Bungarus multicinctus is the most venomous snake distributed in China and neighboring countries. LD50 values of isolated α-, β- and γ-bungarotoxins determined via three administration pathways indicated that the toxicities of β-bungarotoxin were closely related with injection routines but those of both α- and γ-bungarotoxins were not related. Commercial B. multicinctus antivenin weakly recognized α- and γ-bungarotoxins. Although B. multicinctus antivenin showed immunoreaction with high molecular weight fractions of B. fasciatus, Naja atra, Ophiophagus hannah venoms, the antivenin only demonstrated animal protection efficacy against O. hannah venom. Lin, et al. (2020)
Image Credit: Dr. Wen-Hui Lee
Editorial
A tribute to Cecilio Romaña: Romaña’s sign in Chagas disease
PLOS Neglected Tropical Diseases: published November 12, 2020 | https://doi.org/10.1371/journal.pntd.0008836
Viewpoints
NTDs in the age of urbanization, climate change, and conflict: Karachi, Pakistan as a case study
PLOS Neglected Tropical Diseases: published November 12, 2020 | https://doi.org/10.1371/journal.pntd.0008791
Policy Platform
Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with “screen, diagnose and treat” using innovative tools and strategies
PLOS Neglected Tropical Diseases: published November 12, 2020 | https://doi.org/10.1371/journal.pntd.0008738
Research Articles
Comparing machine learning with case-control models to identify confirmed dengue cases
PLOS Neglected Tropical Diseases: published November 10, 2020 | https://doi.org/10.1371/journal.pntd.0008843
Circulating microtranscriptome profiles reveal distinct expression of microRNAs in severe leptospirosis
PLOS Neglected Tropical Diseases: published November 11, 2020 | https://doi.org/10.1371/journal.pntd.0008809
The risk of adverse clinical outcomes following treatment of Plasmodium vivax malaria with and without primaquine in Papua, Indonesia
PLOS Neglected Tropical Diseases: published November 11, 2020 | https://doi.org/10.1371/journal.pntd.0008838
Performance of molecular and serologic tests for the diagnosis of scrub typhus
PLOS Neglected Tropical Diseases: published November 12, 2020 | https://doi.org/10.1371/journal.pntd.0008747
Morbidity management and surveillance of lymphatic filariasis disease and acute dermatolymphangioadenitis attacks using a mobile phone-based tool by community health volunteers in Ghana
PLOS Neglected Tropical Diseases: published November 12, 2020 | https://doi.org/10.1371/journal.pntd.0008839
A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: Application to a dose-finding trial for a novel Russell’s viper antivenom in Myanmar
PLOS Neglected Tropical Diseases: published November 16, 2020 | https://doi.org/10.1371/journal.pntd.0008109
Long-read RNA sequencing of human and animal filarial parasites improves gene models and discovers operons
PLOS Neglected Tropical Diseases: published November 16, 2020 | https://doi.org/10.1371/journal.pntd.0008869
The effects of exposure to pyriproxyfen and predation on Zika virus infection and transmission in Aedes aegypti
PLOS Neglected Tropical Diseases: published November 17, 2020 | https://doi.org/10.1371/journal.pntd.0008846
Antigenicity, stability, and reproducibility of Zika reporter virus particles for long-term applications
PLOS Neglected Tropical Diseases: published November 18, 2020 | https://doi.org/10.1371/journal.pntd.0008730
Comparative analysis of virulence determinants, phylogroups, and antibiotic susceptibility patterns of typical versus atypical Enteroaggregative E. coli in India
PLOS Neglected Tropical Diseases: published November 18, 2020 | https://doi.org/10.1371/journal.pntd.0008769
The awareness of neglected tropical diseases in a sample of medical and nursing students in Cairo University, Egypt: A cross-sectional study
PLOS Neglected Tropical Diseases: published November 18, 2020 | https://doi.org/10.1371/journal.pntd.0008826
West Nile virus in California, 2003–2018: A persistent threat
PLOS Neglected Tropical Diseases: published November 18, 2020 | https://doi.org/10.1371/journal.pntd.0008841
Vaccination with novel low-molecular weight proteins secreted from Trichinella spiralis inhibits establishment of infection
PLOS Neglected Tropical Diseases: published November 18, 2020 | https://doi.org/10.1371/journal.pntd.0008842
From resistance to persistence: Insights of a mathematical model on the indiscriminate use of insecticide
PLOS Neglected Tropical Diseases: published November 18, 2020 | https://doi.org/10.1371/journal.pntd.0008862
Spatial analysis of COVID-19 spread in Iran: Insights into geographical and structural transmission determinants at a province level
PLOS Neglected Tropical Diseases: published November 18, 2020 | https://doi.org/10.1371/journal.pntd.0008875
Detection of the Nav channel kdr-like mutation and modeling of factors affecting survivorship of Culex quinquefasciatus mosquitoes from six areas of Harris County (Houston), Texas, after permethrin field-cage tests
PLOS Neglected Tropical Diseases: published November 19, 2020 | https://doi.org/10.1371/journal.pntd.0008860
Novel small RNAs expressed by Bartonella bacilliformis under multiple conditions reveal potential mechanisms for persistence in the sand fly vector and human host
PLOS Neglected Tropical Diseases: published November 20, 2020 | https://doi.org/10.1371/journal.pntd.0008671
Immortalized stem cell-derived hepatocyte-like cells: An alternative model for studying dengue pathogenesis and therapy
PLOS Neglected Tropical Diseases: published November 20, 2020 | https://doi.org/10.1371/journal.pntd.0008835
Evaluation of the cell culture based and the mouse brain derived inactivated vaccines against Crimean-Congo hemorrhagic fever virus in transiently immune-suppressed (IS) mouse model
