December 2012

To contribute to the sustainable implementation of the Rabies Prevention and Control Program in the province, the Bohol Rabies Prevention and Eradication Council and the Department of Education intensified rabies education among school children. This Rabies Prevention Program Manual on Grade School Curriculum Integration and Instruction was developed for primary school teachers in the province. Contents of the manual promoted responsible pet ownership, and rabies awareness topics were incorporated into the school curriculum. See Lapiz et al.

Image Credit: Mary Elizabeth G. Miranda, Global Alliance for Rabies Control.

Editorial

Will All Scientists Working on Snails and the Diseases They Transmit Please Stand Up?

Coen M. Adema, Christopher J. Bayne, Joanna M. Bridger, Matty Knight, Eric S. Loker, Timothy P. Yoshino, Si-Ming Zhang

PLOS Neglected Tropical Diseases: published December 27, 2012 | https://doi.org/10.1371/journal.pntd.0001835

Viewpoints

Rapid Assessment Procedure for Loiasis and Mapping Lymphatic Filariasis: Two Perfect Illustrations of “To Be in English or Not to Be”

Bernard Carme

PLOS Neglected Tropical Diseases: published December 13, 2012 | https://doi.org/10.1371/journal.pntd.0001863

Human African Trypanosomiasis in the Democratic Republic of the Congo: A Looming Emergency?

Epco Hasker, Pascal Lutumba, François Chappuis, Victor Kande, Julien Potet, Anja De Weggheleire, Charles Kambo, Evelyn Depoortere, Bernard Pécoul, Marleen Boelaert

PLOS Neglected Tropical Diseases: published December 13, 2012 | https://doi.org/10.1371/journal.pntd.0001950

Chagas Disease in Spain: Need for Further Public Health Measures

Miriam Navarro, Bárbara Navaza, Anne Guionnet, Rogelio López-Vélez

PLOS Neglected Tropical Diseases: published December 27, 2012 | https://doi.org/10.1371/journal.pntd.0001962

Symposium

Spleen Rupture in a Case of Untreated Plasmodium vivax Infection

André Machado Siqueira, Belisa Maria Lopes Magalhães, Gisely Cardoso Melo, Mireia Ferrer, Paola Castillo, Lorena Martin-Jaular, Carmen Fernandez-Becerra, Jaume Ordi, Antonio Martinez, Marcus Vinícius Guimarães Lacerda, Hernando A. del Portillo

PLOS Neglected Tropical Diseases: published December 13, 2012 | https://doi.org/10.1371/journal.pntd.0001934

Research Articles

Implementation of an Intersectoral Program to Eliminate Human and Canine Rabies: The Bohol Rabies Prevention and Elimination Project

Stella Marie D. Lapiz, Mary Elizabeth G. Miranda, Romulo G. Garcia, Leonida I. Daguro, Meydalyn D. Paman, Frederick P. Madrinan, Polizena A. Rances, Deborah J. Briggs

PLOS Neglected Tropical Diseases: published December 6, 2012 | https://doi.org/10.1371/journal.pntd.0001891

Efficacy and Safety of Praziquantel in Preschool-Aged Children in an Area Co-Endemic for Schistosoma mansoni and S. haematobium

Jean T. Coulibaly, Yve K. N'Gbesso, Stefanie Knopp, Jennifer Keiser, Eliézer K. N'Goran, Jürg Utzinger

PLOS Neglected Tropical Diseases: published December 6, 2012 | https://doi.org/10.1371/journal.pntd.0001917

Cathepsin B & L Are Not Required for Ebola Virus Replication

Andrea Marzi, Thomas Reinheckel, Heinz Feldmann

PLOS Neglected Tropical Diseases: published December 6, 2012 | https://doi.org/10.1371/journal.pntd.0001923

Clinical Manifestations of Human Brucellosis: A Systematic Review and Meta-Analysis

Anna S. Dean, Lisa Crump, Helena Greter, Jan Hattendorf, Esther Schelling, Jakob Zinsstag

PLOS Neglected Tropical Diseases: published December 6, 2012 | https://doi.org/10.1371/journal.pntd.0001929

