December 2018

When investigating yellow fever cases in Matadi, a port city on the DRC-Angola border, the "urban cycle" of yellow fever transmission involving A. aegypti mosquitoes was less "urban" than anticipated. Shortly after, the dry season started, Matadi's residents were vaccinated, and the outbreak stopped. Ingelbeen, et al (2018)

Image Credit: Brecht Ingelbeen

Editorial

Enteric infection and dysfunction—A new target for PLOS Neglected Tropical Diseases

Michael B. Arndt, Judd L. Walson

PLOS Neglected Tropical Diseases: published December 28, 2018 | https://doi.org/10.1371/journal.pntd.0006906

Policy Platform

The elimination of human African trypanosomiasis is in sight: Report from the third WHO stakeholders meeting on elimination of gambiense human African trypanosomiasis

Michael P. Barrett

PLOS Neglected Tropical Diseases: published December 6, 2018 | https://doi.org/10.1371/journal.pntd.0006925

From Innovation to Application

Rapid and sensitive detection of Chlamydia trachomatis sexually transmitted infections in resource-constrained settings in Thailand at the point-of-care

Naraporn Somboonna, Ilada Choopara, Narong Arunrut, Kanchapan Sukhonpan, Jarun Sayasathid, Deborah Dean, Wansika Kiatpathomchai

PLOS Neglected Tropical Diseases: published December 20, 2018 | https://doi.org/10.1371/journal.pntd.0006900

Review

Integrated Aedes management for the control of Aedes-borne diseases

David Roiz, Anne L. Wilson, Thomas W. Scott, Dina M. Fonseca, Frédéric Jourdain, Pie Müller, Raman Velayudhan, Vincent Corbel

PLOS Neglected Tropical Diseases: published December 6, 2018 | https://doi.org/10.1371/journal.pntd.0006845

Research Articles

Epidemiological characteristics and determinants of dengue transmission during epidemic and non-epidemic years in Fortaleza, Brazil: 2011-2015

Benjamin MacCormack-Gelles, Antonio S. Lima Neto, Geziel S. Sousa, Osmar J. Nascimento, Marcia M. T. Machado, Mary E. Wilson, Marcia C. Castro

PLOS Neglected Tropical Diseases: published December 3, 2018 | https://doi.org/10.1371/journal.pntd.0006990

Development of sandwich ELISA and lateral flow strip assays for diagnosing clinically significant snakebite in Taiwan

Chien-Chun Liu, Jau-Song Yu, Po-Jung Wang, Yung-Chin Hsiao, Chien-Hsin Liu, Yen-Chia Chen, Pei-Fang Lai, Chih-Po Hsu, Wen-Chih Fann, Chih-Chuan Lin

PLOS Neglected Tropical Diseases: published December 3, 2018 | https://doi.org/10.1371/journal.pntd.0007014

Prioritizing surveillance activities for certification of yaws eradication based on a review and model of historical case reporting

Christopher Fitzpatrick, Kingsley Asiedu, Anthony W. Solomon, Oriol Mitja, Michael Marks, Patrick Van der Stuyft, Filip Meheus

PLOS Neglected Tropical Diseases: published December 4, 2018 | https://doi.org/10.1371/journal.pntd.0006953

Human antibody reaction against recombinant salivary proteins of Phlebotomus orientalis in Eastern Africa

Petra Sumova, Michal Sima, Tatiana Spitzova, Maha E. Osman, Anderson B. Guimaraes-Costa, Fabiano Oliveira, Dia-Eldin A. Elnaiem, Asrat Hailu, Alon Warburg, Jesus G. Valenzuela, Petr Volf

PLOS Neglected Tropical Diseases: published December 4, 2018 | https://doi.org/10.1371/journal.pntd.0006981

Trypanosoma cruzi-specific IFN-γ-producing cells in chronic Chagas disease associate with a functional IL-7/IL-7R axis

María A. Natale, Gonzalo A. César, María G. Alvarez, Melisa D. Castro Eiro, Bruno Lococo, Graciela Bertocchi, María C. Albareda, Susana A. Laucella

