Efflux pumps and membrane permeability contribute to intrinsic antibiotic resistance in Mycobacterium abscessus

• Kerry McGowen ,

  Contributed equally to this work with: Kerry McGowen, Tobias Funck

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  ¶☯ These authors contributed equally to this work.

  Affiliation Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Tobias Funck ,

  Contributed equally to this work with: Kerry McGowen, Tobias Funck

  Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

  ¶☯ These authors contributed equally to this work.

  Affiliations Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America, Department of Infectious Disease and Tropical Medicine, Heidelberg University Hospital & German Center of Infection Research partner site, Heidelberg, Germany

  ⨯
• Xin Wang,

  Roles Formal analysis, Investigation

  Affiliation Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Samuel Zinga,

  Roles Formal analysis, Investigation

  Affiliation Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Ian D. Wolf,

  Roles Formal analysis, Investigation

  Affiliation Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Chidiebere Akusobi,

  Roles Resources

  Affiliation Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Claudia M. Denkinger,

  Roles Supervision

  Affiliation Department of Infectious Disease and Tropical Medicine, Heidelberg University Hospital & German Center of Infection Research partner site, Heidelberg, Germany

  ⨯
• Eric J. Rubin,

  Roles Funding acquisition, Supervision

  Affiliation Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

  ⨯
• Mark R. Sullivan

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

  * E-mail: msullivan@hsph.harvard.edu

  Affiliation Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0001-5765-0459

  ⨯