Also known as Rainmaker Mountain, North Pioa Mountain is the fourth highest peak in American Samoa, and has an average annual rainfall of 5,000 mm. This idyllic tropical environment is one of many in which leptospirosis has recently been identified as an emerging infectious disease. Risk factors for infection include high rainfall, flooding, urbanisation, poor sanitation, contact with animals, and environmental degradation. Accurate health data are often not available, making it difficult to develop and target public health intervention strategies. Lau et al. therefore devised a system of estimating infection risk based on environmental factors, and produced the first predictive risk maps for leptospirosis. Such maps have been successfully used to guide public health interventions for many other diseases, and are now available to help control this potentially lethal threat in American Samoa.
Image Credit: Colleen Lau and John DePasquale
Editorial
Chagas Disease: “The New HIV/AIDS of the Americas”
PLOS Neglected Tropical Diseases: published May 29, 2012 | https://doi.org/10.1371/journal.pntd.0001498
Viewpoints
Neurocysticercosis: Neglected but Not Forgotten
PLOS Neglected Tropical Diseases: published May 29, 2012 | https://doi.org/10.1371/journal.pntd.0001500
A Poor-Quality Generic Drug for the Treatment of Visceral Leishmaniasis: A Case Report and Appeal
PLOS Neglected Tropical Diseases: published May 29, 2012 | https://doi.org/10.1371/journal.pntd.0001544
More Efficient Ways of Assessing Treatments for Neglected Tropical Diseases Are Required: Innovative Study Designs, New Endpoints, and Markers of Effects
PLOS Neglected Tropical Diseases: published May 29, 2012 | https://doi.org/10.1371/journal.pntd.0001545
Review
Human African Trypanosomiasis in South Sudan: How Can We Prevent a New Epidemic?
PLOS Neglected Tropical Diseases: published May 29, 2012 | https://doi.org/10.1371/journal.pntd.0001541
Research Articles
Genetic Characterization of Trypanosoma cruzi DTUs in Wild Triatoma infestans from Bolivia: Predominance of TcI
PLOS Neglected Tropical Diseases: published May 29, 2012 | https://doi.org/10.1371/journal.pntd.0001650
Use of Oxfendazole to Control Porcine Cysticercosis in a High-Endemic Area of Mozambique
PLOS Neglected Tropical Diseases: published May 29, 2012 | https://doi.org/10.1371/journal.pntd.0001651
Regulatory T Cells in Human Lymphatic Filariasis: Stronger Functional Activity in Microfilaremics
PLOS Neglected Tropical Diseases: published May 29, 2012 | https://doi.org/10.1371/journal.pntd.0001655
Optimizing the Colour and Fabric of Targets for the Control of the Tsetse Fly Glossina fuscipes fuscipes
PLOS Neglected Tropical Diseases: published May 29, 2012 | https://doi.org/10.1371/journal.pntd.0001661
A Model of DENV-3 Infection That Recapitulates Severe Disease and Highlights the Importance of IFN-γ in Host Resistance to Infection
PLOS Neglected Tropical Diseases: published May 29, 2012 | https://doi.org/10.1371/journal.pntd.0001663
Experimental Induction of Paromomycin Resistance in Antimony-Resistant Strains of L. donovani: Outcome Dependent on In Vitro Selection Protocol
PLOS Neglected Tropical Diseases: published May 29, 2012 | https://doi.org/10.1371/journal.pntd.0001664
The Diagnostic Accuracy of Serologic and Molecular Methods for Detecting Visceral Leishmaniasis in HIV Infected Patients: Meta-Analysis
PLOS Neglected Tropical Diseases: published May 29, 2012 | https://doi.org/10.1371/journal.pntd.0001665
The Sigma Class Glutathione Transferase from the Liver Fluke Fasciola hepatica
PLOS Neglected Tropical Diseases: published May 29, 2012 | https://doi.org/10.1371/journal.pntd.0001666
Leptospirosis in American Samoa – Estimating and Mapping Risk Using Environmental Data
PLOS Neglected Tropical Diseases: published May 29, 2012 | https://doi.org/10.1371/journal.pntd.0001669
Disease Severity in Patients Infected with Leishmania mexicana Relates to IL-1β
PLOS Neglected Tropical Diseases: published May 22, 2012 | https://doi.org/10.1371/journal.pntd.0001533
Improved Canine and Human Visceral Leishmaniasis Immunodiagnosis Using Combinations of Synthetic Peptides in Enzyme-Linked Immunosorbent Assay
PLOS Neglected Tropical Diseases: published May 22, 2012 | https://doi.org/10.1371/journal.pntd.0001622
Surveillance of Dengue Fever Virus: A Review of Epidemiological Models and Early Warning Systems
PLOS Neglected Tropical Diseases: published May 22, 2012 | https://doi.org/10.1371/journal.pntd.0001648
Elevated Plasma IL-6 Associates with Increased Risk of Advanced Fibrosis and Cholangiocarcinoma in Individuals Infected by Opisthorchis viverrini
PLOS Neglected Tropical Diseases: published May 22, 2012 | https://doi.org/10.1371/journal.pntd.0001654
Drug Susceptibility in Leishmania Isolates Following Miltefosine Treatment in Cases of Visceral Leishmaniasis and Post Kala-Azar Dermal Leishmaniasis
PLOS Neglected Tropical Diseases: published May 22, 2012 | https://doi.org/10.1371/journal.pntd.0001657
Junín Virus Infection Activates the Type I Interferon Pathway in a RIG-I-Dependent Manner
