January 2025

This pollen killer, observed within local natural populations of Arabidopsis thaliana, cheats Mendel’s inheritance laws in the progeny of hybrids because an allele possessing poison and antidote genes provokes the death of the pollen grains that do not carry them. Here, Alexander staining of the anther reveals the pollen viability: pollen grains with the killer allele are viable and colored in red while dead pollen grains appear blue. See Ricou et al. Download January’s cover page.

Image Credit: Anthony Ricou

Research Articles

Polymyositis in Kooiker dogs is associated with a 39 kb deletion upstream of the canine IL21/IL2 locus

Yvet Opmeer, Frank G. van Steenbeek, Claudia Rozendom, Hille Fieten, Montse M. Diaz Espineira, Qurine E. M. Stassen, Peter J. van Kooten, Victor P. M. G. Rutten, Marjo K. Hytönen, Hannes Lohi, Paul J. J. Mandigers, Peter A. Leegwater

PLOS Genetics: published January 2, 2025 | https://doi.org/10.1371/journal.pgen.1011538

Multi-modal comparison of molecular programs driving nurse cell death and clearance in Drosophila melanogaster oogenesis

Shruthi Bandyadka, Diane P. V. Lebo, Albert A. Mondragon, Sandy B. Serizier, Julian Kwan, Jeanne S. Peterson, Alexandra Y. Chasse, Victoria K. Jenkins, Anoush Calikyan, Anthony J. Ortega, Joshua D. Campbell, Andrew Emili, Kimberly McCall

PLOS Genetics: published January 3, 2025 | https://doi.org/10.1371/journal.pgen.1011220

Leveraging cancer mutation data to inform the pathogenicity classification of germline missense variants

Bushra Haque, David Cheerie, Amy Pan, Meredith Curtis, Thomas Nalpathamkalam, Jimmy Nguyen, Celine Salhab, Bhooma Thiruvahindrapuram, Jade Zhang, Madeline Couse, Taila Hartley, Michelle M. Morrow, E. Magda Price, Susan Walker, David Malkin, Frederick P. Roth, Gregory Costain

PLOS Genetics: published January 6, 2025 | https://doi.org/10.1371/journal.pgen.1011540

Light-regulated microRNAs shape dynamic gene expression in the zebrafish circadian clock

Zuo Wang, Shuang Wang, Yi Bi, Alessandra Boiti, Shengxiang Zhang, Daniela Vallone, Xianyong Lan, Nicholas S. Foulkes, Haiyu Zhao

PLOS Genetics: published January 8, 2025 | https://doi.org/10.1371/journal.pgen.1011545

Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo

Sara Formichetti, Agnieszka Sadowska, Michela Ascolani, Julia Hansen, Kerstin Ganter, Christophe Lancrin, Neil Humphreys, Mathieu Boulard

PLOS Genetics: published January 9, 2025 | https://doi.org/10.1371/journal.pgen.1011507

Refining fine-mapping: Effect sizes and regional heritability

Christian Benner, Anubha Mahajan, Matti Pirinen

PLOS Genetics: published January 9, 2025 | https://doi.org/10.1371/journal.pgen.1011480

metaGE: Investigating genotype x environment interactions through GWAS meta-analysis

Annaïg De Walsche, Alexis Vergne, Renaud Rincent, Fabrice Roux, Stéphane Nicolas, Claude Welcker, Sofiane Mezmouk, Alain Charcosset, Tristan Mary-Huard

PLOS Genetics: published January 10, 2025 | https://doi.org/10.1371/journal.pgen.1011553

The dependence of shugoshin on Bub1-kinase activity is dispensable for the maintenance of spindle assembly checkpoint response in Cryptococcus neoformans

Satya Dev Polisetty, Krishna Bhat, Kuladeep Das, Ivan Clark, Kevin G. Hardwick, Kaustuv Sanyal

PLOS Genetics: published January 13, 2025 | https://doi.org/10.1371/journal.pgen.1011552

Identification of novel genes responsible for a pollen killer present in local natural populations of Arabidopsis thaliana

Anthony Ricou, Matthieu Simon, Rémi Duflos, Marianne Azzopardi, Fabrice Roux, Françoise Budar, Christine Camilleri

PLOS Genetics: published January 13, 2025 | https://doi.org/10.1371/journal.pgen.1011451

