Functional genomics of chitin degradation by Vibrio parahaemolyticus reveals finely integrated metabolic contributions to support environmental fitness

Landon J. Getz, Oriana S. Robinson, Nikhil A. Thomas

PLOS Genetics: published March 3, 2025 | https://doi.org/10.1371/journal.pgen.1011370

Human CD33 deficiency is associated with mild alteration of circulating white blood cell counts

John Dominy, Jirong Bai, Christopher Koch, Maleeha Zaman Khan, Shareef Khalid, Jonathan H. Chung, Madhura Panditrao, Lulu Liu, Qi Zhang, Muhammad Jahanzaib, Muhammad Rehan Mian, Muhammad Bilal Liaqat, Syed Shahzaib Raza, Riffat Sultana, Anjum Jalal, Muhammad Hamid Saeed, Shahid Abbas, Fazal Rehman Memon, Mohammad Ishaq, Kashif Saleheen, Asif Rasheed, Allan Gurtan, Danish Saleheen

PLOS Genetics: published March 5, 2025 | https://doi.org/10.1371/journal.pgen.1011600

A novel role for Friend of GATA1 (FOG-1) in regulating cholesterol transport in murine erythropoiesis

Ioannis-Marios Roussis, David J. Pearton, Umar Niazi, Grigorios Tsaknakis, Giorgio L. Papadopoulos, Riley Cook, Mansoor Saqi, Jiannis Ragoussis, John Strouboulis

PLOS Genetics: published March 6, 2025 | https://doi.org/10.1371/journal.pgen.1011617

Species-specific circular RNA circDS-1 enhances adaptive evolution in Talaromyces marneffei through regulation of dimorphic transition

Xueyan Hu, Minghao Du, Changyu Tao, Juan Wang, Yun Zhang, Yueqi Jin, Ence Yang

PLOS Genetics: published March 6, 2025 | https://doi.org/10.1371/journal.pgen.1011482

Mutations in the Staphylococcus aureus Global Regulator CodY confer tolerance to an interspecies redox-active antimicrobial

Anthony M. Martini, Sara A. Alexander, Anupama Khare

PLOS Genetics: published March 7, 2025 | https://doi.org/10.1371/journal.pgen.1011610

Haplotype-based analysis distinguishes maternal-fetal genetic contribution to pregnancy-related outcomes

Amit K. Srivastava, Julius Juodakis, Pol Sole-Navais, Jing Chen, Jonas Bacelis, Kari Teramo, Mikko Hallman, Pal R. Njølstad, David M. Evans, Bo Jacobsson, Louis J. Muglia, Ge Zhang

PLOS Genetics: published March 10, 2025 | https://doi.org/10.1371/journal.pgen.1011575

Fission yeast Caprin protein is required for efficient heterochromatin establishment

Haidao Zhang, Ekaterina Kapitonova, Adriana Orrego, Christos Spanos, Joanna Strachan, Elizabeth H. Bayne

PLOS Genetics: published March 10, 2025 | https://doi.org/10.1371/journal.pgen.1011620

Dynamics of X chromosome hyper-expression and inactivation in male tissues during stick insect development

Jelisaveta Djordjevic, Patrick Tran Van, William Toubiana, Marjorie Labédan, Zoé Dumas, Jean-Marc Aury, Corinne Cruaud, Benjamin Istace, Karine Labadie, Benjamin Noel, Darren J. Parker, Tanja Schwander

PLOS Genetics: published March 10, 2025 | https://doi.org/10.1371/journal.pgen.1011615

The USH3A causative gene clarin1 functions in Müller glia to maintain retinal photoreceptors

Hannah J. T. Nonarath, Samantha L. Simpson, Tricia L. Slobodianuk, Hai Tran, Ross F. Collery, Astra Dinculescu, Brian A. Link

PLOS Genetics: published March 11, 2025 | https://doi.org/10.1371/journal.pgen.1011205

Critical functions and key interactions mediated by the RNase E scaffolding domain in Pseudomonas aeruginosa

Sandra Amandine Marie Geslain, Stéphane Hausmann, Johan Geiser, George Edward Allen, Diego Gonzalez, Martina Valentini

PLOS Genetics: published March 17, 2025 | https://doi.org/10.1371/journal.pgen.1011618

TRIM21 modulates stability of pro-survival non-coding RNA vtRNA1–1 in human hepatocellular carcinoma cells

