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Table of Contents

March 2020

Burkholderia thailandensis (green) infected BMDMs lacking GBPs fail to control bacterial-mediated actin (red) polymerization and intercellular spread and fusion with neighboring cells. Structured illumination microscopy image collected in collaboration with the St. Jude Children's Research Hospital Light Microscopy core facility. Place et al.

Image Credit: D Place and St. Jude Children's Research Hospital Light Microscopy Core Facility

Pearls

Let’s shine a light on fungal infections: A noninvasive imaging toolbox

Katrien Van Dyck, Ona Rogiers, Greetje Vande Velde, Patrick Van Dijck

When Pigs Fly: Pandemic influenza enters the 21st century

Nídia S. Trovão, Martha I. Nelson

Maternal gatekeepers: How maternal antibody Fc characteristics influence passive transfer and infant protection

Stephanie N. Langel, Claire E. Otero, David R. Martinez, Sallie R. Permar

Research Articles

African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity

Kevin D. Raehtz, Fredrik Barrenäs, Cuiling Xu, Kathleen Busman-Sahay, Audrey Valentine, Lynn Law, Dongzhu Ma, Benjamin B. Policicchio, Viskam Wijewardana, Egidio Brocca-Cofano, Anita Trichel, Michael Gale Jr., Brandon F. Keele, Jacob D. Estes, Cristian Apetrei, Ivona Pandrea

RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation

Bo Yang, Yue Liu, Yuhan Cui, Di Song, Ge Zhang, Shujun Ma, Yanzi Liu, Mengmeng Chen, Fan Chen, Hui Wang, Jie Wang

Host-glycan metabolism is regulated by a species-conserved two-component system in Streptococcus pneumoniae

Patrick Rosendahl Andreassen, Claudia Trappetti, Vikrant Minhas, Flemming Damgaard Nielsen, Kevin Pakula, James C. Paton, Mikkel Girke Jørgensen

JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor

Bethany A. O’Hara, Jenna Morris-Love, Gretchen V. Gee, Sheila A. Haley, Walter J. Atwood

Resolution of herpes simplex virus reactivation in vivo results in neuronal destruction

Jessica R. Doll, Kasper Hoebe, Richard L. Thompson, Nancy M. Sawtell

Pathogen to commensal? Longitudinal within-host population dynamics, evolution, and adaptation during a chronic >16-year Burkholderia pseudomallei infection

Talima Pearson, Jason W. Sahl, Crystal M. Hepp, Karthik Handady, Heidie Hornstra, Adam J. Vazquez, Erik Settles, Mark Mayo, Mirjam Kaestli, Charles H. D. Williamson, Erin P. Price, Derek S. Sarovich, James M. Cook, Spenser R. Wolken, Richard A. Bowen, Apichai Tuanyok, Jeffrey T. Foster, Kevin P. Drees, Timothy J. Kidd, Scott C. Bell, Bart J. Currie, Paul Keim

High crossreactivity of human T cell responses between Lassa virus lineages

Brian M. Sullivan, Saori Sakabe, Jessica N. Hartnett, Nhi Ngo, Augustine Goba, Mambu Momoh, John Demby Sandi, Lansana Kanneh, Beatrice Cubitt, Selma D. Garcia, Brian C. Ware, Dylan Kotliar, Refugio Robles-Sikisaka, Karthik Gangavarapu, Luis Branco, Philomena Eromon, Ikponmwosa Odia, Ephraim Ogbaini-Emovon, Onikepe Folarin, Sylvanus Okogbenin, Peter O. Okokhere, Christian Happi, Juan Carlos de la Torre, Pardis C. Sabeti, Kristian G. Andersen, Robert F. Garry, Donald S. Grant, John S. Schieffelin, Michael B. A. Oldstone

Monocyte metabolic reprogramming promotes pro-inflammatory activity and Staphylococcus aureus biofilm clearance

Kelsey J. Yamada, Cortney E. Heim, Xinyuan Xi, Kuldeep S. Attri, Dezhen Wang, Wenting Zhang, Pankaj K. Singh, Tatiana K. Bronich, Tammy Kielian

Protein Kinase C subtype δ interacts with Venezuelan equine encephalitis virus capsid protein and regulates viral RNA binding through modulation of capsid phosphorylation

Brian D. Carey, Ivan Akhrymuk, Bibha Dahal, Chelsea L. Pinkham, Nicole Bracci, Sarah Finstuen-Magro, Shih-Chao Lin, Caitlin W. Lehman, Kevin J. Sokoloski, Kylene Kehn-Hall

Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry

Jian Shang, Yushun Wan, Chang Liu, Boyd Yount, Kendra Gully, Yang Yang, Ashley Auerbach, Guiqing Peng, Ralph Baric, Fang Li

Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion

David E. Place, Benoit Briard, Parimal Samir, Rajendra Karki, Anannya Bhattacharya, Clifford S. Guy, Jennifer L. Peters, Sharon Frase, Peter Vogel, Geoffrey Neale, Masahiro Yamamoto, Thirumala-Devi Kanneganti

Crystal structure of Mokola virus glycoprotein in its post-fusion conformation

Laura Belot, Malika Ouldali, Stéphane Roche, Pierre Legrand, Yves Gaudin, Aurélie A. Albertini

Disrupted tongue microbiota and detection of nonindigenous bacteria on the day of allogeneic hematopoietic stem cell transplantation

Saori Oku, Toru Takeshita, Toshiko Futatsuki, Shinya Kageyama, Mikari Asakawa, Yasuo Mori, Toshihiro Miyamoto, Jun Hata, Toshiharu Ninomiya, Haruhiko Kashiwazaki, Yoshihisa Yamashita

Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein

David Oyen, Jonathan L. Torres, Phillip C. Aoto, Yevel Flores-Garcia, Špela Binter, Tossapol Pholcharee, Sean Carroll, Sini Reponen, Rachael Wash, Qi Liang, Franck Lemiale, Emily Locke, Allan Bradley, C. Richter King, Daniel Emerling, Paul Kellam, Fidel Zavala, Andrew B. Ward, Ian A. Wilson

Repurposing the Streptococcus mutans CRISPR-Cas9 System to Understand Essential Gene Function

Robert C. Shields, Alejandro R. Walker, Natalie Maricic, Brinta Chakraborty, Simon A. M. Underhill, Robert A. Burne

The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques

Gabriela M. Webb, Jhomary Molden, Kathleen Busman-Sahay, Shaheed Abdulhaqq, Helen L. Wu, Whitney C. Weber, Katherine B. Bateman, Jason S. Reed, Mina Northrup, Nicholas Maier, Shiho Tanaka, Lina Gao, Brianna Davey, Benjamin L. Carpenter, Michael K. Axthelm, Jeffrey J. Stanton, Jeremy Smedley, Justin M. Greene, Jeffrey T. Safrit, Jacob D. Estes, Pamela J. Skinner, Jonah B. Sacha

Engagement of monocytes, NK cells, and CD4+ Th1 cells by ALVAC-SIV vaccination results in a decreased risk of SIVmac251 vaginal acquisition

Giacomo Gorini, Slim Fourati, Monica Vaccari, Mohammad Arif Rahman, Shari N. Gordon, Dallas R. Brown, Lynn Law, Jean Chang, Richard Green, Fredrik Barrenäs, Namal P. M. Liyanage, Melvin N. Doster, Luca Schifanella, Massimiliano Bissa, Isabela Silva de Castro, Robyn Washington-Parks, Veronica Galli, Deborah H. Fuller, Sampa Santra, Michael Agy, Ranajit Pal, Robert E. Palermo, Georgia D. Tomaras, Xiaoying Shen, Celia C. LaBranche, David C. Montefiori, David J. Venzon, Hung V. Trinh, Mangala Rao, Michael Gale Jr., Rafick P. Sekaly, Genoveffa Franchini

The parasitic worm product ES-62 promotes health- and life-span in a high calorie diet-accelerated mouse model of ageing

Jenny Crowe, Felicity E. Lumb, James Doonan, Margaux Broussard, Anuradha Tarafdar, Miguel A. Pineda, Carmen Landabaso, Lorna Mulvey, Paul A. Hoskisson, Simon A. Babayan, Colin Selman, William Harnett, Margaret M. Harnett

Structural basis of Fusarium myosin I inhibition by phenamacril

Yuxin Zhou, X. Edward Zhou, Yuanping Gong, Yuanye Zhu, Xiaoman Cao, Joseph S. Brunzelle, H. Eric Xu, Mingguo Zhou, Karsten Melcher, Feng Zhang

Broad-spectrum suppression of bacterial pneumonia by aminoglycoside-propagated Acinetobacter baumannii

M. Indriati Hood-Pishchany, Ly Pham, Christiaan D. Wijers, William J. Burns, Kelli L. Boyd, Lauren D. Palmer, Eric P. Skaar, Michael J. Noto

