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December 2016

We investigated the efficacy of rabbit polyclonal antibody (pcAb) against leptospirosis in hamster. The pcAb could cure both same serotype and a heterotype lethal Leptospira infections in hamster, and combination therapy with the antibiotic improved survival compared to antibiotic group in the late treatment of homotype leptospirosis. In addition, a reference dose of pcAb was provided for human or dog leptospirosis treatment. Thus, the pcAb therapy is a potential cure for leptospirosis, especially in the late stage. Jin et al.

Image Credit: Yongguo Cao, Xuemin Jin, Wenlong Zhang

Editorials

Egypt: Its Artists, Intellectuals, and Neglected Tropical Diseases

Peter J. Hotez, Moustapha Kassem

Paying for Worms

Peter J. Hotez, Ashish Damania, Mohsen Naghavi

Viewpoints

Tracking Insecticide Resistance in Mosquito Vectors of Arboviruses: The Worldwide Insecticide resistance Network (WIN)

Vincent Corbel, Nicole L. Achee, Fabrice Chandre, Mamadou B. Coulibaly, Isabelle Dusfour, Dina M. Fonseca, John Grieco, Waraporn Juntarajumnong, Audrey Lenhart, Ademir J. Martins, Catherine Moyes, Lee Ching Ng, João Pinto, Kamaraju Raghavendra, Hassan Vatandoost, John Vontas, David Weetman, Florence Fouque, Raman Velayudhan, Jean-Philippe David

Zika Virus: Promoting Male Involvement in the Health of Women and Families

Pauline E. Osamor, Christine Grady

Historical Profiles and Perspectives

A Historic Report of Zika in Mozambique: Implications for Assessing Current Risk

Eduardo Samo Gudo, Kerstin I. Falk, Sadia Ali, Argentina Felisbela Muianga, Vanessa Monteiro, Julie Cliff

Reviews

Diagnostic Tests to Support Late-Stage Control Programs for Schistosomiasis and Soil-Transmitted Helminthiases

Kenneth R. Hawkins, Jason L. Cantera, Helen L. Storey, Brandon T. Leader, Tala de los Santos

Tick-Borne Diseases in Turkey: A Review Based on One Health Perspective

Abdullah Inci, Alparslan Yildirim, Onder Duzlu, Mehmet Doganay, Serap Aksoy

Potential for Zika Virus to Establish a Sylvatic Transmission Cycle in the Americas

Benjamin M. Althouse, Nikos Vasilakis, Amadou A. Sall, Mawlouth Diallo, Scott C. Weaver, Kathryn A. Hanley

Animals in the Zika Virus Life Cycle: What to Expect from Megadiverse Latin American Countries

Marina Galvão Bueno, Nádia Martinez, Lívia Abdalla, Claudia Nunes Duarte dos Santos, Marcia Chame

Research Articles

Serological Evidence of Contrasted Exposure to Arboviral Infections between Islands of the Union of Comoros (Indian Ocean)

Koussay Dellagi, Nicolas Salez, Marianne Maquart, Sophie Larrieu, Amina Yssouf, Rahamatou Silaï, Isabelle Leparc-Goffart, Pablo Tortosa, Xavier de Lamballerie

Benchmarking the Cost per Person of Mass Treatment for Selected Neglected Tropical Diseases: An Approach Based on Literature Review and Meta-regression with Web-Based Software Application

Christopher Fitzpatrick, Fiona M. Fleming, Matthew Madin-Warburton, Timm Schneider, Filip Meheus, Kingsley Asiedu, Anthony W. Solomon, Antonio Montresor, Gautam Biswas

The Economics of a Successful Raccoon Rabies Elimination Program on Long Island, New York

Julie L. Elser, Laura L. Bigler, Aaron M. Anderson, Joanne L. Maki, Donald H. Lein, Stephanie A. Shwiff

The Impact of a Rights-Based Counselling Intervention to Reduce Stigma in People Affected by Leprosy in Indonesia

Mimi Lusli, Ruth Peters, Wim van Brakel, Marjolein Zweekhorst, Sorana Iancu, Joske Bunders, Irwanto, Barbara Regeer

Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects

Luiz Henrique Guimarães, Adriano Queiroz, Juliana A. Silva, Silvana C. Silva, Viviane Magalhães, Ednaldo L. Lago, Paulo Roberto L. Machado, Olívia Bacellar, Mary E. Wilson, Stephen M. Beverley, Edgar M. Carvalho, Albert Schriefer

