Plasma Membrane Profiling Defines an Expanded Class of Cell Surface Proteins Selectively Targeted for Degradation by HCMV US2 in Cooperation with UL141

Jye-Lin Hsu; Dick J. H. van den Boomen; Peter Tomasec; Michael P. Weekes; Robin Antrobus; Richard J. Stanton; Eva Ruckova; Daniel Sugrue; Gavin S. Wilkie; Andrew J. Davison; Gavin W. G. Wilkinson; Paul J. Lehner

doi:10.1371/journal.ppat.1004811

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Research Article

Plasma Membrane Profiling Defines an Expanded Class of Cell Surface Proteins Selectively Targeted for Degradation by HCMV US2 in Cooperation with UL141

Jye-Lin Hsu ,

Contributed equally to this work with: Jye-Lin Hsu, Dick J. H. van den Boomen, Peter Tomasec, Michael P. Weekes

Current address: Research Center for Tumor Medical Science, China Medical University, Taichung, Taiwan

Affiliation Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
⨯
Dick J. H. van den Boomen ,

Contributed equally to this work with: Jye-Lin Hsu, Dick J. H. van den Boomen, Peter Tomasec, Michael P. Weekes

Affiliation Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
⨯
Peter Tomasec ,

Contributed equally to this work with: Jye-Lin Hsu, Dick J. H. van den Boomen, Peter Tomasec, Michael P. Weekes

Affiliation School of Medicine, Cardiff University, Cardiff, United Kingdom
⨯
Michael P. Weekes ,

Contributed equally to this work with: Jye-Lin Hsu, Dick J. H. van den Boomen, Peter Tomasec, Michael P. Weekes

Affiliation Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
⨯
Robin Antrobus,

Affiliation Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
⨯
Richard J. Stanton,

Affiliation School of Medicine, Cardiff University, Cardiff, United Kingdom
⨯
Eva Ruckova,

Affiliation Regional Centre for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Brno, Czech Republic
⨯
Daniel Sugrue,

Affiliation School of Medicine, Cardiff University, Cardiff, United Kingdom
⨯
Gavin S. Wilkie,

Affiliation MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom
⨯
Andrew J. Davison,

Affiliation MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom
⨯
Gavin W. G. Wilkinson,

Affiliation School of Medicine, Cardiff University, Cardiff, United Kingdom
⨯
Paul J. Lehner

* E-mail: pjl30@cam.ac.uk

Affiliation Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
⨯

Plasma Membrane Profiling Defines an Expanded Class of Cell Surface Proteins Selectively Targeted for Degradation by HCMV US2 in Cooperation with UL141

Jye-Lin Hsu,
Dick J. H. van den Boomen,
Peter Tomasec,
Michael P. Weekes,
Robin Antrobus,
Richard J. Stanton,
Eva Ruckova,
Daniel Sugrue,
Gavin S. Wilkie,
Andrew J. Davison

Published: April 14, 2015
https://doi.org/10.1371/journal.ppat.1004811

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