September 2018

Blood samples were collected aiming to evaluate the recombinant antigens B2t and 2B2t, compared with hydatid fluid, in IgG-ELISA and immunostrips for the diagnosis and follow up of cystic echinococcosis patients within the framework of HERACLES project. Hernández-González, Sánchez-Ovejero, et al. (2018)

Image Credit: Adriano Casulli

Editorial

Minutes to midnight: Turning back the Doomsday Clock through neglected disease vaccine diplomacy

Peter J. Hotez

PLOS Neglected Tropical Diseases: published September 20, 2018 | https://doi.org/10.1371/journal.pntd.0006676

Viewpoints

Bolstering human rabies surveillance in Africa is crucial to eliminating canine-mediated rabies

Anaïs Broban, Mathurin C. Tejiokem, Issaka Tiembré, Sophie Druelles, Maïna L’Azou

PLOS Neglected Tropical Diseases: published September 6, 2018 | https://doi.org/10.1371/journal.pntd.0006367

Misconceptions and paradoxes in soil-transmitted helminthiases control as a public health problem

Alejandro J. Krolewiecki

PLOS Neglected Tropical Diseases: published September 13, 2018 | https://doi.org/10.1371/journal.pntd.0006672

Defeating re-emerging Alkhurma hemorrhagic fever virus outbreak in Saudi Arabia and worldwide

Ernest Tambo, Ashraf G. El-Dessouky

PLOS Neglected Tropical Diseases: published September 27, 2018 | https://doi.org/10.1371/journal.pntd.0006707

Expert Commentary

Recent advances in the Giardia–host relationship reveal danger lurking behind the smile

Camila H. Coelho, Steven M. Singer

PLOS Neglected Tropical Diseases: published September 6, 2018 | https://doi.org/10.1371/journal.pntd.0006625

Policy Platform

Innovative digital technologies for quality assurance of diagnosis of human African trypanosomiasis

Epco Hasker, Jean Kwete, Raquel Inocencio da Luz, Alain Mpanya, Nicolas Bebronne, Jacquies Makabuza, Yves Claeys, Jérémie Ilunga, Veerle Lejon, Dieudonné Mumba Ngoyi, Philippe Büscher, Marleen Boelaert, Erick Mwamba Miaka

PLOS Neglected Tropical Diseases: published September 13, 2018 | https://doi.org/10.1371/journal.pntd.0006664

Reviews

Coinfections and comorbidities in African health systems: At the interface of infectious and noninfectious diseases

Derick Nii Mensah Osakunor, David Moinina Sengeh, Francisca Mutapi

PLOS Neglected Tropical Diseases: published September 20, 2018 | https://doi.org/10.1371/journal.pntd.0006711

Atypical leishmaniasis: A global perspective with emphasis on the Indian subcontinent

Lovlesh Thakur, Kiran K. Singh, Vinay Shanker, Ajeet Negi, Aklank Jain, Greg Matlashewski, Manju Jain

PLOS Neglected Tropical Diseases: published September 27, 2018 | https://doi.org/10.1371/journal.pntd.0006659

Research Articles

Evaluation of Auramine O staining and conventional PCR for leprosy diagnosis: A comparative cross-sectional study from Ethiopia

Selfu Girma, Charlotte Avanzi, Kidist Bobosha, Kassu Desta, Munir H. Idriss, Philippe Busso, Yohannes Tsegaye, Shimelis Nigusse, Tsegaye Hailu, Stewart T. Cole, Abraham Aseffa

PLOS Neglected Tropical Diseases: published September 4, 2018 | https://doi.org/10.1371/journal.pntd.0006706

Optimization of sand fly embryo microinjection for gene editing by CRISPR/Cas9

Ines Martin-Martin, Azadeh Aryan, Claudio Meneses, Zach N. Adelman, Eric Calvo

PLOS Neglected Tropical Diseases: published September 4, 2018 | https://doi.org/10.1371/journal.pntd.0006769

