November 2011

Phlebotomine sandflies can act as vectors for Leishmania spp., causing the different forms of human and canine leishmaniasis. However, the vector competence of Phlebotomus mascittii for Leishmania infantum was strongly suspected, but not proven under laboratory conditions until now. Recent sandfly records and autochthonous cases of leishmaniasis in Central Europe hint at spreading tendencies of these vectors to regions where they have not occurred so far. In a study published in this issue, the responses of five Phlebotomus spp. to future climate change are determined by combining climatic projections with species-specific dispersal ability (see Fischer et al., doi:10.1371/journal.pntd.0001407).

Image Credit: Torsten J. Naucke (University of Hohenheim)

Editorial

Neglected Tropical Diseases and the 2012 US Presidential Election

Peter J. Hotez, Karen A. Goraleski

PLOS Neglected Tropical Diseases: published November 29, 2011 | https://doi.org/10.1371/journal.pntd.0001431

Policy Platform

Economical Value of Vaccines for the Developing Countries—The Case of Instituto Butantan, a Public Institution in Brazil

Paulo Lee Ho, Eliane Namie Miyaji, Maria Leonor Sarno Oliveira, Waldely de Oliveira Dias, Flavia Saldanha Kubrusly, Martha Massako Tanizaki, Elizabeth Angélica Leme Martins, Isaias Raw

PLOS Neglected Tropical Diseases: published November 29, 2011 | https://doi.org/10.1371/journal.pntd.0001300

Symposium

Laboratory-Acquired Dengue Virus Infection—A Case Report

Sumudu Britton, Andrew F. van den Hurk, Russell J. Simmons, Alyssa T. Pyke, Judith A. Northill, James McCarthy, Joe McCormack

PLOS Neglected Tropical Diseases: published November 29, 2011 | https://doi.org/10.1371/journal.pntd.0001324

Review

The NIH-NIAID Filariasis Research Reagent Resource Center

Michelle L. Michalski, Kathryn G. Griffiths, Steven A. Williams, Ray M. Kaplan, Andrew R. Moorhead

PLOS Neglected Tropical Diseases: published November 29, 2011 | https://doi.org/10.1371/journal.pntd.0001261

Research Articles

Entamoeba lysyl-tRNA Synthetase Contains a Cytokine-Like Domain with Chemokine Activity towards Human Endothelial Cells

Manuel Castro de Moura, Francesc Miro, Jung Min Han, Sunghoon Kim, Antonio Celada, Lluís Ribas de Pouplana

PLOS Neglected Tropical Diseases: published November 29, 2011 | https://doi.org/10.1371/journal.pntd.0001398

Visceral Leishmaniasis in the Indian Subcontinent: Modelling Epidemiology and Control

Anette Stauch, Ram Rup Sarkar, Albert Picado, Bart Ostyn, Shyam Sundar, Suman Rijal, Marleen Boelaert, Jean-Claude Dujardin, Hans-Peter Duerr

PLOS Neglected Tropical Diseases: published November 29, 2011 | https://doi.org/10.1371/journal.pntd.0001405

Combining Climatic Projections and Dispersal Ability: A Method for Estimating the Responses of Sandfly Vector Species to Climate Change

Dominik Fischer, Philipp Moeller, Stephanie M. Thomas, Torsten J. Naucke, Carl Beierkuhnlein

PLOS Neglected Tropical Diseases: published November 29, 2011 | https://doi.org/10.1371/journal.pntd.0001407

Inhibition of Dengue Virus Entry and Multiplication into Monocytes Using RNA Interference

Mohammed Abdelfatah Alhoot, Seok Mui Wang, Shamala Devi Sekaran

PLOS Neglected Tropical Diseases: published November 29, 2011 | https://doi.org/10.1371/journal.pntd.0001410

Targeting the Wolbachia Cell Division Protein FtsZ as a New Approach for Antifilarial Therapy

Zhiru Li, Amanda L. Garner, Christian Gloeckner, Kim D. Janda, Clotilde K. Carlow

PLOS Neglected Tropical Diseases: published November 29, 2011 | https://doi.org/10.1371/journal.pntd.0001411

Larval Development of Aedes aegypti and Aedes albopictus in Peri-Urban Brackish Water and Its Implications for Transmission of Arboviral Diseases

Ranjan Ramasamy, Sinnathamby N. Surendran, Pavilupillai J. Jude, Sangaralingam Dharshini, Muthuladchumy Vinobaba

PLOS Neglected Tropical Diseases: published November 22, 2011 | https://doi.org/10.1371/journal.pntd.0001369

The Salivary Secretome of the Tsetse Fly Glossina pallidipes (Diptera: Glossinidae) Infected by Salivary Gland Hypertrophy Virus

Henry M. Kariithi, Ikbal A. Ince, Sjef Boeren, Adly M. M. Abd-Alla, Andrew G. Parker, Serap Aksoy, Just M. Vlak, Monique M. van Oers

PLOS Neglected Tropical Diseases: published November 22, 2011 | https://doi.org/10.1371/journal.pntd.0001371