Identification of amitriptyline HCl, flavin adenine dinucleotide, azacitidine and calcitriol as repurposing drugs for influenza A H5N1 virus-induced lung injury

Fengming Huang, Cong Zhang, Qiang Liu, Yan Zhao, Yuqing Zhang, Yuhao Qin, Xiao Li, Chang Li, Congzhao Zhou, Ningyi Jin, Chengyu Jiang

Nucleolar protein NOP2/NSUN1 suppresses HIV-1 transcription and promotes viral latency by competing with Tat for TAR binding and methylation

Weili Kong, Ayan Biswas, Dawei Zhou, Guillaume Fiches, Koh Fujinaga, Netty Santoso, Jian Zhu

Structural and functional insights into a novel two-component endolysin encoded by a single gene in Enterococcus faecalis phage

Biao Zhou, Xiangkai Zhen, Huan Zhou, Feiyang Zhao, Chenpeng Fan, Vanja Perčulija, Yigang Tong, Zhiqiang Mi, Songying Ouyang

STUB1 is targeted by the SUMO-interacting motif of EBNA1 to maintain Epstein-Barr Virus latency

Yuyan Wang, Shujuan Du, Caixia Zhu, Chong Wang, Nuoya Yu, Ziqi Lin, Jin Gan, Yi Guo, Xinxin Huang, Yuping He, Erle Robertson, Di Qu, Fang Wei, Qiliang Cai

Alcelaphine herpesvirus 1 genes A7 and A8 regulate viral spread and are essential for malignant catarrhal fever

Françoise Myster, Mei-Jiao Gong, Justine Javaux, Nicolás M. Suárez, Gavin S. Wilkie, Tim Connelley, Alain Vanderplasschen, Andrew J. Davison, Benjamin G. Dewals

STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection

Wenbiao Wang, Dingwen Hu, Caifeng Wu, Yuqian Feng, Aixin Li, Weiyong Liu, Yingchong Wang, Keli Chen, Mingfu Tian, Feng Xiao, Qi Zhang, Muhammad Adnan Shereen, Weijie Chen, Pan Pan, Pin Wan, Kailang Wu, Jianguo Wu

Distinct epigenomic and transcriptomic modifications associated with Wolbachia-mediated asexuality

Xin Wu, Amelia R. I. Lindsey, Paramita Chatterjee, John H. Werren, Richard Stouthamer, Soojin V. Yi

Regulation of pneumococcal epigenetic and colony phases by multiple two-component regulatory systems

Juanjuan Wang, Jing-Wen Li, Jing Li, Yijia Huang, Shaomeng Wang, Jing-Ren Zhang

Dynamic interactions within the host-associated microbiota cause tumor formation in the basal metazoan Hydra

Kai Rathje, Benedikt Mortzfeld, Marc P. Hoeppner, Jan Taubenheim, Thomas C. G. Bosch, Alexander Klimovich

Functional redundancy of two ABC transporter proteins in mediating toxicity of Bacillus thuringiensis to cotton bollworm

Jing Wang, Huanhuan Ma, Shan Zhao, Jianlei Huang, Yihua Yang, Bruce E. Tabashnik, Yidong Wu

Klebsiella pneumoniae type VI secretion system-mediated microbial competition is PhoPQ controlled and reactive oxygen species dependent

Daniel Storey, Alan McNally, Mia Åstrand, Joana sa-Pessoa Graca Santos, Isabel Rodriguez-Escudero, Bronagh Elmore, Leyre Palacios, Helina Marshall, Laura Hobley, Maria Molina, Victor J. Cid, Tiina A. Salminen, Jose A. Bengoechea

Latency reversal agents modulate HIV antigen processing and presentation to CD8 T cells

Julie Boucau, Jishnu Das, Neelambari Joshi, Sylvie Le Gall

In silico design of a T-cell epitope vaccine candidate for parasitic helminth infection

Ayat Zawawi, Ruth Forman, Hannah Smith, Iris Mair, Murtala Jibril, Munirah H. Albaqshi, Andrew Brass, Jeremy P. Derrick, Kathryn J. Else

Commensal Neisseria cinerea impairs Neisseria meningitidis microcolony development and reduces pathogen colonisation of epithelial cells

Rafael Custodio, Errin Johnson, Guangyu Liu, Christoph M. Tang, Rachel M. Exley

Molecular basis of P[II] major human rotavirus VP8* domain recognition of histo-blood group antigens

