December 2006

A germline mutation in the palladin gene associated with familial pancreatic cancer causes abnormal distribution of the cytoskeletal palladin protein in transfected cells, as shown here. The research article by Pogue-Geile et al. reports the identification of the mutation in a large kindred with pancreatic cancer, as well as the findings that palladin is overexpressed in sporadic pancreatic cancers and that cells expressing the mutant protein have an increased ability to migrate.

Image Credit: Cover design by Natalie Davis, Public Library of Science, with images taken from Pogue-Geile et al.

Editorial

Drug Development Papers in PLoS Medicine: How We Try to Spot a Winner

The PLoS Medicine Editors, Sanjeev Krishna

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030547

Essays

Do We Need a World Health Insurance to Realise the Right to Health?

Gorik Ooms, Katharine Derderian, David Melody

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030530

Intensive Insulin Therapy in Intensive Care: An Example of the Struggle to Implement Evidence-Based Medicine

Marcus J Schultz, Annick A. N. M Royakkers, Marcel Levi, Hazra S Moeniralam, Peter E Spronk

PLOS Medicine: published December 5, 2006 | https://doi.org/10.1371/journal.pmed.0030456

Perspectives

Stem Cells and Metastatic Cancer: Fatal Attraction?

Riccardo Fodde

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030482

Mining Methylation for Early Detection of Common Cancers

Romulo M Brena, Christoph Plass, Joseph F Costello

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030479

Antibodies and Brain Disease: A Convergence of Immunology and Physiology

Betty Diamond, Bruce T Volpe

PLOS Medicine: published December 19, 2006 | https://doi.org/10.1371/journal.pmed.0030498

Impact of Antiretroviral Therapy on Intestinal Lymphoid Tissues in HIV Infection

Ronald S Veazey, Andrew A Lackner

PLOS Medicine: published December 5, 2006 | https://doi.org/10.1371/journal.pmed.0030515

Visual Loss in Postconflict Southern Sudan

John Buchan

PLOS Medicine: published December 19, 2006 | https://doi.org/10.1371/journal.pmed.0030450

Blindness in Sudan: Is It Time to Scrutinise Survey Methods?

Hannah Kuper, Clare Gilbert

PLOS Medicine: published December 19, 2006 | https://doi.org/10.1371/journal.pmed.0030476

Are Residents' Extended Shifts Associated With Adverse Events?

Mariana Szklo-Coxe

PLOS Medicine: published December 12, 2006 | https://doi.org/10.1371/journal.pmed.0030497

TV and Inactivity Are Separate Contributors to Metabolic Risk Factors in Children

Andrew Prentice, Susan Jebb

PLOS Medicine: published December 12, 2006 | https://doi.org/10.1371/journal.pmed.0030481

Health in Action

Healthy Penis: San Francisco's Social Marketing Campaign to Increase Syphilis Testing among Gay and Bisexual Men

Katherine Ahrens, Charlotte K Kent, Jorge A Montoya, Harlan Rotblatt, Jacque McCright, Peter Kerndt, Jeffrey D Klausner

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030474

The Malaria Atlas Project: Developing Global Maps of Malaria Risk

Simon I Hay, Robert W Snow

PLOS Medicine: published December 5, 2006 | https://doi.org/10.1371/journal.pmed.0030473

Learning Forums

Ophthalmoplegia and Slurred Speech in an Intravenous Drug User

Jaime Vera, Anke Hensiek, Charles Woodrow, Francesca Crawley, Sanjeev Krishna

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030453

Hypogammaglobulinemia with Facial Edema

Adina Kay Knight, Lloyd Mayer, Andrew G Franks Jr., Charlotte Cunningham-Rundles

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030475

Research Articles

Palladin Mutation Causes Familial Pancreatic Cancer and Suggests a New Cancer Mechanism

Kay L Pogue-Geile, Ru Chen, Mary P Bronner, Tatjana Crnogorac-Jurcevic, Kara White Moyes, Sally Dowen, Carol A Otey, David A Crispin, Ryan D George, David C Whitcomb, Teresa A Brentnall

PLOS Medicine: published December 12, 2006 | https://doi.org/10.1371/journal.pmed.0030516

A Gene Expression Signature Predicts Survival of Patients with Stage I Non-Small Cell Lung Cancer

Yan Lu, William Lemon, Peng-Yuan Liu, Yijun Yi, Carl Morrison, Ping Yang, Zhifu Sun, Janos Szoke, William L Gerald, Mark Watson, Ramaswamy Govindan, Ming You

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030467

A Genome-Wide Screen for Promoter Methylation in Lung Cancer Identifies Novel Methylation Markers for Multiple Malignancies

