October 2013

A false-colored scanning electron microscopy image shows the parasite Trypanosoma brucei (blue; length of 15 micrometers) and innate immune myeloid cells (brown), in the hepatic vessels of an infected mouse. The parasites manipulate the myeloid cells in order to get nutrients required for their own growth. Trypanosomes are responsible for human sleeping sickness, a lethal disease in Africa. See De Muylder et al.

Image Credit: Gilles Vanwalleghem, David Monteyne, Etienne Pays, and David Pérez-Morga (Laboratory of Molecular Parasitology, Institut de Biologie Moléculaire et Médicale [IBMM], and Center for Microscopy and Molecular Imaging [CMMI], Université Libre de Bruxelles, Belgium).

Opinion

Chemicals, Climate, and Control: Increasing the Effectiveness of Malaria Vector Control Tools by Considering Relevant Temperatures

Katey D. Glunt, Justine I. Blanford, Krijn P. Paaijmans

PLOS Pathogens: published October 3, 2013 | https://doi.org/10.1371/journal.ppat.1003602

Pearls

Bats and Viruses: Friend or Foe?

James W. Wynne, Lin-Fa Wang

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003651

Sensing of the Microbial Neighborhood by Candida albicans

Emily M. Mallick, Richard J. Bennett

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003661

Unisexual Reproduction Drives Evolution of Eukaryotic Microbial Pathogens

Marianna Feretzaki, Joseph Heitman

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003674

Emergence of Azole-Resistant Aspergillus fumigatus Strains due to Agricultural Azole Use Creates an Increasing Threat to Human Health

Anuradha Chowdhary, Shallu Kathuria, Jianping Xu, Jacques F. Meis

PLOS Pathogens: published October 24, 2013 | https://doi.org/10.1371/journal.ppat.1003633

Are We There Yet? Recent Progress in the Molecular Diagnosis and Novel Antifungal Targeting of Aspergillus fumigatus and Invasive Aspergillosis

William J. Steinbach

PLOS Pathogens: published October 24, 2013 | https://doi.org/10.1371/journal.ppat.1003642

Streptococcus mutans, Candida albicans, and the Human Mouth: A Sticky Situation

Khalid H. Metwalli, Shariq A. Khan, Bastiaan P. Krom, Mary Ann Jabra-Rizk

PLOS Pathogens: published October 17, 2013 | https://doi.org/10.1371/journal.ppat.1003616

RNA Biology in Fungal Phytopathogens

Vera Göhre, Carl Haag, Michael Feldbrügge

PLOS Pathogens: published October 17, 2013 | https://doi.org/10.1371/journal.ppat.1003617

Alternative Roles for CRISPR/Cas Systems in Bacterial Pathogenesis

Timothy R. Sampson, David S. Weiss

PLOS Pathogens: published October 17, 2013 | https://doi.org/10.1371/journal.ppat.1003621

The Cell Biology of Leishmania: How to Teach Using Animations

Dirceu E. Teixeira, Marlene Benchimol, Juliany C. F. Rodrigues, Paulo H. Crepaldi, Paulo F. P. Pimenta, Wanderley de Souza

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003594

Antivirulence Therapy for Animal Production: Filling an Arsenal with Novel Weapons for Sustainable Disease Control

Tom Defoirdt

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003603

Fungal Adenylyl Cyclase Acts As a Signal Sensor and Integrator and Plays a Central Role in Interaction with Bacteria

Yue Wang

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003612

Dengue Vaccines: Strongly Sought but Not a Reality Just Yet

Rosa María del Angel, Jorge Reyes-del Valle

PLOS Pathogens: published October 3, 2013 | https://doi.org/10.1371/journal.ppat.1003551

Feeding Uninvited Guests: mTOR and AMPK Set the Table for Intracellular Pathogens

Jason Brunton, Shaun Steele, Benjamin Ziehr, Nathaniel Moorman, Thomas Kawula

PLOS Pathogens: published October 3, 2013 | https://doi.org/10.1371/journal.ppat.1003552

Review

Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion

Stanislas Tomavo, Christian Slomianny, Markus Meissner, Vern B. Carruthers

PLOS Pathogens: published October 24, 2013 | https://doi.org/10.1371/journal.ppat.1003629

Research Articles

Transcriptional Regulation of Culex pipiens Mosquitoes by Wolbachia Influences Cytoplasmic Incompatibility

Sofia B. Pinto, Kirsty Stainton, Simon Harris, Zakaria Kambris, Elizabeth R. Sutton, Michael B. Bonsall, Julian Parkhill, Steven P. Sinkins