Detection of Echinococcus multilocularis in Carnivores in Razavi Khorasan Province, Iran Using Mitochondrial DNA

Molouk Beiromvand, Lame Akhlaghi, Seyed Hossein Fattahi Massom, Iraj Mobedi, Ahmad Reza Meamar, Hormozd Oormazdi, Abbas Motevalian, Elham Razmjou

PLOS Neglected Tropical Diseases: published November 22, 2011 | https://doi.org/10.1371/journal.pntd.0001379

Accuracy of Urine Circulating Cathodic Antigen (CCA) Test for Schistosoma mansoni Diagnosis in Different Settings of Côte d'Ivoire

Jean T. Coulibaly, Stefanie Knopp, Nicaise A. N'Guessan, Kigbafori D. Silué, Thomas Fürst, Laurent K. Lohourignon, Jean K. Brou, Yve K. N'Gbesso, Penelope Vounatsou, Eliézer K. N'Goran, Jürg Utzinger

PLOS Neglected Tropical Diseases: published November 22, 2011 | https://doi.org/10.1371/journal.pntd.0001384

Dog Bites in Humans and Estimating Human Rabies Mortality in Rabies Endemic Areas of Bhutan

Tenzin, Navneet K. Dhand, Tashi Gyeltshen, Simon Firestone, Chhimi Zangmo, Chimi Dema, Rawang Gyeltshen, Michael P. Ward

PLOS Neglected Tropical Diseases: published November 22, 2011 | https://doi.org/10.1371/journal.pntd.0001391

A Lipopeptide Facilitate Induction of Mycobacterium leprae Killing in Host Cells

Yumi Maeda, Toshiki Tamura, Yasuo Fukutomi, Tetsu Mukai, Masanori Kai, Masahiko Makino

PLOS Neglected Tropical Diseases: published November 22, 2011 | https://doi.org/10.1371/journal.pntd.0001401

The Field-Testing of a Novel Integrated Mapping Protocol for Neglected Tropical Diseases

Sonia Pelletreau, Mawuli Nyaku, Massitan Dembele, Boubacar Sarr, Philip Budge, Rachael Ross, Els Mathieu

PLOS Neglected Tropical Diseases: published November 15, 2011 | https://doi.org/10.1371/journal.pntd.0001380

Global Cross-Talk of Genes of the Mosquito Aedes aegypti in Response to Dengue Virus Infection

Susanta K. Behura, Consuelo Gomez-Machorro, Brent W. Harker, Becky deBruyn, Diane D. Lovin, Ryan R. Hemme, Akio Mori, Jeanne Romero-Severson, David W. Severson

PLOS Neglected Tropical Diseases: published November 15, 2011 | https://doi.org/10.1371/journal.pntd.0001385

Ebola Virus Glycoprotein Needs an Additional Trigger, beyond Proteolytic Priming for Membrane Fusion

Shridhar Bale, Tong Liu, Sheng Li, Yuhao Wang, Dafna Abelson, Marnie Fusco, Virgil L. Woods Jr., Erica Ollmann Saphire

PLOS Neglected Tropical Diseases: published November 15, 2011 | https://doi.org/10.1371/journal.pntd.0001395

Dynamics of Th17 Cells and Their Role in Schistosoma japonicum Infection in C57BL/6 Mice

Xiaoyun Wen, Lei He, Ying Chi, Sha Zhou, Jason Hoellwarth, Cui Zhang, Jifeng Zhu, Calvin Wu, Shawn Dhesi, Xuefeng Wang, Feng Liu, Chuan Su

PLOS Neglected Tropical Diseases: published November 15, 2011 | https://doi.org/10.1371/journal.pntd.0001399

Molecular Typing of Treponema pallidum: A Systematic Review and Meta-Analysis

Rui-Rui Peng, Alberta L. Wang, Jing Li, Joseph D. Tucker, Yue-Ping Yin, Xiang-Sheng Chen

PLOS Neglected Tropical Diseases: published November 8, 2011 | https://doi.org/10.1371/journal.pntd.0001273

Life Quality Impairment Caused by Hookworm-Related Cutaneous Larva Migrans in Resource-Poor Communities in Manaus, Brazil

Angela Schuster, Hannah Lesshafft, Sinésio Talhari, Silás Guedes de Oliveira, Ralf Ignatius, Hermann Feldmeier

PLOS Neglected Tropical Diseases: published November 8, 2011 | https://doi.org/10.1371/journal.pntd.0001355

Comparison of Two Multilocus Sequence Based Genotyping Schemes for Leptospira Species

Ahmed Ahmed, Janjira Thaipadungpanit, Siriphan Boonsilp, Vanaporn Wuthiekanun, Kishore Nalam, Brian G. Spratt, David M. Aanensen, Lee D. Smythe, Niyaz Ahmed, Edward J. Feil, Rudy A. Hartskeerl, Sharon J. Peacock

PLOS Neglected Tropical Diseases: published November 8, 2011 | https://doi.org/10.1371/journal.pntd.0001374

Development and Evaluation of a New Lateral Flow Immunoassay for Serodiagnosis of Human Fasciolosis

