Phosphoinositide signaling and regulation in Trypanosoma brucei: Specialized functions in a protozoan pathogen

Igor Cestari

PLOS Pathogens: published January 2, 2020 | https://doi.org/10.1371/journal.ppat.1008167

B vitamin acquisition by gut commensal bacteria

Emily E. Putnam, Andrew L. Goodman

PLOS Pathogens: published January 23, 2020 | https://doi.org/10.1371/journal.ppat.1008208

Hydropic anthelmintics against parasitic nematodes

Satish Kumar Rajasekharan, Jintae Lee

PLOS Pathogens: published January 30, 2020 | https://doi.org/10.1371/journal.ppat.1008202

Gastrointestinal organoid technology advances studies of enteric virus biology

Abimbola O. Kolawole, Christiane E. Wobus

PLOS Pathogens: published January 30, 2020 | https://doi.org/10.1371/journal.ppat.1008212

The CRISPR toolbox in medical mycology: State of the art and perspectives

Florent Morio, Lisa Lombardi, Geraldine Butler

PLOS Pathogens: published January 16, 2020 | https://doi.org/10.1371/journal.ppat.1008201

Immune recognition of putative alien microbial structures: Host–pathogen interactions in the age of space travel

Mihai G. Netea, Jorge Domínguez-Andrés, Marc Eleveld, Huub J. M. op den Camp, Jos W. M. van der Meer, Neil A. R. Gow, Marien I. de Jonge

PLOS Pathogens: published January 30, 2020 | https://doi.org/10.1371/journal.ppat.1008153

Passing the Torch

Grant McFadden

PLOS Pathogens: published January 30, 2020 | https://doi.org/10.1371/journal.ppat.1008306

USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity

Jin Liu, Lincong Jin, Xiangjie Chen, Yukang Yuan, Yibo Zuo, Ying Miao, Qian Feng, Hongguang Zhang, Fan Huang, Tingting Guo, Liting Zhang, Li Zhu, Feng Qian, Chuanwu Zhu, Hui Zheng

PLOS Pathogens: published January 3, 2020 | https://doi.org/10.1371/journal.ppat.1008215

Novel EBV LMP-2-affibody and affitoxin in molecular imaging and targeted therapy of nasopharyngeal carcinoma

Shanli Zhu, Jun Chen, Yirong Xiong, Saidu Kamara, Meiping Gu, Wanlin Tang, Shao Chen, Haiyan Dong, Xiangyang Xue, Zhi-Ming Zheng, Lifang Zhang

PLOS Pathogens: published January 6, 2020 | https://doi.org/10.1371/journal.ppat.1008223

Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation

Michèle Brocard, Valentina Iadevaia, Philipp Klein, Belinda Hall, Glenys Lewis, Jia Lu, James Burke, Margaret M. Willcocks, Roy Parker, Ian G. Goodfellow, Alessia Ruggieri, Nicolas Locker

PLOS Pathogens: published January 6, 2020 | https://doi.org/10.1371/journal.ppat.1008250

A trans-activator-like structure in RCNMV RNA1 evokes the origin of the trans-activator in RNA2

Laura R. Newburn, K. Andrew White

PLOS Pathogens: published January 6, 2020 | https://doi.org/10.1371/journal.ppat.1008271

Modular mimicry and engagement of the Hippo pathway by Marburg virus VP40: Implications for filovirus biology and budding

Ziying Han, Shantoshini Dash, Cari A. Sagum, Gordon Ruthel, Chaitanya K. Jaladanki, Corbett T. Berry, Michael P. Schwoerer, Nina M. Harty, Bruce D. Freedman, Mark T. Bedford, Hao Fan, Sachdev S. Sidhu, Marius Sudol, Olena Shtanko, Ronald N. Harty

PLOS Pathogens: published January 6, 2020 | https://doi.org/10.1371/journal.ppat.1008231

Pervasive within-host recombination and epistasis as major determinants of the molecular evolution of the foot-and-mouth disease virus capsid

Luca Ferretti, Eva Pérez-Martín, Fuquan Zhang, François Maree, Lin-Mari de Klerk-Lorist, Louis van Schalkwykc, Nicholas D. Juleff, Bryan Charleston, Paolo Ribeca