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003647

Parvoviruses Cause Nuclear Envelope Breakdown by Activating Key Enzymes of Mitosis

Manvi Porwal, Sarah Cohen, Kenza Snoussi, Ruth Popa-Wagner, Fenja Anderson, Nathalie Dugot-Senant, Harald Wodrich, Christiane Dinsart, Jürgen A. Kleinschmidt, Nelly Panté, Michael Kann

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003671

Epigenetic Dominance of Prion Conformers

Eri Saijo, Hae-Eun Kang, Jifeng Bian, Kristi G. Bowling, Shawn Browning, Sehun Kim, Nora Hunter, Glenn C. Telling

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003692

Defective Viral Genomes Arising In Vivo Provide Critical Danger Signals for the Triggering of Lung Antiviral Immunity

Karla Tapia, Won-keun Kim, Yan Sun, Xiomara Mercado-López, Emily Dunay, Megan Wise, Michael Adu, Carolina B. López

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003703

B Cells Enhance Antigen-Specific CD4 T Cell Priming and Prevent Bacteria Dissemination following Chlamydia muridarum Genital Tract Infection

Lin-Xi Li, Stephen J. McSorley

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003707

Mediated Plastid RNA Editing in Plant Immunity

Javier García-Andrade, Vicente Ramírez, Ana López, Pablo Vera

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003713

Structures of B-Lymphotropic Polyomavirus VP1 in Complex with Oligosaccharide Ligands

Ursula Neu, Zaigham Mahmood Khan, Benjamin Schuch, Angelina S. Palma, Yan Liu, Michael Pawlita, Ten Feizi, Thilo Stehle

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003714

Bacterial Effector Activates Jasmonate Signaling by Directly Targeting JAZ Transcriptional Repressors

Shushu Jiang, Jian Yao, Ka-Wai Ma, Huanbin Zhou, Jikui Song, Sheng Yang He, Wenbo Ma

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003715

Penton-Dodecahedral Particles Trigger Opening of Intercellular Junctions and Facilitate Viral Spread during Adenovirus Serotype 3 Infection of Epithelial Cells

Zhuo-Zhuang Lu, Hongjie Wang, YiYi Zhang, Hua Cao, Zongyi Li, Pascal Fender, André Lieber

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003718

DDX24 Negatively Regulates Cytosolic RNA-Mediated Innate Immune Signaling

Zhe Ma, Robert Moore, Xiangxi Xu, Glen N. Barber

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003721

Role of Humoral versus Cellular Responses Induced by a Protective Dengue Vaccine Candidate

Raphaël M. Zellweger, Robyn Miller, William E. Eddy, Laura J. White, Robert E. Johnston, Sujan Shresta

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003723

A Trypanosoma brucei Kinesin Heavy Chain Promotes Parasite Growth by Triggering Host Arginase Activity

Géraldine De Muylder, Sylvie Daulouède, Laurence Lecordier, Pierrick Uzureau, Yannick Morias, Jan Van Den Abbeele, Guy Caljon, Michel Hérin, Philippe Holzmuller, Silla Semballa, Pierrette Courtois, Luc Vanhamme, Benoît Stijlemans, Patrick De Baetselier, Michael P. Barrett, Jillian L. Barlow, Andrew N. J. McKenzie, Luke Barron, Thomas A. Wynn, Alain Beschin, Philippe Vincendeau, Etienne Pays

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003731

Zinc Piracy as a Mechanism of Neisseria meningitidis for Evasion of Nutritional Immunity

Michiel Stork, Jan Grijpstra, Martine P. Bos, Carmen Mañas Torres, Nathalie Devos, Jan T. Poolman, Walter J. Chazin, Jan Tommassen

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003733

Mycobacterium tuberculosis Type VII Secreted Effector EsxH Targets Host ESCRT to Impair Trafficking

Alka Mehra, Aleena Zahra, Victor Thompson, Natalie Sirisaengtaksin, Ashley Wells, Maura Porto, Stefan Köster, Kristen Penberthy, Yoshihisha Kubota, Amelie Dricot, Daniel Rogan, Marc Vidal, David E. Hill, Andrew J. Bean, Jennifer A. Philips

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003734

Viral Escape from HIV-1 Neutralizing Antibodies Drives Increased Plasma Neutralization Breadth through Sequential Recognition of Multiple Epitopes and Immunotypes

