Herpesviruses depend on host nuclear transport factors for efficient nuclear import of viral and host components. Alphaherpesviruses such as Herpes Simplex Viruses (HSV) cause many disease upon productive infection of epithelial and fibroblastic cells as well as neurons. Immunofluorescence microscopy images of neurons (red; white, middle panel) infected with an HSV-1 reporter strain expressing GFP (green; white, right panel). Neurons were cultured in microfluidic chambers which separate the axonal compartment on the top from the somal compartment on the bottom by microgrooves through which the axons had grown, and infected via the axonal compartment. Sodeik et al.
Image Credit: Anna Buch and Beate Sodeik, Institute of Virology, Hannover Medical School, Hannover, Germany.
Opinions
The curious case of APOBEC3 activation by cancer-associated human papillomaviruses
PLOS Pathogens: published January 11, 2018 | https://doi.org/10.1371/journal.ppat.1006717
Although it's painful: The importance of stringent antibody validation
PLOS Pathogens: published January 4, 2018 | https://doi.org/10.1371/journal.ppat.1006701
Pearls
Does nonreproductive swarming adapt to pathogens?
PLOS Pathogens: published January 25, 2018 | https://doi.org/10.1371/journal.ppat.1006742
The oral microbiome: A Lesson in coexistence
PLOS Pathogens: published January 25, 2018 | https://doi.org/10.1371/journal.ppat.1006719
Habits of a highly successful cereal killer, Striga
PLOS Pathogens: published January 11, 2018 | https://doi.org/10.1371/journal.ppat.1006731
Chaperone functional specificity promotes yeast prion diversity
PLOS Pathogens: published January 4, 2018 | https://doi.org/10.1371/journal.ppat.1006695
From phagocytosis to metaforosis: Calcineurin’s deadly role in innate processing of fungi
PLOS Pathogens: published January 4, 2018 | https://doi.org/10.1371/journal.ppat.1006627
Review
Tissue-specific transcriptome analyses provide new insights into GPCR signalling in adult Schistosoma mansoni
PLOS Pathogens: published January 18, 2018 | https://doi.org/10.1371/journal.ppat.1006718
Research Articles
The fungal pathogen Magnaporthe oryzae suppresses innate immunity by modulating a host potassium channel
PLOS Pathogens: published January 31, 2018 | https://doi.org/10.1371/journal.ppat.1006878
Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis
PLOS Pathogens: published January 31, 2018 | https://doi.org/10.1371/journal.ppat.1006797
A new mechanism of interferon’s antiviral action: Induction of autophagy, essential for paramyxovirus replication, is inhibited by the interferon stimulated gene, TDRD7
PLOS Pathogens: published January 30, 2018 | https://doi.org/10.1371/journal.ppat.1006877
The Xanthomonas euvesicatoria type III effector XopAU is an active protein kinase that manipulates plant MAP kinase signaling
PLOS Pathogens: published January 29, 2018 | https://doi.org/10.1371/journal.ppat.1006880
Human cytomegalovirus UL23 inhibits transcription of interferon-γ stimulated genes and blocks antiviral interferon-γ responses by interacting with human N-myc interactor protein
PLOS Pathogens: published January 29, 2018 | https://doi.org/10.1371/journal.ppat.1006867
Attenuation of a very virulent Marek's disease herpesvirus (MDV) by codon pair bias deoptimization
PLOS Pathogens: published January 29, 2018 | https://doi.org/10.1371/journal.ppat.1006857
Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes
PLOS Pathogens: published January 29, 2018 | https://doi.org/10.1371/journal.ppat.1006835
Global synonymous mutagenesis identifies cis-acting RNA elements that regulate HIV-1 splicing and replication
PLOS Pathogens: published January 29, 2018 | https://doi.org/10.1371/journal.ppat.1006824
Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense
PLOS Pathogens: published January 25, 2018 | https://doi.org/10.1371/journal.ppat.1006874
Intracellular trafficking of begomoviruses in the midgut cells of their insect vector
PLOS Pathogens: published January 25, 2018 | https://doi.org/10.1371/journal.ppat.1006866
Two closely related Rho GTPases, Cdc42 and RacA, of the en-dophytic fungus Epichloë festucae have contrasting roles for ROS production and symbiotic infection synchronized with the host plant
PLOS Pathogens: published January 25, 2018 | https://doi.org/10.1371/journal.ppat.1006840
MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection
PLOS Pathogens: published January 25, 2018 | https://doi.org/10.1371/journal.ppat.1006838
Phenotypic deficits in the HIV-1 envelope are associated with the maturation of a V2-directed broadly neutralizing antibody lineage