PLOS Pathogens: published January 6, 2020 | https://doi.org/10.1371/journal.ppat.1008235

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The C. elegans CHP1 homolog, pbo-1, functions in innate immunity by regulating the pH of the intestinal lumen

Saida Benomar, Patrick Lansdon, Aaron M. Bender, Blake R. Peterson, Josephine R. Chandler, Brian D. Ackley

PLOS Pathogens: published January 9, 2020 | https://doi.org/10.1371/journal.ppat.1008134

A shear stress micromodel of urinary tract infection by the Escherichia coli producing Dr adhesin

Beata Zalewska-Piątek, Marcin Olszewski, Tomasz Lipniacki, Sławomir Błoński, Miłosz Wieczór, Piotr Bruździak, Anna Skwarska, Bogdan Nowicki, Stella Nowicki, Rafał Piątek

PLOS Pathogens: published January 9, 2020 | https://doi.org/10.1371/journal.ppat.1008247

Epigenetic factor siRNA screen during primary KSHV infection identifies novel host restriction factors for the lytic cycle of KSHV

Nenavath Gopal Naik, Thomas Hong Nguyen, Lauren Roberts, Luke Todd Fischer, Katherine Glickman, Gavin Golas, Bernadett Papp, Zsolt Toth

PLOS Pathogens: published January 10, 2020 | https://doi.org/10.1371/journal.ppat.1008268

Broad dengue neutralization in mosquitoes expressing an engineered antibody

Anna Buchman, Stephanie Gamez, Ming Li, Igor Antoshechkin, Hsing-Han Li, Hsin-Wei Wang, Chun-Hong Chen, Melissa J. Klein, Jean-Bernard Duchemin, James E. Crowe Jr., Prasad N. Paradkar, Omar S. Akbari

PLOS Pathogens: published January 16, 2020 | https://doi.org/10.1371/journal.ppat.1008103

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Targeting resident memory T cell immunity culminates in pulmonary and systemic protection against Brucella infection

Hongbin Wang, Carol Hoffman, Xinghong Yang, Beata Clapp, David W. Pascual

PLOS Pathogens: published January 17, 2020 | https://doi.org/10.1371/journal.ppat.1008176

Signatures of oral microbiome in HIV-infected individuals with oral Kaposi's sarcoma and cell-associated KSHV DNA

Marion Gruffaz, Tinghe Zhang, Vickie Marshall, Priscila Gonçalves, Ramya Ramaswami, Nazzarena Labo, Denise Whitby, Thomas S. Uldrick, Robert Yarchoan, Yufei Huang, Shou-Jiang Gao

PLOS Pathogens: published January 17, 2020 | https://doi.org/10.1371/journal.ppat.1008114

An RNA thermometer dictates production of a secreted bacterial toxin

Christian Twittenhoff, Ann Kathrin Heroven, Sabrina Mühlen, Petra Dersch, Franz Narberhaus

PLOS Pathogens: published January 17, 2020 | https://doi.org/10.1371/journal.ppat.1008184

Quantifying within-host diversity of H5N1 influenza viruses in humans and poultry in Cambodia

Louise H. Moncla, Trevor Bedford, Philippe Dussart, Srey Viseth Horm, Sareth Rith, Philippe Buchy, Erik A. Karlsson, Lifeng Li, Yongmei Liu, Huachen Zhu, Yi Guan, Thomas C. Friedrich, Paul F. Horwood

PLOS Pathogens: published January 17, 2020 | https://doi.org/10.1371/journal.ppat.1008191

A mosquito juvenile hormone binding protein (mJHBP) regulates the activation of innate immune defenses and hemocyte development

Il Hwan Kim, Julio César Castillo, Azadeh Aryan, Inés Martin-Martin, Marcela Nouzova, Fernando G. Noriega, Ana Beatriz F. Barletta, Eric Calvo, Zachary N. Adelman, José M. C. Ribeiro, John F. Andersen

PLOS Pathogens: published January 21, 2020 | https://doi.org/10.1371/journal.ppat.1008288

Agricultural and geographic factors shaped the North American 2015 highly pathogenic avian influenza H5N2 outbreak

