January 2017

Scanning electron micrograph of Trypanosoma brucei, illustrating the flagellum (pseudo-colored in pink) that adheres to the cell surface. Flagellum-cell body adhesion requires a specialized cytoskeletal structure termed flagellum attachment zone filament. Assembly of this filament requires the Polo-like kinase, whose level is under stringent control. A Cullin4-based ubiquitin ligase targets Polo-like kinase for ubiquitination and degradation after the G1/S cell cycle transition, thereby ensuring flagellum-cell body adhesion. Hu et al.

Image Credit: Ziyin Li and Hung Quang Dang (University of Texas Health Science Center at Houston)

Opinion

Fighting Ebola: A Window for Vaccine Re-evaluation?

Keith J. Chappell, Daniel Watterson

PLOS Pathogens: published January 12, 2017 | https://doi.org/10.1371/journal.ppat.1006037

Pearls

Microbial Partnerships of Pathogenic Oomycetes

Marie Larousse, Eric Galiana

PLOS Pathogens: published January 26, 2017 | https://doi.org/10.1371/journal.ppat.1006028

Common Commensal Cancer Viruses

Patrick S. Moore, Yuan Chang

PLOS Pathogens: published January 19, 2017 | https://doi.org/10.1371/journal.ppat.1006078

Zoonotic Epidemic of Sporotrichosis: Cat to Human Transmission

Isabella Dib Ferreira Gremião, Luisa Helena Monteiro Miranda, Erica Guerino Reis, Anderson Messias Rodrigues, Sandro Antonio Pereira

PLOS Pathogens: published January 19, 2017 | https://doi.org/10.1371/journal.ppat.1006077

Oropharyngeal Candidiasis: Fungal Invasion and Epithelial Cell Responses

Marc Swidergall, Scott G. Filler

PLOS Pathogens: published January 12, 2017 | https://doi.org/10.1371/journal.ppat.1006056

Vibrio vulnificus: From Oyster Colonist to Human Pathogen

Kelsey E. Phillips, Karla J. F. Satchell

PLOS Pathogens: published January 5, 2017 | https://doi.org/10.1371/journal.ppat.1006053

Review

A Receptor’s Tale: An Eon in the Life of a Trypanosome Receptor

Matthew K. Higgins, Harriet Lane-Serff, Paula MacGregor, Mark Carrington

PLOS Pathogens: published January 26, 2017 | https://doi.org/10.1371/journal.ppat.1006055

Research Matters

The Importance of International Collaborations to Advance Research Endeavors

Alfredo G. Torres

PLOS Pathogens: published January 5, 2017 | https://doi.org/10.1371/journal.ppat.1006047

Research Articles

Anthropogenically driven environmental changes shift the ecological dynamics of hemorrhagic fever with renal syndrome

Huaiyu Tian, Pengbo Yu, Ottar N. Bjørnstad, Bernard Cazelles, Jing Yang, Hua Tan, Shanqian Huang, Yujun Cui, Lu Dong, Chaofeng Ma, Changan Ma, Sen Zhou, Marko Laine, Xiaoxu Wu, Yanyun Zhang, Jingjun Wang, Ruifu Yang, Nils Chr. Stenseth, Bing Xu

PLOS Pathogens: published January 31, 2017 | https://doi.org/10.1371/journal.ppat.1006198

Vaccination has minimal impact on the intrahost diversity of H3N2 influenza viruses

Kari Debbink, John T. McCrone, Joshua G. Petrie, Rachel Truscon, Emileigh Johnson, Emily K. Mantlo, Arnold S. Monto, Adam S. Lauring

PLOS Pathogens: published January 31, 2017 | https://doi.org/10.1371/journal.ppat.1006194

Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype

Fanping Kong, Omar A. Saldarriaga, Heidi Spratt, E. Yaneth Osorio, Bruno L. Travi, Bruce A. Luxon, Peter C. Melby

PLOS Pathogens: published January 31, 2017 | https://doi.org/10.1371/journal.ppat.1006165

Naturally Acquired Human Immunity to Pneumococcus Is Dependent on Antibody to Protein Antigens

Robert Wilson, Jonathan M. Cohen, Mark Reglinski, Ricardo J. Jose, Win Yan Chan, Helina Marshall, Corné de Vogel, Stephen Gordon, David Goldblatt, Fernanda C. Petersen, Helen Baxendale, Jeremy S. Brown