Constantinos Kurt Wibmer, Jinal N. Bhiman, Elin S. Gray, Nancy Tumba, Salim S. Abdool Karim, Carolyn Williamson, Lynn Morris, Penny L. Moore

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003738

Hepatitis C Virus-Induced Cytoplasmic Organelles Use the Nuclear Transport Machinery to Establish an Environment Conducive to Virus Replication

Christopher J. Neufeldt, Michael A. Joyce, Aviad Levin, Rineke H. Steenbergen, Daniel Pang, Justin Shields, D. Lorne J. Tyrrell, Richard W. Wozniak

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003744

Identification of Novel Target Genes for Safer and More Specific Control of Root-Knot Nematodes from a Pan-Genome Mining

Etienne G. J. Danchin, Marie-Jeanne Arguel, Amandine Campan-Fournier, Laetitia Perfus-Barbeoch, Marc Magliano, Marie-Noëlle Rosso, Martine Da Rocha, Corinne Da Silva, Nicolas Nottet, Karine Labadie, Julie Guy, François Artiguenave, Pierre Abad

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003745

IRF-4-Mediated CIITA Transcription Is Blocked by KSHV Encoded LANA to Inhibit MHC II Presentation

Qiliang Cai, Shuvomoy Banerjee, Amanda Cervini, Jie Lu, Andrew D. Hislop, Richard Dzeng, Erle S. Robertson

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003751

A Gammaherpesvirus Uses Alternative Splicing to Regulate Its Tropism and Its Sensitivity to Neutralization

Bénédicte Machiels, Philip G. Stevenson, Alain Vanderplasschen, Laurent Gillet

PLOS Pathogens: published October 31, 2013 | https://doi.org/10.1371/journal.ppat.1003753

Usp18 Driven Enforced Viral Replication in Dendritic Cells Contributes to Break of Immunological Tolerance in Autoimmune Diabetes

Nadine Honke, Namir Shaabani, Dong-Er Zhang, George Iliakis, Haifeng C. Xu, Dieter Häussinger, Mike Recher, Max Löhning, Philipp A. Lang, Karl S. Lang

PLOS Pathogens: published October 24, 2013 | https://doi.org/10.1371/journal.ppat.1003650

IL-4Rα-Associated Antigen Processing by B Cells Promotes Immunity in Nippostrongylus brasiliensis Infection

William G. C. Horsnell, Matthew G. Darby, Jennifer C. Hoving, Natalie Nieuwenhuizen, Henry J. McSorley, Hlumani Ndlovu, Saeeda Bobat, Matti Kimberg, Frank Kirstein, Anthony J. Cutler, Benjamin DeWals, Adam F. Cunningham, Frank Brombacher

PLOS Pathogens: published October 24, 2013 | https://doi.org/10.1371/journal.ppat.1003662

Deletion of IL-4 Receptor Alpha on Dendritic Cells Renders BALB/c Mice Hypersusceptible to Leishmania major Infection

Ramona Hurdayal, Natalie E. Nieuwenhuizen, Mélanie Revaz-Breton, Liezel Smith, Jennifer C. Hoving, Suraj P. Parihar, Boris Reizis, Frank Brombacher

PLOS Pathogens: published October 24, 2013 | https://doi.org/10.1371/journal.ppat.1003699

ZASC1 Stimulates HIV-1 Transcription Elongation by Recruiting P-TEFb and TAT to the LTR Promoter

James W. Bruce, Rachel Reddington, Elizabeth Mathieu, Megan Bracken, John A. T. Young, Paul Ahlquist

PLOS Pathogens: published October 24, 2013 | https://doi.org/10.1371/journal.ppat.1003712

Inactivation of p53 Rescues the Maintenance of High Risk HPV DNA Genomes Deficient in Expression of E6

Laurel D. Lorenz, Jessenia Rivera Cardona, Paul F. Lambert

PLOS Pathogens: published October 24, 2013 | https://doi.org/10.1371/journal.ppat.1003717

Steroid Hormone Signaling Is Essential to Regulate Innate Immune Cells and Fight Bacterial Infection in Drosophila

Jennifer C. Regan, Ana S. Brandão, Alexandre B. Leitão, Ângela Raquel Mantas Dias, Élio Sucena, António Jacinto, Anna Zaidman-Rémy

PLOS Pathogens: published October 24, 2013 | https://doi.org/10.1371/journal.ppat.1003720

Viral Interference with DNA Repair by Targeting of the Single-Stranded DNA Binding Protein RPA

