Molecular Mechanisms of Drug Resistance in Natural Leishmania Populations Vary with Genetic Background

Saskia Decuypere; Manu Vanaerschot; Kirstyn Brunker; Hideo Imamura; Sylke Müller; Basudha Khanal; Suman Rijal; Jean-Claude Dujardin; Graham H. Coombs

doi:10.1371/journal.pntd.0001514

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Peer-reviewed

Research Article

Molecular Mechanisms of Drug Resistance in Natural Leishmania Populations Vary with Genetic Background

Saskia Decuypere,

Affiliations Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland, United Kingdom, Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom
⨯
Manu Vanaerschot,

Affiliation Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
⨯
Kirstyn Brunker,

Affiliation Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland, United Kingdom
⨯
Hideo Imamura,

Affiliations Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, England, United Kingdom
⨯
Sylke Müller,

Affiliation Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom
⨯
Basudha Khanal,

Affiliation B.P. Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal
⨯
Suman Rijal,

Affiliation B.P. Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal
⨯
Jean-Claude Dujardin ,

* E-mail: jcdujardin@itg.be

Affiliations Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
⨯
Graham H. Coombs

Affiliation Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, Scotland, United Kingdom
⨯

Molecular Mechanisms of Drug Resistance in Natural Leishmania Populations Vary with Genetic Background

Saskia Decuypere,
Manu Vanaerschot,
Kirstyn Brunker,
Hideo Imamura,
Sylke Müller,
Basudha Khanal,
Suman Rijal,
Jean-Claude Dujardin,
Graham H. Coombs

Published: February 28, 2012
https://doi.org/10.1371/journal.pntd.0001514

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Leishmania donovani
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