We investigated the efficacy of rabbit polyclonal antibody (pcAb) against leptospirosis in hamster. The pcAb could cure both same serotype and a heterotype lethal Leptospira infections in hamster, and combination therapy with the antibiotic improved survival compared to antibiotic group in the late treatment of homotype leptospirosis. In addition, a reference dose of pcAb was provided for human or dog leptospirosis treatment. Thus, the pcAb therapy is a potential cure for leptospirosis, especially in the late stage. Jin et al.
Image Credit: Yongguo Cao, Xuemin Jin, Wenlong Zhang
Editorials
Egypt: Its Artists, Intellectuals, and Neglected Tropical Diseases
PLOS Neglected Tropical Diseases: published December 1, 2016 | https://doi.org/10.1371/journal.pntd.0005072
Paying for Worms
PLOS Neglected Tropical Diseases: published December 29, 2016 | https://doi.org/10.1371/journal.pntd.0005092
Viewpoints
Tracking Insecticide Resistance in Mosquito Vectors of Arboviruses: The Worldwide Insecticide resistance Network (WIN)
PLOS Neglected Tropical Diseases: published December 1, 2016 | https://doi.org/10.1371/journal.pntd.0005054
Zika Virus: Promoting Male Involvement in the Health of Women and Families
PLOS Neglected Tropical Diseases: published December 29, 2016 | https://doi.org/10.1371/journal.pntd.0005127
Historical Profiles and Perspectives
A Historic Report of Zika in Mozambique: Implications for Assessing Current Risk
PLOS Neglected Tropical Diseases: published December 8, 2016 | https://doi.org/10.1371/journal.pntd.0005052
Reviews
Diagnostic Tests to Support Late-Stage Control Programs for Schistosomiasis and Soil-Transmitted Helminthiases
PLOS Neglected Tropical Diseases: published December 22, 2016 | https://doi.org/10.1371/journal.pntd.0004985
Tick-Borne Diseases in Turkey: A Review Based on One Health Perspective
PLOS Neglected Tropical Diseases: published December 15, 2016 | https://doi.org/10.1371/journal.pntd.0005021
Potential for Zika Virus to Establish a Sylvatic Transmission Cycle in the Americas
PLOS Neglected Tropical Diseases: published December 15, 2016 | https://doi.org/10.1371/journal.pntd.0005055
Animals in the Zika Virus Life Cycle: What to Expect from Megadiverse Latin American Countries
PLOS Neglected Tropical Diseases: published December 22, 2016 | https://doi.org/10.1371/journal.pntd.0005073
Research Articles
Serological Evidence of Contrasted Exposure to Arboviral Infections between Islands of the Union of Comoros (Indian Ocean)
PLOS Neglected Tropical Diseases: published December 15, 2016 | https://doi.org/10.1371/journal.pntd.0004840
Plasmodium vivax but Not Plasmodium falciparum Blood-Stage Infection in Humans Is Associated with the Expansion of a CD8+ T Cell Population with Cytotoxic Potential
PLOS Neglected Tropical Diseases: published December 8, 2016 | https://doi.org/10.1371/journal.pntd.0005031
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PLOS Neglected Tropical Diseases: published December 5, 2016 | https://doi.org/10.1371/journal.pntd.0005037
Modelling Vaccination Strategies against Rift Valley Fever in Livestock in Kenya
PLOS Neglected Tropical Diseases: published December 14, 2016 | https://doi.org/10.1371/journal.pntd.0005049
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PLOS Neglected Tropical Diseases: published December 13, 2016 | https://doi.org/10.1371/journal.pntd.0005088
Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects
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Human IgG Antibody Response to Aedes Nterm-34kDa Salivary Peptide, an Epidemiological Tool to Assess Vector Control in Chikungunya and Dengue Transmission Area
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Isothermal Diagnostic Assays for Monitoring Single Nucleotide Polymorphisms in Necator americanus Associated with Benzimidazole Drug Resistance
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Oral Cholera Vaccination Delivery Cost in Low- and Middle-Income Countries: An Analysis Based on Systematic Review
PLOS Neglected Tropical Diseases: published December 8, 2016 | https://doi.org/10.1371/journal.pntd.0005124
Serological and Virological Evidence of Crimean-Congo Haemorrhagic Fever Virus Circulation in the Human Population of Borno State, Northeastern Nigeria
PLOS Neglected Tropical Diseases: published December 7, 2016 | https://doi.org/10.1371/journal.pntd.0005126
High Prevalence of Asymptomatic Neurocysticercosis in an Endemic Rural Community in Peru
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Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria Transmission
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Population Density, Climate Variables and Poverty Synergistically Structure Spatial Risk in Urban Malaria in India
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Using Community-Level Prevalence of Loa loa Infection to Predict the Proportion of Highly-Infected Individuals: Statistical Modelling to Support Lymphatic Filariasis and Onchocerciasis Elimination Programs
PLOS Neglected Tropical Diseases: published December 1, 2016 | https://doi.org/10.1371/journal.pntd.0005157
Archival Isolates Confirm a Single Topotype of West Nile Virus in Australia
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DNA Microarray Detection of 18 Important Human Blood Protozoan Species
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A Phosphorylcholine-Containing Glycolipid-like Antigen Present on the Surface of Infective Stage Larvae of Ascaris spp. Is a Major Antibody Target in Infected Pigs and Humans
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Predicting Rift Valley Fever Inter-epidemic Activities and Outbreak Patterns: Insights from a Stochastic Host-Vector Model
