Newly Synthesized APOBEC3G Is Incorporated into HIV Virions, Inhibited by HIV RNA, and Subsequently Activated by RNase H

Vanessa B Soros; Wes Yonemoto; Warner C Greene

doi:10.1371/journal.ppat.0030015

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Open Access

Peer-reviewed

Research Article

Newly Synthesized APOBEC3G Is Incorporated into HIV Virions, Inhibited by HIV RNA, and Subsequently Activated by RNase H

Vanessa B Soros,

Affiliation Gladstone Institute of Virology and Immunology, San Francisco, California, United States of America
⨯
Wes Yonemoto,

Affiliation Gladstone Institute of Virology and Immunology, San Francisco, California, United States of America
⨯
Warner C Greene

*To whom correspondence should be addressed. E-mail: wgreene@gladstone.ucsf.edu

Affiliations Gladstone Institute of Virology and Immunology, San Francisco, California, United States of America , Department of Medicine, University of California San Francisco, San Francisco, California, United States of America , Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America
⨯

Newly Synthesized APOBEC3G Is Incorporated into HIV Virions, Inhibited by HIV RNA, and Subsequently Activated by RNase H

Vanessa B Soros,
Wes Yonemoto,
Warner C Greene

Published: February 9, 2007
https://doi.org/10.1371/journal.ppat.0030015

About the Authors

Vanessa B Soros

Affiliation Gladstone Institute of Virology and Immunology, San Francisco, California, United States of America

Wes Yonemoto

Affiliation Gladstone Institute of Virology and Immunology, San Francisco, California, United States of America

Warner C Greene

*To whom correspondence should be addressed. E-mail: wgreene@gladstone.ucsf.edu

Affiliations Gladstone Institute of Virology and Immunology, San Francisco, California, United States of America , Department of Medicine, University of California San Francisco, San Francisco, California, United States of America , Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

VBS, WY, and WCG conceived and designed the experiments. VBS and WY performed the experiments, analyzed the data, and contributed reagents/materials/analysis tools. VBS and WCG wrote the paper.

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Virions
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Ribonucleases
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Hidden Markov models
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HIV
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Radiolabeling
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Ribozymes
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Reverse transcription
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Immunoprecipitation
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