H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis

Erhard van der Vries; Patrick J. Collins; Sebastien G. Vachieri; Xiaoli Xiong; Junfeng Liu; Philip A. Walker; Lesley F. Haire; Alan J. Hay; Martin Schutten; Albert D. M. E. Osterhaus; Steve R. Martin; Charles A. B. Boucher; John J. Skehel; Steve J. Gamblin

doi:10.1371/journal.ppat.1002914

Loading metrics

Open Access

Peer-reviewed

Research Article

H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis

Erhard van der Vries,

Affiliation Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands
⨯
Patrick J. Collins,

Affiliation Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
⨯
Sebastien G. Vachieri,

Affiliation Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
⨯
Xiaoli Xiong,

Affiliation Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
⨯
Junfeng Liu,

Affiliations Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom, MOA Key Laboratory of Plant Pathology, China Agricultural University, Beijing, People's Republic of China
⨯
Philip A. Walker,

Affiliation Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
⨯
Lesley F. Haire,

Affiliation Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
⨯
Alan J. Hay,

Affiliation Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
⨯
Martin Schutten,

Affiliation Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands
⨯
Albert D. M. E. Osterhaus,

Affiliation Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands
⨯
Steve R. Martin,

Affiliation Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
⨯
Charles A. B. Boucher,

Affiliation Erasmus Medical Centre, Department of Virology, Rotterdam, The Netherlands
⨯
John J. Skehel ,

* E-mail: skeheljj@nimr.mrc.ac.uk

Affiliation Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
⨯
Steve J. Gamblin

Affiliation Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
⨯

H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis

Erhard van der Vries,
Patrick J. Collins,
Sebastien G. Vachieri,
Xiaoli Xiong,
Junfeng Liu,
Philip A. Walker,
Lesley F. Haire,
Alan J. Hay,
Martin Schutten,
Albert D. M. E. Osterhaus

Published: September 20, 2012
https://doi.org/10.1371/journal.ppat.1002914

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Pandemics
Is the Subject Area "Pandemics" applicable to this article?

Thanks for your feedback.
Crystal structure
Is the Subject Area "Crystal structure" applicable to this article?

Thanks for your feedback.
Influenza viruses
Is the Subject Area "Influenza viruses" applicable to this article?

Thanks for your feedback.
Hydrogen bonding
Is the Subject Area "Hydrogen bonding" applicable to this article?

Thanks for your feedback.
Neuraminidase inhibitors
Is the Subject Area "Neuraminidase inhibitors" applicable to this article?

Thanks for your feedback.
Influenza
Is the Subject Area "Influenza" applicable to this article?

Thanks for your feedback.
Antimicrobial resistance
Is the Subject Area "Antimicrobial resistance" applicable to this article?

Thanks for your feedback.
H1N1
Is the Subject Area "H1N1" applicable to this article?

Thanks for your feedback.