PLOS Neglected Tropical Diseases: published December 5, 2018 | https://doi.org/10.1371/journal.pntd.0006998

Predicted short and long-term impact of deworming and water, hygiene, and sanitation on transmission of soil-transmitted helminths

Luc E. Coffeng, Susana Vaz Nery, Darren J. Gray, Roel Bakker, Sake J. de Vlas, Archie C. A. Clements

PLOS Neglected Tropical Diseases: published December 6, 2018 | https://doi.org/10.1371/journal.pntd.0006758

Reinvestigating the status of malaria parasite (Plasmodium sp.) in Indian non-human primates

Jyotsana Dixit, Arun Zachariah, Sajesh P. K., Bathrachalam Chandramohan, Vinoth Shanmuganatham, K. Praveen Karanth

PLOS Neglected Tropical Diseases: published December 6, 2018 | https://doi.org/10.1371/journal.pntd.0006801

Age trends in asymptomatic and symptomatic Leishmania donovani infection in the Indian subcontinent: A review and analysis of data from diagnostic and epidemiological studies

Lloyd A. C. Chapman, Alex L. K. Morgan, Emily R. Adams, Caryn Bern, Graham F. Medley, T. Déirdre Hollingsworth

PLOS Neglected Tropical Diseases: published December 6, 2018 | https://doi.org/10.1371/journal.pntd.0006803

Visceral leishmaniasis: Spatiotemporal heterogeneity and drivers underlying the hotspots in Muzaffarpur, Bihar, India

Caroline A. Bulstra, Epke A. Le Rutte, Paritosh Malaviya, Epco C. Hasker, Luc E. Coffeng, Albert Picado, Om Prakash Singh, Marleen C. Boelaert, Sake J. de Vlas, Shyam Sundar

PLOS Neglected Tropical Diseases: published December 6, 2018 | https://doi.org/10.1371/journal.pntd.0006888

Monitoring the elimination of human African trypanosomiasis: Update to 2016

José R. Franco, Giuliano Cecchi, Gerardo Priotto, Massimo Paone, Abdoulaye Diarra, Lise Grout, Pere P. Simarro, Weining Zhao, Daniel Argaw

PLOS Neglected Tropical Diseases: published December 6, 2018 | https://doi.org/10.1371/journal.pntd.0006890

2'-Hydroxyflavanone activity in vitro and in vivo against wild-type and antimony-resistant Leishmania amazonensis

Luiza F. O. Gervazoni, Gabriella Gonçalves-Ozório, Elmo E. Almeida-Amaral

PLOS Neglected Tropical Diseases: published December 6, 2018 | https://doi.org/10.1371/journal.pntd.0006930

Statistical modeling of the effect of rainfall flushing on dengue transmission in Singapore

Corey M. Benedum, Osama M. E. Seidahmed, Elfatih A. B. Eltahir, Natasha Markuzon

PLOS Neglected Tropical Diseases: published December 6, 2018 | https://doi.org/10.1371/journal.pntd.0006935

Safety and efficacy of the rSh28GST urinary schistosomiasis vaccine: A phase 3 randomized, controlled trial in Senegalese children

Gilles Riveau, Anne-Marie Schacht, Jean-Pierre Dompnier, Dominique Deplanque, Modou Seck, Nawal Waucquier, Simon Senghor, Delphine Delcroix-Genete, Emmanuel Hermann, Noureddine Idris-Khodja, Claire Levy-Marchal, Monique Capron, André Capron

PLOS Neglected Tropical Diseases: published December 7, 2018 | https://doi.org/10.1371/journal.pntd.0006968

Vector competence of biting midges and mosquitoes for Shuni virus

Tim W. R. Möhlmann, Judith Oymans, Paul J. Wichgers Schreur, Constantianus J. M. Koenraadt, Jeroen Kortekaas, Chantal B. F. Vogels

PLOS Neglected Tropical Diseases: published December 7, 2018 | https://doi.org/10.1371/journal.pntd.0006993