PLOS Pathogens: published January 25, 2018 | https://doi.org/10.1371/journal.ppat.1006825
The Wolbachia strain wAu provides highly efficient virus transmission blocking in Aedes aegypti
PLOS Pathogens: published January 25, 2018 | https://doi.org/10.1371/journal.ppat.1006815
Alterations of HIV-1 envelope phenotype and antibody-mediated neutralization by signal peptide mutations
PLOS Pathogens: published January 25, 2018 | https://doi.org/10.1371/journal.ppat.1006812
Conditional mutagenesis in vivo reveals cell type- and infection stage-specific requirements for LANA in chronic MHV68 infection
PLOS Pathogens: published January 24, 2018 | https://doi.org/10.1371/journal.ppat.1006865
The structure of FIV reverse transcriptase and its implications for non-nucleoside inhibitor resistance
PLOS Pathogens: published January 24, 2018 | https://doi.org/10.1371/journal.ppat.1006849
Cathepsin B aggravates coxsackievirus B3-induced myocarditis through activating the inflammasome and promoting pyroptosis
PLOS Pathogens: published January 23, 2018 | https://doi.org/10.1371/journal.ppat.1006872
Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction
PLOS Pathogens: published January 22, 2018 | https://doi.org/10.1371/journal.ppat.1006868
Infectious blood source alters early foregut infection and regurgitative transmission of Yersinia pestis by rodent fleas
PLOS Pathogens: published January 22, 2018 | https://doi.org/10.1371/journal.ppat.1006859
Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome
PLOS Pathogens: published January 22, 2018 | https://doi.org/10.1371/journal.ppat.1006852
Identification of a novel protein complex essential for effector translocation across the parasitophorous vacuole membrane of Toxoplasma gondii
PLOS Pathogens: published January 22, 2018 | https://doi.org/10.1371/journal.ppat.1006828
The fungal myosin I is essential for Fusarium toxisome formation
PLOS Pathogens: published January 22, 2018 | https://doi.org/10.1371/journal.ppat.1006827
Regional and subtype-dependent miRNA signatures in sporadic Creutzfeldt-Jakob disease are accompanied by alterations in miRNA silencing machinery and biogenesis
PLOS Pathogens: published January 22, 2018 | https://doi.org/10.1371/journal.ppat.1006802
Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication
PLOS Pathogens: published January 19, 2018 | https://doi.org/10.1371/journal.ppat.1006851
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Bunyavirus requirement for endosomal K+ reveals new roles of cellular ion channels during infection
PLOS Pathogens: published January 19, 2018 | https://doi.org/10.1371/journal.ppat.1006845
RNA-Seq of Kaposi’s sarcoma reveals alterations in glucose and lipid metabolism
PLOS Pathogens: published January 19, 2018 | https://doi.org/10.1371/journal.ppat.1006844
A role for domain I of the hepatitis C virus NS5A protein in virus assembly
PLOS Pathogens: published January 19, 2018 | https://doi.org/10.1371/journal.ppat.1006834
IFNγ inhibits G-CSF induced neutrophil expansion and invasion of the CNS to prevent viral encephalitis
PLOS Pathogens: published January 19, 2018 | https://doi.org/10.1371/journal.ppat.1006822
Activation of PI3K, Akt, and ERK during early rotavirus infection leads to V-ATPase-dependent endosomal acidification required for uncoating
PLOS Pathogens: published January 19, 2018 | https://doi.org/10.1371/journal.ppat.1006820
Leishmania proteophosphoglycans regurgitated from infected sand flies accelerate dermal wound repair and exacerbate leishmaniasis via insulin-like growth factor 1-dependent signalling
PLOS Pathogens: published January 19, 2018 | https://doi.org/10.1371/journal.ppat.1006794
Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1
PLOS Pathogens: published January 18, 2018 | https://doi.org/10.1371/journal.ppat.1006855
Initial acquisition and succession of the cystic fibrosis lung microbiome is associated with disease progression in infants and preschool children
PLOS Pathogens: published January 18, 2018 | https://doi.org/10.1371/journal.ppat.1006798
Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs
PLOS Pathogens: published January 18, 2018 | https://doi.org/10.1371/journal.ppat.1006796
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Xylose donor transport is critical for fungal virulence
PLOS Pathogens: published January 18, 2018 | https://doi.org/10.1371/journal.ppat.1006765
Higher sequence diversity in the vaginal tract than in blood at early HIV-1 infection
PLOS Pathogens: published January 18, 2018 | https://doi.org/10.1371/journal.ppat.1006754
Ebola virus requires a host scramblase for externalization of phosphatidylserine on the surface of viral particles