EunBin Kong, Norbert Polacek

PLOS Genetics: published March 17, 2025 | https://doi.org/10.1371/journal.pgen.1011614

Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer’s Disease

Nicholas R. Ray, Joseph Bradley, Elanur Yilmaz, Caghan Kizil, Jiji T. Kurup, Eden R. Martin, Hans-Ulrich Klein, Brian W. Kunkle, David A. Bennett, Philip L. De Jager, Alzheimer’s Disease Genetics Consortium, Gary W. Beecham, Carlos Cruchaga, Christiane Reitz

PLOS Genetics: published March 17, 2025 | https://doi.org/10.1371/journal.pgen.1011631

Roles of P-body factors in Candida albicans filamentation and stress response

Melissa A. Tosiano, Frederick Lanni, Aaron P. Mitchell, C. Joel McManus

PLOS Genetics: published March 17, 2025 | https://doi.org/10.1371/journal.pgen.1011632

map3k1 suppresses terminal differentiation of migratory eye progenitors in planarian regeneration

Katherine C. Lo, Christian P. Petersen

PLOS Genetics: published March 17, 2025 | https://doi.org/10.1371/journal.pgen.1011457

MEOX1-mediated transcriptional regulation of circABHD3 exacerbates hepatic fibrosis through promoting m6A/YTHDF2-dependent YPEL3 mRNA decay to activate β-catenin signaling

Limin Chen, Hui Yang, Juan Wang, Haoye Zhang, Kangkang Fu, Yu Yan, Zhenguo Liu

PLOS Genetics: published March 18, 2025 | https://doi.org/10.1371/journal.pgen.1011622

Evolution of canonical circadian clock genes underlies unique sleep strategies of marine mammals for secondary aquatic adaptation

Daiqing Yin, Zhaomin Zhong, Fan Zeng, Zhikang Xu, Jing Li, Wenhua Ren, Guang Yang, Han Wang, Shixia Xu

PLOS Genetics: published March 18, 2025 | https://doi.org/10.1371/journal.pgen.1011598

Mouse-Geneformer: A deep learning model for mouse single-cell transcriptome and its cross-species utility

Keita Ito, Tsubasa Hirakawa, Shuji Shigenobu, Hironobu Fujiyoshi, Takayoshi Yamashita

PLOS Genetics: published March 19, 2025 | https://doi.org/10.1371/journal.pgen.1011420

Valve cells are crucial for efficient cardiac performance in Drosophila

Christian Meyer, Achim Paululat

PLOS Genetics: published March 20, 2025 | https://doi.org/10.1371/journal.pgen.1011613

A defining member of the new cysteine-cradle family is an aECM protein signalling skin damage in C. elegans

Thomas Sonntag, Shizue Omi, Antonina Andreeva, Claire Valotteau, Jeanne Eichelbrenner, Andrew D. Chisholm, Jordan D. Ward, Nathalie Pujol

PLOS Genetics: published March 20, 2025 | https://doi.org/10.1371/journal.pgen.1011593

Chemical genomics informs antibiotic and essential gene function in Acinetobacter baumannii

Jennifer Suzanne Tran, Ryan David Ward, Rubén Iruegas-López, Ingo Ebersberger, Jason Matthew Peters

PLOS Genetics: published March 28, 2025 | https://doi.org/10.1371/journal.pgen.1011642

Alternative promoter usage during organ development

Jiang Tan, Yidan Sun

PLOS Genetics: published March 28, 2025 | https://doi.org/10.1371/journal.pgen.1011635

Quantitative analysis of relationship between mutation rate and speed of adaptation under antibiotic exposure in Escherichia coli

Atsushi Shibai, Minako Izutsu, Hazuki Kotani, Chikara Furusawa

PLOS Genetics: published March 28, 2025 | https://doi.org/10.1371/journal.pgen.1011627

Generation of prostate cancer assembloids modeling the patient-specific tumor microenvironment

Juhee Lee, Yunhee Kim, Cheol Lee, Seong Soo Jeon, Hae Seo, Jongwon Lee, Jungmin Choi, Minyong Kang, Eunjee Kim, Kunyoo Shin

PLOS Genetics: published March 31, 2025 | https://doi.org/10.1371/journal.pgen.1011652

Human genetic evidence enriched for side effects of approved drugs

Eric Vallabh Minikel, Matthew R. Nelson

PLOS Genetics: published March 31, 2025 | https://doi.org/10.1371/journal.pgen.1011638