Shenyuan Xu, Luay U. Ahmed, Michael Robert Stuckert, Kristen Rose McGinnis, Yang Liu, Ming Tan, Pengwei Huang, Weiming Zhong, Dandan Zhao, Xi Jiang, Michael A. Kennedy

Variations in microbiota composition of laboratory mice influence Citrobacter rodentium infection via variable short-chain fatty acid production

Lisa Osbelt, Sophie Thiemann, Nathiana Smit, Till Robin Lesker, Madita Schröter, Eric J. C. Gálvez, Kerstin Schmidt-Hohagen, Marina C. Pils, Sabrina Mühlen, Petra Dersch, Karsten Hiller, Dirk Schlüter, Meina Neumann-Schaal, Till Strowig

BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses

Jiang Wang, Guo-Li Li, Sheng-Li Ming, Chun-Feng Wang, Li-Juan Shi, Bing-Qian Su, Hong-Tao Wu, Lei Zeng, Ying-Qian Han, Zhong-Hu Liu, Da-Wei Jiang, Yong-Kun Du, Xiang-Dong Li, Gai-Ping Zhang, Guo-Yu Yang, Bei-Bei Chu

Surfing motility is a complex adaptation dependent on the stringent stress response in Pseudomonas aeruginosa LESB58

Daniel Pletzer, Evelyn Sun, Caleb Ritchie, Lauren Wilkinson, Leo T. Liu, Michael J. Trimble, Heidi Wolfmeier, Travis M. Blimkie, Robert E. W. Hancock

When a Palearctic bacterium meets a Nearctic insect vector: Genetic and ecological insights into the emergence of the grapevine Flavescence dorée epidemics in Europe

Sylvie Malembic-Maher, Delphine Desqué, Dima Khalil, Pascal Salar, Bernard Bergey, Jean-Luc Danet, Sybille Duret, Marie-Pierre Dubrana-Ourabah, Laure Beven, Ibolya Ember, Zoltan Acs, Michele Della Bartola, Alberto Materazzi, Luisa Filippin, Slobodan Krnjajic, Oliver Krstić, Ivo Toševski, Friederike Lang, Barbara Jarausch, Maria Kölber, Jelena Jović, Elisa Angelini, Nathalie Arricau-Bouvery, Michael Maixner, Xavier Foissac

TLR4 abrogates the Th1 immune response through IRF1 and IFN-β to prevent immunopathology during L. infantum infection

Laís Amorim Sacramento, Luciana Benevides, Sandra Regina Maruyama, Lucas Tavares, Kiyoshi Ferreira Fukutani, Marcela Francozo, Tim Sparwasser, Fernando Queiroz Cunha, Roque Pacheco Almeida, João Santana da Silva, Vanessa Carregaro

Cervicovaginal microbiome and natural history of HPV in a longitudinal study

Mykhaylo Usyk, Christine P. Zolnik, Philip E. Castle, Carolina Porras, Rolando Herrero, Ana Gradissimo, Paula Gonzalez, Mahboobeh Safaeian, Mark Schiffman, Robert D. Burk, Costa Rica HPV Vaccine Trial (CVT) Group

Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology

Paul David, Malgorzata Drabczyk-Pluta, Eva Pastille, Torben Knuschke, Tanja Werner, Nadine Honke, Dominik A. Megger, Ilseyar Akhmetzyanova, Namir Shaabani, Annette Eyking-Singer, Elke Cario, Olivia Kershaw, Achim D. Gruber, Matthias Tenbusch, Kirsten K. Dietze, Mirko Trilling, Jia Liu, Dirk Schadendorf, Hendrik Streeck, Karl S. Lang, Youhua Xie, Lisa Zimmer, Barbara Sitek, Annette Paschen, Astrid M. Westendorf, Ulf Dittmer, Gennadiy Zelinskyy

Acute experimental infection of bats and ferrets with Hendra virus: Insights into the early host response of the reservoir host and susceptible model species

Amanda P. Woon, Victoria Boyd, Shawn Todd, Ina Smith, Reuben Klein, Isaac B. Woodhouse, Sarah Riddell, Gary Crameri, John Bingham, Lin-Fa Wang, Anthony W. Purcell, Deborah Middleton, Michelle L. Baker

An improved animal model for herpesvirus encephalitis in humans

Julia Sehl, Julia E. Hölper, Barbara G. Klupp, Christina Baumbach, Jens P. Teifke, Thomas C. Mettenleiter