October 2016

Mucosal inflammation is visualized in bladder sections from Asc-/- mice, infected with uropathogenic E. coli. Infection triggered a massive recruitment of neutrophils (red) to the mucosa. In susceptible mice, large numbers of bacteria were detected in the mucosa (green) and were shown to colocalize with neutrophil aggregates in micro-abscesses (yellow). Frozen tissue sections were stained for immunohistochemistry with specific antibodies to neutrophils and E. coli. Nuclei were counterstained with DAPI (cyan). Ambite et al.

Image Credit: Manoj Puthia, Biomedical Centre, Lund University, Sweden

Opinion

What Is Stopping the Use of Genetically Modified Insects for Disease Control?

Anusha Panjwani, Anthony Wilson

PLOS Pathogens: published October 6, 2016 | https://doi.org/10.1371/journal.ppat.1005830

Pearls

Community-Associated Methicillin-Resistant Staphylococcus aureus: An Enemy amidst Us

Eric F. Kong, Jennifer K. Johnson, Mary Ann Jabra-Rizk

PLOS Pathogens: published October 6, 2016 | https://doi.org/10.1371/journal.ppat.1005837

Carrion’s Disease: More Than a Sand Fly–Vectored Illness

Maria J. Pons, Cláudia Gomes, Juana del Valle-Mendoza, Joaquim Ruiz

PLOS Pathogens: published October 13, 2016 | https://doi.org/10.1371/journal.ppat.1005863

The Missing Link between Candida albicans Hyphal Morphogenesis and Host Cell Damage

Duncan Wilson, Julian R. Naglik, Bernhard Hube

PLOS Pathogens: published October 20, 2016 | https://doi.org/10.1371/journal.ppat.1005867

A Sixth Modality of Infectious Disease: Contagious Cancer from Devils to Clams and Beyond

Michael J. Metzger, Stephen P. Goff

PLOS Pathogens: published October 27, 2016 | https://doi.org/10.1371/journal.ppat.1005904

Building Viral Replication Organelles: Close Encounters of the Membrane Types

Peter D. Nagy, Jeroen R. P. M. Strating, Frank J. M. van Kuppeveld

PLOS Pathogens: published October 27, 2016 | https://doi.org/10.1371/journal.ppat.1005912

Review

Entamoeba Encystation: New Targets to Prevent the Transmission of Amebiasis

Fumika Mi-ichi, Hiroki Yoshida, Shinjiro Hamano

PLOS Pathogens: published October 20, 2016 | https://doi.org/10.1371/journal.ppat.1005845

Research Matters

Basic Research in Bacterial Pathogenesis: “What’s Your Job about, Exactly?”

Isabelle Derré

PLOS Pathogens: published October 13, 2016 | https://doi.org/10.1371/journal.ppat.1005612

Research Articles

Th17 Cells Are More Protective Than Th1 Cells Against the Intracellular Parasite Trypanosoma cruzi

Catherine W. Cai, Jennifer R. Blase, Xiuli Zhang, Christopher S. Eickhoff, Daniel F. Hoft

PLOS Pathogens: published October 3, 2016 | https://doi.org/10.1371/journal.ppat.1005902

Regulation of the Abundance of Kaposi’s Sarcoma-Associated Herpesvirus ORF50 Protein by Oncoprotein MDM2

Tzu-Hsuan Chang, Shie-Shan Wang, Lee-Wen Chen, Ying-Ju Shih, Li-Kwan Chang, Shih-Tung Liu, Pey-Jium Chang

PLOS Pathogens: published October 3, 2016 | https://doi.org/10.1371/journal.ppat.1005918

Staphylococcus aureus Tissue Infection During Sepsis Is Supported by Differential Use of Bacterial or Host-Derived Lipoic Acid

Azul Zorzoli, James P. Grayczyk, Francis Alonzo III

PLOS Pathogens: published October 4, 2016 | https://doi.org/10.1371/journal.ppat.1005933

The Replicative Consequences of Papillomavirus E2 Protein Binding to the Origin Replication Factor ORC2

Marsha DeSmet, Sriramana Kanginakudru, Anne Rietz, Wai-Hong Wu, Richard Roden, Elliot J. Androphy

PLOS Pathogens: published October 4, 2016 | https://doi.org/10.1371/journal.ppat.1005934

