March 2015

The image shows PDK1 S135 phosphorylation (green) detected in grade IV GBM tissue together with adjacent “safety margin of healthy looking tissue” (small square). PDK1phosphoS135 was identified by Bär et al., as a potential tumor promoting marker. The phosphoinositide-dependent kinase 1 (PDK1) is a master kinase regulating cell metabolism and survival. PKCη/Rdx-mediated phosphorylation of PDK1:S135 renders the enzyme independent of growth factor signaling through receptor tyrosine kinase and PI3-kinase. This intracellular loop-back pathway was found to be active in cancer but not in normal cells and tissue.

Image Credit: Séverine Bär

Opinion

Is Antigenic Sin Always “Original?” Re-examining the Evidence Regarding Circulation of a Human H1 Influenza Virus Immediately Prior to the 1918 Spanish Flu

Alain Gagnon, J. Enrique Acosta, Joaquin Madrenas, Matthew S. Miller

PLOS Pathogens: published March 5, 2015 | https://doi.org/10.1371/journal.ppat.1004615

Pearls

Antimicrobial-Induced DNA Damage and Genomic Instability in Microbial Pathogens

Rebecca S. Shapiro

PLOS Pathogens: published March 26, 2015 | https://doi.org/10.1371/journal.ppat.1004678

Catch Me If You Can: The Link between Autophagy and Viruses

Nicholas J. Lennemann, Carolyn B. Coyne

PLOS Pathogens: published March 26, 2015 | https://doi.org/10.1371/journal.ppat.1004685

To Be or Not IIb: A Multi-Step Process for Epstein-Barr Virus Latency Establishment and Consequences for B Cell Tumorigenesis

Alexander M. Price, Micah A. Luftig

PLOS Pathogens: published March 19, 2015 | https://doi.org/10.1371/journal.ppat.1004656

Coping with Stress and the Emergence of Multidrug Resistance in Fungi

Erika Shor, David S. Perlin

PLOS Pathogens: published March 19, 2015 | https://doi.org/10.1371/journal.ppat.1004668

The Great Escape: Pathogen Versus Host

Eric Kong, Mary Ann Jabra-Rizk

PLOS Pathogens: published March 12, 2015 | https://doi.org/10.1371/journal.ppat.1004661

Bacterial Immune Evasion through Manipulation of Host Inhibitory Immune Signaling

Kristof Van Avondt, Nina M. van Sorge, Linde Meyaard

PLOS Pathogens: published March 5, 2015 | https://doi.org/10.1371/journal.ppat.1004644

Review

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

Philipp Kruger, Mona Saffarzadeh, Alexander N. R. Weber, Nikolaus Rieber, Markus Radsak, Horst von Bernuth, Charaf Benarafa, Dirk Roos, Julia Skokowa, Dominik Hartl

PLOS Pathogens: published March 12, 2015 | https://doi.org/10.1371/journal.ppat.1004651

Research Articles

Impact of Leishmania Infection on Host Macrophage Nuclear Physiology and Nucleopore Complex Integrity

Amandine Isnard, Jan G. Christian, Mohamed Kodiha, Ursula Stochaj, W. Robert McMaster, Martin Olivier

PLOS Pathogens: published March 31, 2015 | https://doi.org/10.1371/journal.ppat.1004776

The Impact of Host Diet on Wolbachia Titer in Drosophila

Laura R. Serbus, Pamela M. White, Jessica Pintado Silva, Amanda Rabe, Luis Teixeira, Roger Albertson, William Sullivan

PLOS Pathogens: published March 31, 2015 | https://doi.org/10.1371/journal.ppat.1004777

BILBO1 Is a Scaffold Protein of the Flagellar Pocket Collar in the Pathogen Trypanosoma brucei

Célia Florimond, Annelise Sahin, Keni Vidilaseris, Gang Dong, Nicolas Landrein, Denis Dacheux, Anna Albisetti, Edward H. Byard, Mélanie Bonhivers, Derrick R. Robinson

PLOS Pathogens: published March 30, 2015 | https://doi.org/10.1371/journal.ppat.1004654

Identification of a Peptide-Pheromone that Enhances Listeria monocytogenes Escape from Host Cell Vacuoles

Bobbi Xayarath, Francis Alonzo III, Nancy E. Freitag

PLOS Pathogens: published March 30, 2015 | https://doi.org/10.1371/journal.ppat.1004707

Spatiotemporal Analysis of Hepatitis C Virus Infection

Ana Shulla, Glenn Randall

PLOS Pathogens: published March 30, 2015 | https://doi.org/10.1371/journal.ppat.1004758

