As a novel target organism of the cell-autonomous IRG resistance system, Jonathan Howard and colleagues identified the fungal parasite Encephalitozoon cuniculi, which while growing unrestricted incidentally formed here a heart-shaped vacuole with its spores (immunostained in red, DAPI blue). See Jonathan Howard and colleagues.
Image Credit: Helen Springer-Frauenhoff
Pearls
Adaptive Prediction As a Strategy in Microbial Infections
PLOS Pathogens: published October 2, 2014 | https://doi.org/10.1371/journal.ppat.1004356
Chrysosporium-Related Fungi and Reptiles: A Fatal Attraction
PLOS Pathogens: published October 16, 2014 | https://doi.org/10.1371/journal.ppat.1004367
Theory and Empiricism in Virulence Evolution
PLOS Pathogens: published October 23, 2014 | https://doi.org/10.1371/journal.ppat.1004387
Paracoccidioides Species Complex: Ecology, Phylogeny, Sexual Reproduction, and Virulence
PLOS Pathogens: published October 30, 2014 | https://doi.org/10.1371/journal.ppat.1004397
Review
Role of Non-conventional T Lymphocytes in Respiratory Infections: The Case of the Pneumococcus
PLOS Pathogens: published October 9, 2014 | https://doi.org/10.1371/journal.ppat.1004300
Research Articles
Insights into Vibrio cholerae Intestinal Colonization from Monitoring Fluorescently Labeled Bacteria
PLOS Pathogens: published October 2, 2014 | https://doi.org/10.1371/journal.ppat.1004405
Cyclophilin A Associates with Enterovirus-71 Virus Capsid and Plays an Essential Role in Viral Infection as an Uncoating Regulator
PLOS Pathogens: published October 2, 2014 | https://doi.org/10.1371/journal.ppat.1004422
HIV Acquisition Is Associated with Increased Antimicrobial Peptides and Reduced HIV Neutralizing IgA in the Foreskin Prepuce of Uncircumcised Men
PLOS Pathogens: published October 2, 2014 | https://doi.org/10.1371/journal.ppat.1004416
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Characterization of Uncultivable Bat Influenza Virus Using a Replicative Synthetic Virus
PLOS Pathogens: published October 2, 2014 | https://doi.org/10.1371/journal.ppat.1004420
Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90
PLOS Pathogens: published October 2, 2014 | https://doi.org/10.1371/journal.ppat.1004424
Dengue Viruses Are Enhanced by Distinct Populations of Serotype Cross-Reactive Antibodies in Human Immune Sera
PLOS Pathogens: published October 2, 2014 | https://doi.org/10.1371/journal.ppat.1004386
Epstein-Barr Virus Nuclear Antigen 3A Promotes Cellular Proliferation by Repression of the Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1
PLOS Pathogens: published October 2, 2014 | https://doi.org/10.1371/journal.ppat.1004415
Mycobacterial Antigen Driven Activation of CD14++CD16− Monocytes Is a Predictor of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome
PLOS Pathogens: published October 2, 2014 | https://doi.org/10.1371/journal.ppat.1004433
A Relay Network of Extracellular Heme-Binding Proteins Drives C. albicans Iron Acquisition from Hemoglobin
PLOS Pathogens: published October 2, 2014 | https://doi.org/10.1371/journal.ppat.1004407
Glutamate Secretion and Metabotropic Glutamate Receptor 1 Expression during Kaposi's Sarcoma-Associated Herpesvirus Infection Promotes Cell Proliferation
PLOS Pathogens: published October 9, 2014 | https://doi.org/10.1371/journal.ppat.1004389
Neutrophil Crawling in Capillaries; A Novel Immune Response to Staphylococcus aureus
PLOS Pathogens: published October 9, 2014 | https://doi.org/10.1371/journal.ppat.1004379