PLOS Neglected Tropical Diseases: published May 22, 2012 | https://doi.org/10.1371/journal.pntd.0001659
Salivary Gland Transcriptomes and Proteomes of Phlebotomus tobbi and Phlebotomus sergenti, Vectors of Leishmaniasis
PLOS Neglected Tropical Diseases: published May 22, 2012 | https://doi.org/10.1371/journal.pntd.0001660
Related Articles
Modeling the Control of Trypanosomiasis Using Trypanocides or Insecticide-Treated Livestock
PLOS Neglected Tropical Diseases: published May 15, 2012 | https://doi.org/10.1371/journal.pntd.0001615
In Vitro and In Vivo Activity of a Palladacycle Complex on Leishmania (Leishmania) amazonensis
PLOS Neglected Tropical Diseases: published May 15, 2012 | https://doi.org/10.1371/journal.pntd.0001626
Characterisation of the Native Lipid Moiety of Echinococcus granulosus Antigen B
PLOS Neglected Tropical Diseases: published May 15, 2012 | https://doi.org/10.1371/journal.pntd.0001642
Dengue-1 Envelope Protein Domain III along with PELC and CpG Oligodeoxynucleotides Synergistically Enhances Immune Responses
PLOS Neglected Tropical Diseases: published May 15, 2012 | https://doi.org/10.1371/journal.pntd.0001645
Lower Richness of Small Wild Mammal Species and Chagas Disease Risk
PLOS Neglected Tropical Diseases: published May 15, 2012 | https://doi.org/10.1371/journal.pntd.0001647
Detection, Isolation and Confirmation of Crimean-Congo Hemorrhagic Fever Virus in Human, Ticks and Animals in Ahmadabad, India, 2010–2011
PLOS Neglected Tropical Diseases: published May 15, 2012 | https://doi.org/10.1371/journal.pntd.0001653
Soil-Transmitted Helminth Reinfection after Drug Treatment: A Systematic Review and Meta-Analysis
PLOS Neglected Tropical Diseases: published May 8, 2012 | https://doi.org/10.1371/journal.pntd.0001621
High Diversity of Rabies Viruses Associated with Insectivorous Bats in Argentina: Presence of Several Independent Enzootics
PLOS Neglected Tropical Diseases: published May 8, 2012 | https://doi.org/10.1371/journal.pntd.0001635
Dengue Infection and Miscarriage: A Prospective Case Control Study
PLOS Neglected Tropical Diseases: published May 8, 2012 | https://doi.org/10.1371/journal.pntd.0001637
Proteomic Analysis of the Cyst Stage of Entamoeba histolytica
PLOS Neglected Tropical Diseases: published May 8, 2012 | https://doi.org/10.1371/journal.pntd.0001643
Inducible Nitric Oxide Synthase in Heart Tissue and Nitric Oxide in Serum of Trypanosoma cruzi-Infected Rhesus Monkeys: Association with Heart Injury
PLOS Neglected Tropical Diseases: published May 8, 2012 | https://doi.org/10.1371/journal.pntd.0001644
Untargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei
PLOS Neglected Tropical Diseases: published May 1, 2012 | https://doi.org/10.1371/journal.pntd.0001618
Severe Dengue Is Associated with Consumption of von Willebrand Factor and Its Cleaving Enzyme ADAMTS-13
PLOS Neglected Tropical Diseases: published May 1, 2012 | https://doi.org/10.1371/journal.pntd.0001628
Evaluation of Nephroprotective and Immunomodulatory Activities of Antioxidants in Combination with Cisplatin against Murine Visceral Leishmaniasis
PLOS Neglected Tropical Diseases: published May 1, 2012 | https://doi.org/10.1371/journal.pntd.0001629
Cultivation-Independent Methods Reveal Differences among Bacterial Gut Microbiota in Triatomine Vectors of Chagas Disease
PLOS Neglected Tropical Diseases: published May 1, 2012 | https://doi.org/10.1371/journal.pntd.0001631
Linking Oviposition Site Choice to Offspring Fitness in Aedes aegypti: Consequences for Targeted Larval Control of Dengue Vectors
PLOS Neglected Tropical Diseases: published May 1, 2012 | https://doi.org/10.1371/journal.pntd.0001632
Temporal Dynamics and Impact of Climate Factors on the Incidence of Zoonotic Cutaneous Leishmaniasis in Central Tunisia
PLOS Neglected Tropical Diseases: published May 1, 2012 | https://doi.org/10.1371/journal.pntd.0001633
Treatment for Schistosoma japonicum, Reduction of Intestinal Parasite Load, and Cognitive Test Score Improvements in School-Aged Children
PLOS Neglected Tropical Diseases: published May 1, 2012 | https://doi.org/10.1371/journal.pntd.0001634
Development of a Humanized Antibody with High Therapeutic Potential against Dengue Virus Type 2
PLOS Neglected Tropical Diseases: published May 1, 2012 | https://doi.org/10.1371/journal.pntd.0001636
Related Articles
Correlation of Serotype-Specific Dengue Virus Infection with Clinical Manifestations
PLOS Neglected Tropical Diseases: published May 1, 2012 | https://doi.org/10.1371/journal.pntd.0001638
Infection and Transmission of Rift Valley Fever Viruses Lacking the NSs and/or NSm Genes in Mosquitoes: Potential Role for NSm in Mosquito Infection
PLOS Neglected Tropical Diseases: published May 1, 2012 | https://doi.org/10.1371/journal.pntd.0001639
The Spatial and Temporal Dynamics of Rabies in China
PLOS Neglected Tropical Diseases: published May 1, 2012 | https://doi.org/10.1371/journal.pntd.0001640
Diabetes with Hypertension as Risk Factors for Adult Dengue Hemorrhagic Fever in a Predominantly Dengue Serotype 2 Epidemic: A Case Control Study
PLOS Neglected Tropical Diseases: published May 1, 2012 | https://doi.org/10.1371/journal.pntd.0001641