Spatial and Temporal Resolution of Global Protein Synthesis during HSV Infection Using Bioorthogonal Precursors and Click Chemistry

Catherine Su Hui Teo, Remigiusz A. Serwa, Peter O’Hare

PLOS Pathogens: published October 5, 2016 | https://doi.org/10.1371/journal.ppat.1005927

Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex

Siyuan Ding, Nancie Mooney, Bin Li, Marcus R. Kelly, Ningguo Feng, Alexander V. Loktev, Adrish Sen, John T. Patton, Peter K. Jackson, Harry B. Greenberg

PLOS Pathogens: published October 5, 2016 | https://doi.org/10.1371/journal.ppat.1005929

XRN1 Is a Species-Specific Virus Restriction Factor in Yeasts

Paul A. Rowley, Brandon Ho, Sarah Bushong, Arlen Johnson, Sara L. Sawyer

PLOS Pathogens: published October 6, 2016 | https://doi.org/10.1371/journal.ppat.1005890

Acute Infectious Gastroenteritis Potentiates a Crohn's Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period

Cherrie L. Small, Lydia Xing, Joseph B. McPhee, Hong T. Law, Brian K. Coombes

PLOS Pathogens: published October 6, 2016 | https://doi.org/10.1371/journal.ppat.1005907

Vasodilator-Stimulated Phosphoprotein Activity Is Required for Coxiella burnetii Growth in Human Macrophages

Punsiri M. Colonne, Caylin G. Winchell, Joseph G. Graham, Frances I. Onyilagha, Laura J. MacDonald, Heike R. Doeppler, Peter Storz, Richard C. Kurten, Paul A. Beare, Robert A. Heinzen, Daniel E. Voth

PLOS Pathogens: published October 6, 2016 | https://doi.org/10.1371/journal.ppat.1005915

Magnaporthe oryzae Glycine-Rich Secretion Protein, Rbf1 Critically Participates in Pathogenicity through the Focal Formation of the Biotrophic Interfacial Complex

Takeshi Nishimura, Susumu Mochizuki, Naoko Ishii-Minami, Yukiko Fujisawa, Yoshihiro Kawahara, Yuri Yoshida, Kazunori Okada, Sugihiro Ando, Hideo Matsumura, Ryohei Terauchi, Eiichi Minami, Yoko Nishizawa

PLOS Pathogens: published October 6, 2016 | https://doi.org/10.1371/journal.ppat.1005921

Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier

Xiangru Wang, Ravi Maruvada, Andrew J. Morris, Jun O. Liu, Michael J. Wolfgang, Dong Jae Baek, Robert Bittman, Kwang Sik Kim

PLOS Pathogens: published October 6, 2016 | https://doi.org/10.1371/journal.ppat.1005926

Distinct Effects of p19 RNA Silencing Suppressor on Small RNA Mediated Pathways in Plants

Levente Kontra, Tibor Csorba, Mario Tavazza, Alessandra Lucioli, Raffaela Tavazza, Simon Moxon, Viktória Tisza, Anna Medzihradszky, Massimo Turina, József Burgyán

PLOS Pathogens: published October 6, 2016 | https://doi.org/10.1371/journal.ppat.1005935

Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection

Brodie Miles, Shannon M. Miller, Joy M. Folkvord, David N. Levy, Eva G. Rakasz, Pamela J. Skinner, Elizabeth Connick

PLOS Pathogens: published October 7, 2016 | https://doi.org/10.1371/journal.ppat.1005924

Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model

Xiangyu Yao, Jian Wu, Meng Lin, Wenxiang Sun, Xiao He, Channe Gowda, Silvia Bolland, Carole A. Long, Rongfu Wang, Xin-zhuan Su

PLOS Pathogens: published October 7, 2016 | https://doi.org/10.1371/journal.ppat.1005930

Clinically Relevant Reactivation of Polyomavirus BK (BKPyV) in HLA-A02-Positive Renal Transplant Recipients Is Associated with Impaired Effector-Memory Differentiation of BKPyV-Specific CD8⁺ T Cells

Michiel C. van Aalderen, Ester B. M. Remmerswaal, Kirstin M. Heutinck, Anja ten Brinke, Mariet C. W. Feltkamp, Neelke C. van der Weerd, Karlijn A. M. I. van der Pant, Frederike J. Bemelman, René A. W. van Lier, Ineke J. M. ten Berge