PLOS Pathogens: published January 30, 2017 | https://doi.org/10.1371/journal.ppat.1006137

Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation

Alison M. Day, Deborah A. Smith, Mélanie A. C. Ikeh, Mohammed Haider, Carmen M. Herrero-de-Dios, Alistair J. P. Brown, Brian A. Morgan, Lars P. Erwig, Donna M. MacCallum, Janet Quinn

PLOS Pathogens: published January 30, 2017 | https://doi.org/10.1371/journal.ppat.1006131

Synthetic lethal mutations in the cyclin A interface of human cytomegalovirus

Henry Weisbach, Christoph Schablowsky, Barbara Vetter, Iris Gruska, Christian Hagemeier, Lüder Wiebusch

PLOS Pathogens: published January 27, 2017 | https://doi.org/10.1371/journal.ppat.1006193

A Legionella Effector Disrupts Host Cytoskeletal Structure by Cleaving Actin

Yao Liu, Wenhan Zhu, Yunhao Tan, Ernesto S. Nakayasu, Christopher J. Staiger, Zhao-Qing Luo

PLOS Pathogens: published January 27, 2017 | https://doi.org/10.1371/journal.ppat.1006186

Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1

Jason E. Hammonds, Neal Beeman, Lingmei Ding, Sarah Takushi, Ashwanth C. Francis, Jaang-Jiun Wang, Gregory B. Melikyan, Paul Spearman

PLOS Pathogens: published January 27, 2017 | https://doi.org/10.1371/journal.ppat.1006181

IL-27 Limits Type 2 Immunopathology Following Parainfluenza Virus Infection

Gaia Muallem, Sagie Wagage, Yan Sun, Jonathan H. DeLong, Alex Valenzuela, David A. Christian, Gretchen Harms Pritchard, Qun Fang, Elizabeth L. Buza, Deepika Jain, M. Merle Elloso, Carolina B. López, Christopher A. Hunter

PLOS Pathogens: published January 27, 2017 | https://doi.org/10.1371/journal.ppat.1006173

Characterization of Early-Phase Neutrophil Extracellular Traps in Urinary Tract Infections

Yanbao Yu, Keehwan Kwon, Tamara Tsitrin, Shiferaw Bekele, Patricia Sikorski, Karen E. Nelson, Rembert Pieper

PLOS Pathogens: published January 27, 2017 | https://doi.org/10.1371/journal.ppat.1006151

Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKCα

Hyun-Jung Koh, Ye-Ram Kim, Jae-Sung Kim, Jin-Seung Yun, Kiseok Jang, Chul-Su Yang

PLOS Pathogens: published January 26, 2017 | https://doi.org/10.1371/journal.ppat.1006126

Dysregulation of Systemic and Mucosal Humoral Responses to Microbial and Food Antigens as a Factor Contributing to Microbial Translocation and Chronic Inflammation in HIV-1 Infection

Zdenek Hel, Jun Xu, Warren L. Denning, E. Scott Helton, Richard P. H. Huijbregts, Sonya L. Heath, E. Turner Overton, Benjamin S. Christmann, Charles O. Elson, Paul A. Goepfert, Jiri Mestecky

PLOS Pathogens: published January 26, 2017 | https://doi.org/10.1371/journal.ppat.1006087

Epigenetic Landscape of Kaposi's Sarcoma-Associated Herpesvirus Genome in Classic Kaposi's Sarcoma Tissues

Rui Sun, Xiaohua Tan, Xing Wang, Xiaodong Wang, Lei Yang, Erle S. Robertson, Ke Lan

PLOS Pathogens: published January 24, 2017 | https://doi.org/10.1371/journal.ppat.1006167

Studies on the Virome of the Entomopathogenic Fungus Beauveria bassiana Reveal Novel dsRNA Elements and Mild Hypervirulence

Ioly Kotta-Loizou, Robert H. A. Coutts

PLOS Pathogens: published January 23, 2017 | https://doi.org/10.1371/journal.ppat.1006183