David S Shames, Luc Girard, Boning Gao, Mitsuo Sato, Cheryl M Lewis, Narayan Shivapurkar, Aixiang Jiang, Charles M Perou, Young H Kim, Jonathan R Pollack, Kwun M Fong, Chi-Leung Lam, Maria Wong, Yu Shyr, Rita Nanda, Olufunmilayo I Olopade, William Gerald, David M Euhus, Jerry W Shay, Adi F Gazdar, John D Minna

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030486

Epidermal Growth Factor Receptor Activation in Glioblastoma through Novel Missense Mutations in the Extracellular Domain

Jeffrey C Lee, Igor Vivanco, Rameen Beroukhim, Julie H. Y Huang, Whei L Feng, Ralph M DeBiasi, Koji Yoshimoto, Jennifer C King, Phioanh Nghiemphu, Yuki Yuza, Qing Xu, Heidi Greulich, Roman K Thomas, J. Guillermo Paez, Timothy C Peck, David J Linhart, Karen A Glatt, Gad Getz, Robert Onofrio, Liuda Ziaugra, Ross L Levine, Stacey Gabriel, Tomohiro Kawaguchi, Keith O'Neill, Haumith Khan, Linda M Liau, Stanley F Nelson, P. Nagesh Rao, Paul Mischel, Russell O Pieper, Tim Cloughesy, Daniel J Leahy, William R Sellers, Charles L Sawyers, Matthew Meyerson, Ingo K Mellinghoff

PLOS Medicine: published December 19, 2006 | https://doi.org/10.1371/journal.pmed.0030485

Elevated Serum Levels of Interferon-Regulated Chemokines Are Biomarkers for Active Human Systemic Lupus Erythematosus

Jason W Bauer, Emily C Baechler, Michelle Petri, Franak M Batliwalla, Dianna Crawford, Ward A Ortmann, Karl J Espe, Wentian Li, Dhavalkumar D Patel, Peter K Gregersen, Timothy W Behrens

PLOS Medicine: published December 19, 2006 | https://doi.org/10.1371/journal.pmed.0030491

Selective Involvement of the Amygdala in Systemic Lupus Erythematosus

Bart J Emmer, Jeroen van der Grond, Gerda M Steup-Beekman, Tom W. J Huizinga, Mark A van Buchem

PLOS Medicine: published December 19, 2006 | https://doi.org/10.1371/journal.pmed.0030499

Hyaluronate Fragments Reverse Skin Atrophy by a CD44-Dependent Mechanism

Gürkan Kaya, Christian Tran, Olivier Sorg, Raymonde Hotz, Denise Grand, Pierre Carraux, Liliane Didierjean, Ivan Stamenkovic, Jean-Hilaire Saurat

PLOS Medicine: published December 19, 2006 | https://doi.org/10.1371/journal.pmed.0030493

Angiotensin-Converting Enzyme I/D Polymorphism and Preeclampsia Risk: Evidence of Small-Study Bias

Norma C Serrano, Luis A Díaz, Maria C Páez, Clara M Mesa, Rodrigo Cifuentes, Alvaro Monterrosa, Adriana González, Liam Smeeth, Aroon D Hingorani, Juan P Casas

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030520

Lipoprotein Particle Profiles Mark Familial and Sporadic Human Longevity

Bastiaan T Heijmans, Marian Beekman, Jeanine J Houwing-Duistermaat, Mark R Cobain, Jonathan Powell, Gerard Jan Blauw, Frans van der Ouderaa, Rudi G. J Westendorp, P. Eline Slagboom

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030495

Impaired Hepatitis C Virus-Specific T Cell Responses and Recurrent Hepatitis C Virus in HIV Coinfection

Arthur Y Kim, Julian Schulze zur Wiesch, Thomas Kuntzen, Joerg Timm, Daniel E Kaufmann, Jared E Duncan, Andrea M Jones, Alysse G Wurcel, Benjamin T Davis, Rajesh T Gandhi, Gregory K Robbins, Todd M Allen, Raymond T Chung, Georg M Lauer, Bruce D Walker

PLOS Medicine: published December 12, 2006 | https://doi.org/10.1371/journal.pmed.0030492

Lack of Mucosal Immune Reconstitution during Prolonged Treatment of Acute and Early HIV-1 Infection

Saurabh Mehandru, Michael A Poles, Klara Tenner-Racz, Patrick Jean-Pierre, Victoria Manuelli, Peter Lopez, Anita Shet, Andrea Low, Hiroshi Mohri, Daniel Boden, Paul Racz, Martin Markowitz

PLOS Medicine: published December 5, 2006 | https://doi.org/10.1371/journal.pmed.0030484

Cost-Effectiveness of Male Circumcision for HIV Prevention in a South African Setting

James G Kahn, Elliot Marseille, Bertran Auvert

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030517

Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants

Damon Deming, Timothy Sheahan, Mark Heise, Boyd Yount, Nancy Davis, Amy Sims, Mehul Suthar, Jack Harkema, Alan Whitmore, Raymond Pickles, Ande West, Eric Donaldson, Kristopher Curtis, Robert Johnston, Ralph Baric