PLOS Pathogens: published October 10, 2016 | https://doi.org/10.1371/journal.ppat.1005903

CdiA Effectors from Uropathogenic Escherichia coli Use Heterotrimeric Osmoporins as Receptors to Recognize Target Bacteria

Christina M. Beck, Julia L. E. Willett, David A. Cunningham, Jeff J. Kim, David A. Low, Christopher S. Hayes

PLOS Pathogens: published October 10, 2016 | https://doi.org/10.1371/journal.ppat.1005925

Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets

Ines Ambite, Manoj Puthia, Karoly Nagy, Caterina Cafaro, Aftab Nadeem, Daniel S. C. Butler, Gustav Rydström, Nina A. Filenko, Björn Wullt, Thomas Miethke, Catharina Svanborg

PLOS Pathogens: published October 12, 2016 | https://doi.org/10.1371/journal.ppat.1005848

A Single Nucleotide Polymorphism in Human APOBEC3C Enhances Restriction of Lentiviruses

Cristina J. Wittkopp, Madison B. Adolph, Lily I. Wu, Linda Chelico, Michael Emerman

PLOS Pathogens: published October 12, 2016 | https://doi.org/10.1371/journal.ppat.1005865

Single Cell Bottlenecks in the Pathogenesis of Streptococcus pneumoniae

Masamitsu Kono, M. Ammar Zafar, Marisol Zuniga, Aoife M. Roche, Shigeto Hamaguchi, Jeffrey N. Weiser

PLOS Pathogens: published October 12, 2016 | https://doi.org/10.1371/journal.ppat.1005887

Combined Activity of DCL2 and DCL3 Is Crucial in the Defense against Potato Spindle Tuber Viroid

Konstantina Katsarou, Eleni Mavrothalassiti, Wannes Dermauw, Thomas Van Leeuwen, Kriton Kalantidis

PLOS Pathogens: published October 12, 2016 | https://doi.org/10.1371/journal.ppat.1005936

A Resource Allocation Trade-Off between Virulence and Proliferation Drives Metabolic Versatility in the Plant Pathogen Ralstonia solanacearum

Rémi Peyraud, Ludovic Cottret, Lucas Marmiesse, Jérôme Gouzy, Stéphane Genin

PLOS Pathogens: published October 12, 2016 | https://doi.org/10.1371/journal.ppat.1005939

Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria

Ryan A. Zander, Jenna J. Guthmiller, Amy C. Graham, Rosemary L. Pope, Bradly E. Burke, Daniel J.J. Carr, Noah S. Butler

PLOS Pathogens: published October 12, 2016 | https://doi.org/10.1371/journal.ppat.1005945

Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus

Jennifer L. Uhrlaub, Vesna Pulko, Victor R. DeFilippis, Rebecca Broeckel, Daniel N. Streblow, Gary D. Coleman, Byung S. Park, John F. Lindo, Ivan Vickers, Joshua J. Anzinger, Janko Nikolich-Žugich

PLOS Pathogens: published October 13, 2016 | https://doi.org/10.1371/journal.ppat.1005891

An RNAi-Based Control of Fusarium graminearum Infections Through Spraying of Long dsRNAs Involves a Plant Passage and Is Controlled by the Fungal Silencing Machinery

Aline Koch, Dagmar Biedenkopf, Alexandra Furch, Lennart Weber, Oliver Rossbach, Eltayb Abdellatef, Lukas Linicus, Jan Johannsmeier, Lukas Jelonek, Alexander Goesmann, Vinitha Cardoza, John McMillan, Tobias Mentzel, Karl-Heinz Kogel

PLOS Pathogens: published October 13, 2016 | https://doi.org/10.1371/journal.ppat.1005901

Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death

Naomi H. Philip, Alexandra DeLaney, Lance W. Peterson, Melanie Santos-Marrero, Jennifer T. Grier, Yan Sun, Meghan A. Wynosky-Dolfi, Erin E. Zwack, Baofeng Hu, Tayla M. Olsen, Anthony Rongvaux, Scott D. Pope, Carolina B. López, Andrew Oberst, Daniel P. Beiting, Jorge Henao-Mejia, Igor E. Brodsky

PLOS Pathogens: published October 13, 2016 | https://doi.org/10.1371/journal.ppat.1005910

Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model

Susanna K. P. Lau, Patrick C. Y. Woo, Kenneth S. M. Li, Hao-Ji Zhang, Rachel Y. Y. Fan, Anna J. X. Zhang, Brandon C. C. Chan, Carol S. F. Lam, Cyril C. Y. Yip, Ming-Chi Yuen, Kwok-Hung Chan, Zhi-Wei Chen, Kwok-Yung Yuen

PLOS Pathogens: published October 13, 2016 | https://doi.org/10.1371/journal.ppat.1005911

CpxR Activates MexAB-OprM Efflux Pump Expression and Enhances Antibiotic Resistance in Both Laboratory and Clinical nalB-Type Isolates of Pseudomonas aeruginosa

Zhe-Xian Tian, Xue-Xian Yi, Anna Cho, Fergal O’Gara, Yi-Ping Wang

PLOS Pathogens: published October 13, 2016 | https://doi.org/10.1371/journal.ppat.1005932

A Clostridium difficile Cell Wall Glycopolymer Locus Influences Bacterial Shape, Polysaccharide Production and Virulence

Michele Chu, Michael J. G. Mallozzi, Bryan P. Roxas, Lisa Bertolo, Mario A. Monteiro, Al Agellon, V. K. Viswanathan, Gayatri Vedantam

PLOS Pathogens: published October 14, 2016 | https://doi.org/10.1371/journal.ppat.1005946

Rabies Virus Infection Induces the Formation of Stress Granules Closely Connected to the Viral Factories

Jovan Nikolic, Ahmet Civas, Zoé Lama, Cécile Lagaudrière-Gesbert, Danielle Blondel

PLOS Pathogens: published October 17, 2016 | https://doi.org/10.1371/journal.ppat.1005942

The Ebola Virus VP30-NP Interaction Is a Regulator of Viral RNA Synthesis

Robert N. Kirchdoerfer, Crystal L. Moyer, Dafna M. Abelson, Erica Ollmann Saphire

PLOS Pathogens: published October 18, 2016 | https://doi.org/10.1371/journal.ppat.1005937

Fine-Tuning of the Kaposi’s Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway

Shasha Li, Hao Hu, Zhiheng He, Deguang Liang, Rui Sun, Ke Lan

PLOS Pathogens: published October 19, 2016 | https://doi.org/10.1371/journal.ppat.1005900

Kingella kingae Expresses Four Structurally Distinct Polysaccharide Capsules That Differ in Their Correlation with Invasive Disease

Kimberly F. Starr, Eric A. Porsch, Patrick C. Seed, Christian Heiss, Radnaa Naran, L. Scott Forsberg, Uri Amit, Pablo Yagupsky, Parastoo Azadi, Joseph W. St. Geme III

PLOS Pathogens: published October 19, 2016 | https://doi.org/10.1371/journal.ppat.1005944

Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs

Marissa B. Guzzo, Hoa T. Nguyen, Thanh H. Pham, Monika Wyszczelska-Rokiel, Hieronim Jakubowski, Kerstin A. Wolff, Sam Ogwang, Joseph L. Timpona, Soumya Gogula, Michael R. Jacobs, Markus Ruetz, Bernhard Kräutler, Donald W. Jacobsen, Guo-Fang Zhang, Liem Nguyen

PLOS Pathogens: published October 19, 2016 | https://doi.org/10.1371/journal.ppat.1005949

Pyruvate Oxidase as a Critical Link between Metabolism and Capsule Biosynthesis in Streptococcus pneumoniae

Haley Echlin, Matthew W. Frank, Amy Iverson, Ti-Cheng Chang, Michael D. L. Johnson, Charles O. Rock, Jason W. Rosch

PLOS Pathogens: published October 19, 2016 | https://doi.org/10.1371/journal.ppat.1005951

Defective T Memory Cell Differentiation after Varicella Zoster Vaccination in Older Individuals

Qian Qi, Mary M. Cavanagh, Sabine Le Saux, Lisa E. Wagar, Sally Mackey, Jinyu Hu, Holden Maecker, Gary E. Swan, Mark M. Davis, Cornelia L. Dekker, Lu Tian, Cornelia M. Weyand, Jörg J. Goronzy

PLOS Pathogens: published October 20, 2016 | https://doi.org/10.1371/journal.ppat.1005892

HIV-1 Integrates Widely throughout the Genome of the Human Blood Fluke Schistosoma mansoni