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Heterologous Protection against Asian Zika Virus Challenge in Rhesus Macaques
PLOS Neglected Tropical Diseases: published December 2, 2016 | https://doi.org/10.1371/journal.pntd.0005168
Quantitative Laser Biospeckle Method for the Evaluation of the Activity of Trypanosoma cruzi Using VDRL Plates and Digital Analysis
PLOS Neglected Tropical Diseases: published December 5, 2016 | https://doi.org/10.1371/journal.pntd.0005169
Filariae-Retrovirus Co-infection in Mice is Associated with Suppressed Virus-Specific IgG Immune Response and Higher Viral Loads
PLOS Neglected Tropical Diseases: published December 6, 2016 | https://doi.org/10.1371/journal.pntd.0005170
Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms
PLOS Neglected Tropical Diseases: published December 2, 2016 | https://doi.org/10.1371/journal.pntd.0005171
Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell’s Viper (Daboia russelii) Envenoming
PLOS Neglected Tropical Diseases: published December 2, 2016 | https://doi.org/10.1371/journal.pntd.0005172
Comparative Analysis of Dengue and Zika Outbreaks Reveals Differences by Setting and Virus
PLOS Neglected Tropical Diseases: published December 7, 2016 | https://doi.org/10.1371/journal.pntd.0005173
Emerging Infectious Disease Implications of Invasive Mammalian Species: The Greater White-Toothed Shrew (Crocidura russula) Is Associated With a Novel Serovar of Pathogenic Leptospira in Ireland
PLOS Neglected Tropical Diseases: published December 9, 2016 | https://doi.org/10.1371/journal.pntd.0005174
Uncovering the Pathogenic Landscape of Helminth (Opisthorchis viverrini) Infections: A Cross-Sectional Study on Contributions of Physical and Social Environment and Healthcare Interventions
PLOS Neglected Tropical Diseases: published December 7, 2016 | https://doi.org/10.1371/journal.pntd.0005175
Public Health Interventions for Aedes Control in the Time of Zikavirus– A Meta-Review on Effectiveness of Vector Control Strategies
PLOS Neglected Tropical Diseases: published December 7, 2016 | https://doi.org/10.1371/journal.pntd.0005176
The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants
PLOS Neglected Tropical Diseases: published December 13, 2016 | https://doi.org/10.1371/journal.pntd.0005177
Crystal Structure of Schistosoma mansoni Adenosine Phosphorylase/5’-Methylthioadenosine Phosphorylase and Its Importance on Adenosine Salvage Pathway
PLOS Neglected Tropical Diseases: published December 9, 2016 | https://doi.org/10.1371/journal.pntd.0005178
The Impact of the Newly Licensed Dengue Vaccine in Endemic Countries
PLOS Neglected Tropical Diseases: published December 21, 2016 | https://doi.org/10.1371/journal.pntd.0005179
Schistosoma mansoni Infection Can Jeopardize the Duration of Protective Levels of Antibody Responses to Immunizations against Hepatitis B and Tetanus Toxoid
PLOS Neglected Tropical Diseases: published December 7, 2016 | https://doi.org/10.1371/journal.pntd.0005180
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PLOS Neglected Tropical Diseases: published December 16, 2016 | https://doi.org/10.1371/journal.pntd.0005181
Melioidosis in Malaysia: A Review of Case Reports
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CystiSim – An Agent-Based Model for Taenia solium Transmission and Control
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First Identification and Description of Rickettsioses and Q Fever as Causes of Acute Febrile Illness in Nicaragua
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Synchrony of Dengue Incidence in Ho Chi Minh City and Bangkok
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PLOS Neglected Tropical Diseases: published December 27, 2016 | https://doi.org/10.1371/journal.pntd.0005191
Plasmodium falciparum Infection Status among Children with Schistosoma in Sub-Saharan Africa: A Systematic Review and Meta-analysis
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Dengue in the Middle East and North Africa: A Systematic Review
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Hydrological Regime and Water Shortage as Drivers of the Seasonal Incidence of Diarrheal Diseases in a Tropical Montane Environment
PLOS Neglected Tropical Diseases: published December 9, 2016 | https://doi.org/10.1371/journal.pntd.0005195
Longitudinal Study of Transmission in Households with Visceral Leishmaniasis, Asymptomatic Infections and PKDL in Highly Endemic Villages in Bihar, India
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Evaluation of Lymphatic Filariasis and Onchocerciasis in Three Senegalese Districts Treated for Onchocerciasis with Ivermectin
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The Impact of Lymphatic Filariasis Mass Drug Administration Scaling Down on Soil-Transmitted Helminth Control in School-Age Children. Present Situation and Expected Impact from 2016 to 2020
PLOS Neglected Tropical Diseases: published December 19, 2016 | https://doi.org/10.1371/journal.pntd.0005202
Utility of a Lateral Flow Immunoassay (LFI) to Detect Burkholderia pseudomallei in Soil Samples
PLOS Neglected Tropical Diseases: published December 14, 2016 | https://doi.org/10.1371/journal.pntd.0005204
Role of T3SS-1 SipD Protein in Protecting Mice against Non-typhoidal Salmonella Typhimurium
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Mapping Soil Transmitted Helminths and Schistosomiasis under Uncertainty: A Systematic Review and Critical Appraisal of Evidence
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Use of Oral Cholera Vaccine and Knowledge, Attitudes, and Practices Regarding Safe Water, Sanitation and Hygiene in a Long-Standing Refugee Camp, Thailand, 2012-2014
PLOS Neglected Tropical Diseases: published December 19, 2016 | https://doi.org/10.1371/journal.pntd.0005210
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