Rapid changes in plasma corticosterone and medial amygdala transcriptome profiles during social status change reveal molecular pathways associated with a major life history transition in mouse dominance hierarchies

Tyler M. Milewski, Won Lee, Rebecca L. Young, Hans A. Hofmann, James P. Curley

PLOS Genetics: published January 13, 2025 | https://doi.org/10.1371/journal.pgen.1011548

Ambivalent partnership of the Drosophila posterior class Hox protein Abdominal-B with Extradenticle and Homothorax

Jesús R. Curt, Paloma Martín, David Foronda, Bruno Hudry, Ramakrishnan Kannan, Srividya Shetty, Samir Merabet, Andrew J. Saurin, Yacine Graba, Ernesto Sánchez- Herrero

PLOS Genetics: published January 13, 2025 | https://doi.org/10.1371/journal.pgen.1011355

IP3 receptor depletion in a spontaneous canine model of Charcot-Marie-Tooth disease 1J with amelogenesis imperfecta

Marjo K. Hytönen, Julius Rönkkö, Sruthi Hundi, Tarja S. Jokinen, Emilia Suonto, Eeva Teräväinen, Jonas Donner, Rita La Rovere, Geert Bultynck, Emil Ylikallio, Henna Tyynismaa, Hannes Lohi

PLOS Genetics: published January 13, 2025 | https://doi.org/10.1371/journal.pgen.1011328

Diversification and recurrent adaptation of the synaptonemal complex in Drosophila

Rana Zakerzade, Ching-Ho Chang, Kamalakar Chatla, Ananya Krishnapura, Samuel P. Appiah, Jacki Zhang, Robert L. Unckless, Justin P. Blumenstiel, Doris Bachtrog, Kevin H-C. Wei

PLOS Genetics: published January 13, 2025 | https://doi.org/10.1371/journal.pgen.1011549

The piRNA protein Asz1 is essential for germ cell and gonad development in zebrafish and exhibits differential necessities in distinct types of germ granules

Adam Ahmad, Yoel Bogoch, Gal Shvaizer, Noga Guler, Karine Levy, Yaniv M. Elkouby

PLOS Genetics: published January 13, 2025 | https://doi.org/10.1371/journal.pgen.1010868

Evolutionary lineage-specific genomic imprinting at the ZNF791 locus

Jinsoo Ahn, In-Sul Hwang, Mi-Ryung Park, Milca Rosa-Velazquez, In-Cheol Cho, Alejandro E. Relling, Seongsoo Hwang, Kichoon Lee

PLOS Genetics: published January 15, 2025 | https://doi.org/10.1371/journal.pgen.1011532

Investigative genetic genealogy practices warranting policy attention: Results of a modified policy Delphi

Christi J. Guerrini, Louiza Kalokairinou, Jill O. Robinson, Whitney Bash Brooks, Stephanie M. Fullerton, Sara Huston, Jacklyn Dahlquist, Diana Madden, Norah Crossnohere, Nicola Campoamor, John F. P. Bridges, Amy L. McGuire

PLOS Genetics: published January 16, 2025 | https://doi.org/10.1371/journal.pgen.1011520

Short- and long-range roles of UNC-6/Netrin in dorsal-ventral axon guidance in vivo in Caenorhabditis elegans

Kelsey M. Hooper, Vedant D. Jain, Celeste J. Gormly, Brian J. Sanderson, Erik A. Lundquist

PLOS Genetics: published January 17, 2025 | https://doi.org/10.1371/journal.pgen.1011526

Tail Anchored protein insertion mediated by CAML and TRC40 links to neuromuscular function in mice

Ying Zhang, Lihong He, Justin Gundelach, Anjie Ge, Helena Edlund, Stefan Norlin, Richard J. Bram

PLOS Genetics: published January 17, 2025 | https://doi.org/10.1371/journal.pgen.1011547

Characterizing the regulatory effects of H2A.Z and SWR1-C on gene expression during hydroxyurea exposure in Saccharomyces cerevisiae

Hilary T. Brewis, Peter C. Stirling, Michael S. Kobor

PLOS Genetics: published January 21, 2025 | https://doi.org/10.1371/journal.pgen.1011566

F-box protein Fbx23 acts as a transcriptional coactivator to recognize and activate transcription factor Ace1