Agrobacterium Uses a Unique Ligand-Binding Mode for Trapping Opines and Acquiring A Competitive Advantage in the Niche Construction on Plant Host
PLOS Pathogens: published October 9, 2014 | https://doi.org/10.1371/journal.ppat.1004444
Leishmania donovani Infection Causes Distinct Epigenetic DNA Methylation Changes in Host Macrophages
PLOS Pathogens: published October 9, 2014 | https://doi.org/10.1371/journal.ppat.1004419
Structural Basis for the Recognition of Human Cytomegalovirus Glycoprotein B by a Neutralizing Human Antibody
PLOS Pathogens: published October 9, 2014 | https://doi.org/10.1371/journal.ppat.1004377
Vaginal Challenge with an SIV-Based Dual Reporter System Reveals That Infection Can Occur throughout the Upper and Lower Female Reproductive Tract
PLOS Pathogens: published October 9, 2014 | https://doi.org/10.1371/journal.ppat.1004440
mRNA Structural Constraints on EBNA1 Synthesis Impact on In Vivo Antigen Presentation and Early Priming of CD8+ T Cells
PLOS Pathogens: published October 9, 2014 | https://doi.org/10.1371/journal.ppat.1004423
Systematic Analysis of Zn2Cys6 Transcription Factors Required for Development and Pathogenicity by High-Throughput Gene Knockout in the Rice Blast Fungus
PLOS Pathogens: published October 9, 2014 | https://doi.org/10.1371/journal.ppat.1004432
Antimicrobials, Stress and Mutagenesis
PLOS Pathogens: published October 9, 2014 | https://doi.org/10.1371/journal.ppat.1004445
A Novel Alpha Kinase EhAK1 Phosphorylates Actin and Regulates Phagocytosis in Entamoeba histolytica
PLOS Pathogens: published October 9, 2014 | https://doi.org/10.1371/journal.ppat.1004411
The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis
PLOS Pathogens: published October 16, 2014 | https://doi.org/10.1371/journal.ppat.1004413
Related Articles
Allele-Specific Induction of IL-1β Expression by C/EBPβ and PU.1 Contributes to Increased Tuberculosis Susceptibility
PLOS Pathogens: published October 16, 2014 | https://doi.org/10.1371/journal.ppat.1004426
Novel Cyclic di-GMP Effectors of the YajQ Protein Family Control Bacterial Virulence
PLOS Pathogens: published October 16, 2014 | https://doi.org/10.1371/journal.ppat.1004429
Human Cytomegalovirus Drives Epigenetic Imprinting of the IFNG Locus in NKG2Chi Natural Killer Cells
PLOS Pathogens: published October 16, 2014 | https://doi.org/10.1371/journal.ppat.1004441
The Host Protein Calprotectin Modulates the Helicobacter pylori cag Type IV Secretion System via Zinc Sequestration
PLOS Pathogens: published October 16, 2014 | https://doi.org/10.1371/journal.ppat.1004450
Characteristics of Memory B Cells Elicited by a Highly Efficacious HPV Vaccine in Subjects with No Pre-existing Immunity
PLOS Pathogens: published October 16, 2014 | https://doi.org/10.1371/journal.ppat.1004461
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Expression Profiling during Arabidopsis/Downy Mildew Interaction Reveals a Highly-Expressed Effector That Attenuates Responses to Salicylic Acid
PLOS Pathogens: published October 16, 2014 | https://doi.org/10.1371/journal.ppat.1004443
APOBEC3D and APOBEC3F Potently Promote HIV-1 Diversification and Evolution in Humanized Mouse Model
PLOS Pathogens: published October 16, 2014 | https://doi.org/10.1371/journal.ppat.1004453
Interaction with Tsg101 Is Necessary for the Efficient Transport and Release of Nucleocapsids in Marburg Virus-Infected Cells
PLOS Pathogens: published October 16, 2014 | https://doi.org/10.1371/journal.ppat.1004463