Low Doses of Imatinib Induce Myelopoiesis and Enhance Host Anti-microbial Immunity

Ruth J. Napier, Brian A. Norris, Alyson Swimm, Cynthia R. Giver, Wayne A. C. Harris, Julie Laval, Brooke A. Napier, Gopi Patel, Ryan Crump, Zhenghong Peng, William Bornmann, Bali Pulendran, R. Mark Buller, David S. Weiss, Rabindra Tirouvanziam, Edmund K. Waller, Daniel Kalman

PLOS Pathogens: published March 30, 2015 | https://doi.org/10.1371/journal.ppat.1004770

Transgenic Expression of the Dicotyledonous Pattern Recognition Receptor EFR in Rice Leads to Ligand-Dependent Activation of Defense Responses

Benjamin Schwessinger, Ofir Bahar, Nicolas Thomas, Nicolas Holton, Vladimir Nekrasov, Deling Ruan, Patrick E. Canlas, Arsalan Daudi, Christopher J. Petzold, Vasanth R. Singan, Rita Kuo, Mansi Chovatia, Christopher Daum, Joshua L. Heazlewood, Cyril Zipfel, Pamela C. Ronald

PLOS Pathogens: published March 30, 2015 | https://doi.org/10.1371/journal.ppat.1004809

Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues following Vaccination with Defined Secreted Antigens, Providing Sterile Immunity to Challenge Infection

James P. Hewitson, Kara J. Filbey, Julia Esser-von Bieren, Mali Camberis, Christian Schwartz, Janice Murray, Lisa A. Reynolds, Natalie Blair, Elaine Robertson, Yvonne Harcus, Louis Boon, Stanley Ching-Cheng Huang, Lihua Yang, Yizheng Tu, Mark J. Miller, David Voehringer, Graham Le Gros, Nicola Harris, Rick M. Maizels

PLOS Pathogens: published March 27, 2015 | https://doi.org/10.1371/journal.ppat.1004676

Early Virological and Immunological Events in Asymptomatic Epstein-Barr Virus Infection in African Children

Shamanthi Jayasooriya, Thushan I. de Silva, Jainaba Njie-jobe, Chilel Sanyang, Alison M. Leese, Andrew I. Bell, Karen A. McAulay, Peng Yanchun, Heather M. Long, Tao Dong, Hilton C. Whittle, Alan B. Rickinson, Sarah L. Rowland-Jones, Andrew D. Hislop, Katie L. Flanagan

PLOS Pathogens: published March 27, 2015 | https://doi.org/10.1371/journal.ppat.1004746

Japanese Encephalitis Virus Nonstructural Protein NS5 Interacts with Mitochondrial Trifunctional Protein and Impairs Fatty Acid β-Oxidation

Yu-Ting Kao, Bi-Lan Chang, Jian-Jong Liang, Hang-Jen Tsai, Yi-Ling Lee, Ren-Jye Lin, Yi-Ling Lin

PLOS Pathogens: published March 27, 2015 | https://doi.org/10.1371/journal.ppat.1004750

Decreased HIV-Specific T-Regulatory Responses Are Associated with Effective DC-Vaccine Induced Immunity

Vedran Brezar, Nicolas Ruffin, Laura Richert, Mathieu Surenaud, Christine Lacabaratz, Karolina Palucka, Rodolphe Thiébaut, Jacques Banchereau, Yves Levy, Nabila Seddiki

PLOS Pathogens: published March 27, 2015 | https://doi.org/10.1371/journal.ppat.1004752

Exome and Transcriptome Sequencing of Aedes aegypti Identifies a Locus That Confers Resistance to Brugia malayi and Alters the Immune Response

Punita Juneja, Cristina V. Ariani, Yung Shwen Ho, Jewelna Akorli, William J. Palmer, Arnab Pain, Francis M. Jiggins

PLOS Pathogens: published March 27, 2015 | https://doi.org/10.1371/journal.ppat.1004765

PPM1A Regulates Antiviral Signaling by Antagonizing TBK1-Mediated STING Phosphorylation and Aggregation

Zexing Li, Ge Liu, Liwei Sun, Yan Teng, Xuejiang Guo, Jianhang Jia, Jiahao Sha, Xiao Yang, Dahua Chen, Qinmiao Sun

PLOS Pathogens: published March 27, 2015 | https://doi.org/10.1371/journal.ppat.1004783

Lipidomic Analysis Links Mycobactin Synthase K to Iron Uptake and Virulence in M. tuberculosis

Cressida A. Madigan, Amanda Jezek Martinot, Jun-Rong Wei, Ashoka Madduri, Tan-Yun Cheng, David C. Young, Emilie Layre, Jeffrey P. Murry, Eric J. Rubin, D. Branch Moody