PLOS Neglected Tropical Diseases: published November 23, 2020 | https://doi.org/10.1371/journal.pntd.0008834
Modelling habitat suitability in Jordan for the cutaneous leishmaniasis vector (Phlebotomus papatasi) using multicriteria decision analysis
PLOS Neglected Tropical Diseases: published November 23, 2020 | https://doi.org/10.1371/journal.pntd.0008852
Linking mosquito surveillance to dengue fever through Bayesian mechanistic modeling
PLOS Neglected Tropical Diseases: published November 23, 2020 | https://doi.org/10.1371/journal.pntd.0008868
Salmonella identified in pigs in Kenya and Malawi reveals the potential for zoonotic transmission in emerging pork markets
PLOS Neglected Tropical Diseases: published November 24, 2020 | https://doi.org/10.1371/journal.pntd.0008796
Hazara virus and Crimean-Congo Hemorrhagic Fever Virus show a different pattern of entry in fully-polarized Caco-2 cell line
PLOS Neglected Tropical Diseases: published November 24, 2020 | https://doi.org/10.1371/journal.pntd.0008863
A pilot study demonstrating the identification of Trypanosoma brucei gambiense and T. b. rhodesiense in vectors using a multiplexed high-resolution melt qPCR
PLOS Neglected Tropical Diseases: published November 25, 2020 | https://doi.org/10.1371/journal.pntd.0008308
Gender differences in the perceived need for community-wide deworming: Formative qualitative research from the DeWorm3 study, India
PLOS Neglected Tropical Diseases: published November 25, 2020 | https://doi.org/10.1371/journal.pntd.0008829
Mass administration of medicines in changing contexts: Acceptability, adaptability and community directed approaches in Kaduna and Ogun States, Nigeria
PLOS Neglected Tropical Diseases: published November 25, 2020 | https://doi.org/10.1371/journal.pntd.0008857
Population genomic evidence that human and animal infections in Africa come from the same populations of Dracunculus medinensis
PLOS Neglected Tropical Diseases: published November 30, 2020 | https://doi.org/10.1371/journal.pntd.0008623
SARS-CoV-2 lineage B.6 was the major contributor to early pandemic transmission in Malaysia
PLOS Neglected Tropical Diseases: published November 30, 2020 | https://doi.org/10.1371/journal.pntd.0008744
Hantavirus pulmonary syndrome outbreaks associated with climate variability in Northwestern Argentina, 1997–2017
PLOS Neglected Tropical Diseases: published November 30, 2020 | https://doi.org/10.1371/journal.pntd.0008786
Knowledge of health workers on snakes and snakebite management and treatment seeking behavior of snakebite victims in Bhutan
PLOS Neglected Tropical Diseases: published November 30, 2020 | https://doi.org/10.1371/journal.pntd.0008793
Early impairment of myocardial deformation assessed by regional speckle-tracking echocardiography in the indeterminate form of Chagas disease without fibrosis detected by cardiac magnetic resonance
PLOS Neglected Tropical Diseases: published November 30, 2020 | https://doi.org/10.1371/journal.pntd.0008795
Determinants of two-year mortality among HIV positive patients with Cryptococcal meningitis initiating standard antifungal treatment with or without adjunctive dexamethasone in Uganda
PLOS Neglected Tropical Diseases: published November 30, 2020 | https://doi.org/10.1371/journal.pntd.0008823
The economic burden of dengue fever in the Kingdom of Saudi Arabia
PLOS Neglected Tropical Diseases: published November 30, 2020 | https://doi.org/10.1371/journal.pntd.0008847
A community survey of coverage and adverse events following country-wide triple-drug mass drug administration for lymphatic filariasis elimination, Samoa 2018
PLOS Neglected Tropical Diseases: published November 30, 2020 | https://doi.org/10.1371/journal.pntd.0008854
Analyses of the performance of the Ebola virus disease alert management system in South Sudan: August 2018 to November 2019
PLOS Neglected Tropical Diseases: published November 30, 2020 | https://doi.org/10.1371/journal.pntd.0008872
Immunoreactivity and neutralization study of Chinese Bungarus multicinctus antivenin and lab-prepared anti-bungarotoxin antisera towards purified bungarotoxins and snake venoms
PLOS Neglected Tropical Diseases: published November 30, 2020 | https://doi.org/10.1371/journal.pntd.0008873
Epilepsy surveillance in normocephalic children with and without prenatal Zika virus exposure
PLOS Neglected Tropical Diseases: published November 30, 2020 | https://doi.org/10.1371/journal.pntd.0008874
Extracellular non-coding RNA signatures of the metacestode stage of Echinococcus multilocularis
PLOS Neglected Tropical Diseases: published November 30, 2020 | https://doi.org/10.1371/journal.pntd.0008890
Evaluation of the sensitivity and specificity of GST-tagged recombinant antigens 2B2t, Ag5t and DIPOL in ELISA for the diagnosis and follow up of patients with cystic echinococcosis
PLOS Neglected Tropical Diseases: published November 30, 2020 | https://doi.org/10.1371/journal.pntd.0008892
Broad diversity of Mycobacterium tuberculosis complex strains isolated from humans and cattle in Northern Algeria suggests a zoonotic transmission cycle
PLOS Neglected Tropical Diseases: published November 30, 2020 | https://doi.org/10.1371/journal.pntd.0008894
Time delays in treatment of snakebite patients in rural Sri Lanka and the need for rapid diagnostic tests
PLOS Neglected Tropical Diseases: published November 30, 2020 | https://doi.org/10.1371/journal.pntd.0008914
Transmission competence of a new mesonivirus, Yichang virus, in mosquitoes and its interference with representative flaviviruses
PLOS Neglected Tropical Diseases: published November 30, 2020 | https://doi.org/10.1371/journal.pntd.0008920