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Table of Contents

January 2025

This pollen killer, observed within local natural populations of Arabidopsis thaliana, cheats Mendel’s inheritance laws in the progeny of hybrids because an allele possessing poison and antidote genes provokes the death of the pollen grains that do not carry them. Here, Alexander staining of the anther reveals the pollen viability: pollen grains with the killer allele are viable and colored in red while dead pollen grains appear blue. See Ricou et al. Download January’s cover page.

Image Credit: Anthony Ricou

Research Articles

Polymyositis in Kooiker dogs is associated with a 39 kb deletion upstream of the canine IL21/IL2 locus

Yvet Opmeer, Frank G. van Steenbeek, Claudia Rozendom, Hille Fieten, Montse M. Diaz Espineira, Qurine E. M. Stassen, Peter J. van Kooten, Victor P. M. G. Rutten, Marjo K. Hytönen, Hannes Lohi, Paul J. J. Mandigers, Peter A. Leegwater

Multi-modal comparison of molecular programs driving nurse cell death and clearance in Drosophila melanogaster oogenesis

Shruthi Bandyadka, Diane P. V. Lebo, Albert A. Mondragon, Sandy B. Serizier, Julian Kwan, Jeanne S. Peterson, Alexandra Y. Chasse, Victoria K. Jenkins, Anoush Calikyan, Anthony J. Ortega, Joshua D. Campbell, Andrew Emili, Kimberly McCall

Leveraging cancer mutation data to inform the pathogenicity classification of germline missense variants

Bushra Haque, David Cheerie, Amy Pan, Meredith Curtis, Thomas Nalpathamkalam, Jimmy Nguyen, Celine Salhab, Bhooma Thiruvahindrapuram, Jade Zhang, Madeline Couse, Taila Hartley, Michelle M. Morrow, E. Magda Price, Susan Walker, David Malkin, Frederick P. Roth, Gregory Costain

Light-regulated microRNAs shape dynamic gene expression in the zebrafish circadian clock

Zuo Wang, Shuang Wang, Yi Bi, Alessandra Boiti, Shengxiang Zhang, Daniela Vallone, Xianyong Lan, Nicholas S. Foulkes, Haiyu Zhao

Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo

Sara Formichetti, Agnieszka Sadowska, Michela Ascolani, Julia Hansen, Kerstin Ganter, Christophe Lancrin, Neil Humphreys, Mathieu Boulard

Refining fine-mapping: Effect sizes and regional heritability

Christian Benner, Anubha Mahajan, Matti Pirinen

metaGE: Investigating genotype x environment interactions through GWAS meta-analysis

Annaïg De Walsche, Alexis Vergne, Renaud Rincent, Fabrice Roux, Stéphane Nicolas, Claude Welcker, Sofiane Mezmouk, Alain Charcosset, Tristan Mary-Huard

The dependence of shugoshin on Bub1-kinase activity is dispensable for the maintenance of spindle assembly checkpoint response in Cryptococcus neoformans

Satya Dev Polisetty, Krishna Bhat, Kuladeep Das, Ivan Clark, Kevin G. Hardwick, Kaustuv Sanyal

Identification of novel genes responsible for a pollen killer present in local natural populations of Arabidopsis thaliana

Anthony Ricou, Matthieu Simon, Rémi Duflos, Marianne Azzopardi, Fabrice Roux, Françoise Budar, Christine Camilleri

Ambivalent partnership of the Drosophila posterior class Hox protein Abdominal-B with Extradenticle and Homothorax

Jesús R. Curt, Paloma Martín, David Foronda, Bruno Hudry, Ramakrishnan Kannan, Srividya Shetty, Samir Merabet, Andrew J. Saurin, Yacine Graba, Ernesto Sánchez- Herrero

IP3 receptor depletion in a spontaneous canine model of Charcot-Marie-Tooth disease 1J with amelogenesis imperfecta

Marjo K. Hytönen, Julius Rönkkö, Sruthi Hundi, Tarja S. Jokinen, Emilia Suonto, Eeva Teräväinen, Jonas Donner, Rita La Rovere, Geert Bultynck, Emil Ylikallio, Henna Tyynismaa, Hannes Lohi

Diversification and recurrent adaptation of the synaptonemal complex in Drosophila

Rana Zakerzade, Ching-Ho Chang, Kamalakar Chatla, Ananya Krishnapura, Samuel P. Appiah, Jacki Zhang, Robert L. Unckless, Justin P. Blumenstiel, Doris Bachtrog, Kevin H-C. Wei

Evolutionary lineage-specific genomic imprinting at the ZNF791 locus

Jinsoo Ahn, In-Sul Hwang, Mi-Ryung Park, Milca Rosa-Velazquez, In-Cheol Cho, Alejandro E. Relling, Seongsoo Hwang, Kichoon Lee

Investigative genetic genealogy practices warranting policy attention: Results of a modified policy Delphi

