/journal.ppat.1008354
Protein Kinase C subtype δ interacts with Venezuelan equine encephalitis virus capsid protein and regulates viral RNA binding through modulation of capsid phosphorylation
PLOS Pathogens: published March 9, 2020 | https://doi.org/10.1371/journal.ppat.1008282
Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry
PLOS Pathogens: published March 9, 2020 | https://doi.org/10.1371/journal.ppat.1008392
Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion
PLOS Pathogens: published March 9, 2020 | https://doi.org/10.1371/journal.ppat.1008364
Crystal structure of Mokola virus glycoprotein in its post-fusion conformation
PLOS Pathogens: published March 9, 2020 | https://doi.org/10.1371/journal.ppat.1008383
Disrupted tongue microbiota and detection of nonindigenous bacteria on the day of allogeneic hematopoietic stem cell transplantation
PLOS Pathogens: published March 9, 2020 | https://doi.org/10.1371/journal.ppat.1008348
Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein
PLOS Pathogens: published March 9, 2020 | https://doi.org/10.1371/journal.ppat.1008373
Repurposing the Streptococcus mutans CRISPR-Cas9 System to Understand Essential Gene Function
PLOS Pathogens: published March 9, 2020 | https://doi.org/10.1371/journal.ppat.1008344
Reactive oxygen species and nitric oxide imbalances lead to in vivo and in vitro arrhythmogenic phenotype in acute phase of experimental Chagas disease
PLOS Pathogens: published March 11, 2020 | https://doi.org/10.1371/journal.ppat.1008379
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Distinct epigenomic and transcriptomic modifications associated with Wolbachia-mediated asexuality
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Latency reversal agents modulate HIV antigen processing and presentation to CD8 T cells
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