3-D projection of a z stack from the lymph node of a CDllcYFP mouse that was adoptively transferred with ovalbumin-specific CD8+ GFP+ T cells and infected with T. gondii expressing ovalbumin. An increased proportion of dendritic cells (yellow) and T cells (green) are associated with the sub-capsular region (capsule seen in blue) of the lymph node following infection. Also note the vacuolar structures within the dendritic cells, which are induced during infection. This image was acquired on a Leica SP5 2-photon microscope equipped with a picosecond laser and tunable internal detectors (see John et al., doi:10.1371/journal.ppat.1000505).
Image Credit: Beena John and Christopher A. Hunter, University of Pennsylvania.
Opinions
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