Roles of Small GTPase Rac1 in the Regulation of Actin Cytoskeleton during Dengue Virus Infection

Jia-Li Wang; Jun-Lei Zhang; Wei Chen; Xiao-Feng Xu; Na Gao; Dong-Ying Fan; Jing An

doi:10.1371/journal.pntd.0000809

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Open Access

Peer-reviewed

Research Article

Roles of Small GTPase Rac1 in the Regulation of Actin Cytoskeleton during Dengue Virus Infection

Jia-Li Wang,

Affiliation Department of Microbiology, Third Military Medical University, Chongqing, People's Republic of China
⨯
Jun-Lei Zhang,

Affiliation Department of Microbiology, Third Military Medical University, Chongqing, People's Republic of China
⨯
Wei Chen,

Affiliation Department of Microbiology, Third Military Medical University, Chongqing, People's Republic of China
⨯
Xiao-Feng Xu,

Affiliation Department of Genetics, Third Military Medical University, Chongqing, People's Republic of China
⨯
Na Gao,

Affiliation Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, People's Republic of China
⨯
Dong-Ying Fan,

Affiliation Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, People's Republic of China
⨯
Jing An

* E-mail: anjing60@yahoo.com.cn

Affiliation Department of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, People's Republic of China
⨯

Roles of Small GTPase Rac1 in the Regulation of Actin Cytoskeleton during Dengue Virus Infection

Jia-Li Wang,
Jun-Lei Zhang,
Wei Chen,
Xiao-Feng Xu,
Na Gao,
Dong-Ying Fan,
Jing An

Published: August 31, 2010
https://doi.org/10.1371/journal.pntd.0000809

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Is ECV304 an endothelial cell line?

Posted by trjm on 18 Feb 2012 at 22:03 GMT

I am surprised to see that ECV304 cell line is still being used as an endothelial cell line after two papers in 1999 and 2000 clearly showed that it is not.

The two papers are

1: Dirks WG, MacLeod RA, Drexler HG. ECV304 (endothelial) is really T24 (bladder carcinoma): cell line cross- contamination at source. In Vitro Cell Dev Biol Anim. 1999 Nov-Dec;35(10):558-9. PubMed PMID: 10614862.

2: Brown J, Reading SJ, Jones S, Fitchett CJ, Howl J, Martin A, Longland CL, Michelangeli F, Dubrova YE, Brown CA. Critical evaluation of ECV304 as a human endothelial cell model defined by genetic analysis and functional responses: a comparison with the human bladder cancer derived epithelial cell line T24/83. Lab Invest. 2000 Jan;80(1):37-45. PubMed PMID: 10653001.

No competing interests declared.

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Actins
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Cytoskeleton
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Guanosine triphosphatase
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Actin filaments
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Vascular permeability
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Endocytosis
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Dengue fever
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West Nile virus
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Roles of Small GTPase Rac1 in the Regulation of Actin Cytoskeleton during Dengue Virus Infection

Roles of Small GTPase Rac1 in the Regulation of Actin Cytoskeleton during Dengue Virus Infection

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Is ECV304 an endothelial cell line?

Posted by trjm on 18 Feb 2012 at 22:03 GMT