Urban yellow fever outbreak—Democratic Republic of the Congo, 2016: Towards more rapid case detection

Brecht Ingelbeen, Nadine A. Weregemere, Harold Noel, Gaston P. Tshapenda, Mathias Mossoko, Justus Nsio, Axelle Ronsse, Steve Ahuka-Mundeke, Sandra Cohuet, Benoît I. Kebela

PLOS Neglected Tropical Diseases: published December 7, 2018 | https://doi.org/10.1371/journal.pntd.0007029

Asymptomatic carriage of Streptococcus pneumoniae detected by qPCR on the palm of hands of populations in rural Senegal

Codou Ndiaye, Hubert Bassene, Jean-Christophe Lagier, Didier Raoult, Cheikh Sokhna

PLOS Neglected Tropical Diseases: published December 10, 2018 | https://doi.org/10.1371/journal.pntd.0006945

Potential inconsistencies in Zika surveillance data and our understanding of risk during pregnancy

James A. Hay, Pierre Nouvellet, Christl A. Donnelly, Steven Riley

PLOS Neglected Tropical Diseases: published December 10, 2018 | https://doi.org/10.1371/journal.pntd.0006991

The disabling consequences of Mycetoma

Mustafa Abbas, Peter Siordet Scolding, Abubaker Ahmed Yosif, Roa Fath EL Rahman, Melka O. EL-Amin, Mohamed Kamal Elbashir, Nora Groce, Ahmed Hassan Fahal

PLOS Neglected Tropical Diseases: published December 10, 2018 | https://doi.org/10.1371/journal.pntd.0007019

Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum

John B. Patton, Sasisekhar Bennuru, Mark L. Eberhard, Jessica A. Hess, April Torigian, Sara Lustigman, Thomas B. Nutman, David Abraham

PLOS Neglected Tropical Diseases: published December 12, 2018 | https://doi.org/10.1371/journal.pntd.0006977

Schistosomiasis is associated with incident HIV transmission and death in Zambia

Kristin M. Wall, William Kilembe, Bellington Vwalika, Cecile Dinh, Paul Livingston, Yeuk-Mui Lee, Shabir Lakhi, Debi Boeras, Htee Khu Naw, Ilene Brill, Elwyn Chomba, Tyronza Sharkey, Rachel Parker, Erin Shutes, Amanda Tichacek, W. Evan Secor, Susan Allen

PLOS Neglected Tropical Diseases: published December 13, 2018 | https://doi.org/10.1371/journal.pntd.0006902

Economic impact of dengue in Mexico considering reported cases for 2012 to 2016

Adriana Zubieta-Zavala, Malaquias López-Cervantes, Guillermo Salinas-Escudero, Adrian Ramírez-Chávez, José Ramos Castañeda, Sendy Isarel Hernández-Gaytán, Juan Guillermo López Yescas, Luis Durán-Arenas

PLOS Neglected Tropical Diseases: published December 14, 2018 | https://doi.org/10.1371/journal.pntd.0006938

Translating preventive chemotherapy prevalence thresholds for Schistosoma mansoni from the Kato-Katz technique into the point-of-care circulating cathodic antigen diagnostic test

Oliver Bärenbold, Amadou Garba, Daniel G. Colley, Fiona M. Fleming, Ayat A. Haggag, Reda M. R. Ramzy, Rufin K. Assaré, Edridah M. Tukahebwa, Jean B. Mbonigaba, Victor Bucumi, Biruck Kebede, Makoy S. Yibi, Aboulaye Meité, Jean T. Coulibaly, Eliézer K. N’Goran, Louis-Albert Tchuem Tchuenté, Pauline Mwinzi, Jürg Utzinger, Penelope Vounatsou

PLOS Neglected Tropical Diseases: published December 14, 2018 | https://doi.org/10.1371/journal.pntd.0006941

Novel mass spectrometry based detection and identification of variants of rabies virus nucleoprotein in infected brain tissues

Matthew Reed, Olga Stuchlik, William C. Carson, Lillian Orciari, Pamela A. Yager, Victoria Olson, Yu Li, Xianfu Wu, Jan Pohl, Panayampalli Subbian Satheshkumar