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030525

Tuberculosis among Health-Care Workers in Low- and Middle-Income Countries: A Systematic Review

Rajnish Joshi, Arthur L Reingold, Dick Menzies, Madhukar Pai

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030494

A Plant-Derived Morphinan as a Novel Lead Compound Active against Malaria Liver Stages

Maëlle Carraz, Akino Jossang, Jean-François Franetich, Anthony Siau, Liliane Ciceron, Laurent Hannoun, Robert Sauerwein, François Frappier, Philippe Rasoanaivo, Georges Snounou, Dominique Mazier

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030513

Erythrocyte G Protein as a Novel Target for Malarial Chemotherapy

Sean C Murphy, Travis Harrison, Heidi E Hamm, Jon W Lomasney, Narla Mohandas, Kasturi Haldar

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030528

Prevalence and Causes of Blindness and Low Vision in Southern Sudan

Jeremiah Ngondi, Francis Ole-Sempele, Alice Onsarigo, Ibrahim Matende, Samson Baba, Mark Reacher, Fiona Matthews, Carol Brayne, Paul M Emerson

PLOS Medicine: published December 19, 2006 | https://doi.org/10.1371/journal.pmed.0030477

Blinding Trachoma in Postconflict Southern Sudan

Jeremiah Ngondi, Francis Ole-Sempele, Alice Onsarigo, Ibrahim Matende, Samson Baba, Mark Reacher, Fiona Matthews, Carol Brayne, Paul Emerson

PLOS Medicine: published December 19, 2006 | https://doi.org/10.1371/journal.pmed.0030478

Children with Severe Malnutrition: Can Those at Highest Risk of Death Be Identified with the WHO Protocol?

Kathryn Maitland, James A Berkley, Mohammed Shebbe, Norbert Peshu, Michael English, Charles R. J. C Newton

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030500

Impact of Extended-Duration Shifts on Medical Errors, Adverse Events, and Attentional Failures

Laura K Barger, Najib T Ayas, Brian E Cade, John W Cronin, Bernard Rosner, Frank E Speizer, Charles A Czeisler

PLOS Medicine: published December 12, 2006 | https://doi.org/10.1371/journal.pmed.0030487

TV Viewing and Physical Activity Are Independently Associated with Metabolic Risk in Children: The European Youth Heart Study

Ulf Ekelund, Søren Brage, Karsten Froberg, Maarike Harro, Sigmund A Anderssen, Luis B Sardinha, Chris Riddoch, Lars Bo Andersen

PLOS Medicine: published December 12, 2006 | https://doi.org/10.1371/journal.pmed.0030488

Correspondence

Multidrug-Resistant TB in the Philippines: Totem and Taboo

Jose Luis Portero, Maria Rubio

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030539

Multidrug-Resistant TB in the Philippines: Authors' Reply

Thelma Tupasi

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030549

HIV-1 Viral Load Assays for Resource-Limited Settings: Clades Matter

Wolfgang Preiser, Jan Felix Drexler, Christian Drosten

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030538

Enrolling Adolescents in Research on HIV: Young Women Must Be Included

Alana de Kock, Stephanie Skoler, Khatija Ahmed, Sumen Govender

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030537

HIV-1 Subtype and Reverse Transcriptase Genotype: Role for Geographical Location and Founder Effects

Akinyemi I Ojesina, Phyllis J Kanki

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030540

Cost-Effective Control of Drug-Resistant TB: Listening to Other Voices

Jose Luis Portero, Maria Rubio

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030542

Reassurance: Medically Unexplained Physical Symptoms

Bill Anderson

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030541

HIV-1 Viral Load Assays for Resource-Limited Settings: Authors' Reply

Susan A Fiscus

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030550

Corrections

Correction: Lack of Mucosal Immune Reconstitution during Prolonged Treatment of Acute and Early HIV-1 Infection

Saurabh Mehandru, Michael A Poles, Klara Tenner-Racz, Patrick Jean-Pierre, Victoria Manuelli, Peter Lopez, Anita Shet, Andrea Low, Hiroshi Mohri, Daniel Boden, Paul Racz, Martin Markowitz

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030546

Correction: Eight Americas: Investigating Mortality Disparities across Races, Counties, and Race-Counties in the United States

Christopher J. L Murray, Sandeep C Kulkarni, Catherine Michaud, Niels Tomijima, Maria T Bulzacchelli, Terrell J Iandiorio, Majid Ezzati

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030545

Correction: Is the Current Management of Severe Sepsis and Septic Shock Really Evidence Based?

Jean-Louis Vincent

PLOS Medicine: published December 26, 2006 | https://doi.org/10.1371/journal.pmed.0030543

Cover

Mutant Palladin Protein in Pancreatic Cancer.

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