PLOS Pathogens: published March 27, 2015 | https://doi.org/10.1371/journal.ppat.1004792

Parallel Epigenomic and Transcriptomic Responses to Viral Infection in Honey Bees (Apis mellifera)

David A. Galbraith, Xingyu Yang, Elina Lastro Niño, Soojin Yi, Christina Grozinger

PLOS Pathogens: published March 26, 2015 | https://doi.org/10.1371/journal.ppat.1004713

Compartmentalized Replication of R5 T Cell-Tropic HIV-1 in the Central Nervous System Early in the Course of Infection

Christa Buckheit Sturdevant, Sarah B. Joseph, Gretja Schnell, Richard W. Price, Ronald Swanstrom, Serena Spudich

PLOS Pathogens: published March 26, 2015 | https://doi.org/10.1371/journal.ppat.1004720

Herpesviral G Protein-Coupled Receptors Activate NFAT to Induce Tumor Formation via Inhibiting the SERCA Calcium ATPase

Junjie Zhang, Shanping He, Yi Wang, Kevin Brulois, Ke Lan, Jae U. Jung, Pinghui Feng

PLOS Pathogens: published March 26, 2015 | https://doi.org/10.1371/journal.ppat.1004768

Induction of Interferon-Stimulated Genes by IRF3 Promotes Replication of Toxoplasma gondii

Tanmay Majumdar, Saurabh Chattopadhyay, Evgeny Ozhegov, Jayeeta Dhar, Ramansu Goswami, Ganes C. Sen, Sailen Barik

PLOS Pathogens: published March 26, 2015 | https://doi.org/10.1371/journal.ppat.1004779

Positive Role of Promyelocytic Leukemia Protein in Type I Interferon Response and Its Regulation by Human Cytomegalovirus

Young-Eui Kim, Jin-Hyun Ahn

PLOS Pathogens: published March 26, 2015 | https://doi.org/10.1371/journal.ppat.1004785

Intracellular Growth Is Dependent on Tyrosine Catabolism in the Dimorphic Fungal Pathogen Penicillium marneffei

Kylie J. Boyce, Alisha McLauchlan, Lena Schreider, Alex Andrianopoulos

PLOS Pathogens: published March 26, 2015 | https://doi.org/10.1371/journal.ppat.1004790

Roles and Programming of Arabidopsis ARGONAUTE Proteins during Turnip Mosaic Virus Infection

Hernan Garcia-Ruiz, Alberto Carbonell, J. Steen Hoyer, Noah Fahlgren, Kerrigan B. Gilbert, Atsushi Takeda, Annalisa Giampetruzzi, Mayra T. Garcia Ruiz, Michaela G. McGinn, Nicholas Lowery, Maria T. Martinez Baladejo, James C. Carrington

PLOS Pathogens: published March 25, 2015 | https://doi.org/10.1371/journal.ppat.1004755

HCV Induces the Expression of Rubicon and UVRAG to Temporally Regulate the Maturation of Autophagosomes and Viral Replication

Linya Wang, Yongjun Tian, Jing-hsiung James Ou

PLOS Pathogens: published March 25, 2015 | https://doi.org/10.1371/journal.ppat.1004764

Comprehensive Antigenic Map of a Cleaved Soluble HIV-1 Envelope Trimer

Ronald Derking, Gabriel Ozorowski, Kwinten Sliepen, Anila Yasmeen, Albert Cupo, Jonathan L. Torres, Jean-Philippe Julien, Jeong Hyun Lee, Thijs van Montfort, Steven W. de Taeye, Mark Connors, Dennis R. Burton, Ian A. Wilson, Per-Johan Klasse, Andrew B. Ward, John P. Moore, Rogier W. Sanders

PLOS Pathogens: published March 25, 2015 | https://doi.org/10.1371/journal.ppat.1004767

Antigenic Properties of the Human Immunodeficiency Virus Envelope Glycoprotein Gp120 on Virions Bound to Target Cells

Meron Mengistu, Krishanu Ray, George K. Lewis, Anthony L. DeVico

PLOS Pathogens: published March 25, 2015 | https://doi.org/10.1371/journal.ppat.1004772

Immune Antibodies and Helminth Products Drive CXCR2-Dependent Macrophage-Myofibroblast Crosstalk to Promote Intestinal Repair

Julia Esser-von Bieren, Beatrice Volpe, Duncan B. Sutherland, Jérôme Bürgi, J. Sjef Verbeek, Benjamin J. Marsland, Joseph F. Urban Jr, Nicola L. Harris

