Figures
HIV-1 VLPs are internalized by macrophages within CLIC/GEEC tubules
The virus-containing compartment (VCC) is a membranous structure found deep within HIV-1-infected macrophages that accumulates infectious particles. HIV-1 virus-like particles (red) captured by Siglec-1 (magenta) were taken into the macrophage within tubules of the CLIC/GEEC pathway (CD98 staining, green). This study demonstrates that CLIC/GEEC-mediated endocytosis of particles leads to the formation of the VCC and contributes to cell-cell spread of HIV. Candor et al. 2025
Image Credit: Kathleen Candor
Citation: (2025) PLoS Pathogens Issue Image | Vol. 21(3) April 2025. PLoS Pathog 21(3): ev21.i03. https://doi.org/10.1371/image.ppat.v21.i03
Published: April 3, 2025
Copyright: © 2025 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The virus-containing compartment (VCC) is a membranous structure found deep within HIV-1-infected macrophages that accumulates infectious particles. HIV-1 virus-like particles (red) captured by Siglec-1 (magenta) were taken into the macrophage within tubules of the CLIC/GEEC pathway (CD98 staining, green). This study demonstrates that CLIC/GEEC-mediated endocytosis of particles leads to the formation of the VCC and contributes to cell-cell spread of HIV. Candor et al. 2025
Image Credit: Kathleen Candor