PLOS Neglected Tropical Diseases: published December 14, 2018 | https://doi.org/10.1371/journal.pntd.0006984

Interventions to treat cutaneous leishmaniasis in children: A systematic review

Andrés Uribe-Restrepo, Alexandra Cossio, Mayur M. Desai, Diana Dávalos, María del Mar Castro

PLOS Neglected Tropical Diseases: published December 14, 2018 | https://doi.org/10.1371/journal.pntd.0006986

A high throughput neutralization test based on GFP expression by recombinant rabies virus

Jillybeth Burgado, Lauren Greenberg, Mike Niezgoda, Amrita Kumar, Victoria Olson, Xianfu Wu, Panayampalli Subbian Satheshkumar

PLOS Neglected Tropical Diseases: published December 14, 2018 | https://doi.org/10.1371/journal.pntd.0007011

Serological and PCR-based markers of ocular Chlamydia trachomatis transmission in northern Ghana after elimination of trachoma as a public health problem

Laura G. Senyonjo, Oscar Debrah, Diana L. Martin, Adwoa Asante-Poku, Stephanie J. Migchelsen, Sarah Gwyn, Dzeidzom K. deSouza, Anthony W. Solomon, David Agyemang, Nana Biritwum-Kwadwo, Benjamin Marfo, Didier Bakajika, Ernest O. Mensah, Agatha Aboe, Joseph Koroma, James Addy, Robin Bailey

PLOS Neglected Tropical Diseases: published December 14, 2018 | https://doi.org/10.1371/journal.pntd.0007027

Protective versus pathologic pre-exposure cytokine profiles in dengue virus infection

Heather Friberg, Coreen M. Beaumier, Sangshin Park, Pamela Pazoles, Timothy P. Endy, Anuja Mathew, Jeffrey R. Currier, Richard G. Jarman, Kathryn B. Anderson, Steven Hatch, Stephen J. Thomas, Alan L. Rothman

PLOS Neglected Tropical Diseases: published December 17, 2018 | https://doi.org/10.1371/journal.pntd.0006975

Acanthamoeba profilin elicits allergic airway inflammation in mice

So Myung Song, Shin Ae Kang, Hye Kyung Park, Dong Hee Kim, So Young Park, Se Bok Jang, Hak Sun Yu

PLOS Neglected Tropical Diseases: published December 17, 2018 | https://doi.org/10.1371/journal.pntd.0006979

Robustness of the reproductive number estimates in vector-borne disease systems

Warren Tennant, Mario Recker

PLOS Neglected Tropical Diseases: published December 17, 2018 | https://doi.org/10.1371/journal.pntd.0006999

Diisopropylphenyl-imidazole (DII): A new compound that exerts anthelmintic activity through novel molecular mechanisms

María Gabriela Blanco, María Soledad Vela Gurovic, Gustavo Fabián Silbestri, Andrés Garelli, Sebastián Giunti, Diego Rayes, María José De Rosa

PLOS Neglected Tropical Diseases: published December 17, 2018 | https://doi.org/10.1371/journal.pntd.0007021

Widespread circulation of West Nile virus, but not Zika virus in southern Iran

Mazyar Ziyaeyan, Mohammad Amin Behzadi, Victor Hugo Leyva-Grado, Kourosh Azizi, Gholamreza Pouladfar, Hedayat Dorzaban, Atoosa Ziyaeyan, Sanaz Salek, Aghyl Jaber Hashemi, Marzieh Jamalidoust

PLOS Neglected Tropical Diseases: published December 17, 2018 | https://doi.org/10.1371/journal.pntd.0007022

NMR metabolomics of cerebrospinal fluid differentiates inflammatory diseases of the central nervous system

Caitlin D. French, Rodney E. Willoughby, Amy Pan, Susan J. Wong, John F. Foley, L. Joseph Wheat, Josefina Fernandez, Rafael Encarnacion, Joanne M. Ondrush, Naaz Fatteh, Andres Paez, Dan David, Waleed Javaid, Ioana G. Amzuta, Anne M. Neilan, Gregory K. Robbins, Andrew M. Brunner, William T. Hu, Darya O. Mishchuk, Carolyn M. Slupsky