PLOS Pathogens: published March 25, 2015 | https://doi.org/10.1371/journal.ppat.1004778

Human CD8⁺ T-cells Recognizing Peptides from Mycobacterium tuberculosis (Mtb) Presented by HLA-E Have an Unorthodox Th2-like, Multifunctional, Mtb Inhibitory Phenotype and Represent a Novel Human T-cell Subset

Krista E. van Meijgaarden, Mariëlle C. Haks, Nadia Caccamo, Francesco Dieli, Tom H. M. Ottenhoff, Simone A. Joosten

PLOS Pathogens: published March 24, 2015 | https://doi.org/10.1371/journal.ppat.1004671

β-HPV 5 and 8 E6 Disrupt Homology Dependent Double Strand Break Repair by Attenuating BRCA1 and BRCA2 Expression and Foci Formation

Nicholas A. Wallace, Kristin Robinson, Heather L. Howie, Denise A. Galloway

PLOS Pathogens: published March 24, 2015 | https://doi.org/10.1371/journal.ppat.1004687

Structure of the Low pH Conformation of Chandipura Virus G Reveals Important Features in the Evolution of the Vesiculovirus Glycoprotein

Eduard Baquero, Aurélie A. Albertini, Hélène Raux, Linda Buonocore, John K. Rose, Stéphane Bressanelli, Yves Gaudin

PLOS Pathogens: published March 24, 2015 | https://doi.org/10.1371/journal.ppat.1004756

Persistence of Transmitted HIV-1 Drug Resistance Mutations Associated with Fitness Costs and Viral Genetic Backgrounds

Wan-Lin Yang, Roger D. Kouyos, Jürg Böni, Sabine Yerly, Thomas Klimkait, Vincent Aubert, Alexandra U. Scherrer, Mohaned Shilaih, Trevor Hinkley, Christos Petropoulos, Sebastian Bonhoeffer, Huldrych F. Günthard, the Swiss HIV Cohort Study (SHCS)

PLOS Pathogens: published March 23, 2015 | https://doi.org/10.1371/journal.ppat.1004722

The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family

Lonneke van der Linden, Laia Vives-Adrián, Barbara Selisko, Cristina Ferrer-Orta, Xinran Liu, Kjerstin Lanke, Rachel Ulferts, Armando M. De Palma, Federica Tanchis, Nesya Goris, David Lefebvre, Kris De Clercq, Pieter Leyssen, Céline Lacroix, Gerhard Pürstinger, Bruno Coutard, Bruno Canard, David D. Boehr, Jamie J. Arnold, Craig E. Cameron, Nuria Verdaguer, Johan Neyts, Frank J. M. van Kuppeveld

PLOS Pathogens: published March 23, 2015 | https://doi.org/10.1371/journal.ppat.1004733

An 18 kDa Scaffold Protein Is Critical for Staphylococcus epidermidis Biofilm Formation

Rahel Decker, Christoph Burdelski, Melanie Zobiak, Henning Büttner, Gefion Franke, Martin Christner, Katharina Saß, Bernd Zobiak, Hanae A. Henke, Alexander R. Horswill, Markus Bischoff, Stephanie Bur, Torsten Hartmann, Carolyn R. Schaeffer, Paul D. Fey, Holger Rohde

PLOS Pathogens: published March 23, 2015 | https://doi.org/10.1371/journal.ppat.1004735

An O Antigen Capsule Modulates Bacterial Pathogenesis in Shigella sonnei

Mariaelena Caboni, Thierry Pédron, Omar Rossi, David Goulding, Derek Pickard, Francesco Citiulo, Calman A. MacLennan, Gordon Dougan, Nicholas R. Thomson, Allan Saul, Philippe J. Sansonetti, Christiane Gerke

PLOS Pathogens: published March 20, 2015 | https://doi.org/10.1371/journal.ppat.1004749

NEDDylation Is Essential for Kaposi’s Sarcoma-Associated Herpesvirus Latency and Lytic Reactivation and Represents a Novel Anti-KSHV Target

David J. Hughes, Jennifer J. Wood, Brian R. Jackson, Belinda Baquero-Pérez, Adrian Whitehouse

PLOS Pathogens: published March 20, 2015 | https://doi.org/10.1371/journal.ppat.1004771

Rhadinovirus Host Entry by Co-operative Infection

Clara Lawler, Ricardo Milho, Janet S. May, Philip G. Stevenson

PLOS Pathogens: published March 19, 2015 | https://doi.org/10.1371/journal.ppat.1004761

A Plasmodium Phospholipase Is Involved in Disruption of the Liver Stage Parasitophorous Vacuole Membrane