Improving systematic rabies surveillance in Cameroon: A pilot initiative and results for 2014-2016

Casimir Ledoux Sofeu, Anaïs Broban, Amadou Njifou Njimah, Jean Blaise Momo, Serge Alain Sadeuh-Mba, Sophie Druelles, Maïna L’Azou, Mathurin Cyrille Tejiokem

PLOS Neglected Tropical Diseases: published September 6, 2018 | https://doi.org/10.1371/journal.pntd.0006597

Human rabies in Côte d'Ivoire 2014-2016: Results following reinforcements to rabies surveillance

Issaka Tiembré, Anaïs Broban, Joseph Bénié, Mathilde Tetchi, Sophie Druelles, Maïna L’Azou

PLOS Neglected Tropical Diseases: published September 6, 2018 | https://doi.org/10.1371/journal.pntd.0006649

Burden of leishmaniasis in Brazil and federated units, 1990-2016: Findings from Global Burden of Disease Study 2016

Juliana Maria Trindade Bezerra, Valdelaine Etelvina Miranda de Araújo, David Soeiro Barbosa, Francisco Rogerlândio Martins-Melo, Guilherme Loureiro Werneck, Mariângela Carneiro

PLOS Neglected Tropical Diseases: published September 6, 2018 | https://doi.org/10.1371/journal.pntd.0006697

Phylogenomic analysis unravels evolution of yellow fever virus within hosts

Chen Chen, Dong Jiang, Ming Ni, Jing Li, Zhihai Chen, Jingyuan Liu, Hanhui Ye, Gary Wong, Wei Li, Yuanyuan Zhang, Beibei Wang, Yuhai Bi, Danying Chen, Ping Zhang, Xuesen Zhao, Yaxian Kong, Weifeng Shi, Pengcheng Du, Gengfu Xiao, Juncai Ma, George F. Gao, Jie Cui, Fujie Zhang, Wenjun Liu, Xiaochen Bo, Ang Li, Hui Zeng, Di Liu

PLOS Neglected Tropical Diseases: published September 6, 2018 | https://doi.org/10.1371/journal.pntd.0006738

Evaluation of the recombinant antigens B2t and 2B2t, compared with hydatid fluid, in IgG-ELISA and immunostrips for the diagnosis and follow up of CE patients

Ana Hernández-González, Carlos Sánchez-Ovejero, Raúl Manzano-Román, María González Sánchez, José Manuel Delgado, Teresa Pardo-García, Francisco Soriano-Gálvez, Okan Akhan, Carmen M. Cretu, Kamenna Vutova, Francesca Tamarozzi, Mara Mariconti, Enrico Brunetti, Ambra Vola, Massimo Fabiani, Adriano Casulli, Mar Siles-Lucas

PLOS Neglected Tropical Diseases: published September 6, 2018 | https://doi.org/10.1371/journal.pntd.0006741

Typhoid fever in Santiago, Chile: Insights from a mathematical model utilizing venerable archived data from a successful disease control program

Jillian S. Gauld, Hao Hu, Daniel J. Klein, Myron M. Levine

PLOS Neglected Tropical Diseases: published September 6, 2018 | https://doi.org/10.1371/journal.pntd.0006759

Feasibility and initial outcomes of a multifaceted prevention programme of melioidosis in diabetic patients in Ubon Ratchathani, northeast Thailand

Pornpan Suntornsut, Wipada Chaowagul, Wilasinee Thongklang, Thidarat Phosri, Nicholas P. J. Day, Susan Michie, Direk Limmathurotsakul

PLOS Neglected Tropical Diseases: published September 6, 2018 | https://doi.org/10.1371/journal.pntd.0006765

Comparison of individual and pooled diagnostic examination strategies during the national mapping of soil-transmitted helminths and Schistosoma mansoni in Ethiopia

Gemechu Tadesse Leta, Mike French, Pierre Dorny, Jozef Vercruysse, Bruno Levecke

PLOS Neglected Tropical Diseases: published September 10, 2018 | https://doi.org/10.1371/journal.pntd.0006723