Co-infecting Reptarenaviruses Can Be Vertically Transmitted in Boa Constrictor

Saskia Keller, Udo Hetzel, Tarja Sironen, Yegor Korzyukov, Olli Vapalahti, Anja Kipar, Jussi Hepojoki

PLOS Pathogens: published January 23, 2017 | https://doi.org/10.1371/journal.ppat.1006179

L-glutamine Induces Expression of Listeria monocytogenes Virulence Genes

Adi Haber, Sivan Friedman, Lior Lobel, Tamar Burg-Golani, Nadejda Sigal, Jessica Rose, Nurit Livnat-Levanon, Oded Lewinson, Anat A. Herskovits

PLOS Pathogens: published January 23, 2017 | https://doi.org/10.1371/journal.ppat.1006161

Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector

Brian S. Mantilla, Letícia Marchese, Aitor Casas-Sánchez, Naomi A. Dyer, Nicholas Ejeh, Marc Biran, Frédéric Bringaud, Michael J. Lehane, Alvaro Acosta-Serrano, Ariel M. Silber

PLOS Pathogens: published January 23, 2017 | https://doi.org/10.1371/journal.ppat.1006158

Evidence for Integrin – Venus Kinase Receptor 1 Alliance in the Ovary of Schistosoma mansoni Females Controlling Cell Survival

Verena Gelmedin, Marion Morel, Steffen Hahnel, Katia Cailliau, Colette Dissous, Christoph G. Grevelding

PLOS Pathogens: published January 23, 2017 | https://doi.org/10.1371/journal.ppat.1006147

The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis

Cordula M. Boehm, Samson Obado, Catarina Gadelha, Alexandra Kaupisch, Paul T. Manna, Gwyn W. Gould, Mary Munson, Brian T. Chait, Michael P. Rout, Mark C. Field

PLOS Pathogens: published January 23, 2017 | https://doi.org/10.1371/journal.ppat.1006063

Cutaneous HPV8 and MmuPV1 E6 Proteins Target the NOTCH and TGF-β Tumor Suppressors to Inhibit Differentiation and Sustain Keratinocyte Proliferation

Jordan M. Meyers, Aayushi Uberoi, Miranda Grace, Paul F. Lambert, Karl Munger

PLOS Pathogens: published January 20, 2017 | https://doi.org/10.1371/journal.ppat.1006171

RNAi-Based Functional Genomics Identifies New Virulence Determinants in Mucormycosis

Trung Anh Trieu, María Isabel Navarro-Mendoza, Carlos Pérez-Arques, Marta Sanchis, Javier Capilla, Patricia Navarro-Rodriguez, Loida Lopez-Fernandez, Santiago Torres-Martínez, Victoriano Garre, Rosa María Ruiz-Vázquez, Francisco E. Nicolás

PLOS Pathogens: published January 20, 2017 | https://doi.org/10.1371/journal.ppat.1006150

BET-Inhibitors Disrupt Rad21-Dependent Conformational Control of KSHV Latency

Horng-Shen Chen, Alessandra De Leo, Zhuo Wang, Andrew Kerekovic, Robert Hills, Paul M. Lieberman

PLOS Pathogens: published January 20, 2017 | https://doi.org/10.1371/journal.ppat.1006100

HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains

Yuri Shibata, Fuminori Tokunaga, Eiji Goto, Ginga Komatsu, Jin Gohda, Yasushi Saeki, Keiji Tanaka, Hirotaka Takahashi, Tatsuya Sawasaki, Satoshi Inoue, Hiroyuki Oshiumi, Tsukasa Seya, Hiroyasu Nakano, Yuetsu Tanaka, Kazuhiro Iwai, Jun-ichiro Inoue

PLOS Pathogens: published January 19, 2017 | https://doi.org/10.1371/journal.ppat.1006162

An HSV-2 Trivalent Vaccine Is Immunogenic in Rhesus Macaques and Highly Efficacious in Guinea Pigs

Sita Awasthi, Lauren M. Hook, Carolyn E. Shaw, Bapi Pahar, Jacob A. Stagray, David Liu, Ronald S. Veazey, Harvey M. Friedman

PLOS Pathogens: published January 19, 2017 | https://doi.org/10.1371/journal.ppat.1006141

Static and Evolving Norovirus Genotypes: Implications for Epidemiology and Immunity