Co-opted Oxysterol-Binding ORP and VAP Proteins Channel Sterols to RNA Virus Replication Sites via Membrane Contact Sites
PLOS Pathogens: published October 16, 2014 | https://doi.org/10.1371/journal.ppat.1004388
Involvement of a 1-Cys Peroxiredoxin in Bacterial Virulence
PLOS Pathogens: published October 16, 2014 | https://doi.org/10.1371/journal.ppat.1004442
MicroRNAs Suppress NB Domain Genes in Tomato That Confer Resistance to Fusarium oxysporum
PLOS Pathogens: published October 16, 2014 | https://doi.org/10.1371/journal.ppat.1004464
Kaposi's Sarcoma-Associated Herpesvirus Induces Nrf2 during De Novo Infection of Endothelial Cells to Create a Microenvironment Conducive to Infection
PLOS Pathogens: published October 23, 2014 | https://doi.org/10.1371/journal.ppat.1004460
Myosins VIII and XI Play Distinct Roles in Reproduction and Transport of Tobacco Mosaic Virus
PLOS Pathogens: published October 16, 2014 | https://doi.org/10.1371/journal.ppat.1004448
Live Attenuated Francisella novicida Vaccine Protects against Francisella tularensis Pulmonary Challenge in Rats and Non-human Primates
PLOS Pathogens: published October 23, 2014 | https://doi.org/10.1371/journal.ppat.1004439
Chromobacterium Csp_P Reduces Malaria and Dengue Infection in Vector Mosquitoes and Has Entomopathogenic and In Vitro Anti-pathogen Activities
PLOS Pathogens: published October 23, 2014 | https://doi.org/10.1371/journal.ppat.1004398
Sensing of Immature Particles Produced by Dengue Virus Infected Cells Induces an Antiviral Response by Plasmacytoid Dendritic Cells
PLOS Pathogens: published October 23, 2014 | https://doi.org/10.1371/journal.ppat.1004434
A Sialic Acid Binding Site in a Human Picornavirus
PLOS Pathogens: published October 16, 2014 | https://doi.org/10.1371/journal.ppat.1004401
A Novel Function of Human Pumilio Proteins in Cytoplasmic Sensing of Viral Infection
PLOS Pathogens: published October 23, 2014 | https://doi.org/10.1371/journal.ppat.1004417
Sterol Biosynthesis Is Required for Heat Resistance but Not Extracellular Survival in Leishmania
PLOS Pathogens: published October 23, 2014 | https://doi.org/10.1371/journal.ppat.1004427
HTLV-1 Tax Stabilizes MCL-1 via TRAF6-Dependent K63-Linked Polyubiquitination to Promote Cell Survival and Transformation
PLOS Pathogens: published October 23, 2014 | https://doi.org/10.1371/journal.ppat.1004458
HPV16-E7 Expression in Squamous Epithelium Creates a Local Immune Suppressive Environment via CCL2- and CCL5- Mediated Recruitment of Mast Cells
PLOS Pathogens: published October 23, 2014 | https://doi.org/10.1371/journal.ppat.1004466
Listeria monocytogenes Dampens the DNA Damage Response
PLOS Pathogens: published October 23, 2014 | https://doi.org/10.1371/journal.ppat.1004470
A Critical Role for IL-17RB Signaling in HTLV-1 Tax-Induced NF-κB Activation and T-Cell Transformation
PLOS Pathogens: published October 23, 2014 | https://doi.org/10.1371/journal.ppat.1004418
Contact Heterogeneity, Rather Than Transmission Efficiency, Limits the Emergence and Spread of Canine Influenza Virus
PLOS Pathogens: published October 23, 2014 | https://doi.org/10.1371/journal.ppat.1004455
Candida albicans Ethanol Stimulates Pseudomonas aeruginosa WspR-Controlled Biofilm Formation as Part of a Cyclic Relationship Involving Phenazines
PLOS Pathogens: published October 23, 2014 | https://doi.org/10.1371/journal.ppat.1004480
CD4 Depletion in SIV-Infected Macaques Results in Macrophage and Microglia Infection with Rapid Turnover of Infected Cells
PLOS Pathogens: published October 30, 2014 | https://doi.org/10.1371/journal.ppat.1004467