Tick-borne zoonoses in the Order Rickettsiales and Legionellales in Iran: A systematic review

Faham Khamesipour, Gabriel O. Dida, Douglas N. Anyona, S. Mostafa Razavi, Ehsan Rakhshandehroo

PLOS Neglected Tropical Diseases: published September 11, 2018 | https://doi.org/10.1371/journal.pntd.0006722

Distribution and breeding sites of Aedes aegypti and Aedes albopictus in 32 urban/peri-urban districts of Mozambique: implication for assessing the risk of arbovirus outbreaks

Ana Paula Abílio, Gastão Abudasse, Ayubo Kampango, Baltazar Candrinho, Salomão Sitoi, Jacinta Luciano, Dário Tembisse, Samira Sibindy, António Paulo Gouveia de Almeida, Gabriela Azambuja Garcia, Mariana Rocha David, Rafael Maciel-de-Freitas, Eduardo Samo Gudo

PLOS Neglected Tropical Diseases: published September 12, 2018 | https://doi.org/10.1371/journal.pntd.0006692

Contact tracing performance during the Ebola epidemic in Liberia, 2014-2015

Krista C. Swanson, Chiara Altare, Chea Sanford Wesseh, Tolbert Nyenswah, Tashrik Ahmed, Nir Eyal, Esther L. Hamblion, Justin Lessler, David H. Peters, Mathias Altmann

PLOS Neglected Tropical Diseases: published September 12, 2018 | https://doi.org/10.1371/journal.pntd.0006762

Implementing active community-based surveillance-response system for Buruli ulcer early case detection and management in Ghana

Collins S. K. Ahorlu, Daniel Okyere, Edwin Ampadu

PLOS Neglected Tropical Diseases: published September 12, 2018 | https://doi.org/10.1371/journal.pntd.0006776

Isometamidium chloride and homidium chloride fail to cure mice infected with Ethiopian Trypanosoma evansi type A and B

Gebrekrustos Mekonnen, Elmi Fahiye Mohammed, Weldu Kidane, Awol Nesibu, Hagos Yohannes, Nick Van Reet, Philippe Büscher, Hadush Birhanu

PLOS Neglected Tropical Diseases: published September 12, 2018 | https://doi.org/10.1371/journal.pntd.0006790

Isolation of pathogenic Leptospira strains from naturally infected cattle in Uruguay reveals high serovar diversity, and uncovers a relevant risk for human leptospirosis

Leticia Zarantonelli, Alejandra Suanes, Paulina Meny, Florencia Buroni, Cecilia Nieves, Ximena Salaberry, Carolina Briano, Natalia Ashfield, Caroline Da Silva Silveira, Fernando Dutra, Cristina Easton, Martin Fraga, Federico Giannitti, Camila Hamond, Melissa Macías-Rioseco, Clara Menéndez, Alberto Mortola, Mathieu Picardeau, Jair Quintero, Cristina Ríos, Víctor Rodríguez, Agustín Romero, Gustavo Varela, Rodolfo Rivero, Felipe Schelotto, Franklin Riet-Correa, Alejandro Buschiazzo, on behalf of the Grupo de Trabajo Interinstitucional de Leptospirosis Consortium

PLOS Neglected Tropical Diseases: published September 13, 2018 | https://doi.org/10.1371/journal.pntd.0006694

Bacterial community composition in the salivary glands of triatomines (Hemiptera: Reduviidae)

Michele Souza Lima, Marinella Silva Laport, Elias Seixas Lorosa, José Jurberg, Kátia Regina Netto dos Santos, Mário Alberto Cardoso da Silva Neto, Caio Tavora Coelho da Costa Rachid, Georgia Correa Atella

PLOS Neglected Tropical Diseases: published September 13, 2018 | https://doi.org/10.1371/journal.pntd.0006739

Rural youths' understanding of gene x environmental contributors to heritable health conditions: The case of podoconiosis in Ethiopia