Identification of Wb123 as an Early and Specific Marker of Wuchereria bancrofti Infection

Joseph Kubofcik, Doran L. Fink, Thomas B. Nutman

PLOS Neglected Tropical Diseases: published December 6, 2012 | https://doi.org/10.1371/journal.pntd.0001930

Immunization of Mice with Recombinant Mosquito Salivary Protein D7 Enhances Mortality from Subsequent West Nile Virus Infection via Mosquito Bite

Krystle L. Reagan, Carlos Machain-Williams, Tian Wang, Carol D. Blair

PLOS Neglected Tropical Diseases: published December 6, 2012 | https://doi.org/10.1371/journal.pntd.0001935

Clofazimine Modulates the Expression of Lipid Metabolism Proteins in Mycobacterium leprae-Infected Macrophages

Yang Degang, Takeshi Akama, Takeshi Hara, Kazunari Tanigawa, Yuko Ishido, Masaichi Gidoh, Masahiko Makino, Norihisa Ishii, Koichi Suzuki

PLOS Neglected Tropical Diseases: published December 6, 2012 | https://doi.org/10.1371/journal.pntd.0001936

Molecular Characterization of a Tetraspanin from the Human Liver Fluke, Opisthorchis viverrini

Supawadee Piratae, Smarn Tesana, Malcolm K. Jones, Paul J. Brindley, Alex Loukas, Erica Lovas, Veerachai Eursitthichai, Banchob Sripa, Sirikanda Thanasuwan, Thewarach Laha

PLOS Neglected Tropical Diseases: published December 6, 2012 | https://doi.org/10.1371/journal.pntd.0001939

Antibody to the Filarial Antigen Wb123 Reflects Reduced Transmission and Decreased Exposure in Children Born following Single Mass Drug Administration (MDA)

Cathy Steel, Joseph Kubofcik, Eric A. Ottesen, Thomas B. Nutman

PLOS Neglected Tropical Diseases: published December 6, 2012 | https://doi.org/10.1371/journal.pntd.0001940

Longitudinal Monitoring of the Development of Antifilarial Antibodies and Acquisition of Wuchereria bancrofti in a Highly Endemic Area of Haiti

Katy L. Hamlin, Delynn M. Moss, Jeffrey W. Priest, Jacquelin Roberts, Joseph Kubofcik, Katherine Gass, Thomas G. Streit, Thomas B. Nutman, Mark L. Eberhard, Patrick J. Lammie

PLOS Neglected Tropical Diseases: published December 6, 2012 | https://doi.org/10.1371/journal.pntd.0001941

A Global Comparison of the Human and T. brucei Degradomes Gives Insights about Possible Parasite Drug Targets

Susan T. Mashiyama, Kyriacos Koupparis, Conor R. Caffrey, James H. McKerrow, Patricia C. Babbitt

PLOS Neglected Tropical Diseases: published December 6, 2012 | https://doi.org/10.1371/journal.pntd.0001942

Can Human Movements Explain Heterogeneous Propagation of Dengue Fever in Cambodia?

Magali Teurlai, Rekol Huy, Bernard Cazelles, Raphaël Duboz, Christophe Baehr, Sirenda Vong

PLOS Neglected Tropical Diseases: published December 6, 2012 | https://doi.org/10.1371/journal.pntd.0001957

Azithromycin and Ciprofloxacin Resistance in Salmonella Bloodstream Infections in Cambodian Adults

Erika R. Vlieghe, Thong Phe, Birgit De Smet, Chhun H. Veng, Chun Kham, Sophie Bertrand, Raymond Vanhoof, Lut Lynen, Willy E. Peetermans, Jan A. Jacobs

PLOS Neglected Tropical Diseases: published December 13, 2012 | https://doi.org/10.1371/journal.pntd.0001933

Leishmaniasis Direct Agglutination Test: Using Pictorials as Training Materials to Reduce Inter-Reader Variability and Improve Accuracy

