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March 2013

Chikungunya is an emerging mosquito-borne virus that causes arthritic disease in humans. Metz et al. describe a prototype chikungunya vaccine that is produced in insect cells using the baculovirus expression system. The vaccine consists of virus-like particles, which elicit a potent immune response and provide complete protection upon viral challenge against viremia and disease symptoms in mice. The picture shows a chikungunya virus-like particle visualized by transmission electron microscopy, merged with a chikungunya virion image (created with VMD, based on PDB ID:2XFB). This new effective and scalable vaccine candidate represents a step forward in the prevention of chikungunya virus infections.

Image Credit: Stefan W. Metz (Wageningen University, The Netherlands) and Jean-Yves Sgro (University of Wisconsin, Madison, United States)

Editorial

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