Joseph T. Hicks, Dong-Hun Lee, Venkata R. Duvvuri, Mia Kim Torchetti, David E. Swayne, Justin Bahl

PLOS Pathogens: published January 21, 2020 | https://doi.org/10.1371/journal.ppat.1007857

G protein α subunit suppresses sporangium formation through a serine/threonine protein kinase in Phytophthora sojae

Min Qiu, Yaning Li, Xin Zhang, Mingrun Xuan, Baiyu Zhang, Wenwu Ye, Xiaobo Zheng, Francine Govers, Yuanchao Wang

PLOS Pathogens: published January 21, 2020 | https://doi.org/10.1371/journal.ppat.1008138

CFTR dysregulation drives active selection of the gut microbiome

Stacey M. Meeker, Kevin S. Mears, Naseer Sangwan, Mitchell J. Brittnacher, Eli J. Weiss, Piper M. Treuting, Nicholas Tolley, Christopher E. Pope, Kyle R. Hager, Anh T. Vo, Jisun Paik, Charles W. Frevert, Hillary S. Hayden, Lucas R. Hoffman, Samuel I. Miller, Adeline M. Hajjar

PLOS Pathogens: published January 21, 2020 | https://doi.org/10.1371/journal.ppat.1008251

USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA

Hong-Yan Zhang, Bo-Wei Liao, Zhi-Sheng Xu, Yong Ran, Dong-Peng Wang, Yan Yang, Wei-Wei Luo, Yan-Yi Wang

PLOS Pathogens: published January 22, 2020 | https://doi.org/10.1371/journal.ppat.1008178

Stress keratin 17 enhances papillomavirus infection-induced disease by downregulating T cell recruitment

Wei Wang, Aayushi Uberoi, Megan Spurgeon, Ellery Gronski, Vladimir Majerciak, Alexei Lobanov, Mitchell Hayes, Amanda Loke, Zhi-Ming Zheng, Paul F. Lambert

PLOS Pathogens: published January 22, 2020 | https://doi.org/10.1371/journal.ppat.1008206

Mobilizable antibiotic resistance genes are present in dust microbial communities

Sarah Ben Maamar, Adam J. Glawe, Taylor K. Brown, Nancy Hellgeth, Jinglin Hu, Ji-Ping Wang, Curtis Huttenhower, Erica M. Hartmann

PLOS Pathogens: published January 23, 2020 | https://doi.org/10.1371/journal.ppat.1008211

West Nile virus capsid protein inhibits autophagy by AMP-activated protein kinase degradation in neurological disease development

Shintaro Kobayashi, Kentaro Yoshii, Wallaya Phongphaew, Memi Muto, Minato Hirano, Yasuko Orba, Hirofumi Sawa, Hiroaki Kariwa

PLOS Pathogens: published January 23, 2020 | https://doi.org/10.1371/journal.ppat.1008238

New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis

Andréanne Lupien, Caroline Shi-Yan Foo, Svetlana Savina, Anthony Vocat, Jérémie Piton, Natalia Monakhova, Andrej Benjak, Dirk A. Lamprecht, Adrie J. C. Steyn, Kevin Pethe, Vadim A. Makarov, Stewart T. Cole

PLOS Pathogens: published January 23, 2020 | https://doi.org/10.1371/journal.ppat.1008270

Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys

Quintin Lee, Matthew P. Padula, Natalia Pinello, Simon H. Williams, Matthew B. O'Rourke, Marcilio Jorge Fumagalli, Joseph D. Orkin, Renhua Song, Babak Shaban, Ori Brenner, John E. Pimanda, Wolfgang Weninger, William Marciel de Souza, Amanda D. Melin, Justin J.-L. Wong, Marcus J. Crim, Sébastien Monette, Ben Roediger, Christopher J. Jolly

PLOS Pathogens: published January 23, 2020 | https://doi.org/10.1371/journal.ppat.1008262

The cervicovaginal mucus barrier to HIV-1 is diminished in bacterial vaginosis

Thuy Hoang, Emily Toler, Kevin DeLong, Nomfuneko A. Mafunda, Seth M. Bloom, Hannah C. Zierden, Thomas R. Moench, Jenell S. Coleman, Justin Hanes, Douglas S. Kwon, Samuel K. Lai, Richard A. Cone, Laura M. Ensign