Pubali Banerjee, Rowena deJesus, Ole Gjoerup, Brian S. Schaffhausen

PLOS Pathogens: published October 24, 2013 | https://doi.org/10.1371/journal.ppat.1003725

Plasmacytoid Dendritic Cells Contribute to Systemic but Not Local Antiviral Responses to HSV Infections

Melissa Swiecki, Yaming Wang, Susan Gilfillan, Marco Colonna

PLOS Pathogens: published October 24, 2013 | https://doi.org/10.1371/journal.ppat.1003728

A Structural Basis for BRD2/4-Mediated Host Chromatin Interaction and Oligomer Assembly of Kaposi Sarcoma-Associated Herpesvirus and Murine Gammaherpesvirus LANA Proteins

Jan Hellert, Magdalena Weidner-Glunde, Joern Krausze, Ulrike Richter, Heiko Adler, Roman Fedorov, Marcel Pietrek, Jessica Rückert, Christiane Ritter, Thomas F. Schulz, Thorsten Lührs

PLOS Pathogens: published October 17, 2013 | https://doi.org/10.1371/journal.ppat.1003640

The DAF-16/FOXO Transcription Factor Functions as a Regulator of Epidermal Innate Immunity

Cheng-Gang Zou, Qiu Tu, Jie Niu, Xing-Lai Ji, Ke-Qin Zhang

PLOS Pathogens: published October 17, 2013 | https://doi.org/10.1371/journal.ppat.1003660

Toxoplasma gondii Relies on Both Host and Parasite Isoprenoids and Can Be Rendered Sensitive to Atorvastatin

Zhu-Hong Li, Srinivasan Ramakrishnan, Boris Striepen, Silvia N. J. Moreno

PLOS Pathogens: published October 17, 2013 | https://doi.org/10.1371/journal.ppat.1003665

Molecular Basis for Oligomeric-DNA Binding and Episome Maintenance by KSHV LANA

John F. Domsic, Horng-Shen Chen, Fang Lu, Ronen Marmorstein, Paul M. Lieberman

PLOS Pathogens: published October 17, 2013 | https://doi.org/10.1371/journal.ppat.1003672

Crystal Structure of the Gamma-2 Herpesvirus LANA DNA Binding Domain Identifies Charged Surface Residues Which Impact Viral Latency

Bruno Correia, Sofia A. Cerqueira, Chantal Beauchemin, Marta Pires de Miranda, Shijun Li, Rajesh Ponnusamy, Lénia Rodrigues, Thomas R. Schneider, Maria A. Carrondo, Kenneth M. Kaye, J. Pedro Simas, Colin E. McVey

PLOS Pathogens: published October 17, 2013 | https://doi.org/10.1371/journal.ppat.1003673

Fungal Iron Availability during Deep Seated Candidiasis Is Defined by a Complex Interplay Involving Systemic and Local Events

Joanna Potrykus, David Stead, Donna M. MacCallum, Dagmar S. Urgast, Andrea Raab, Nico van Rooijen, Jörg Feldmann, Alistair J. P. Brown

PLOS Pathogens: published October 17, 2013 | https://doi.org/10.1371/journal.ppat.1003676

Ebola Virus RNA Editing Depends on the Primary Editing Site Sequence and an Upstream Secondary Structure

Masfique Mehedi, Thomas Hoenen, Shelly Robertson, Stacy Ricklefs, Michael A. Dolan, Travis Taylor, Darryl Falzarano, Hideki Ebihara, Stephen F. Porcella, Heinz Feldmann

PLOS Pathogens: published October 17, 2013 | https://doi.org/10.1371/journal.ppat.1003677

The Cycle of EBV Infection Explains Persistence, the Sizes of the Infected Cell Populations and Which Come under CTL Regulation

Jared B. Hawkins, Edgar Delgado-Eckert, David A. Thorley-Lawson, Michael Shapiro

PLOS Pathogens: published October 17, 2013 | https://doi.org/10.1371/journal.ppat.1003685

Independent Pathways Can Transduce the Life-Cycle Differentiation Signal in Trypanosoma brucei

Balazs Szöőr, Naomi A. Dyer, Irene Ruberto, Alvaro Acosta-Serrano, Keith R. Matthews

PLOS Pathogens: published October 17, 2013 | https://doi.org/10.1371/journal.ppat.1003689

The Microvesicle Component of HIV-1 Inocula Modulates Dendritic Cell Infection and Maturation and Enhances Adhesion to and Activation of T Lymphocytes