Kibur Engdawork, Colleen M. McBride, Desta Ayode, Caitlin G. Allen, Gail Davey, Getnet Tadele

PLOS Neglected Tropical Diseases: published September 13, 2018 | https://doi.org/10.1371/journal.pntd.0006763

The association of rainfall and Buruli ulcer in southeastern Australia

Arvind Yerramilli, Ee Laine Tay, Andrew J. Stewardson, Janet Fyfe, Daniel P. O’Brien, Paul D. R. Johnson

PLOS Neglected Tropical Diseases: published September 17, 2018 | https://doi.org/10.1371/journal.pntd.0006757

PCR-RFLP screening of polymorphisms associated with benzimidazole resistance in Necator americanus and Ascaris lumbricoides from different geographical regions in Brazil

Luciana Werneck Zuccherato, Luis Fernando Furtado, Celi da Silva Medeiros, Carina da Silva Pinheiro, Élida M. Rabelo

PLOS Neglected Tropical Diseases: published September 17, 2018 | https://doi.org/10.1371/journal.pntd.0006766

Towards elimination of lymphatic filariasis in southeastern Madagascar: Successes and challenges for interrupting transmission

Andres Garchitorena, Estelle M. Raza-Fanomezanjanahary, Sedera A. Mioramalala, Cédric B. Chesnais, Claude A. Ratsimbasoa, Herinirina Ramarosata, Matthew H. Bonds, Holivololona Rabenantoandro

PLOS Neglected Tropical Diseases: published September 17, 2018 | https://doi.org/10.1371/journal.pntd.0006780

Corneal complications following Post Kala-azar Dermal Leishmaniasis treatment

Shomik Maruf, Proggananda Nath, Muhammad Rafiqul Islam, Fatima Aktar, Azim Anuwarul, Dinesh Mondal, Ariful Basher

PLOS Neglected Tropical Diseases: published September 17, 2018 | https://doi.org/10.1371/journal.pntd.0006781

Phospho-proteomic analysis of primary human colon epithelial cells during the early Trypanosoma cruzi infection phase

Shankar Suman, Girish Rachakonda, Sammed N. Mandape, Shruti S. Sakhare, Fernando Villalta, Siddharth Pratap, Maria F. Lima, Pius N. Nde

PLOS Neglected Tropical Diseases: published September 17, 2018 | https://doi.org/10.1371/journal.pntd.0006792

Estimating the efficacy of community-wide use of systemic insecticides in dogs to control zoonotic visceral leishmaniasis: A modelling study in a Brazilian scenario

Sonia A. Gomez, Lloyd A. C. Chapman, Erin Dilger, Orin Courtenay, Albert Picado

PLOS Neglected Tropical Diseases: published September 17, 2018 | https://doi.org/10.1371/journal.pntd.0006797

A Delphi consultation to assess indicators of readiness to provide quality health facility-based lymphoedema management services

Victoria L. Walsh, LeAnne M. Fox, Molly Brady, Jonathan King, Caitlin M. Worrell

PLOS Neglected Tropical Diseases: published September 18, 2018 | https://doi.org/10.1371/journal.pntd.0006699

Impact of repeated annual community directed treatment with ivermectin on loiasis parasitological indicators in Cameroon: Implications for onchocerciasis and lymphatic filariasis elimination in areas co-endemic with Loa loa in Africa

Samuel Wanji, Winston Patrick Chounna Ndongmo, Fanny Fri Fombad, Jonas Arnaud Kengne-Ouafo, Abdel Jelil Njouendou, Yolande Flore Longang Tchounkeu, Benjamin Koudou, Moses Bockarie, Grace Fobi, Jean Baptiste Roungou, Peter A. Enyong

PLOS Neglected Tropical Diseases: published September 18, 2018 | https://doi.org/10.1371/journal.pntd.0006750

Outbreak of human brucellosis in Southern Brazil and historical review of data from 2009 to 2018