Gabriel I. Parra, R. Burke Squires, Consolee K. Karangwa, Jordan A. Johnson, Cara J. Lepore, Stanislav V. Sosnovtsev, Kim Y. Green

PLOS Pathogens: published January 19, 2017 | https://doi.org/10.1371/journal.ppat.1006136

A Superoxide Dismutase Capable of Functioning with Iron or Manganese Promotes the Resistance of Staphylococcus aureus to Calprotectin and Nutritional Immunity

Yuritzi M. Garcia, Anna Barwinska-Sendra, Emma Tarrant, Eric P. Skaar, Kevin J. Waldron, Thomas E. Kehl-Fie

PLOS Pathogens: published January 19, 2017 | https://doi.org/10.1371/journal.ppat.1006125

Multiple Acid Sensors Control Helicobacter pylori Colonization of the Stomach

Julie Y. Huang, Emily Goers Sweeney, Karen Guillemin, Manuel R. Amieva

PLOS Pathogens: published January 19, 2017 | https://doi.org/10.1371/journal.ppat.1006118

Genetically Thermo-Stabilised, Immunogenic Poliovirus Empty Capsids; a Strategy for Non-replicating Vaccines

Helen Fox, Sarah Knowlson, Philip D. Minor, Andrew J. Macadam

PLOS Pathogens: published January 19, 2017 | https://doi.org/10.1371/journal.ppat.1006117

Mycobacterium marinum Degrades Both Triacylglycerols and Phospholipids from Its Dictyostelium Host to Synthesise Its Own Triacylglycerols and Generate Lipid Inclusions

Caroline Barisch, Thierry Soldati

PLOS Pathogens: published January 19, 2017 | https://doi.org/10.1371/journal.ppat.1006095

Nuclear Localization and Cleavage of STAT6 Is Induced by Kaposi’s Sarcoma-Associated Herpesvirus for Viral Latency

Chong Wang, Caixia Zhu, Fang Wei, Shujun Gao, Liming Zhang, Yuhong Li, Yanling Feng, Yin Tong, Jianqing Xu, Bin Wang, Zhenghong Yuan, Erle S. Robertson, Qiliang Cai

PLOS Pathogens: published January 18, 2017 | https://doi.org/10.1371/journal.ppat.1006124

Central Role of IL-23 and IL-17 Producing Eosinophils as Immunomodulatory Effector Cells in Acute Pulmonary Aspergillosis and Allergic Asthma

Evelyn Santos Guerra, Chrono K. Lee, Charles A. Specht, Bhawna Yadav, Haibin Huang, Ali Akalin, Jun R. Huh, Christian Mueller, Stuart M. Levitz

PLOS Pathogens: published January 17, 2017 | https://doi.org/10.1371/journal.ppat.1006175

Replication-Coupled Recruitment of Viral and Cellular Factors to Herpes Simplex Virus Type 1 Replication Forks for the Maintenance and Expression of Viral Genomes

Jill A. Dembowski, Sarah E. Dremel, Neal A. DeLuca

PLOS Pathogens: published January 17, 2017 | https://doi.org/10.1371/journal.ppat.1006166

SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing

Ye Cui, Huansha Yu, Xin Zheng, Rui Peng, Qiang Wang, Yi Zhou, Rui Wang, Jiehua Wang, Bo Qu, Nan Shen, Qiang Guo, Xing Liu, Chen Wang

PLOS Pathogens: published January 17, 2017 | https://doi.org/10.1371/journal.ppat.1006156

Molecular Control of Innate Immune Response to Pseudomonas aeruginosa Infection by Intestinal let-7 in Caenorhabditis elegans

Lingtong Zhi, Yonglin Yu, Xueying Li, Daoyong Wang, Dayong Wang

PLOS Pathogens: published January 17, 2017 | https://doi.org/10.1371/journal.ppat.1006152

Leishmania HASP and SHERP Genes Are Required for In Vivo Differentiation, Parasite Transmission and Virulence Attenuation in the Host

Johannes S. P. Doehl, Jovana Sádlová, Hamide Aslan, Kateřina Pružinová, Sonia Metangmo, Jan Votýpka, Shaden Kamhawi, Petr Volf, Deborah F. Smith

PLOS Pathogens: published January 17, 2017 | https://doi.org/10.1371/journal.ppat.1006130