Paul-Christian Burda, Matthias A. Roelli, Marco Schaffner, Shahid M. Khan, Chris J. Janse, Volker T. Heussler

PLOS Pathogens: published March 18, 2015 | https://doi.org/10.1371/journal.ppat.1004760

Yersinia pestis Activates Both IL-1β and IL-1 Receptor Antagonist to Modulate Lung Inflammation during Pneumonic Plague

Vijay Sivaraman, Roger D. Pechous, Nikolas M. Stasulli, Kara R. Eichelberger, Edward A. Miao, William E. Goldman

PLOS Pathogens: published March 17, 2015 | https://doi.org/10.1371/journal.ppat.1004688

Variable Processing and Cross-presentation of HIV by Dendritic Cells and Macrophages Shapes CTL Immunodominance and Immune Escape

Jens Dinter, Ellen Duong, Nicole Y. Lai, Matthew J. Berberich, Georgio Kourjian, Edith Bracho-Sanchez, Duong Chu, Hang Su, Shao Chong Zhang, Sylvie Le Gall

PLOS Pathogens: published March 17, 2015 | https://doi.org/10.1371/journal.ppat.1004725

Escherichia coli α-Hemolysin Counteracts the Anti-Virulence Innate Immune Response Triggered by the Rho GTPase Activating Toxin CNF1 during Bacteremia

Mamady Diabate, Patrick Munro, Elsa Garcia, Arnaud Jacquel, Gregory Michel, Sandrine Obba, Diogo Goncalves, Carmelo Luci, Sandrine Marchetti, Dieter Demon, Clara Degos, Yassina Bechah, Jean-Louis Mege, Mohamed Lamkanfi, Patrick Auberger, Jean-Pierre Gorvel, Lynda Maria Stuart, Luce Landraud, Emmanuel Lemichez, Laurent Boyer

PLOS Pathogens: published March 17, 2015 | https://doi.org/10.1371/journal.ppat.1004732

Dermal Neutrophil, Macrophage and Dendritic Cell Responses to Yersinia pestis Transmitted by Fleas

Jeffrey G. Shannon, Christopher F. Bosio, B. Joseph Hinnebusch

PLOS Pathogens: published March 17, 2015 | https://doi.org/10.1371/journal.ppat.1004734

Evidence for Ubiquitin-Regulated Nuclear and Subnuclear Trafficking among Paramyxovirinae Matrix Proteins

Mickey Pentecost, Ajay A. Vashisht, Talia Lester, Tim Voros, Shannon M. Beaty, Arnold Park, Yao E. Wang, Tatyana E Yun, Alexander N. Freiberg, James A. Wohlschlegel, Benhur Lee

PLOS Pathogens: published March 17, 2015 | https://doi.org/10.1371/journal.ppat.1004739

Elucidation of Sigma Factor-Associated Networks in Pseudomonas aeruginosa Reveals a Modular Architecture with Limited and Function-Specific Crosstalk

Sebastian Schulz, Denitsa Eckweiler, Agata Bielecka, Tanja Nicolai, Raimo Franke, Andreas Dötsch, Klaus Hornischer, Sebastian Bruchmann, Juliane Düvel, Susanne Häussler

PLOS Pathogens: published March 17, 2015 | https://doi.org/10.1371/journal.ppat.1004744

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

Yongqian Zhao, Tingjin Sherryl Soh, Jie Zheng, Kitti Wing Ki Chan, Wint Wint Phoo, Chin Chin Lee, Moon Y. F. Tay, Kunchithapadam Swaminathan, Tobias C. Cornvik, Siew Pheng Lim, Pei-Yong Shi, Julien Lescar, Subhash G. Vasudevan, Dahai Luo

PLOS Pathogens: published March 16, 2015 | https://doi.org/10.1371/journal.ppat.1004682

Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose

Darren J. Creek, Muriel Mazet, Fiona Achcar, Jana Anderson, Dong-Hyun Kim, Ruwida Kamour, Pauline Morand, Yoann Millerioux, Marc Biran, Eduard J. Kerkhoven, Achuthanunni Chokkathukalam, Stefan K. Weidt, Karl E. V. Burgess, Rainer Breitling, David G. Watson, Frédéric Bringaud, Michael P. Barrett

PLOS Pathogens: published March 16, 2015 | https://doi.org/10.1371/journal.ppat.1004689

Spatiotemporal Regulation of a Legionella pneumophila T4SS Substrate by the Metaeffector SidJ

Kwang Cheol Jeong, Jessica A. Sexton, Joseph P. Vogel

PLOS Pathogens: published March 16, 2015 | https://doi.org/10.1371/journal.ppat.1004695

Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax Requires CADM1/TSLC1 for Inactivation of the NF-κB Inhibitor A20 and Constitutive NF-κB Signaling

Rajeshree Pujari, Richard Hunte, Remy Thomas, Louise van der Weyden, Dan Rauch, Lee Ratner, Jennifer K. Nyborg, Juan Carlos Ramos, Yoshimi Takai, Noula Shembade

PLOS Pathogens: published March 16, 2015 | https://doi.org/10.1371/journal.ppat.1004721

The Causes and Consequences of Changes in Virulence following Pathogen Host Shifts

Ben Longdon, Jarrod D. Hadfield, Jonathan P. Day, Sophia C. L. Smith, John E. McGonigle, Rodrigo Cogni, Chuan Cao, Francis M. Jiggins

PLOS Pathogens: published March 16, 2015 | https://doi.org/10.1371/journal.ppat.1004728

A Conserved NS3 Surface Patch Orchestrates NS2 Protease Stimulation, NS5A Hyperphosphorylation and HCV Genome Replication

Olaf Isken, Ulrike Langerwisch, Vlastimil Jirasko, Dirk Rehders, Lars Redecke, Harish Ramanathan, Brett D. Lindenbach, Ralf Bartenschlager, Norbert Tautz

PLOS Pathogens: published March 16, 2015 | https://doi.org/10.1371/journal.ppat.1004736

Adenovirus Entry From the Apical Surface of Polarized Epithelia Is Facilitated by the Host Innate Immune Response

Poornima L. N. Kotha, Priyanka Sharma, Abimbola O. Kolawole, Ran Yan, Mahmoud S. Alghamri, Trisha L. Brockman, Julian Gomez-Cambronero, Katherine J. D. A. Excoffon

PLOS Pathogens: published March 13, 2015 | https://doi.org/10.1371/journal.ppat.1004696

Production of Anti-LPS IgM by B1a B Cells Depends on IL-1β and Is Protective against Lung Infection with Francisella tularensis LVS

Laura del Barrio, Manoranjan Sahoo, Louis Lantier, Joseph M. Reynolds, Ivonne Ceballos-Olvera, Fabio Re

PLOS Pathogens: published March 13, 2015 | https://doi.org/10.1371/journal.ppat.1004706

Characterization of CD8⁺ T Cell Differentiation following SIVΔnef Vaccination by Transcription Factor Expression Profiling

James M. Billingsley, Premeela A. Rajakumar, Michelle A. Connole, Nadine C. Salisch, Sama Adnan, Yury V. Kuzmichev, Henoch S. Hong, R. Keith Reeves, Hyung-joo Kang, Wenjun Li, Qingsheng Li, Ashley T. Haase, R. Paul Johnson

PLOS Pathogens: published March 13, 2015 | https://doi.org/10.1371/journal.ppat.1004740

RSV Vaccine-Enhanced Disease Is Orchestrated by the Combined Actions of Distinct CD4 T Cell Subsets

Cory J. Knudson, Stacey M. Hartwig, David K. Meyerholz, Steven M. Varga

PLOS Pathogens: published March 13, 2015 | https://doi.org/10.1371/journal.ppat.1004757

Impaired Systemic Tetrahydrobiopterin Bioavailability and Increased Oxidized Biopterins in Pediatric Falciparum Malaria: Association with Disease Severity

Matthew P. Rubach, Jackson Mukemba, Salvatore Florence, Bert K. Lopansri, Keith Hyland, Alicia D. Volkheimer, Tsin W. Yeo, Nicholas M. Anstey, J. Brice Weinberg, Esther D. Mwaikambo, Donald L. Granger

PLOS Pathogens: published March 12, 2015 | https://doi.org/10.1371/journal.ppat.1004655

Impaired Systemic Tetrahydrobiopterin Bioavailability and Increased Dihydrobiopterin in Adult Falciparum Malaria: Association with Disease Severity, Impaired Microvascular Function and Increased Endothelial Activation

Tsin W. Yeo, Daniel A. Lampah, Enny Kenangalem, Emiliana Tjitra, Ric N. Price, J. Brice Weinberg, Keith Hyland, Donald L. Granger, Nicholas M. Anstey

PLOS Pathogens: published March 12, 2015 | https://doi.org/10.1371/journal.ppat.1004667

Chitin Recognition via Chitotriosidase Promotes Pathologic Type-2 Helper T Cell Responses to Cryptococcal Infection