PLOS Neglected Tropical Diseases: published December 17, 2018 | https://doi.org/10.1371/journal.pntd.0007045

Differential replication efficiencies between Japanese encephalitis virus genotype I and III in avian cultured cells and young domestic ducklings

Changguang Xiao, Chenxi Li, Di Di, Julien Cappelle, Lihong Liu, Xin Wang, Linlin Pang, Jinpeng Xu, Ke Liu, Beibei Li, Donghua Shao, Yafeng Qiu, Weijie Ren, Frederik Widén, Véronique Chevalier, Jianchao Wei, Xiaodong Wu, Zhiyong Ma

PLOS Neglected Tropical Diseases: published December 18, 2018 | https://doi.org/10.1371/journal.pntd.0007046

Ticks as potential vectors of Mycobacterium leprae: Use of tick cell lines to culture the bacilli and generate transgenic strains

Jéssica da Silva Ferreira, Diego Augusto Souza Oliveira, João Pedro Santos, Carla Carolina Dias Uzedo Ribeiro, Bruna A. Baêta, Rafaella Câmara Teixeira, Arthur da Silva Neumann, Patricia Sammarco Rosa, Maria Cristina Vidal Pessolani, Milton Ozório Moraes, Gervásio Henrique Bechara, Pedro L. de Oliveira, Marcos Henrique Ferreira Sorgine, Philip Noel Suffys, Amanda Nogueira Brum Fontes, Lesley Bell-Sakyi, Adivaldo H. Fonseca, Flavio Alves Lara

PLOS Neglected Tropical Diseases: published December 19, 2018 | https://doi.org/10.1371/journal.pntd.0007001

Attraction of Lutzomyia longipalpis to synthetic sex-aggregation pheromone: Effect of release rate and proximity of adjacent pheromone sources

Melissa J. Bell, Luigi Sedda, Mikel A. Gonzalez, Cristian F. de Souza, Erin Dilger, Reginaldo P. Brazil, Orin Courtenay, James G. C. Hamilton

PLOS Neglected Tropical Diseases: published December 19, 2018 | https://doi.org/10.1371/journal.pntd.0007007

Achieving the endgame: Integrated NTD case searches

Lucas Buyon, Randall Slaven, Paul M. Emerson, Jonathan King, Oscar Debrah, Agatha Aboe, Ernesto Ruiz-Tiben, E. Kelly Callahan

PLOS Neglected Tropical Diseases: published December 20, 2018 | https://doi.org/10.1371/journal.pntd.0006623

Trend analysis of leprosy in Morocco between 2000 and 2017: Evidence on the single dose rifampicin chemoprophylaxis

Ibtissam Khoudri, Zainab Elyoussfi, Yassine Mourchid, Mohammed Youbi, Nada Bennani Mechita, Redouane Abouqal, Abderrahmane Maaroufi

PLOS Neglected Tropical Diseases: published December 20, 2018 | https://doi.org/10.1371/journal.pntd.0006910

Sounding the alarm: Defining thresholds to trigger a public health response to monkeypox

Sarah Anne J. Guagliardo, Mary G. Reynolds, Joelle Kabamba, Beata Nguete, Robert Shongo Lushima, Okito E. Wemakoy, Andrea M. McCollum

PLOS Neglected Tropical Diseases: published December 20, 2018 | https://doi.org/10.1371/journal.pntd.0007034

Does appreciative inquiry decrease false positive diagnosis during leprosy case detection campaigns in Bihar, India? An operational research study

Ashish Nareshkumar Wagh, Shivakumar Mugudalabetta, Nimer Ortuno Gutierrez, Krishnamurthy Padebettu, Ajay Kumar Pandey, Bijoy Kumar Pandey, Mahalakshmy Thulasingam, Srinath Satyanarayana, Amol Dongre