Transgenic Expression of the Anti-parasitic Factor TEP1 in the Malaria Mosquito Anopheles gambiae

Gloria Volohonsky, Ann-Katrin Hopp, Mélanie Saenger, Julien Soichot, Heidi Scholze, Jens Boch, Stéphanie A. Blandin, Eric Marois

PLOS Pathogens: published January 17, 2017 | https://doi.org/10.1371/journal.ppat.1006113

Alveolar Macrophages Prevent Lethal Influenza Pneumonia By Inhibiting Infection Of Type-1 Alveolar Epithelial Cells

Amber Cardani, Adam Boulton, Taeg S. Kim, Thomas J. Braciale

PLOS Pathogens: published January 13, 2017 | https://doi.org/10.1371/journal.ppat.1006140

The Rice Dynamin-Related Protein OsDRP1E Negatively Regulates Programmed Cell Death by Controlling the Release of Cytochrome c from Mitochondria

Zhiqiang Li, Bo Ding, Xueping Zhou, Guo-Liang Wang

PLOS Pathogens: published January 12, 2017 | https://doi.org/10.1371/journal.ppat.1006157

The Plasmin-Sensitive Protein Pls in Methicillin-Resistant Staphylococcus aureus (MRSA) Is a Glycoprotein

Isabelle Bleiziffer, Julian Eikmeier, Gottfried Pohlentz, Kathryn McAulay, Guoqing Xia, Muzaffar Hussain, Andreas Peschel, Simon Foster, Georg Peters, Christine Heilmann

PLOS Pathogens: published January 12, 2017 | https://doi.org/10.1371/journal.ppat.1006110

Probability of Transmission of Malaria from Mosquito to Human Is Regulated by Mosquito Parasite Density in Naïve and Vaccinated Hosts

Thomas S. Churcher, Robert E. Sinden, Nick J. Edwards, Ian D. Poulton, Thomas W. Rampling, Patrick M. Brock, Jamie T. Griffin, Leanna M. Upton, Sara E. Zakutansky, Katarzyna A. Sala, Fiona Angrisano, Adrian V. S. Hill, Andrew M. Blagborough

PLOS Pathogens: published January 12, 2017 | https://doi.org/10.1371/journal.ppat.1006108

Neutrophil Interactions Stimulate Evasive Hyphal Branching by Aspergillus fumigatus

Felix Ellett, Julianne Jorgensen, Galit H. Frydman, Caroline N. Jones, Daniel Irimia

PLOS Pathogens: published January 11, 2017 | https://doi.org/10.1371/journal.ppat.1006154

Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress

Jingjing Liang, Cari A. Sagum, Mark T. Bedford, Sachdev S. Sidhu, Marius Sudol, Ziying Han, Ronald N. Harty

PLOS Pathogens: published January 11, 2017 | https://doi.org/10.1371/journal.ppat.1006132

Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape

Constantinos Kurt Wibmer, Jason Gorman, Gabriel Ozorowski, Jinal N. Bhiman, Daniel J. Sheward, Debra H. Elliott, Julie Rouelle, Ashley Smira, M. Gordon Joyce, Nonkululeko Ndabambi, Aliaksandr Druz, Mangai Asokan, Dennis R. Burton, Mark Connors, Salim S. Abdool Karim, John R. Mascola, James E. Robinson, Andrew B. Ward, Carolyn Williamson, Peter D. Kwong, Lynn Morris, Penny L. Moore

PLOS Pathogens: published January 11, 2017 | https://doi.org/10.1371/journal.ppat.1006074

When Viruses Don’t Go Viral: The Importance of Host Phylogeographic Structure in the Spatial Spread of Arenaviruses

Sophie Gryseels, Stuart J. E. Baird, Benny Borremans, Rhodes Makundi, Herwig Leirs, Joëlle Goüy de Bellocq

PLOS Pathogens: published January 11, 2017 | https://doi.org/10.1371/journal.ppat.1006073

Social and Genetic Networks of HIV-1 Transmission in New York City

Joel O. Wertheim, Sergei L. Kosakovsky Pond, Lisa A. Forgione, Sanjay R. Mehta, Ben Murrell, Sharmila Shah, Davey M. Smith, Konrad Scheffler, Lucia V. Torian

