Influenza A virus polymerase acidic protein E23G/K substitutions weaken key baloxavir drug-binding contacts with minimal impact on replication and transmission

• Jeremy C. Jones ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: jeremy.jones@stjude.org

  Affiliation Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

  https://orcid.org/0000-0002-9980-2112

  ⨯
• Bogdan Zagribelnyy,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemistry, Lomonosov State University, Moscow, Russian Federation

  ⨯
• Philippe Noriel Q. Pascua,

  Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Current address: Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

  Affiliation Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

  ⨯
• Dmitry S. Bezrukov,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemistry, Lomonosov State University, Moscow, Russian Federation

  ⨯
• Subrata Barman,

  Roles Conceptualization, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  Affiliation Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

  ⨯
• Faten Okda,

  Roles Investigation, Methodology, Writing – original draft

  Affiliation Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

  ⨯
• Richard J. Webby,

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

  ⨯
• Yan A. Ivanenkov,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Chemistry, Lomonosov State University, Moscow, Russian Federation

  ⨯
• Elena A. Govorkova

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

  ⨯