Zhongjiao Liu, Kexuan Ma, Panpan Zhang, Siqi Zhang, Xin Song, Yuqi Qin

PLOS Genetics: published January 21, 2025 | https://doi.org/10.1371/journal.pgen.1011539

Multi-modal investigation reveals pathogenic features of diverse DDX3X missense mutations

Federica Mosti, Mariah L. Hoye, Carla F. Escobar-Tomlienovich, Debra L. Silver

PLOS Genetics: published January 21, 2025 | https://doi.org/10.1371/journal.pgen.1011555

SEM-2/SoxC regulates multiple aspects of C. elegans postembryonic mesoderm development

Marissa Baccas, Vanathi Ganesan, Amy Leung, Lucas R. Pineiro, Alexandra N. McKillop, Jun Liu

PLOS Genetics: published January 21, 2025 | https://doi.org/10.1371/journal.pgen.1011361

Sequence specificity of an essential nuclear localization sequence in Mcm3

Ziyi Wang, Yun Jing Zhang, Qian-yi Zhang, Kate Bilsborrow, Matthew Leslie, Raymond T. Suhandynata, Huilin Zhou

PLOS Genetics: published January 21, 2025 | https://doi.org/10.1371/journal.pgen.1011499

The Cul3 ubiquitin ligase engages Insomniac as an adaptor to impact sleep and synaptic homeostasis

Qiuling Li, Kayla Y. Lim, Raad Altawell, Faith Verderose, Xiling Li, Wanying Dong, Joshua Martinez, Dion Dickman, Nicholas Stavropoulos

PLOS Genetics: published January 22, 2025 | https://doi.org/10.1371/journal.pgen.1011574

A versatile site-directed gene trap strategy to manipulate gene activity and control gene expression in Caenorhabditis elegans

Haania Khan, Xinyu Huang, Vishnu Raj, Han Wang

PLOS Genetics: published January 22, 2025 | https://doi.org/10.1371/journal.pgen.1011541

Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation

Dylan Carter-Cusack, Stephen Huang, Sahar Keshvari, Omkar Patkar, Anuj Sehgal, Rachel Allavena, Robert A. J. Byrne, B. Paul Morgan, Stephen J. Bush, Kim M. Summers, Katharine M. Irvine, David A. Hume

PLOS Genetics: published January 27, 2025 | https://doi.org/10.1371/journal.pgen.1011525

A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs

Jia Li, Ruoling Bai, Yulian Zhou, Xu Song, Ling Li

PLOS Genetics: published January 27, 2025 | https://doi.org/10.1371/journal.pgen.1011580

Minimization of the Bacillus subtilis divisome suggests FtsZ and SepF can form an active Z-ring, and reveals the amino acid transporter BraB as a new cell division influencing factor

Ilkay Celik Gulsoy, Terrens N. V. Saaki, Michaela Wenzel, Simon Syvertsson, Taku Morimoto, Tjalling K. Siersma, Leendert W. Hamoen

PLOS Genetics: published January 27, 2025 | https://doi.org/10.1371/journal.pgen.1011567

Coordinated neuron-glia regeneration through Notch signaling in planarians

M. Lucila Scimone, Bryanna Isela-Inez Canales, Patrick Aoude, Kutay D. Atabay, Peter W. Reddien

PLOS Genetics: published January 27, 2025 | https://doi.org/10.1371/journal.pgen.1011577

Distinct checkpoint and homolog biorientation pathways regulate meiosis I in Drosophila oocytes

Joanatta G. Shapiro, Neha Changela, Janet K. Jang, Jay N. Joshi, Kim S. McKim

PLOS Genetics: published January 29, 2025 | https://doi.org/10.1371/journal.pgen.1011400

Tolerance mechanisms in polysaccharide biosynthesis: Implications for undecaprenol phosphate recycling in Escherichia coli and Shigella flexneri

Jilong Qin, Yaoqin Hong, Nicholas T. Maczuga, Renato Morona, Makrina Totsika

PLOS Genetics: published January 30, 2025 | https://doi.org/10.1371/journal.pgen.1011591

Editorial Note

Editorial Note: MiR172-APETALA2-like genes integrate vernalization and plant age to control flowering time in wheat

The PLOS Genetics Editors

PLOS Genetics: published January 6, 2025 | https://doi.org/10.1371/journal.pgen.1011544

Cover

Anther of an Arabidopsis plant in which a pollen killer is present

Research Articles

Methods

Editorial Note

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