Darin L. Wiesner, Charles A. Specht, Chrono K. Lee, Kyle D. Smith, Liliane Mukaremera, S. Thera Lee, Chun G. Lee, Jack A. Elias, Judith N. Nielsen, David R. Boulware, Paul R. Bohjanen, Marc K. Jenkins, Stuart M. Levitz, Kirsten Nielsen

PLOS Pathogens: published March 12, 2015 | https://doi.org/10.1371/journal.ppat.1004701

Disruption of IL-21 Signaling Affects T Cell-B Cell Interactions and Abrogates Protective Humoral Immunity to Malaria

Damián Pérez-Mazliah, Dorothy Hui Lin Ng, Ana Paula Freitas do Rosário, Sarah McLaughlin, Béatris Mastelic-Gavillet, Jan Sodenkamp, Garikai Kushinga, Jean Langhorne

PLOS Pathogens: published March 12, 2015 | https://doi.org/10.1371/journal.ppat.1004715

TRIM26 Negatively Regulates Interferon-β Production and Antiviral Response through Polyubiquitination and Degradation of Nuclear IRF3

Peng Wang, Wei Zhao, Kai Zhao, Lei Zhang, Chengjiang Gao

PLOS Pathogens: published March 12, 2015 | https://doi.org/10.1371/journal.ppat.1004726

Dependence of Intracellular and Exosomal microRNAs on Viral E6/E7 Oncogene Expression in HPV-positive Tumor Cells

Anja Honegger, Daniela Schilling, Sandra Bastian, Jasmin Sponagel, Vladimir Kuryshev, Holger Sültmann, Martin Scheffner, Karin Hoppe-Seyler, Felix Hoppe-Seyler

PLOS Pathogens: published March 11, 2015 | https://doi.org/10.1371/journal.ppat.1004712

Vaccinia Virus Protein Complex F12/E2 Interacts with Kinesin Light Chain Isoform 2 to Engage the Kinesin-1 Motor Complex

David C. J. Carpentier, William N. D. Gao, Helen Ewles, Gareth W. Morgan, Geoffrey L. Smith

PLOS Pathogens: published March 11, 2015 | https://doi.org/10.1371/journal.ppat.1004723

Establishment of HSV1 Latency in Immunodeficient Mice Facilitates Efficient In Vivo Reactivation

Chandran Ramakrishna, Adrianna Ferraioli, Aleth Calle, Thanh K. Nguyen, Harry Openshaw, Patric S. Lundberg, Patrick Lomonte, Edouard M. Cantin

PLOS Pathogens: published March 11, 2015 | https://doi.org/10.1371/journal.ppat.1004730

CD169-Mediated Trafficking of HIV to Plasma Membrane Invaginations in Dendritic Cells Attenuates Efficacy of Anti-gp120 Broadly Neutralizing Antibodies

Hisashi Akiyama, Nora-Guadalupe Pina Ramirez, Manasa V. Gudheti, Suryaram Gummuluru

PLOS Pathogens: published March 11, 2015 | https://doi.org/10.1371/journal.ppat.1004751

Metalloprotease NleC Suppresses Host NF-κB/Inflammatory Responses by Cleaving p65 and Interfering with the p65/RPS3 Interaction

Andrea Hodgson, Eric M. Wier, Kai Fu, Xin Sun, Hongbing Yu, Wenxin Zheng, Ho Pan Sham, Kaitlin Johnson, Scott Bailey, Bruce A. Vallance, Fengyi Wan

PLOS Pathogens: published March 10, 2015 | https://doi.org/10.1371/journal.ppat.1004705

The Role of Misshapen NCK-related kinase (MINK), a Novel Ste20 Family Kinase, in the IRES-Mediated Protein Translation of Human Enterovirus 71

Shi Yun Leong, Bryan Kit Teck Ong, Justin Jang Hann Chu

PLOS Pathogens: published March 6, 2015 | https://doi.org/10.1371/journal.ppat.1004686

γδ T Cells Confer Protection against Murine Cytomegalovirus (MCMV)

Camille Khairallah, Sonia Netzer, Arnaud Villacreces, Marina Juzan, Benoît Rousseau, Sara Dulanto, Alban Giese, Pierre Costet, Vincent Praloran, Jean-François Moreau, Pierre Dubus, David Vermijlen, Julie Déchanet-Merville, Myriam Capone

PLOS Pathogens: published March 6, 2015 | https://doi.org/10.1371/journal.ppat.1004702

XRN1 Stalling in the 5’ UTR of Hepatitis C Virus and Bovine Viral Diarrhea Virus Is Associated with Dysregulated Host mRNA Stability

Stephanie L. Moon, Jeffrey G. Blackinton, John R. Anderson, Mary K. Dozier, Benjamin J. T. Dodd, Jack D. Keene, Carol J. Wilusz, Shelton S. Bradrick, Jeffrey Wilusz