Tamilly Silva Lemos, Juliana Clelia Cequinel, Tania Portela Costa, Amanda Boni Navarro, Andressa Sprada, Flávia Kazumi Shibata, Regina Gondolfo, Felipe Francisco Tuon

PLOS Neglected Tropical Diseases: published September 18, 2018 | https://doi.org/10.1371/journal.pntd.0006770

Clinical manifestations of dengue in relation to dengue serotype and genotype in Malaysia: A retrospective observational study

Jeyanthi Suppiah, Siew-Mooi Ching, Syafinaz Amin-Nordin, Lailatul-Akmar Mat-Nor, Naematul-Ain Ahmad-Najimudin, Gary Kim-Kuan Low, Manisya-Zauri Abdul-Wahid, Ravindran Thayan, Hui-Yee Chee

PLOS Neglected Tropical Diseases: published September 18, 2018 | https://doi.org/10.1371/journal.pntd.0006817

Improved methods to capture the total societal benefits of zoonotic disease control: Demonstrating the cost-effectiveness of an integrated control programme for Taenia solium, soil transmitted helminths and classical swine fever in northern Lao PDR

Walter O. Okello, Anna L. Okello, Phouth Inthavong, Tassilo Tiemann, Ammaly Phengsivalouk, Brecht Devleesschauwer, Alexandra Shaw, John Allen

PLOS Neglected Tropical Diseases: published September 19, 2018 | https://doi.org/10.1371/journal.pntd.0006782

Prediction of leprosy in the Chinese population based on a weighted genetic risk score

Na Wang, Zhenzhen Wang, Chuan Wang, Xi'an Fu, Gongqi Yu, Zhenhua Yue, Tingting Liu, Huimin Zhang, Lulu Li, Mingfei Chen, Honglei Wang, Guiye Niu, Dan Liu, Mingkai Zhang, Yuanyuan Xu, Yan Zhang, Jinghui Li, Zhen Li, Jiabao You, Tongsheng Chu, Furong Li, Dianchang Liu, Hong Liu, Furen Zhang

PLOS Neglected Tropical Diseases: published September 19, 2018 | https://doi.org/10.1371/journal.pntd.0006789

Health preparedness plan for dengue detection during the 2020 summer Olympic and Paralympic games in Tokyo

Naoki Yanagisawa, Koji Wada, John D. Spengler, Ramon Sanchez-Pina

PLOS Neglected Tropical Diseases: published September 20, 2018 | https://doi.org/10.1371/journal.pntd.0006755

Molecular characterization and phylogenetic analysis of dengue viruses imported into Taiwan during 2011-2016

Cheng-Fen Yang, Shu-Fen Chang, Tung-Chien Hsu, Chien-Ling Su, Tzy-Chen Wang, Shih-Hung Lin, Su-Lin Yang, Chien-Chou Lin, Pei-Yun Shu

PLOS Neglected Tropical Diseases: published September 20, 2018 | https://doi.org/10.1371/journal.pntd.0006773

Detection and distribution of Sca autotransporter protein antigens in diverse isolates of Orientia tsutsugamushi

Munegowda C. Koralur, Arunachalam Ramaiah, Gregory A. Dasch

PLOS Neglected Tropical Diseases: published September 20, 2018 | https://doi.org/10.1371/journal.pntd.0006784

Spatial distribution of Taenia solium exposure in humans and pigs in the Central Highlands of Vietnam

Dinh Ng-Nguyen, Rebecca Justine Traub, Van-Anh Thi Nguyen, Kathleen Breen, Mark Anthony Stevenson

PLOS Neglected Tropical Diseases: published September 20, 2018 | https://doi.org/10.1371/journal.pntd.0006810

Anti-parasitic effect of vitamin C alone and in combination with benznidazole against Trypanosoma cruzi

Vanesa Puente, Agostina Demaria, Fernanda M. Frank, Alcira Batlle, Maria Elisa Lombardo

PLOS Neglected Tropical Diseases: published September 21, 2018 | https://doi.org/10.1371/journal.pntd.0006764