Sarah K. Mercier, Heather Donaghy, Rachel A. Botting, Stuart G. Turville, Andrew N. Harman, Najla Nasr, Hong Ji, Ulrike Kusebauch, Luis Mendoza, David Shteynberg, Kerrie Sandgren, Richard J. Simpson, Robert L. Moritz, Anthony L. Cunningham

PLOS Pathogens: published October 17, 2013 | https://doi.org/10.1371/journal.ppat.1003700

The Structure of Classical Swine Fever Virus N^pro: A Novel Cysteine Autoprotease and Zinc-Binding Protein Involved in Subversion of Type I Interferon Induction

Keerthi Gottipati, Nicolas Ruggli, Markus Gerber, Jon-Duri Tratschin, Matthew Benning, Henry Bellamy, Kyung H. Choi

PLOS Pathogens: published October 17, 2013 | https://doi.org/10.1371/journal.ppat.1003704

ISG15 Regulates Peritoneal Macrophages Functionality against Viral Infection

Emilio Yángüez, Alicia García-Culebras, Aldo Frau, Catalina Llompart, Klaus-Peter Knobeloch, Sylvia Gutierrez-Erlandsson, Adolfo García-Sastre, Mariano Esteban, Amelia Nieto, Susana Guerra

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003632

Human Cytomegalovirus Latency-Associated Proteins Elicit Immune-Suppressive IL-10 Producing CD4⁺ T Cells

Gavin M. Mason, Sarah Jackson, Georgina Okecha, Emma Poole, J. G. Patrick Sissons, John Sinclair, Mark R. Wills

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003635

Novel Staphylococcal Glycosyltransferases SdgA and SdgB Mediate Immunogenicity and Protection of Virulence-Associated Cell Wall Proteins

Wouter L. W. Hazenbos, Kimberly K. Kajihara, Richard Vandlen, J. Hiroshi Morisaki, Sophie M. Lehar, Mark J. Kwakkenbos, Tim Beaumont, Arjen Q. Bakker, Qui Phung, Lee R. Swem, Satish Ramakrishnan, Janice Kim, Min Xu, Ishita M. Shah, Binh An Diep, Tao Sai, Andrew Sebrell, Yana Khalfin, Angela Oh, Chris Koth, S. Jack Lin, Byoung-Chul Lee, Magnus Strandh, Klaus Koefoed, Peter S. Andersen, Hergen Spits, Eric J. Brown, Man-Wah Tan, Sanjeev Mariathasan

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003653

New World Bats Harbor Diverse Influenza A Viruses

Suxiang Tong, Xueyong Zhu, Yan Li, Mang Shi, Jing Zhang, Melissa Bourgeois, Hua Yang, Xianfeng Chen, Sergio Recuenco, Jorge Gomez, Li-Mei Chen, Adam Johnson, Ying Tao, Cyrille Dreyfus, Wenli Yu, Ryan McBride, Paul J. Carney, Amy T. Gilbert, Jessie Chang, Zhu Guo, Charles T. Davis, James C. Paulson, James Stevens, Charles E. Rupprecht, Edward C. Holmes, Ian A. Wilson, Ruben O. Donis

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003657

Type I Interferon Upregulates Bak and Contributes to T Cell Loss during Human Immunodeficiency Virus (HIV) Infection

Joseph A. Fraietta, Yvonne M. Mueller, Guibin Yang, Alina C. Boesteanu, Donald T. Gracias, Duc H. Do, Jennifer L. Hope, Noshin Kathuria, Shannon E. McGettigan, Mark G. Lewis, Luis D. Giavedoni, Jeffrey M. Jacobson, Peter D. Katsikis

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003658

Caspase-1 Promotes Epstein-Barr Virus Replication by Targeting the Large Tegument Protein Deneddylase to the Nucleus of Productively Infected Cells

Stefano Gastaldello, Xinsong Chen, Simone Callegari, Maria G. Masucci

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003664

An RxLR Effector from Phytophthora infestans Prevents Re-localisation of Two Plant NAC Transcription Factors from the Endoplasmic Reticulum to the Nucleus

Hazel McLellan, Petra C. Boevink, Miles R. Armstrong, Leighton Pritchard, Sonia Gomez, Juan Morales, Stephen C. Whisson, Jim L. Beynon, Paul R. J. Birch