PLOS Pathogens: published January 23, 2020 | https://doi.org/10.1371/journal.ppat.1008236

Multiple regions of E6AP (UBE3A) contribute to interaction with papillomavirus E6 proteins and the activation of ubiquitin ligase activity

Camille M. Drews, Nicole Brimer, Scott B. Vande Pol

PLOS Pathogens: published January 23, 2020 | https://doi.org/10.1371/journal.ppat.1008295

Structures of immature EIAV Gag lattices reveal a conserved role for IP6 in lentivirus assembly

Robert A. Dick, Chaoyi Xu, Dustin R. Morado, Vladyslav Kravchuk, Clifton L. Ricana, Terri D. Lyddon, Arianna M. Broad, J. Ryan Feathers, Marc C. Johnson, Volker M. Vogt, Juan R. Perilla, John A. G. Briggs, Florian K. M. Schur

PLOS Pathogens: published January 27, 2020 | https://doi.org/10.1371/journal.ppat.1008277

A kinesin-3 recruitment complex facilitates axonal sorting of enveloped alpha herpesvirus capsids

Julian Scherer, Ian B. Hogue, Zachary A. Yaffe, Nikhila S. Tanneti, Benjamin Y. Winer, Michael Vershinin, Lynn W. Enquist

PLOS Pathogens: published January 29, 2020 | https://doi.org/10.1371/journal.ppat.1007985

Chromatin maturation of the HIV-1 provirus in primary resting CD4⁺ T cells

Birgitta Lindqvist, Sara Svensson Akusjärvi, Anders Sönnerborg, Marios Dimitriou, J. Peter Svensson

PLOS Pathogens: published January 30, 2020 | https://doi.org/10.1371/journal.ppat.1008264

EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria

Thayer K. Darling, Patrice N. Mimche, Christian Bray, Banlanjo Umaru, Lauren M. Brady, Colleen Stone, Carole Else Eboumbou Moukoko, Thomas E. Lane, Lawrence S. Ayong, Tracey J. Lamb

PLOS Pathogens: published January 30, 2020 | https://doi.org/10.1371/journal.ppat.1008261

MyD88-dependent influx of monocytes and neutrophils impairs lymph node B cell responses to chikungunya virus infection via Irf5, Nos2 and Nox2

Mary K. McCarthy, Glennys V. Reynoso, Emma S. Winkler, Matthias Mack, Michael S. Diamond, Heather D. Hickman, Thomas E. Morrison

PLOS Pathogens: published January 30, 2020 | https://doi.org/10.1371/journal.ppat.1008292

Mannan detecting C-type lectin receptor probes recognise immune epitopes with diverse chemical, spatial and phylogenetic heterogeneity in fungal cell walls

Ingrida Vendele, Janet A. Willment, Lisete M. Silva, Angelina S. Palma, Wengang Chai, Yan Liu, Ten Feizi, Maria Spyrou, Mark H. T. Stappers, Gordon D. Brown, Neil A. R. Gow

PLOS Pathogens: published January 30, 2020 | https://doi.org/10.1371/journal.ppat.1007927

Correction: Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na⁺/K⁺ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses

Masaharu Iwasaki, Petra Minder, Yíngyún Caì, Jens H. Kuhn, John R. Yates III, Bruce E. Torbett, Juan C. de la Torre

PLOS Pathogens: published January 6, 2020 | https://doi.org/10.1371/journal.ppat.1008289

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Correction: Genetics, Receptor Binding Property, and Transmissibility in Mammals of Naturally Isolated H9N2 Avian Influenza Viruses

Xuyong Li, Jianzhong Shi, Jing Guo, Guohua Deng, Qianyi Zhang, Jinliang Wang, Xijun He, Kaicheng Wang, Jiming Chen, Yuanyuan Li, Jun Fan, Huiui Kong, Chunyang Gu, Yuantao Guan, Yasuo Suzuki, Yoshihiro Kawaoka, Liling Liu, Yongping Jiang, Guobin Tian, Yanbing Li, Zhigao Bu, Hualan Chen

PLOS Pathogens: published January 8, 2020 | https://doi.org/10.1371/journal.ppat.1008284

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