PLOS Pathogens: published January 9, 2017 | https://doi.org/10.1371/journal.ppat.1006000

TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP)

Melody M. H. Li, Zerlina Lau, Pamela Cheung, Eduardo G. Aguilar, William M. Schneider, Leonia Bozzacco, Henrik Molina, Eugen Buehler, Akinori Takaoka, Charles M. Rice, Dan P. Felsenfeld, Margaret R. MacDonald

PLOS Pathogens: published January 6, 2017 | https://doi.org/10.1371/journal.ppat.1006145

EV71 3D Protein Binds with NLRP3 and Enhances the Assembly of Inflammasome Complex

Wenbiao Wang, Feng Xiao, Pin Wan, Pan Pan, Yecheng Zhang, Fang Liu, Kailang Wu, Yingle Liu, Jianguo Wu

PLOS Pathogens: published January 6, 2017 | https://doi.org/10.1371/journal.ppat.1006123

The Effector Domain Region of the Vibrio vulnificus MARTX Toxin Confers Biphasic Epithelial Barrier Disruption and Is Essential for Systemic Spread from the Intestine

Hannah E. Gavin, Nike T. Beubier, Karla J. F. Satchell

PLOS Pathogens: published January 6, 2017 | https://doi.org/10.1371/journal.ppat.1006119

The TIR Homologue Lies near Resistance Genes in Staphylococcus aureus, Coupling Modulation of Virulence and Antimicrobial Susceptibility

Sabine Patot, Paul RC Imbert, Jessica Baude, Patricia Martins Simões, Jean-Baptiste Campergue, Arthur Louche, Reindert Nijland, Michèle Bès, Anne Tristan, Frédéric Laurent, Adrien Fischer, Jacques Schrenzel, François Vandenesch, Suzana P Salcedo, Patrice François, Gérard Lina

PLOS Pathogens: published January 6, 2017 | https://doi.org/10.1371/journal.ppat.1006092

Respiration of Microbiota-Derived 1,2-propanediol Drives Salmonella Expansion during Colitis

Franziska Faber, Parameth Thiennimitr, Luisella Spiga, Mariana X. Byndloss, Yael Litvak, Sara Lawhon, Helene L. Andrews-Polymenis, Sebastian E. Winter, Andreas J. Bäumler

PLOS Pathogens: published January 5, 2017 | https://doi.org/10.1371/journal.ppat.1006129

Autophagy Is an Innate Mechanism Associated with Leprosy Polarization

Bruno Jorge de Andrade Silva, Mayara Garcia de Mattos Barbosa, Priscila Ribeiro Andrade, Helen Ferreira, José Augusto da Costa Nery, Suzana Côrte-Real, Gilberto Marcelo Sperandio da Silva, Patricia Sammarco Rosa, Mario Fabri, Euzenir Nunes Sarno, Roberta Olmo Pinheiro

PLOS Pathogens: published January 5, 2017 | https://doi.org/10.1371/journal.ppat.1006103

Molecular Characterization of N-glycan Degradation and Transport in Streptococcus pneumoniae and Its Contribution to Virulence

Melissa Robb, Joanne K. Hobbs, Shireen A. Woodiga, Sarah Shapiro-Ward, Michael D. L. Suits, Nicholas McGregor, Harry Brumer, Hasan Yesilkaya, Samantha J. King, Alisdair B. Boraston

PLOS Pathogens: published January 5, 2017 | https://doi.org/10.1371/journal.ppat.1006090

Detection of Viral RNA in Tissues following Plasma Clearance from an Ebola Virus Infected Patient

Mirella Biava, Claudia Caglioti, Licia Bordi, Concetta Castilletti, Francesca Colavita, Serena Quartu, Emanuele Nicastri, Francesco Nicola Lauria, Nicola Petrosillo, Simone Lanini, Thomas Hoenen, Gary Kobinger, Alimuddin Zumla, Antonino Di Caro, Giuseppe Ippolito, Maria Rosaria Capobianchi, Eleonora Lalle

PLOS Pathogens: published January 5, 2017 | https://doi.org/10.1371/journal.ppat.1006065

Wolbachia Infections in Aedes aegypti Differ Markedly in Their Response to Cyclical Heat Stress

