Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6

• Taha Y. Taha ,

  Contributed equally to this work with: Taha Y. Taha, Shahrzad Ezzatpour, Jennifer M. Hayashi, Chengjin Ye

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Gladstone Institutes, San Francisco, California, United States of America, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America

  ⨯
• Shahrzad Ezzatpour ,

  Contributed equally to this work with: Taha Y. Taha, Shahrzad Ezzatpour, Jennifer M. Hayashi, Chengjin Ye

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliations Department of Microbiology, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, United States of America, Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, New York, United States of America

  ⨯
• Jennifer M. Hayashi ,

  Contributed equally to this work with: Taha Y. Taha, Shahrzad Ezzatpour, Jennifer M. Hayashi, Chengjin Ye

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Gladstone Institutes, San Francisco, California, United States of America

  ⨯
• Chengjin Ye ,

  Contributed equally to this work with: Taha Y. Taha, Shahrzad Ezzatpour, Jennifer M. Hayashi, Chengjin Ye

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Texas Biomedical Research Institute, San Antonio, Texas, United States of America

  ⨯
• Francisco J. Zapatero-Belinchón,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Gladstone Institutes, San Francisco, California, United States of America

  ⨯
• Julia A. Rosecrans,

  Roles Data curation, Investigation

  Affiliation Gladstone Institutes, San Francisco, California, United States of America

  ⨯
• Gabriella R. Kimmerly,

  Roles Data curation, Investigation

  Affiliation Gladstone Institutes, San Francisco, California, United States of America

  ⨯
• Irene P. Chen,

  Roles Data curation, Investigation

  Affiliations Gladstone Institutes, San Francisco, California, United States of America, Department of Medicine, University of California, San Francisco, California, United States of America

  ⨯
• Keith Walcott,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Gladstone Institutes, San Francisco, California, United States of America

  ⨯
• Anna Kurianowicz,

  Roles Data curation, Investigation

  Affiliation Gladstone Institutes, San Francisco, California, United States of America

  ⨯
• Danielle M. Jorgens,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

  Affiliation Electron Microscope Laboratory, University of California, Berkeley, California, United States of America

  ⨯
• Natalie R. Chaplin,

  Roles Data curation, Investigation

  Affiliation Electron Microscope Laboratory, University of California, Berkeley, California, United States of America

  ⨯
• Annette Choi,

  Roles Data curation, Investigation

  Affiliation Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, New York, United States of America

  ⨯
• David W. Buchholz,

  Roles Data curation, Investigation

  Affiliation Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, New York, United States of America

  ⨯
• Julie Sahler,

  Roles Data curation, Investigation

  Affiliation Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, New York, United States of America

  ⨯
• Zachary T. Hilt,

  Roles Data curation, Investigation

  Affiliation Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, New York, United States of America

  ⨯
• Brian Imbiakha,

  Roles Data curation, Investigation

  Affiliation Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, New York, United States of America

  ⨯
• Cecilia Vagi-Szmola,

  Roles Data curation, Investigation

  Affiliation Gladstone Institutes, San Francisco, California, United States of America

  ⨯
• Mauricio Montano,

  Roles Methodology, Resources

  Affiliation Gladstone Institutes, San Francisco, California, United States of America

  ⨯
• Erica Stevenson,

  Roles Data curation, Investigation

  Affiliations Gladstone Institutes, San Francisco, California, United States of America, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America, Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, United States of America, Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America

  ⨯
• Martin Gordon,

  Roles Data curation, Investigation

  Affiliations Gladstone Institutes, San Francisco, California, United States of America, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America, Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, United States of America, Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America

  ⨯
• Danielle L. Swaney,

  Roles Resources, Supervision

  Affiliations Gladstone Institutes, San Francisco, California, United States of America, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America, Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, United States of America, Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America

  ⨯
• Nevan J. Krogan,

  Roles Funding acquisition, Resources, Supervision

  Affiliations Gladstone Institutes, San Francisco, California, United States of America, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America, Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, United States of America, Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America

  ⨯
• Gary R. Whittaker,

  Roles Resources, Supervision

  Affiliation Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, New York, United States of America

  ⨯
• Luis Martinez-Sobrido ,

  Roles Resources, Supervision, Writing – review & editing

  * E-mail: lmartinez@txbiomed.org (LMS); ha363@cornell.edu (HCA); melanie.ott@gladstone.ucsf.edu (MO)

  Affiliation Texas Biomedical Research Institute, San Antonio, Texas, United States of America

  ⨯
• Hector C. Aguilar ,

  Roles Resources, Supervision

  * E-mail: lmartinez@txbiomed.org (LMS); ha363@cornell.edu (HCA); melanie.ott@gladstone.ucsf.edu (MO)

  Affiliations Department of Microbiology, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, United States of America, Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, New York, United States of America

  ⨯
•  [ ... ],
• Melanie Ott

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  * E-mail: lmartinez@txbiomed.org (LMS); ha363@cornell.edu (HCA); melanie.ott@gladstone.ucsf.edu (MO)

  Affiliations Gladstone Institutes, San Francisco, California, United States of America, Department of Medicine, University of California, San Francisco, California, United States of America, Chan Zuckerberg Biohub – San Francisco, San Francisco, California, United States of America

  https://orcid.org/0000-0002-5697-1274

  ⨯
• [ view all ]
• [ view less ]