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003670

MAIT Cells Detect and Efficiently Lyse Bacterially-Infected Epithelial Cells

Lionel Le Bourhis, Mathilde Dusseaux, Armelle Bohineust, Stéphanie Bessoles, Emmanuel Martin, Virginie Premel, Maxime Coré, David Sleurs, Nacer-Eddine Serriari, Emmanuel Treiner, Claire Hivroz, Philippe Sansonetti, Marie-Lise Gougeon, Claire Soudais, Olivier Lantz

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003681

Crystal Structure of the Hendra Virus Attachment G Glycoprotein Bound to a Potent Cross-Reactive Neutralizing Human Monoclonal Antibody

Kai Xu, Barry Rockx, Yihu Xie, Blair L. DeBuysscher, Deborah L. Fusco, Zhongyu Zhu, Yee-Peng Chan, Yan Xu, Truong Luu, Regina Z. Cer, Heinz Feldmann, Vishwesh Mokashi, Dimiter S. Dimitrov, Kimberly A. Bishop-Lilly, Christopher C. Broder, Dimitar B. Nikolov

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003684

A Structure-Guided Mutation in the Major Capsid Protein Retargets BK Polyomavirus

Ursula Neu, Stacy-ann A. Allen, Bärbel S. Blaum, Yan Liu, Martin Frank, Angelina S. Palma, Luisa J. Ströh, Ten Feizi, Thomas Peters, Walter J. Atwood, Thilo Stehle

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003688

Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity

Kwangkook Lee, Shenyan Gu, Lei Jin, Thi Tuc Nghi Le, Luisa W. Cheng, Jasmin Strotmeier, Anna Magdalena Kruel, Guorui Yao, Kay Perry, Andreas Rummel, Rongsheng Jin

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003690

Prospective Antiretroviral Treatment of Asymptomatic, HIV-1 Infected Controllers

Hiroyu Hatano, Steven A. Yukl, April L. Ferre, Erin H. Graf, Ma Somsouk, Elizabeth Sinclair, Mohamed Abdel-Mohsen, Teri Liegler, Kara Harvill, Rebecca Hoh, Sarah Palmer, Peter Bacchetti, Peter W. Hunt, Jeffrey N. Martin, Joseph M. McCune, Russell P. Tracy, Michael P. Busch, Una O'Doherty, Barbara L. Shacklett, Joseph K. Wong, Steven G. Deeks

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003691

Nucleoporin NUP153 Phenylalanine-Glycine Motifs Engage a Common Binding Pocket within the HIV-1 Capsid Protein to Mediate Lentiviral Infectivity

Kenneth A. Matreyek, Sara S. Yücel, Xiang Li, Alan Engelman

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003693

The Differential Mobilization of Histones H3.1 and H3.3 by Herpes Simplex Virus 1 Relates Histone Dynamics to the Assembly of Viral Chromatin

Kristen L. Conn, Michael J. Hendzel, Luis M. Schang

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003695

Activation of the Cph1-Dependent MAP Kinase Signaling Pathway Induces White-Opaque Switching in Candida albicans

Bernardo Ramírez-Zavala, Michael Weyler, Tsvia Gildor, Christian Schmauch, Daniel Kornitzer, Robert Arkowitz, Joachim Morschhäuser

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003696

MicroRNA-155 Promotes Autophagy to Eliminate Intracellular Mycobacteria by Targeting Rheb

Jinli Wang, Kun Yang, Lin Zhou, MinhaoWu, Yongjian Wu, Min Zhu, XiaoMin Lai, Tao Chen, Lianqiang Feng, Meiyu Li, Chunyu Huang, Qiu Zhong, Xi Huang

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003697

IL-22 Mediates Goblet Cell Hyperplasia and Worm Expulsion in Intestinal Helminth Infection

Jan-Eric Turner, Brigitta Stockinger, Helena Helmby

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003698

Dual Function of CD81 in Influenza Virus Uncoating and Budding

Jiang He, Eileen Sun, Miriam V. Bujny, Doory Kim, Michael W. Davidson, Xiaowei Zhuang

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003701

Quaternary Structure of Pathological Prion Protein as a Determining Factor of Strain-Specific Prion Replication Dynamics

Florent Laferrière, Philippe Tixador, Mohammed Moudjou, Jérôme Chapuis, Pierre Sibille, Laetitia Herzog, Fabienne Reine, Emilie Jaumain, Hubert Laude, Human Rezaei, Vincent Béringue

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003702

O-mannosylation of the Mycobacterium tuberculosis Adhesin Apa Is Crucial for T Cell Antigenicity during Infection but Is Expendable for Protection