RatXcan: A framework for cross-species integration of genome-wide association and gene expression data

Natasha Santhanam, Sandra Sanchez-Roige, Sabrina Mi, Yanyu Liang, Apurva S. Chitre, Daniel Munro, Denghui Chen, Jianjun Gao, Angel Garcia-Martinez, Anthony M. George, Alexander F. Gileta, Wenyan Han, Katie Holl, Alesa Hughson, Christopher P. King, Alexander C. Lamparelli, Connor D. Martin, Festus Nyasimi, Celine L. St. Pierre, Sarah Sumner, Jordan Tripi, Tengfei Wang, Hao Chen, Shelly Flagel, Keita Ishiwari, Paul Meyer, Oksana Polesskaya, Laura Saba, Leah C. Solberg Woods, Abraham A. Palmer, Hae Kyung Im

PLOS Genetics: published March 31, 2025 | https://doi.org/10.1371/journal.pgen.1011583

Parental germline mosaicism in genome-wide phased de novo variants: Recurrence risk assessment and implications for precision genetic counselling

François Lecoquierre, Nathalie Drouot, Sophie Coutant, Olivier Quenez, Steeve Fourneaux, Fanny Jumeau, Nathalie Rives, Françoise Charbonnier, Céline Derambure, Anne Boland, Robert Olaso, Vincent Meyer, Jean-François Deleuze, Alice Goldenberg, Anne-Marie Guerrot, Camille Charbonnier, Gaël Nicolas

PLOS Genetics: published March 31, 2025 | https://doi.org/10.1371/journal.pgen.1011651

Gene expression in soft-shell clam (Mya arenaria) transmissible cancer reveals survival mechanisms during host infection and seawater transfer

Samuel F.M. Hart, Fiona E. S. Garrett, Jesse S. Kerr, Michael J. Metzger

PLOS Genetics: published March 31, 2025 | https://doi.org/10.1371/journal.pgen.1011629

Archaic introgression and the distribution of shared variation under stabilizing selection

Aaron P Ragsdale

PLOS Genetics: published March 31, 2025 | https://doi.org/10.1371/journal.pgen.1011623

The nuclear poly(A)-binding protein Pab2/PABPN1 promotes heterochromatin assembly through the formation of Pab2 nuclear condensates

Ziyue Liu, Xiuyi Song, Gobi Thillainadesan, Tomoyasu Sugiyama

PLOS Genetics: published March 31, 2025 | https://doi.org/10.1371/journal.pgen.1011647

Significant roles in RNA-binding for the amino-terminal regions of Drosophila Pumilio and Nanos

Tammy H. Wharton, Mohammad Marhabaie, Robin P. Wharton

PLOS Genetics: published March 31, 2025 | https://doi.org/10.1371/journal.pgen.1011616

Fluctuating reproductive isolation and stable ancestry structure in a fine-scaled mosaic of hybridizing Mimulus monkeyflowers

Matthew C. Farnitano, Keith Karoly, Andrea L. Sweigart

PLOS Genetics: published March 31, 2025 | https://doi.org/10.1371/journal.pgen.1011624

Doxifluridine promotes host longevity through bacterial metabolism

Rui Wei, Yuling Peng, Yamei Luo, Xinyuan Wang, Zhenzhong Pan, Ran Zhou, Huan Yang, Zongyao Huang, Yaojia Liu, Lunzhi Dai, Yuan Wang, Yan Zhang

PLOS Genetics: published March 31, 2025 | https://doi.org/10.1371/journal.pgen.1011648

Correction: Canadian COVID-19 host genetics cohort replicates known severity associations

Elika Garg, Paola Arguello-Pascualli, Olga Vishnyakova, Anat R. Halevy, Samantha Yoo, Jennifer D. Brooks, Shelley B. Bull, France Gagnon, Celia M. T. Greenwood, Rayjean J. Hung, Jerald F. Lawless, Jordan Lerner-Ellis, Jessica K. Dennis, Rohan J. S. Abraham, Jean-Michel Garant, Bhooma Thiruvahindrapuram, Steven J. M. Jones, CGEn HostSeq Initiative, Lisa J. Strug, Andrew D. Paterson, Lei Sun, Lloyd T. Elliott

PLOS Genetics: published March 4, 2025 | https://doi.org/10.1371/journal.pgen.1011628

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1. Canadian COVID-19 host genetics cohort replicates known severity associations