Sutas Suttiprapa, Gabriel Rinaldi, Isheng J. Tsai, Victoria H. Mann, Larisa Dubrovsky, Hong-bin Yan, Nancy Holroyd, Thomas Huckvale, Caroline Durrant, Anna V. Protasio, Tatiana Pushkarsky, Sergey Iordanskiy, Matthew Berriman, Michael I. Bukrinsky, Paul J. Brindley

PLOS Pathogens: published October 20, 2016 | https://doi.org/10.1371/journal.ppat.1005931

An Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4

Ke Ren, Wei Zhang, Xiaoqing Chen, Yingyu Ma, Yue Dai, Yimei Fan, Yayi Hou, Ren Xiang Tan, Erguang Li

PLOS Pathogens: published October 20, 2016 | https://doi.org/10.1371/journal.ppat.1005950

SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease

Xianxiu Wan, Jian-jun Wen, Sue-Jie Koo, Lisa Yi Liang, Nisha Jain Garg

PLOS Pathogens: published October 20, 2016 | https://doi.org/10.1371/journal.ppat.1005954

ESCRT-I Protein Tsg101 Plays a Role in the Post-macropinocytic Trafficking and Infection of Endothelial Cells by Kaposi’s Sarcoma-Associated Herpesvirus

Binod Kumar, Dipanjan Dutta, Jawed Iqbal, Mairaj Ahmed Ansari, Arunava Roy, Leela Chikoti, Gina Pisano, Mohanan Valiya Veettil, Bala Chandran

PLOS Pathogens: published October 20, 2016 | https://doi.org/10.1371/journal.ppat.1005960

Histone H2B-IFI16 Recognition of Nuclear Herpesviral Genome Induces Cytoplasmic Interferon-β Responses

Jawed Iqbal, Mairaj Ahmed Ansari, Binod Kumar, Dipanjan Dutta, Arunava Roy, Leela Chikoti, Gina Pisano, Sujoy Dutta, Shahrooz Vahedi, Mohanan Valiya Veettil, Bala Chandran

PLOS Pathogens: published October 20, 2016 | https://doi.org/10.1371/journal.ppat.1005967

The Tax-Inducible Actin-Bundling Protein Fascin Is Crucial for Release and Cell-to-Cell Transmission of Human T-Cell Leukemia Virus Type 1 (HTLV-1)

Christine Gross, Veit Wiesmann, Sebastian Millen, Martina Kalmer, Thomas Wittenberg, Jan Gettemans, Andrea K. Thoma-Kress

PLOS Pathogens: published October 24, 2016 | https://doi.org/10.1371/journal.ppat.1005916

Additive Promotion of Viral Internal Ribosome Entry Site-Mediated Translation by Far Upstream Element-Binding Protein 1 and an Enterovirus 71-Induced Cleavage Product

Chuan-Tien Hung, Yu-An Kung, Mei-Ling Li, Gary Brewer, Kuo-Ming Lee, Shih-Tung Liu, Shin-Ru Shih

PLOS Pathogens: published October 25, 2016 | https://doi.org/10.1371/journal.ppat.1005959

The Drosophila CD36 Homologue croquemort Is Required to Maintain Immune and Gut Homeostasis during Development and Aging

Aurélien Guillou, Katia Troha, Hui Wang, Nathalie C. Franc, Nicolas Buchon

PLOS Pathogens: published October 25, 2016 | https://doi.org/10.1371/journal.ppat.1005961

A Single Amino Acid Dictates Protein Kinase R Susceptibility to Unrelated Viral Antagonists

Kathryn S. Carpentier, Nicolle M. Esparo, Stephanie J. Child, Adam P. Geballe

PLOS Pathogens: published October 25, 2016 | https://doi.org/10.1371/journal.ppat.1005966

Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc

Pablo Guardado-Calvo, Eduardo A. Bignon, Eva Stettner, Scott Allen Jeffers, Jimena Pérez-Vargas, Gerard Pehau-Arnaudet, M. Alejandra Tortorici, Jean-Luc Jestin, Patrick England, Nicole D. Tischler, Félix A. Rey

PLOS Pathogens: published October 26, 2016 | https://doi.org/10.1371/journal.ppat.1005813

DNA Polymerase κ Is a Key Cellular Factor for the Formation of Covalently Closed Circular DNA of Hepatitis B Virus