PLOS Pathogens: published January 16, 2018 | https://doi.org/10.1371/journal.ppat.1006848
A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles
PLOS Pathogens: published January 16, 2018 | https://doi.org/10.1371/journal.ppat.1006826
STAT3 expression by myeloid cells is detrimental for the T- cell-mediated control of infection with Mycobacterium tuberculosis
PLOS Pathogens: published January 16, 2018 | https://doi.org/10.1371/journal.ppat.1006809
Effect of analytical treatment interruption and reinitiation of antiretroviral therapy on HIV reservoirs and immunologic parameters in infected individuals
PLOS Pathogens: published January 11, 2018 | https://doi.org/10.1371/journal.ppat.1006792
Beta HPV38 oncoproteins act with a hit-and-run mechanism in ultraviolet radiation-induced skin carcinogenesis in mice
PLOS Pathogens: published January 11, 2018 | https://doi.org/10.1371/journal.ppat.1006783
Continental synchronicity of human influenza virus epidemics despite climactic variation
PLOS Pathogens: published January 11, 2018 | https://doi.org/10.1371/journal.ppat.1006780
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Prohibitin plays a critical role in Enterovirus 71 neuropathogenesis
PLOS Pathogens: published January 11, 2018 | https://doi.org/10.1371/journal.ppat.1006778
Strains of bacterial species induce a greatly varied acute adaptive immune response: The contribution of the accessory genome
PLOS Pathogens: published January 11, 2018 | https://doi.org/10.1371/journal.ppat.1006726
The potent effect of mycolactone on lipid membranes
PLOS Pathogens: published January 10, 2018 | https://doi.org/10.1371/journal.ppat.1006814
Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection
PLOS Pathogens: published January 8, 2018 | https://doi.org/10.1371/journal.ppat.1006769
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Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors
PLOS Pathogens: published January 5, 2018 | https://doi.org/10.1371/journal.ppat.1006830
Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons
PLOS Pathogens: published January 5, 2018 | https://doi.org/10.1371/journal.ppat.1006823
Infection and depletion of CD4+ group-1 innate lymphoid cells by HIV-1 via type-I interferon pathway
PLOS Pathogens: published January 5, 2018 | https://doi.org/10.1371/journal.ppat.1006819
The Vibrio cholerae RND efflux systems impact virulence factor production and adaptive responses via periplasmic sensor proteins
PLOS Pathogens: published January 5, 2018 | https://doi.org/10.1371/journal.ppat.1006804
Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice
PLOS Pathogens: published January 4, 2018 | https://doi.org/10.1371/journal.ppat.1006821
Mycobacterium tuberculosis-induced miR-155 subverts autophagy by targeting ATG3 in human dendritic cells
PLOS Pathogens: published January 4, 2018 | https://doi.org/10.1371/journal.ppat.1006790
Exosomes serve as novel modes of tick-borne flavivirus transmission from arthropod to human cells and facilitates dissemination of viral RNA and proteins to the vertebrate neuronal cells
PLOS Pathogens: published January 4, 2018 | https://doi.org/10.1371/journal.ppat.1006764
The paradox of HBV evolution as revealed from a 16th century mummy
PLOS Pathogens: published January 4, 2018 | https://doi.org/10.1371/journal.ppat.1006750
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The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires’ disease in humans
PLOS Pathogens: published January 3, 2018 | https://doi.org/10.1371/journal.ppat.1006829
Indole-3-acetaldehyde dehydrogenase-dependent auxin synthesis contributes to virulence of Pseudomonas syringae strain DC3000
PLOS Pathogens: published January 2, 2018 | https://doi.org/10.1371/journal.ppat.1006811
Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection
PLOS Pathogens: published January 2, 2018 | https://doi.org/10.1371/journal.ppat.1006810
Tomato leaf curl Yunnan virus-encoded C4 induces cell division through enhancing stability of Cyclin D 1.1 via impairing NbSKη -mediated phosphorylation in Nicotiana benthamiana
PLOS Pathogens: published January 2, 2018 | https://doi.org/10.1371/journal.ppat.1006789
Herpes simplex viruses activate phospholipid scramblase to redistribute phosphatidylserines and Akt to the outer leaflet of the plasma membrane and promote viral entry
PLOS Pathogens: published January 2, 2018 | https://doi.org/10.1371/journal.ppat.1006766
A role for small RNA in regulating innate immunity during plant growth
PLOS Pathogens: published January 2, 2018 | https://doi.org/10.1371/journal.ppat.1006756