Human IgG Antibody Response to Aedes Nterm-34kDa Salivary Peptide, an Epidemiological Tool to Assess Vector Control in Chikungunya and Dengue Transmission Area

Emmanuel Elanga Ndille, Souleymane Doucoure, Anne Poinsignon, François Mouchet, Sylvie Cornelie, Eric D’Ortenzio, Jean Sébastien DeHecq, Franck Remoue

Isothermal Diagnostic Assays for Monitoring Single Nucleotide Polymorphisms in Necator americanus Associated with Benzimidazole Drug Resistance

Nour Rashwan, Catherine Bourguinat, Kathy Keller, Nipul Kithsiri Gunawardena, Nilanthi de Silva, Roger Prichard

Oral Cholera Vaccination Delivery Cost in Low- and Middle-Income Countries: An Analysis Based on Systematic Review

Vittal Mogasale, Enusa Ramani, Hyeseung Wee, Jerome H. Kim

Serological and Virological Evidence of Crimean-Congo Haemorrhagic Fever Virus Circulation in the Human Population of Borno State, Northeastern Nigeria

David N. Bukbuk, Stuart D. Dowall, Kuiama Lewandowski, Andrew Bosworth, Saka S. Baba, Anitha Varghese, Robert J. Watson, Andrew Bell, Barry Atkinson, Roger Hewson

High Prevalence of Asymptomatic Neurocysticercosis in an Endemic Rural Community in Peru

Luz M. Moyano, Seth E. O’Neal, Viterbo Ayvar, Guillermo Gonzalvez, Ricardo Gamboa, Percy Vilchez, Silvia Rodriguez, Joe Reistetter, Victor C. W. Tsang, Robert H. Gilman, Armando E. Gonzalez, Hector H. Garcia, The Cysticercosis Working Group in Peru

Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria Transmission

Paul Griffin, Cielo Pasay, Suzanne Elliott, Silvana Sekuloski, Maggy Sikulu, Leon Hugo, David Khoury, Deborah Cromer, Miles Davenport, Jetsumon Sattabongkot, Karen Ivinson, Christian Ockenhouse, James McCarthy

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Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis

Isabel M. Vincent, Rónán Daly, Bertrand Courtioux, Amy M. Cattanach, Sylvain Biéler, Joseph M. Ndung’u, Sylvie Bisser, Michael P. Barrett

Head Lice of Pygmies Reveal the Presence of Relapsing Fever Borreliae in the Republic of Congo

Nadia Amanzougaghene, Jean Akiana, Géor Mongo Ndombe, Bernard Davoust, Nardiouf Sjelin Nsana, Henri-Joseph Parra, Florence Fenollar, Didier Raoult, Oleg Mediannikov

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Effect of Mass Stool Examination and Mass Treatment For Decreasing Intestinal Helminth and Protozoan Infection Rates in Bolivian Children: A Cross-Sectional Study

Takao Asai, Claudia Còrdova Vidal, Wilma Strauss, Toshikazu Ikoma, Kazuo Endoh, Masaharu Yamamoto

Intensive Circulation of Japanese Encephalitis Virus in Peri-urban Sentinel Pigs near Phnom Penh, Cambodia

Julien Cappelle, Veasna Duong, Long Pring, Lida Kong, Maud Yakovleff, Didot Budi Prasetyo, Borin Peng, Rithy Choeung, Raphaël Duboz, Sivuth Ong, San Sorn, Philippe Dussart, Arnaud Tarantola, Philippe Buchy, Véronique Chevalier

Genetic Evidence of Contemporary Dispersal of the Intermediate Snail Host of Schistosoma japonicum: Movement of an NTD Host Is Facilitated by Land Use and Landscape Connectivity

Jennifer R. Head, Howard Chang, Qunna Li, Christopher M. Hoover, Thomas Wilke, Catharina Clewing, Elizabeth J. Carlton, Song Liang, Ding Lu, Bo Zhong, Justin V. Remais

Transfected Babesia bovis Expressing a Tick GST as a Live Vector Vaccine

Daiane P. Oldiges, Jacob M. Laughery, Nelson Junior Tagliari, Ronaldo Viana Leite Filho, William C. Davis, Itabajara da Silva Vaz Jr, Carlos Termignoni, Donald P. Knowles, Carlos E. Suarez

Population Density, Climate Variables and Poverty Synergistically Structure Spatial Risk in Urban Malaria in India