PLOS Neglected Tropical Diseases: published December 21, 2018 | https://doi.org/10.1371/journal.pntd.0007004

General contextual effects on neglected tropical disease risk in rural Kenya

William A. de Glanville, Lian F. Thomas, Elizabeth A. J. Cook, Barend M. de C. Bronsvoort, Nicola Wardrop, Claire N. Wamae, Samuel Kariuki, Eric M. Fèvre

PLOS Neglected Tropical Diseases: published December 21, 2018 | https://doi.org/10.1371/journal.pntd.0007016

Evaluation of the analytical and diagnostic performance of a digital droplet polymerase chain reaction (ddPCR) assay to detect Trypanosoma cruzi DNA in blood samples

Juan David Ramírez, Giovanny Herrera, Carolina Hernández, Lissa Cruz-Saavedra, Marina Muñoz, Carolina Flórez, Robert Butcher

PLOS Neglected Tropical Diseases: published December 26, 2018 | https://doi.org/10.1371/journal.pntd.0007063

Using physical contact heterogeneity and frequency to characterize dynamics of human exposure to nonhuman primate bodily fluids in central Africa

Victor Narat, Mamadou Kampo, Thibaut Heyer, Stephanie Rupp, Philippe Ambata, Richard Njouom, Tamara Giles-Vernick

PLOS Neglected Tropical Diseases: published December 27, 2018 | https://doi.org/10.1371/journal.pntd.0006976

Exploration of a simplified clinical examination for scabies to support public health decision-making

Michael Marks, Daniel Engelman, Lucia Romani, Daniel Mason, Oliver Sokana, Mike Kama, Margot Whitfeld, Andrew C. Steer, John Kaldor

PLOS Neglected Tropical Diseases: published December 27, 2018 | https://doi.org/10.1371/journal.pntd.0006996

Toll-like receptor-2 regulates macrophage polarization induced by excretory-secretory antigens from Schistosoma japonicum eggs and promotes liver pathology in murine schistosomiasis

Wenci Gong, Fengjuan Huang, Lei Sun, Aiping Yu, Xiaofan Zhang, Yuxin Xu, Yujuan Shen, Jianping Cao

PLOS Neglected Tropical Diseases: published December 27, 2018 | https://doi.org/10.1371/journal.pntd.0007000

Health, financial, and education gains of investing in preventive chemotherapy for schistosomiasis, soil-transmitted helminthiases, and lymphatic filariasis in Madagascar: A modeling study

Jan-Walter De Neve, Rija L. Andriantavison, Kevin Croke, Johannes Krisam, Voahirana H. Rajoela, Rary A. Rakotoarivony, Valérie Rambeloson, Linda Schultz, Jumana Qamruddin, Stéphane Verguet

PLOS Neglected Tropical Diseases: published December 27, 2018 | https://doi.org/10.1371/journal.pntd.0007002

The effects of prednisolone treatment on serological responses and lipid profiles in Ethiopian leprosy patients with Erythema Nodosum Leprosum reactions

Edessa Negera, Melaku Tilahun, Kidist Bobosha, Saba M. Lambert, Stephen L. Walker, John S. Spencer, Abraham Aseffa, Hazel M. Dockrell, Diana N. Lockwood

PLOS Neglected Tropical Diseases: published December 28, 2018 | https://doi.org/10.1371/journal.pntd.0007035

A longitudinal systems immunologic investigation of acute Zika virus infection in an individual infected while traveling to Caracas, Venezuela

Aaron F. Carlin, Jinsheng Wen, Edward A. Vizcarra, Melanie McCauley, Antoine Chaillon, Kevan Akrami, Cheryl Kim, Annie Elong Ngono, Maria Luz Lara-Marquez, Davey M. Smith, Christopher K. Glass, Robert T. Schooley, Christopher Benner, Sujan Shresta

PLOS Neglected Tropical Diseases: published December 31, 2018 | https://doi.org/10.1371/journal.pntd.0007053

Cover

Yellow fever case investigation in Matadi, Kongo-Central, DRC, May 2016

Editorial

Policy Platform

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