Emily R. Adams, Diane Jacquet, Gerard Schoone, Kamlesh Gidwani, Marleen Boelaert, Jane Cunningham

PLOS Neglected Tropical Diseases: published December 13, 2012 | https://doi.org/10.1371/journal.pntd.0001946

Diagnosis of Brugian Filariasis by Loop-Mediated Isothermal Amplification

Catherine B. Poole, Nathan A. Tanner, Yinhua Zhang, Thomas C. Evans Jr., Clotilde K. S. Carlow

PLOS Neglected Tropical Diseases: published December 13, 2012 | https://doi.org/10.1371/journal.pntd.0001948

Epidemiology of Sleeping Sickness in Boffa (Guinea): Where Are the Trypanosomes?

Moise Saa Kagbadouno, Mamadou Camara, Jeremi Rouamba, Jean-Baptiste Rayaisse, Ibrahima Sory Traoré, Oumou Camara, Mory Fassou Onikoyamou, Fabrice Courtin, Sophie Ravel, Thierry de Meeûs, Bruno Bucheton, Vincent Jamonneau, Philippe Solano

PLOS Neglected Tropical Diseases: published December 13, 2012 | https://doi.org/10.1371/journal.pntd.0001949

Regulation of Biotransformation Systems and ABC Transporters by Benznidazole in HepG2 Cells: Involvement of Pregnane X-Receptor

Juan P. Rigalli, Virginia G. Perdomo, Marcelo G. Luquita, Silvina S. M. Villanueva, Agostina Arias, Dirk Theile, Johanna Weiss, Aldo D. Mottino, María L. Ruiz, Viviana A. Catania

PLOS Neglected Tropical Diseases: published December 13, 2012 | https://doi.org/10.1371/journal.pntd.0001951

Effectiveness of the Viet Nam Produced, Mouse Brain-Derived, Inactivated Japanese Encephalitis Vaccine in Northern Viet Nam

Florian Marks, Thi Thu Yen Nguyen, Nhu Duong Tran, Minh Hong Nguyen, Hai Ha Vu, Christian G. Meyer, Young Ae You, Frank Konings, Wei Liu, Thomas F. Wierzba, Zhi-Yi Xu

PLOS Neglected Tropical Diseases: published December 13, 2012 | https://doi.org/10.1371/journal.pntd.0001952

Low Parasite Load Estimated by qPCR in a Cohort of Children Living in Urban Area Endemic for Visceral Leishmaniasis in Brazil

Letícia Helena dos Santos Marques, Luciana Inácia Gomes, Iara Caixeta Marques da Rocha, Thaís Almeida Marques da Silva, Edward Oliveira, Maria Helena Franco Morais, Ana Rabello, Mariângela Carneiro

PLOS Neglected Tropical Diseases: published December 13, 2012 | https://doi.org/10.1371/journal.pntd.0001955

Cruzipain Promotes Trypanosoma cruzi Adhesion to Rhodnius prolixus Midgut

Lívia Almeida Uehara, Otacílio C. Moreira, Ana Carolina Oliveira, Patrícia Azambuja, Ana Paula Cabral Araujo Lima, Constança Britto, André Luis Souza dos Santos, Marta Helena Branquinha, Claudia Masini d'Avila-Levy

PLOS Neglected Tropical Diseases: published December 13, 2012 | https://doi.org/10.1371/journal.pntd.0001958

Mesenchymal Bone Marrow Cell Therapy in a Mouse Model of Chagas Disease. Where Do the Cells Go?

Jasmin, Linda A. Jelicks, Wade Koba, Herbert B. Tanowitz, Rosalia Mendez-Otero, Antonio C. Campos de Carvalho, David C. Spray

PLOS Neglected Tropical Diseases: published December 13, 2012 | https://doi.org/10.1371/journal.pntd.0001971

Severe Anemia in Papua New Guinean Children from a Malaria-Endemic Area: A Case-Control Etiologic Study

Laurens Manning, Moses Laman, Anna Rosanas-Urgell, Pascal Michon, Susan Aipit, Cathy Bona, Peter Siba, Ivo Mueller, Timothy M. E. Davis