Victoria Martínez-Sernández, Laura Muiño, María Jesús Perteguer, Teresa Gárate, Mercedes Mezo, Marta González-Warleta, Antonio Muro, José Manuel Correia da Costa, Fernanda Romarís, Florencio M. Ubeira

PLOS Neglected Tropical Diseases: published November 8, 2011 | https://doi.org/10.1371/journal.pntd.0001376

Induction of CD4⁺CD25⁺FOXP3⁺ Regulatory T Cells during Human Hookworm Infection Modulates Antigen-Mediated Lymphocyte Proliferation

Natasha Delaqua Ricci, Jacqueline Araújo Fiúza, Lilian Lacerda Bueno, Guilherme Grossi Lopes Cançado, Pedro Henrique Gazzinelli-Guimarães, Virgillio Gandra Martins, Leonardo Ferreira Matoso, Rodrigo Rodrigues Cambraia de Miranda, Stefan Michael Geiger, Rodrigo Correa-Oliveira, Andréa Gazzinelli, Daniella Castanheira Bartholomeu, Ricardo Toshio Fujiwara

PLOS Neglected Tropical Diseases: published November 8, 2011 | https://doi.org/10.1371/journal.pntd.0001383

Fatal Attraction Phenomenon in Humans – Cat Odour Attractiveness Increased for Toxoplasma-Infected Men While Decreased for Infected Women

Jaroslav Flegr, Pavlína Lenochová, Zdeněk Hodný, Marta Vondrová

PLOS Neglected Tropical Diseases: published November 8, 2011 | https://doi.org/10.1371/journal.pntd.0001389

Adequate Wound Care and Use of Bed Nets as Protective Factors against Buruli Ulcer: Results from a Case Control Study in Cameroon

Jordi Landier, Pascal Boisier, Félix Fotso Piam, Blanbin Noumen-Djeunga, Joseph Simé, Fidèle Gaetan Wantong, Laurent Marsollier, Arnaud Fontanet, Sara Eyangoh

PLOS Neglected Tropical Diseases: published November 8, 2011 | https://doi.org/10.1371/journal.pntd.0001392

Unusual Dengue Virus 3 Epidemic in Nicaragua, 2009

Gamaliel Gutierrez, Katherine Standish, Federico Narvaez, Maria Angeles Perez, Saira Saborio, Douglas Elizondo, Oscar Ortega, Andrea Nuñez, Guillermina Kuan, Angel Balmaseda, Eva Harris

PLOS Neglected Tropical Diseases: published November 8, 2011 | https://doi.org/10.1371/journal.pntd.0001394

Evaluation of the Traditional and Revised WHO Classifications of Dengue Disease Severity

Federico Narvaez, Gamaliel Gutierrez, Maria Angeles Pérez, Douglas Elizondo, Andrea Nuñez, Angel Balmaseda, Eva Harris

PLOS Neglected Tropical Diseases: published November 8, 2011 | https://doi.org/10.1371/journal.pntd.0001397

The JAK-STAT Pathway Controls Plasmodium vivax Load in Early Stages of Anopheles aquasalis Infection

Ana C. Bahia, Marina S. Kubota, Antonio J. Tempone, Helena R. C. Araújo, Bruno A. M. Guedes, Alessandra S. Orfanó, Wanderli P. Tadei, Claudia M. Ríos-Velásquez, Yeon S. Han, Nágila F. C. Secundino, Carolina Barillas-Mury, Paulo F. P. Pimenta, Yara M. Traub-Csekö

PLOS Neglected Tropical Diseases: published November 1, 2011 | https://doi.org/10.1371/journal.pntd.0001317

Sleeping Sickness in Travelers - Do They Really Sleep?

Karin Urech, Andreas Neumayr, Johannes Blum

PLOS Neglected Tropical Diseases: published November 1, 2011 | https://doi.org/10.1371/journal.pntd.0001358

Cell-Associated Flagella Enhance the Protection Conferred by Mucosally-Administered Attenuated Salmonella Paratyphi A Vaccines

Orit Gat, James E. Galen, Sharon Tennant, Raphael Simon, William C. Blackwelder, David J. Silverman, Marcela F. Pasetti, Myron M. Levine

PLOS Neglected Tropical Diseases: published November 1, 2011 | https://doi.org/10.1371/journal.pntd.0001373

Crystal Structure of the Complex mAb 17.2 and the C-Terminal Region of Trypanosoma cruzi P2β Protein: Implications in Cross-Reactivity

Juan Carlos Pizarro, Ginette Boulot, Graham A. Bentley, Karina A. Gómez, Johan Hoebeke, Mireille Hontebeyrie, Mariano J. Levin, Cristian R. Smulski

PLOS Neglected Tropical Diseases: published November 1, 2011 | https://doi.org/10.1371/journal.pntd.0001375

Challenges in Estimating Insecticide Selection Pressures from Mosquito Field Data

Susana Barbosa, William C. Black IV, Ian Hastings

PLOS Neglected Tropical Diseases: published November 1, 2011 | https://doi.org/10.1371/journal.pntd.0001387

Cover

Female phlebotomine sandfly (Phlebotomus mascittii) during blood meal on human skin.