Yonghe Qi, Zhenchao Gao, Guangwei Xu, Bo Peng, Chenxuan Liu, Huan Yan, Qiyan Yao, Guoliang Sun, Yang Liu, Dingbin Tang, Zilin Song, Wenhui He, Yinyan Sun, Ju-Tao Guo, Wenhui Li

PLOS Pathogens: published October 26, 2016 | https://doi.org/10.1371/journal.ppat.1005893

NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection

Satyanarayana Swamy Cheekatla, Deepak Tripathi, Sambasivan Venkatasubramanian, Pavan Kumar Nathella, Padmaja Paidipally, Munenori Ishibashi, Elwyn Welch, Amy R. Tvinnereim, Mitsuo Ikebe, Vijaya Lakshmi Valluri, Subash Babu, Hardy Kornfeld, Ramakrishna Vankayalapati

PLOS Pathogens: published October 26, 2016 | https://doi.org/10.1371/journal.ppat.1005972

Dual microRNA Screens Reveal That the Immune-Responsive miR-181 Promotes Henipavirus Entry and Cell-Cell Fusion

Chwan Hong Foo, Christina L. Rootes, Karla Cowley, Glenn A. Marsh, Cathryn M. Gould, Celine Deffrasnes, Christopher J. Cowled, Reuben Klein, Sarah J. Riddell, Deborah Middleton, Kaylene J. Simpson, Lin-Fa Wang, Andrew G. D. Bean, Cameron R. Stewart

PLOS Pathogens: published October 26, 2016 | https://doi.org/10.1371/journal.ppat.1005974

Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses

Huib H. Rabouw, Martijn A. Langereis, Robert C. M. Knaap, Tim J. Dalebout, Javier Canton, Isabel Sola, Luis Enjuanes, Peter J. Bredenbeek, Marjolein Kikkert, Raoul J. de Groot, Frank J. M. van Kuppeveld

PLOS Pathogens: published October 26, 2016 | https://doi.org/10.1371/journal.ppat.1005982

The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria

Kshipra Singh, Nicole T. Al-Greene, Thomas G. Verriere, Lori A. Coburn, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Dana M. Hardbower, Alberto G. Delgado, M. Blanca Piazuelo, Bruce A. Vallance, Alain P. Gobert, Keith T. Wilson

PLOS Pathogens: published October 26, 2016 | https://doi.org/10.1371/journal.ppat.1005984

Crystal Structure of Glycoprotein C from a Hantavirus in the Post-fusion Conformation

Shmuel Willensky, Hagit Bar-Rogovsky, Eduardo A. Bignon, Nicole D. Tischler, Yorgo Modis, Moshe Dessau

PLOS Pathogens: published October 26, 2016 | https://doi.org/10.1371/journal.ppat.1005948

Resveratrol Reverses Functional Chagas Heart Disease in Mice

Glaucia Vilar-Pereira, Vitor C. Carneiro, Hilton Mata-Santos, Amanda R. R. Vicentino, Isalira P. Ramos, Naira L. L. Giarola, Daniel F. Feijó, José R. Meyer-Fernandes, Heitor A. Paula-Neto, Emiliano Medei, Marcelo T. Bozza, Joseli Lannes-Vieira, Claudia N. Paiva

PLOS Pathogens: published October 27, 2016 | https://doi.org/10.1371/journal.ppat.1005947

A Viral Immunity Chromosome in the Marine Picoeukaryote, Ostreococcus tauri

Sheree Yau, Claire Hemon, Evelyne Derelle, Hervé Moreau, Gwenaël Piganeau, Nigel Grimsley

PLOS Pathogens: published October 27, 2016 | https://doi.org/10.1371/journal.ppat.1005965

STING-Licensed Macrophages Prime Type I IFN Production by Plasmacytoid Dendritic Cells in the Bone Marrow during Severe Plasmodium yoelii Malaria

Emily Spaulding, David Fooksman, Jamie M. Moore, Alex Saidi, Catherine M. Feintuch, Boris Reizis, Laurent Chorro, Johanna Daily, Grégoire Lauvau

PLOS Pathogens: published October 28, 2016 | https://doi.org/10.1371/journal.ppat.1005975

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Experimental acute cystitis — an Interleukin-1β-driven, hyper-inflammatory disease

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