Association of Tat with Promoters of PTEN and PP2A Subunits Is Key to Transcriptional Activation of Apoptotic Pathways in HIV-Infected CD4+ T Cells

Nayoung Kim; Sami Kukkonen; Sumeet Gupta; Anna Aldovini

doi:10.1371/journal.ppat.1001103

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Open Access

Peer-reviewed

Research Article

Association of Tat with Promoters of PTEN and PP2A Subunits Is Key to Transcriptional Activation of Apoptotic Pathways in HIV-Infected CD4+ T Cells

Nayoung Kim,

Affiliation Children's Hospital Boston, Department of Medicine, and Harvard Medical School, Department of Pediatrics, Boston, Massachusetts, United States of America
⨯
Sami Kukkonen,

Affiliation Children's Hospital Boston, Department of Medicine, and Harvard Medical School, Department of Pediatrics, Boston, Massachusetts, United States of America
⨯
Sumeet Gupta,

Affiliation Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America
⨯
Anna Aldovini

* E-mail: anna.aldovini@childrens.harvard.edu

Affiliation Children's Hospital Boston, Department of Medicine, and Harvard Medical School, Department of Pediatrics, Boston, Massachusetts, United States of America
⨯

Association of Tat with Promoters of PTEN and PP2A Subunits Is Key to Transcriptional Activation of Apoptotic Pathways in HIV-Infected CD4+ T Cells

Nayoung Kim,
Sami Kukkonen,
Sumeet Gupta,
Anna Aldovini

Published: September 16, 2010
https://doi.org/10.1371/journal.ppat.1001103

About the Authors

Nayoung Kim

Affiliation Children's Hospital Boston, Department of Medicine, and Harvard Medical School, Department of Pediatrics, Boston, Massachusetts, United States of America

Sami Kukkonen

Affiliation Children's Hospital Boston, Department of Medicine, and Harvard Medical School, Department of Pediatrics, Boston, Massachusetts, United States of America

Sumeet Gupta

Affiliation Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

Anna Aldovini

* E-mail: anna.aldovini@childrens.harvard.edu

Affiliation Children's Hospital Boston, Department of Medicine, and Harvard Medical School, Department of Pediatrics, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NK AA. Performed the experiments: NK SG. Analyzed the data: NK SG AA. Contributed reagents/materials/analysis tools: SK. Wrote the paper: NK AA. Obtained funding for the experiment: AA.

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T cells
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Apoptosis
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Small interfering RNA
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DNA transcription
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Phosphatases
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Gene expression
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HIV infections
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Immunoprecipitation
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