PLOS Neglected Tropical Diseases: published December 13, 2012 | https://doi.org/10.1371/journal.pntd.0001972

Degree of Skin Denervation and Its Correlation to Objective Thermal Sensory Test in Leprosy Patients

Ismael Alves Rodrigues Júnior, Isabel Cristina Costa Silva, Letícia Trivellato Gresta, Sandra Lyon, Manoel de Figueiredo Villarroel, Rosa Maria Esteves Arantes

PLOS Neglected Tropical Diseases: published December 13, 2012 | https://doi.org/10.1371/journal.pntd.0001975

Distinct Transcriptional Signatures of Bone Marrow-Derived C57BL/6 and DBA/2 Dendritic Leucocytes Hosting Live Leishmania amazonensis Amastigotes

Emilie Giraud, Hervé Lecoeur, Guillaume Soubigou, Jean-Yves Coppée, Geneviève Milon, Eric Prina, Thierry Lang

PLOS Neglected Tropical Diseases: published December 13, 2012 | https://doi.org/10.1371/journal.pntd.0001980

Calodium hepaticum: Household Clustering Transmission and the Finding of a Source of Human Spurious Infection in a Community of the Amazon Region

Alessandra Queiroga Gonçalves, Carlos Ascaso, Ivanildes Santos, Paula Taquita Serra, Genimar Rebouças Julião, Patricia Puccinelli Orlandi

PLOS Neglected Tropical Diseases: published December 20, 2012 | https://doi.org/10.1371/journal.pntd.0001943

Sphingolipid Degradation in Leishmania (Leishmania) amazonensis

Agiesh Balakrishna Pillai, Wei Xu, Ou Zhang, Kai Zhang

PLOS Neglected Tropical Diseases: published December 20, 2012 | https://doi.org/10.1371/journal.pntd.0001944

Relationship between Snail Population Density and Infection Status of Snails and Fish with Zoonotic Trematodes in Vietnamese Carp Nurseries

Jesper Hedegaard Clausen, Henry Madsen, K. Darwin Murrell, Van Phan Thi, Hung Nguyen Manh, Khue Nguyen Viet, Anders Dalsgaard

PLOS Neglected Tropical Diseases: published December 20, 2012 | https://doi.org/10.1371/journal.pntd.0001945

IFN-γ Production to Leishmania Antigen Supplements the Leishmania Skin Test in Identifying Exposure to L. braziliensis Infection

Daniel Schnorr, Aline C. Muniz, Sara Passos, Luiz H. Guimaraes, Ednaldo L. Lago, Olívia Bacellar, Marshall J. Glesby, Edgar M. Carvalho

PLOS Neglected Tropical Diseases: published December 20, 2012 | https://doi.org/10.1371/journal.pntd.0001947

Geographic Correlation between Tapeworm Carriers and Heavily Infected Cysticercotic Pigs

Seth E. O'Neal, Luz M. Moyano, Viterbo Ayvar, Guillermo Gonzalvez, Andre Diaz, Silvia Rodriguez, Patricia P. Wilkins, Victor C. W. Tsang, Robert H. Gilman, Hector H. Garcia, Armando E. Gonzalez, The Cysticercosis Working Group in Peru

PLOS Neglected Tropical Diseases: published December 20, 2012 | https://doi.org/10.1371/journal.pntd.0001953

Temporal Dynamics of the Transcriptional Response to Dengue Virus Infection in Nicaraguan Children

Stephen J. Popper, Aubree Gordon, Minghsun Liu, Angel Balmaseda, Eva Harris, David A. Relman

PLOS Neglected Tropical Diseases: published December 20, 2012 | https://doi.org/10.1371/journal.pntd.0001966

An In-Depth Analysis of a Piece of Shit: Distribution of Schistosoma mansoni and Hookworm Eggs in Human Stool

Stefanie J. Krauth, Jean T. Coulibaly, Stefanie Knopp, Mahamadou Traoré, Eliézer K. N'Goran, Jürg Utzinger