Subhadra Nandakumar, Sunil Kannanganat, Karen M. Dobos, Megan Lucas, John S. Spencer, Sunan Fang, Melissa A. McDonald, Jan Pohl, Kristin Birkness, Venkateswarlu Chamcha, Melissa V. Ramirez, Bonnie B. Plikaytis, James E. Posey, Rama Rao Amara, Suraj B. Sable

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003705

CXCR3-Dependent CD4⁺ T Cells Are Required to Activate Inflammatory Monocytes for Defense against Intestinal Infection

Sara B. Cohen, Kirk J. Maurer, Charlotte E. Egan, Steve Oghumu, Abhay R. Satoskar, Eric Y. Denkers

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003706

Regulation of Innate Responses during Pre-patent Schistosome Infection Provides an Immune Environment Permissive for Parasite Development

Diana K. Riner, Christine E. Ferragine, Sean K. Maynard, Stephen J. Davies

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003708

Haemophilus Responses to Nutritional Immunity: Epigenetic and Morphological Contribution to Biofilm Architecture, Invasion, Persistence and Disease Severity

Blake R. Szelestey, Derek R. Heimlich, Forrest K. Raffel, Sheryl S. Justice, Kevin M. Mason

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003709

Identification of Trans-Sialidases as a Common Mediator of Endothelial Cell Activation by African Trypanosomes

Zeinab Ammar, Nicolas Plazolles, Théo Baltz, Virginie Coustou

PLOS Pathogens: published October 10, 2013 | https://doi.org/10.1371/journal.ppat.1003710

Kinetics of Myeloid Dendritic Cell Trafficking and Activation: Impact on Progressive, Nonprogressive and Controlled SIV Infections

Viskam Wijewardana, Jan Kristoff, Cuiling Xu, Dongzhu Ma, George Haret-Richter, Jennifer L. Stock, Benjamin B. Policicchio, Adam D. Mobley, Rebecca Nusbaum, Hadega Aamer, Anita Trichel, Ruy M. Ribeiro, Cristian Apetrei, Ivona Pandrea

PLOS Pathogens: published October 3, 2013 | https://doi.org/10.1371/journal.ppat.1003600

Glycogen Metabolic Genes Are Involved in Trehalose-6-Phosphate Synthase-Mediated Regulation of Pathogenicity by the Rice Blast Fungus Magnaporthe oryzae

Muhammad Badaruddin, Lucy J. Holcombe, Richard A. Wilson, Zheng-Yi Wang, Michael J. Kershaw, Nicholas J. Talbot

PLOS Pathogens: published October 3, 2013 | https://doi.org/10.1371/journal.ppat.1003604

Role of the Vibrio cholerae Matrix Protein Bap1 in Cross-Resistance to Antimicrobial Peptides

Marylise Duperthuy, Annika E. Sjöström, Dharmesh Sabharwal, Fatemeh Damghani, Bernt Eric Uhlin, Sun Nyunt Wai

PLOS Pathogens: published October 3, 2013 | https://doi.org/10.1371/journal.ppat.1003620

NADPH Oxidase-Driven Phagocyte Recruitment Controls Candida albicans Filamentous Growth and Prevents Mortality

Kimberly M. Brothers, Remi L. Gratacap, Sarah E. Barker, Zachary R. Newman, Ashley Norum, Robert T. Wheeler

PLOS Pathogens: published October 3, 2013 | https://doi.org/10.1371/journal.ppat.1003634

APOBEC3G Polymorphism as a Selective Barrier to Cross-Species Transmission and Emergence of Pathogenic SIV and AIDS in a Primate Host

Annabel Krupp, Kevin R. McCarthy, Marcel Ooms, Michael Letko, Jennifer S. Morgan, Viviana Simon, Welkin E. Johnson

PLOS Pathogens: published October 3, 2013 | https://doi.org/10.1371/journal.ppat.1003641

The Role of TcdB and TccC Subunits in Secretion of the Photorhabdus Tcd Toxin Complex

Guowei Yang, Nicholas R. Waterfield

PLOS Pathogens: published October 3, 2013 | https://doi.org/10.1371/journal.ppat.1003644

TXNIP Deficiency Exacerbates Endotoxic Shock via the Induction of Excessive Nitric Oxide Synthesis

Young-Jun Park, Sung-Jin Yoon, Hyun-Woo Suh, Dong Oh Kim, Jeong-Ran Park, Haiyoung Jung, Tae-Don Kim, Suk Ran Yoon, Jeong-Ki Min, Hee-Jun Na, Seon-Jin Lee, Hee Gu Lee, Young Ho Lee, Hee-Bong Lee, Inpyo Choi