Christi J. Guerrini, Louiza Kalokairinou, Jill O. Robinson, Whitney Bash Brooks, Stephanie M. Fullerton, Sara Huston, Jacklyn Dahlquist, Diana Madden, Norah Crossnohere, Nicola Campoamor, John F. P. Bridges, Amy L. McGuire

Short- and long-range roles of UNC-6/Netrin in dorsal-ventral axon guidance in vivo in Caenorhabditis elegans

Kelsey M. Hooper, Vedant D. Jain, Celeste J. Gormly, Brian J. Sanderson, Erik A. Lundquist

Tail Anchored protein insertion mediated by CAML and TRC40 links to neuromuscular function in mice

Ying Zhang, Lihong He, Justin Gundelach, Anjie Ge, Helena Edlund, Stefan Norlin, Richard J. Bram

F-box protein Fbx23 acts as a transcriptional coactivator to recognize and activate transcription factor Ace1

Zhongjiao Liu, Kexuan Ma, Panpan Zhang, Siqi Zhang, Xin Song, Yuqi Qin

Multi-modal investigation reveals pathogenic features of diverse DDX3X missense mutations

Federica Mosti, Mariah L. Hoye, Carla F. Escobar-Tomlienovich, Debra L. Silver

SEM-2/SoxC regulates multiple aspects of C. elegans postembryonic mesoderm development

Marissa Baccas, Vanathi Ganesan, Amy Leung, Lucas R. Pineiro, Alexandra N. McKillop, Jun Liu

Sequence specificity of an essential nuclear localization sequence in Mcm3

Ziyi Wang, Yun Jing Zhang, Qian-yi Zhang, Kate Bilsborrow, Matthew Leslie, Raymond T. Suhandynata, Huilin Zhou

The Cul3 ubiquitin ligase engages Insomniac as an adaptor to impact sleep and synaptic homeostasis

Qiuling Li, Kayla Y. Lim, Raad Altawell, Faith Verderose, Xiling Li, Wanying Dong, Joshua Martinez, Dion Dickman, Nicholas Stavropoulos

Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation

Dylan Carter-Cusack, Stephen Huang, Sahar Keshvari, Omkar Patkar, Anuj Sehgal, Rachel Allavena, Robert A. J. Byrne, B. Paul Morgan, Stephen J. Bush, Kim M. Summers, Katharine M. Irvine, David A. Hume

A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs

Jia Li, Ruoling Bai, Yulian Zhou, Xu Song, Ling Li

Minimization of the Bacillus subtilis divisome suggests FtsZ and SepF can form an active Z-ring, and reveals the amino acid transporter BraB as a new cell division influencing factor

Ilkay Celik Gulsoy, Terrens N. V. Saaki, Michaela Wenzel, Simon Syvertsson, Taku Morimoto, Tjalling K. Siersma, Leendert W. Hamoen

Coordinated neuron-glia regeneration through Notch signaling in planarians

M. Lucila Scimone, Bryanna Isela-Inez Canales, Patrick Aoude, Kutay D. Atabay, Peter W. Reddien

Distinct checkpoint and homolog biorientation pathways regulate meiosis I in Drosophila oocytes

Joanatta G. Shapiro, Neha Changela, Janet K. Jang, Jay N. Joshi, Kim S. McKim

Sox2 interacts with Atoh1 and Huwe1 loci to regulate Atoh1 transcription and stability during hair cell differentiation

Yen-Fu Cheng, Judith S. Kempfle, Hao Chiang, Kohsuke Tani, Quan Wang, Sheng-Hong Chen, Danielle Lenz, Wei-Yi Chen, Wenjin Wu, Marco Petrillo, Albert S. B. Edge

PRC2 promotes canalisation during endodermal differentiation

Jurriaan Jochem Hölzenspies, Dipta Sengupta, Wendy Anne Bickmore, Joshua Mark Brickman, Robert Scott Illingworth

An extreme mutational hotspot in nlpD depends on transcriptional induction of rpoS

Andrew D. Farr, Christina Vasileiou, Peter A. Lind, Paul B. Rainey

Rapid expansion and specialization of the TAS2R bitter taste receptor family in amphibians

Kathleen W. Higgins, Akihiro Itoigawa, Yasuka Toda, Daniel Winston Bellott, Rachel Anderson, Roberto Márquez, Jing-Ke Weng

Methods

Improving polygenic prediction from summary data by learning patterns of effect sharing across multiple phenotypes

Deborah Kunkel, Peter Sørensen, Vijay Shankar, Fabio Morgante

Estimating evolutionary and demographic parameters via ARG-derived IBD

Zhendong Huang, Jerome Kelleher, Yao-ban Chan, David Balding

ADELLE: A global testing method for trans-eQTL mapping

Takintayo Akinbiyi, Mary Sara McPeek, Mark Abney