PLOS Neglected Tropical Diseases: published December 20, 2012 | https://doi.org/10.1371/journal.pntd.0001969

Chronic Helminth Infection Does Not Exacerbate Mycobacterium tuberculosis Infection

Marc P. Hübner, Kristin E. Killoran, Michael Rajnik, Samuel Wilson, Kevin C. Yim, Marina N. Torrero, Christopher P. Morris, Boris Nikonenko, Jorge C. G. Blanco, Val G. Hemming, Edward Mitre

PLOS Neglected Tropical Diseases: published December 20, 2012 | https://doi.org/10.1371/journal.pntd.0001970

Treatment of Visceral Leishmaniasis: Model-Based Analyses on the Spread of Antimony-Resistant L. donovani in Bihar, India

Anette Stauch, Hans-Peter Duerr, Jean-Claude Dujardin, Manu Vanaerschot, Shyam Sundar, Martin Eichner

PLOS Neglected Tropical Diseases: published December 20, 2012 | https://doi.org/10.1371/journal.pntd.0001973

Leishmania donovani Develops Resistance to Drug Combinations

Raquel García-Hernández, José Ignacio Manzano, Santiago Castanys, Francisco Gamarro

PLOS Neglected Tropical Diseases: published December 20, 2012 | https://doi.org/10.1371/journal.pntd.0001974

Post-Operative Recurrent Trachomatous Trichiasis Is Associated with Increased Conjunctival Expression of S100A7 (Psoriasin)

Matthew J. Burton, Saul N. Rajak, Athumani Ramadhani, Helen A. Weiss, Esmael Habtamu, Baye Abera, Paul M. Emerson, Peng T. Khaw, David C. W. Mabey, Martin J. Holland, Robin L. Bailey

PLOS Neglected Tropical Diseases: published December 20, 2012 | https://doi.org/10.1371/journal.pntd.0001985

Deletion of Parasite Immune Modulatory Sequences Combined with Immune Activating Signals Enhances Vaccine Mediated Protection against Filarial Nematodes

Simon A. Babayan, HongLin Luo, Nick Gray, David W. Taylor, Judith E. Allen

PLOS Neglected Tropical Diseases: published December 27, 2012 | https://doi.org/10.1371/journal.pntd.0001968

Towards an Early Warning System for Rhodesian Sleeping Sickness in Savannah Areas: Man-Like Traps for Tsetse Flies

Glyn A. Vale, David R. Hall, Andrew Chamisa, Stephen J. Torr

PLOS Neglected Tropical Diseases: published December 27, 2012 | https://doi.org/10.1371/journal.pntd.0001978

Imipramine Is an Orally Active Drug against Both Antimony Sensitive and Resistant Leishmania donovani Clinical Isolates in Experimental Infection

Sandip Mukherjee, Budhaditya Mukherjee, Rupkatha Mukhopadhyay, Kshudiram Naskar, Shyam Sundar, Jean Claude Dujardin, Anjan Kumar Das, Syamal Roy

PLOS Neglected Tropical Diseases: published December 27, 2012 | https://doi.org/10.1371/journal.pntd.0001987

The Native Wolbachia Symbionts Limit Transmission of Dengue Virus in Aedes albopictus

Laurence Mousson, Karima Zouache, Camilo Arias-Goeta, Vincent Raquin, Patrick Mavingui, Anna-Bella Failloux

PLOS Neglected Tropical Diseases: published December 27, 2012 | https://doi.org/10.1371/journal.pntd.0001989

Field Evaluation and Impact on Clinical Management of a Rapid Diagnostic Kit That Detects Dengue NS1, IgM and IgG

Anne-Claire Andries, Veasna Duong, Chantha Ngan, Sivuth Ong, Rekol Huy, Kim Kim Sroin, Vantha Te, Bunthin Y, Patrich Lorn Try, Philippe Buchy

PLOS Neglected Tropical Diseases: published December 27, 2012 | https://doi.org/10.1371/journal.pntd.0001993

Cover

Rabies prevention program teacher's manual, Bohol, Philippines.

Editorial

Viewpoints

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Symposium

Research Articles

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