PLOS Pathogens: published October 3, 2013 | https://doi.org/10.1371/journal.ppat.1003646

A Mechanism for the Inhibition of DNA-PK-Mediated DNA Sensing by a Virus

Nicholas E. Peters, Brian J. Ferguson, Michela Mazzon, Aodhnait S. Fahy, Ewelina Krysztofinska, Raquel Arribas-Bosacoma, Laurence H. Pearl, Hongwei Ren, Geoffrey L. Smith

PLOS Pathogens: published October 3, 2013 | https://doi.org/10.1371/journal.ppat.1003649

Herpes Simplex Virus Type 1 Single Strand DNA Binding Protein and Helicase/Primase Complex Disable Cellular ATR Signaling

Kareem N. Mohni, Samantha Smith, Alexander R. Dee, April J. Schumacher, Sandra K. Weller

PLOS Pathogens: published October 3, 2013 | https://doi.org/10.1371/journal.ppat.1003652

Type I J-Domain NbMIP1 Proteins Are Required for Both Tobacco Mosaic Virus Infection and Plant Innate Immunity

Yumei Du, Jinping Zhao, Tianyuan Chen, Qi Liu, Haili Zhang, Yan Wang, Yiguo Hong, Fangming Xiao, Ling Zhang, Qianhua Shen, Yule Liu

PLOS Pathogens: published October 3, 2013 | https://doi.org/10.1371/journal.ppat.1003659

Sequestration by IFIT1 Impairs Translation of 2′O-unmethylated Capped RNA

Matthias Habjan, Philipp Hubel, Livia Lacerda, Christian Benda, Cathleen Holze, Christian H. Eberl, Angelika Mann, Eveline Kindler, Cristina Gil-Cruz, John Ziebuhr, Volker Thiel, Andreas Pichlmair

PLOS Pathogens: published October 3, 2013 | https://doi.org/10.1371/journal.ppat.1003663

Ehrlichia chaffeensis Uses Its Surface Protein EtpE to Bind GPI-Anchored Protein DNase X and Trigger Entry into Mammalian Cells

Dipu Mohan Kumar, Mamoru Yamaguchi, Koshiro Miura, Mingqun Lin, Marek Los, Johannes F. Coy, Yasuko Rikihisa

PLOS Pathogens: published October 3, 2013 | https://doi.org/10.1371/journal.ppat.1003666

Salmonella Modulation of Host Cell Gene Expression Promotes Its Intracellular Growth

Sebastian Hannemann, Beile Gao, Jorge E. Galán

PLOS Pathogens: published October 3, 2013 | https://doi.org/10.1371/journal.ppat.1003668

Loss of the TGFβ-Activating Integrin αvβ8 on Dendritic Cells Protects Mice from Chronic Intestinal Parasitic Infection via Control of Type 2 Immunity

John J. Worthington, Joanna E. Klementowicz, Sayema Rahman, Beata I. Czajkowska, Catherine Smedley, Herman Waldmann, Tim Sparwasser, Richard K. Grencis, Mark A. Travis

PLOS Pathogens: published October 3, 2013 | https://doi.org/10.1371/journal.ppat.1003675

Inhibition of Pyrimidine Biosynthesis Pathway Suppresses Viral Growth through Innate Immunity

Marianne Lucas-Hourani, Daniel Dauzonne, Pierre Jorda, Gaëlle Cousin, Alexandru Lupan, Olivier Helynck, Grégory Caignard, Geneviève Janvier, Gwénaëlle André-Leroux, Samira Khiar, Nicolas Escriou, Philippe Desprès, Yves Jacob, Hélène Munier-Lehmann, Frédéric Tangy, Pierre-Olivier Vidalain

PLOS Pathogens: published October 3, 2013 | https://doi.org/10.1371/journal.ppat.1003678

Massive Depletion of Bovine Leukemia Virus Proviral Clones Located in Genomic Transcriptionally Active Sites during Primary Infection

Nicolas A. Gillet, Gerónimo Gutiérrez, Sabrina M. Rodriguez, Alix de Brogniez, Nathalie Renotte, Irene Alvarez, Karina Trono, Luc Willems

PLOS Pathogens: published October 3, 2013 | https://doi.org/10.1371/journal.ppat.1003687

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African trypanosomes swim in the liver sinusoids and interact with immune myeloid cells.

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