Mauricio Santos-Vega, Menno J Bouma, Vijay Kohli, Mercedes Pascual

Using Community-Level Prevalence of Loa loa Infection to Predict the Proportion of Highly-Infected Individuals: Statistical Modelling to Support Lymphatic Filariasis and Onchocerciasis Elimination Programs

Daniela K Schlüter, Martial L Ndeffo-Mbah, Innocent Takougang, Tony Ukety, Samuel Wanji, Alison P Galvani, Peter J Diggle

Archival Isolates Confirm a Single Topotype of West Nile Virus in Australia

Bixing Huang, Natalie A Prow, Andrew F. van den Hurk, Richard J. N. Allcock, Peter R. Moore, Stephen L. Doggett, David Warrilow

DNA Microarray Detection of 18 Important Human Blood Protozoan Species

Mu-Xin Chen, Lin Ai, Jun-Hu Chen, Xin-Yu Feng, Shao-Hong Chen, Yu-Chun Cai, Yan Lu, Xiao-Nong Zhou, Jia-Xu Chen, Wei Hu

Contribution of Wastewater Irrigation to Soil Transmitted Helminths Infection among Vegetable Farmers in Kumasi, Ghana

Isaac Dennis Amoah, Amina Abubakari, Thor Axel Stenström, Robert Clement Abaidoo, Razak Seidu

Comparison of the Estimated Incidence of Acute Leptospirosis in the Kilimanjaro Region of Tanzania between 2007–08 and 2012–14

Michael J. Maze, Holly M. Biggs, Matthew P. Rubach, Renee L. Galloway, Shama Cash-Goldwasser, Kathryn J. Allan, Jo E. B. Halliday, Julian T. Hertz, Wilbrod Saganda, Bingileki F. Lwezaula, Sarah Cleaveland, Blandina T. Mmbaga, Venance P. Maro, John A. Crump

A Phosphorylcholine-Containing Glycolipid-like Antigen Present on the Surface of Infective Stage Larvae of Ascaris spp. Is a Major Antibody Target in Infected Pigs and Humans

Johnny Vlaminck, Dries Masure, Tao Wang, Peter Nejsum, Cornelis H. Hokke, Peter Geldhof

Predicting Rift Valley Fever Inter-epidemic Activities and Outbreak Patterns: Insights from a Stochastic Host-Vector Model

Sansao A. Pedro, Shirley Abelman, Henri E. Z. Tonnang

Heterologous Protection against Asian Zika Virus Challenge in Rhesus Macaques

Matthew T. Aliota, Dawn M. Dudley, Christina M. Newman, Emma L. Mohr, Dane D. Gellerup, Meghan E. Breitbach, Connor R. Buechler, Mustafa N. Rasheed, Mariel S. Mohns, Andrea M. Weiler, Gabrielle L. Barry, Kim L. Weisgrau, Josh A. Eudailey, Eva G. Rakasz, Logan J. Vosler, Jennifer Post, Saverio Capuano III, Thaddeus G. Golos, Sallie R. Permar, Jorge E. Osorio, Thomas C. Friedrich, Shelby L. O’Connor, David H. O’Connor

Quantitative Laser Biospeckle Method for the Evaluation of the Activity of Trypanosoma cruzi Using VDRL Plates and Digital Analysis

Hilda Cristina Grassi, Lisbette C. García, María Lorena Lobo-Sulbarán, Ana Velásquez, Francisco A. Andrades-Grassi, Humberto Cabrera, Jesús E. Andrades-Grassi, Efrén D. J. Andrades

Filariae-Retrovirus Co-infection in Mice is Associated with Suppressed Virus-Specific IgG Immune Response and Higher Viral Loads

Kirsten Katrin Dietze, Ulf Dittmer, Daniel Karim Koudaimi, Simone Schimmer, Martina Reitz, Minka Breloer, Wiebke Hartmann

Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms

Christopher Fernandez-Prada, Isabel M. Vincent, Marie-Christine Brotherton, Mathew Roberts, Gaétan Roy, Luis Rivas, Philippe Leprohon, Terry K. Smith, Marc Ouellette

Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell’s Viper (Daboia russelii) Envenoming

Anjana Silva, Christopher Johnston, Sanjaya Kuruppu, Daniela Kneisz, Kalana Maduwage, Oded Kleifeld, A. Ian Smith, Sisira Siribaddana, Nicholas A. Buckley, Wayne C. Hodgson, Geoffrey K. Isbister

Comparative Analysis of Dengue and Zika Outbreaks Reveals Differences by Setting and Virus

