Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral Cap-Dependent Transcription

Juan Reguera; Friedemann Weber; Stephen Cusack

doi:10.1371/journal.ppat.1001101

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Peer-reviewed

Research Article

Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral Cap-Dependent Transcription

Juan Reguera,

Affiliations European Molecular Biology Laboratory, Grenoble Outstation, Grenoble, France, Unit of Virus Host-Cell Interactions (UMI 3265), UJF-EMBL-CNRS, Grenoble, France
⨯
Friedemann Weber,

Affiliations Department of Virology, Institute for Medical Microbiology and Hygiene, Freiburg, Germany, Institute for Virology, Philipps University Marburg, Marburg, Germany
⨯
Stephen Cusack

* E-mail: cusack@embl.fr

Affiliations European Molecular Biology Laboratory, Grenoble Outstation, Grenoble, France, Unit of Virus Host-Cell Interactions (UMI 3265), UJF-EMBL-CNRS, Grenoble, France
⨯

Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral Cap-Dependent Transcription

Juan Reguera,
Friedemann Weber,
Stephen Cusack

Published: September 16, 2010
https://doi.org/10.1371/journal.ppat.1001101

About the Authors

Juan Reguera

Affiliations European Molecular Biology Laboratory, Grenoble Outstation, Grenoble, France, Unit of Virus Host-Cell Interactions (UMI 3265), UJF-EMBL-CNRS, Grenoble, France

Friedemann Weber

Affiliations Department of Virology, Institute for Medical Microbiology and Hygiene, Freiburg, Germany, Institute for Virology, Philipps University Marburg, Marburg, Germany

Stephen Cusack

* E-mail: cusack@embl.fr

Affiliations European Molecular Biology Laboratory, Grenoble Outstation, Grenoble, France, Unit of Virus Host-Cell Interactions (UMI 3265), UJF-EMBL-CNRS, Grenoble, France

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JR FW SC. Performed the experiments: JR FW. Analyzed the data: JR FW SC. Wrote the paper: SC.

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Manganese
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Polymerases
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Nucleases
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Bunyaviruses
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Influenza viruses
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RNA structure
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RNA viruses
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