Perran A. Ross, Itsanun Wiwatanaratanabutr, Jason K. Axford, Vanessa L. White, Nancy M. Endersby-Harshman, Ary A. Hoffmann

PLOS Pathogens: published January 5, 2017 | https://doi.org/10.1371/journal.ppat.1006006

Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting

Nicole A. Doria-Rose, Han R. Altae-Tran, Ryan S. Roark, Stephen D. Schmidt, Matthew S. Sutton, Mark K. Louder, Gwo-Yu Chuang, Robert T. Bailer, Valerie Cortez, Rui Kong, Krisha McKee, Sijy O’Dell, Felicia Wang, Salim S. Abdool Karim, James M. Binley, Mark Connors, Barton F. Haynes, Malcolm A. Martin, David C. Montefiori, Lynn Morris, Julie Overbaugh, Peter D. Kwong, John R. Mascola, Ivelin S. Georgiev

PLOS Pathogens: published January 4, 2017 | https://doi.org/10.1371/journal.ppat.1006148

CRL4^WDR1 Controls Polo-like Kinase Protein Abundance to Promote Bilobe Duplication, Basal Body Segregation and Flagellum Attachment in Trypanosoma brucei

Huiqing Hu, Qing Zhou, Xianxian Han, Ziyin Li

PLOS Pathogens: published January 4, 2017 | https://doi.org/10.1371/journal.ppat.1006146

A Novel Zn₂-Cys₆ Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions

Daisuke Hagiwara, Daisuke Miura, Kiminori Shimizu, Sanjoy Paul, Ayumi Ohba, Tohru Gonoi, Akira Watanabe, Katsuhiko Kamei, Takahiro Shintani, W. Scott Moye-Rowley, Susumu Kawamoto, Katsuya Gomi

PLOS Pathogens: published January 4, 2017 | https://doi.org/10.1371/journal.ppat.1006096

RNA Sequencing Reveals that Kaposi Sarcoma-Associated Herpesvirus Infection Mimics Hypoxia Gene Expression Signature

Coralie Viollet, David A. Davis, Shewit S. Tekeste, Martin Reczko, Joseph M. Ziegelbauer, Francesco Pezzella, Jiannis Ragoussis, Robert Yarchoan

PLOS Pathogens: published January 3, 2017 | https://doi.org/10.1371/journal.ppat.1006143

Glucocorticoid Insensitivity in Virally Infected Airway Epithelial Cells Is Dependent on Transforming Growth Factor-β Activity

Yuxiu C. Xia, Asmaa Radwan, Christine R. Keenan, Shenna Y. Langenbach, Meina Li, Danica Radojicic, Sarah L. Londrigan, Rosa C. Gualano, Alastair G. Stewart

PLOS Pathogens: published January 3, 2017 | https://doi.org/10.1371/journal.ppat.1006138

HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors

Haruka Kinosada, Jun-ichirou Yasunaga, Kazuya Shimura, Paola Miyazato, Chiho Onishi, Tomonori Iyoda, Kayo Inaba, Masao Matsuoka

PLOS Pathogens: published January 3, 2017 | https://doi.org/10.1371/journal.ppat.1006120

An Oxygen-Sensing Two-Component System in the Burkholderia cepacia Complex Regulates Biofilm, Intracellular Invasion, and Pathogenicity

Matthew M. Schaefers, Tiffany L. Liao, Nicole M. Boisvert, Damien Roux, Deborah Yoder-Himes, Gregory P. Priebe

PLOS Pathogens: published January 3, 2017 | https://doi.org/10.1371/journal.ppat.1006116

Early Antiretroviral Therapy Is Associated with Lower HIV DNA Molecular Diversity and Lower Inflammation in Cerebrospinal Fluid but Does Not Prevent the Establishment of Compartmentalized HIV DNA Populations

Michelli F. Oliveira, Antoine Chaillon, Masato Nakazawa, Milenka Vargas, Scott L. Letendre, Matthew C. Strain, Ronald J. Ellis, Sheldon Morris, Susan J. Little, Davey M. Smith, Sara Gianella

PLOS Pathogens: published January 3, 2017 | https://doi.org/10.1371/journal.ppat.1006112

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Control of Polo-like kinase protein abundance to ensure flagellum adhesion in trypanosomes

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