Sebastian Funk, Adam J. Kucharski, Anton Camacho, Rosalind M. Eggo, Laith Yakob, Lawrence M. Murray, W. John Edmunds

Emerging Infectious Disease Implications of Invasive Mammalian Species: The Greater White-Toothed Shrew (Crocidura russula) Is Associated With a Novel Serovar of Pathogenic Leptospira in Ireland

Jarlath E. Nally, Zbigniew Arent, Darrell O. Bayles, Richard L. Hornsby, Colm Gilmore, Siobhan Regan, Allan D. McDevitt, Jon Yearsley, Séamus Fanning, Barry J. McMahon

Uncovering the Pathogenic Landscape of Helminth (Opisthorchis viverrini) Infections: A Cross-Sectional Study on Contributions of Physical and Social Environment and Healthcare Interventions

Xueyuan Ong, Yi-Chen Wang, Paiboon Sithithaworn, Jutamas Namsanor, David Taylor, Luxana Laithavewat

Public Health Interventions for Aedes Control in the Time of Zikavirus– A Meta-Review on Effectiveness of Vector Control Strategies

Maha Bouzid, Julii Brainard, Lee Hooper, Paul R. Hunter

The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants

Flora S. Kano, Flávia A. Souza-Silva, Leticia M. Torres, Barbara A. S. Lima, Taís N. Sousa, Jéssica R. S. Alves, Roberto S. Rocha, Cor J. F. Fontes, Bruno A. M. Sanchez, John H. Adams, Cristiana F. A. Brito, Douglas E. V. Pires, David B. Ascher, Ana Maria Sell, Luzia H. Carvalho

Crystal Structure of Schistosoma mansoni Adenosine Phosphorylase/5’-Methylthioadenosine Phosphorylase and Its Importance on Adenosine Salvage Pathway

Juliana Roberta Torini, José Brandão-Neto, Ricardo DeMarco, Humberto D'Muniz Pereira

The Impact of the Newly Licensed Dengue Vaccine in Endemic Countries

Maíra Aguiar, Nico Stollenwerk, Scott B. Halstead

Schistosoma mansoni Infection Can Jeopardize the Duration of Protective Levels of Antibody Responses to Immunizations against Hepatitis B and Tetanus Toxoid

Diana K. Riner, Eric M. Ndombi, Jennifer M. Carter, Amos Omondi, Nupur Kittur, Emmy Kavere, Harrison K. Korir, Briana Flaherty, Diana Karanja, Daniel G. Colley

Replication Protein A Presents Canonical Functions and Is Also Involved in the Differentiation Capacity of Trypanosoma cruzi

Raphael Souza Pavani, Marcelo Santos da Silva, Carlos Alexandre Henrique Fernandes, Flavia Souza Morini, Christiane Bezerra Araujo, Marcos Roberto de Mattos Fontes, Osvaldo Augusto Sant’Anna, Carlos Renato Machado, Maria Isabel Cano, Stenio Perdigão Fragoso, Maria Carolina Elias

Melioidosis in Malaysia: A Review of Case Reports

Paul Vijay Kingsley, Mark Leader, Nandika Suranjith Nagodawithana, Meghan Tipre, Nalini Sathiakumar

CystiSim – An Agent-Based Model for Taenia solium Transmission and Control

Uffe Christian Braae, Brecht Devleesschauwer, Sarah Gabriël, Pierre Dorny, Niko Speybroeck, Pascal Magnussen, Paul Torgerson, Maria Vang Johansen

First Identification and Description of Rickettsioses and Q Fever as Causes of Acute Febrile Illness in Nicaragua

Megan E. Reller, Ijeuru Chikeka, Jeremy J. Miles, J. Stephen Dumler, Christopher W. Woods, Orlando Mayorga, Armando J. Matute

Synchrony of Dengue Incidence in Ho Chi Minh City and Bangkok

Cuong Hoang Quoc, Salje Henrik, Rodriguez-Barraquer Isabel, Yoon In-Kyu, Nguyen Van Vinh Chau, Nguyen Thanh Hung, Ha Manh Tuan, Phan Trong Lan, Bridget Willis, Ananda Nisalak, Siripen Kalayanarooj, Derek A. T. Cummings, Cameron P. Simmons

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Biompha-LAMP: A New Rapid Loop-Mediated Isothermal Amplification Assay for Detecting Schistosoma mansoni in Biomphalaria glabrata Snail Host

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