Identification of the Microsporidian Encephalitozoon cuniculi as a New Target of the IFNγ-Inducible IRG Resistance System
PLOS Pathogens: published October 30, 2014 | https://doi.org/10.1371/journal.ppat.1004449
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Detecting Differential Transmissibilities That Affect the Size of Self-Limited Outbreaks
PLOS Pathogens: published October 30, 2014 | https://doi.org/10.1371/journal.ppat.1004452
The ESAT-6 Protein of Mycobacterium tuberculosis Interacts with Beta-2-Microglobulin (β2M) Affecting Antigen Presentation Function of Macrophage
PLOS Pathogens: published October 30, 2014 | https://doi.org/10.1371/journal.ppat.1004446
Mycobacterium tuberculosis Lipoprotein LprG Binds Lipoarabinomannan and Determines Its Cell Envelope Localization to Control Phagolysosomal Fusion
PLOS Pathogens: published October 30, 2014 | https://doi.org/10.1371/journal.ppat.1004471
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Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly
PLOS Pathogens: published October 30, 2014 | https://doi.org/10.1371/journal.ppat.1004459
One Small Step for a Yeast - Microevolution within Macrophages Renders Candida glabrata Hypervirulent Due to a Single Point Mutation
PLOS Pathogens: published October 30, 2014 | https://doi.org/10.1371/journal.ppat.1004478
The N-Terminus of Murine Leukaemia Virus p12 Protein Is Required for Mature Core Stability
PLOS Pathogens: published October 30, 2014 | https://doi.org/10.1371/journal.ppat.1004474
Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer
PLOS Pathogens: published October 30, 2014 | https://doi.org/10.1371/journal.ppat.1004485
Social Motility of African Trypanosomes Is a Property of a Distinct Life-Cycle Stage That Occurs Early in Tsetse Fly Transmission
PLOS Pathogens: published October 30, 2014 | https://doi.org/10.1371/journal.ppat.1004493
Densovirus Is a Mutualistic Symbiont of a Global Crop Pest (Helicoverpa armigera) and Protects against a Baculovirus and Bt Biopesticide
PLOS Pathogens: published October 30, 2014 | https://doi.org/10.1371/journal.ppat.1004490
Corrections
Correction: Myeloid Dendritic Cells Induce HIV-1 Latency in Non-proliferating CD4+ T Cells
PLOS Pathogens: published October 2, 2014 | https://doi.org/10.1371/journal.ppat.1004486
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Correction: LprG-Mediated Surface Expression of Lipoarabinomannan Is Essential for Virulence of Mycobacterium tuberculosis
PLOS Pathogens: published October 6, 2014 | https://doi.org/10.1371/journal.ppat.1004489
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Correction: Identification and Functional Expression of a Glutamate- and Avermectin-Gated Chloride Channel from Caligus rogercresseyi, a Southern Hemisphere Sea Louse Affecting Farmed Fish
PLOS Pathogens: published October 13, 2014 | https://doi.org/10.1371/journal.ppat.1004494
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Correction: HIV Acquisition Is Associated with Increased Antimicrobial Peptides and Reduced HIV Neutralizing IgA in the Foreskin Prepuce of Uncircumcised Men
PLOS Pathogens: published October 27, 2014 | https://doi.org/10.1371/journal.ppat.1004515
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Correction: Human Genome-Wide RNAi Screen Identifies an Essential Role for Inositol Pyrophosphates in Type-I Interferon Response
PLOS Pathogens: published October 23, 2014 | https://doi.org/10.1371/journal.ppat.1004519