PLOS Pathogens: published March 6, 2015 | https://doi.org/10.1371/journal.ppat.1004708

Suppression of RNAi by dsRNA-Degrading RNaseIII Enzymes of Viruses in Animals and Plants

Isabel Weinheimer, Yaming Jiu, Minna-Liisa Rajamäki, Olli Matilainen, Jukka Kallijärvi, Wilmer J. Cuellar, Rui Lu, Mart Saarma, Carina I. Holmberg, Jussi Jäntti, Jari P. T. Valkonen

PLOS Pathogens: published March 6, 2015 | https://doi.org/10.1371/journal.ppat.1004711

Visualization of HIV-1 Interactions with Penile and Foreskin Epithelia: Clues for Female-to-Male HIV Transmission

Minh H. Dinh, Meegan R. Anderson, Michael D. McRaven, Gianguido C. Cianci, Scott G. McCoombe, Z. L. Kelley, Casey J. Gioia, Angela J. Fought, Alfred W. Rademaker, Ronald S. Veazey, Thomas J. Hope

PLOS Pathogens: published March 6, 2015 | https://doi.org/10.1371/journal.ppat.1004729

Host ESCRT Proteins Are Required for Bromovirus RNA Replication Compartment Assembly and Function

Arturo Diaz, Jiantao Zhang, Abigail Ollwerther, Xiaofeng Wang, Paul Ahlquist

PLOS Pathogens: published March 6, 2015 | https://doi.org/10.1371/journal.ppat.1004742

Subgingival Microbial Communities in Leukocyte Adhesion Deficiency and Their Relationship with Local Immunopathology

Niki M. Moutsopoulos, Natalia I. Chalmers, Jennifer J. Barb, Loreto Abusleme, Teresa Greenwell-Wild, Nicolas Dutzan, Bruce J. Paster, Peter J. Munson, Daniel H. Fine, Gulbu Uzel, Steven M. Holland

PLOS Pathogens: published March 5, 2015 | https://doi.org/10.1371/journal.ppat.1004698

PKCη/Rdx-driven Phosphorylation of PDK1: A Novel Mechanism Promoting Cancer Cell Survival and Permissiveness for Parvovirus-induced Lysis

Séverine Bär, Jean Rommelaere, Jürg P. F. Nüesch

PLOS Pathogens: published March 5, 2015 | https://doi.org/10.1371/journal.ppat.1004703

Yip1A, a Novel Host Factor for the Activation of the IRE1 Pathway of the Unfolded Protein Response during Brucella Infection

Yuki Taguchi, Koichi Imaoka, Michiyo Kataoka, Akihiko Uda, Daiki Nakatsu, Sakuya Horii-Okazaki, Rina Kunishige, Fumi Kano, Masayuki Murata

PLOS Pathogens: published March 5, 2015 | https://doi.org/10.1371/journal.ppat.1004747

Virulence Regulation with Venus Flytrap Domains: Structure and Function of the Periplasmic Moiety of the Sensor-Kinase BvgS

Elian Dupré, Julien Herrou, Marc F. Lensink, René Wintjens, Alexey Vagin, Andrey Lebedev, Sean Crosson, Vincent Villeret, Camille Locht, Rudy Antoine, Françoise Jacob-Dubuisson

PLOS Pathogens: published March 4, 2015 | https://doi.org/10.1371/journal.ppat.1004700

Sensing Cytosolic RpsL by Macrophages Induces Lysosomal Cell Death and Termination of Bacterial Infection

Wenhan Zhu, Lili Tao, Marsha L. Quick, Johanna A. Joyce, Jie-Ming Qu, Zhao-Qing Luo

PLOS Pathogens: published March 4, 2015 | https://doi.org/10.1371/journal.ppat.1004704

Attenuation of Tick-Borne Encephalitis Virus Using Large-Scale Random Codon Re-encoding

Lauriane de Fabritus, Antoine Nougairède, Fabien Aubry, Ernest A Gould, Xavier de Lamballerie

PLOS Pathogens: published March 3, 2015 | https://doi.org/10.1371/journal.ppat.1004738

Small GTPase Rab21 Mediates Fibronectin Induced Actin Reorganization in Entamoeba histolytica: Implications in Pathogen Invasion

Merlyn Emmanuel, Yumiko Saito Nakano, Tomoyoshi Nozaki, Sunando Datta

PLOS Pathogens: published March 2, 2015 | https://doi.org/10.1371/journal.ppat.1004666

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PDK1phosphoS135 a potential marker for malignant transformation in human glioma.

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