Phylogeography and demographic history of the Chagas disease vector Rhodnius nasutus (Hemiptera: Reduviidae) in the Brazilian Caatinga biome

Tatiana Peretolchina, Márcio G. Pavan, Jessica Corrêa-Antônio, Rodrigo Gurgel-Gonçalves, Marli M. Lima, Fernando A. Monteiro

PLOS Neglected Tropical Diseases: published September 24, 2018 | https://doi.org/10.1371/journal.pntd.0006731

Evaluation of antigen-specific immune responses for leprosy diagnosis in a hyperendemic area in China

Xiaohua Chen, Yuan-Gang You, You-Hua Yuan, Lian Chao Yuan, Ying Zhang, Wen Yan

PLOS Neglected Tropical Diseases: published September 24, 2018 | https://doi.org/10.1371/journal.pntd.0006777

An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria

Ana C. Bahia, Marina S. Kubota, Jayme A. Souza-Neto, Leonardo B. Koerich, Ana Beatriz Barletta, Helena R. C. Araújo, Caroline M. Gonçalves, Cláudia M. Ríos-Velásquez, Paulo F. P. Pimenta, Yara M. Traub-Csekö

PLOS Neglected Tropical Diseases: published September 24, 2018 | https://doi.org/10.1371/journal.pntd.0006785

Nanoparticle delivery of a tetravalent E protein subunit vaccine induces balanced, type-specific neutralizing antibodies to each dengue virus serotype

Stefan W. Metz, Ashlie Thomas, Alex Brackbill, Yi Xianwen, Michele Stone, Katie Horvath, Michael J. Miley, Chris Luft, Joseph M. DeSimone, Shaomin Tian, Aravinda M. de Silva

PLOS Neglected Tropical Diseases: published September 24, 2018 | https://doi.org/10.1371/journal.pntd.0006793

Reactive and pre-emptive vaccination strategies to control hepatitis E infection in emergency and refugee settings: A modelling study

Ben S. Cooper, Lisa J. White, Ruby Siddiqui

PLOS Neglected Tropical Diseases: published September 25, 2018 | https://doi.org/10.1371/journal.pntd.0006807

Development and validation of a scale to assess attitudes of health care providers towards persons affected by leprosy in southern India

Govindarajulu Srinivas, Shuba Kumar, Rani Mohanraj, Geethalakshmi Sekkizhar, Thirumugam Muthuvel, Vivek Lal, Burkard Koemm, Christa Kasang

PLOS Neglected Tropical Diseases: published September 25, 2018 | https://doi.org/10.1371/journal.pntd.0006808

Filarial infection during pregnancy has profound consequences on immune response and disease outcome in children: A birth cohort study

Madhusmita Bal, Manoranjan Ranjit, Ashok K. Satapathy, Hemant K. Khuntia, Sanghamitra Pati

PLOS Neglected Tropical Diseases: published September 25, 2018 | https://doi.org/10.1371/journal.pntd.0006824

Impact of ivermectin administered for scabies treatment on the prevalence of head lice in Atoifi, Solomon Islands

Suny Coscione, Tommy Esau, Esau Kekeubata, Jason Diau, Rowena Asugeni, David MacLaren, Andrew C. Steer, Christian Kositz, Michael Marks

PLOS Neglected Tropical Diseases: published September 25, 2018 | https://doi.org/10.1371/journal.pntd.0006825

Standardising visual control devices for Tsetse: East and Central African Savannah species Glossina swynnertoni, Glossina morsitans centralis and Glossina pallidipes

Mechtilda Byamungu, Tusevo Zacarie, Alexis Makumyaviri M’Pondi, Philémon Mansinsa Diabakana, Andrew McMullin, Thomas Kröber, Steve Mihok, Patrick M. Guerin

PLOS Neglected Tropical Diseases: published September 25, 2018 | https://doi.org/10.1371/journal.pntd.0006831

Cover

Blood sampling during the HERACLES project

Editorial

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