An intronic CTG triplet repeat expansion in the transcription factor gene TCF4 frequently underlies a common age-related corneal disease called Fuchs endothelial corneal dystrophy (FECD). This image depicts two distinct mechanisms of downstream pathogenicity in affected corneal endothelial cells elicited by the repeat: TCF4 isoform dysregulation on the left as visualized via RNAScope staining (white puncta), and toxic repeat-containing RNA foci on the right visualized via fluorescence in situ hybridization (red foci). See Bhattacharyya et al. Download May’s cover page.
Image Credit: Nihar Bhattacharyya
Editorial
A general passion
PLOS Genetics: published May 30, 2024 | https://doi.org/10.1371/journal.pgen.1011291
Research Articles
Collaborative Cross mice have diverse phenotypic responses to infection with Methicillin-resistant Staphylococcus aureus USA300
PLOS Genetics: published May 2, 2024 | https://doi.org/10.1371/journal.pgen.1011229
A comprehensive genome-wide cross-trait analysis of sexual factors and uterine leiomyoma
PLOS Genetics: published May 3, 2024 | https://doi.org/10.1371/journal.pgen.1011268
Mitochondrial genome fragmentation is correlated with increased rates of molecular evolution
PLOS Genetics: published May 3, 2024 | https://doi.org/10.1371/journal.pgen.1011266
Genetically dissecting the electron transport chain of a soil bacterium reveals a generalizable mechanism for biological phenazine-1-carboxylic acid oxidation
PLOS Genetics: published May 6, 2024 | https://doi.org/10.1371/journal.pgen.1011064
Deciphering novel TCF4-driven mechanisms underlying a common triplet repeat expansion-mediated disease
PLOS Genetics: published May 7, 2024 | https://doi.org/10.1371/journal.pgen.1011230
Resf1 is a compound G4 quadruplex-associated tumor suppressor for triple negative breast cancer
PLOS Genetics: published May 9, 2024 | https://doi.org/10.1371/journal.pgen.1011236
LRK-1/LRRK2 and AP-3 regulate trafficking of synaptic vesicle precursors through active zone protein SYD-2/Liprin-α
PLOS Genetics: published May 9, 2024 | https://doi.org/10.1371/journal.pgen.1011253
iGWAS: Image-based genome-wide association of self-supervised deep phenotyping of retina fundus images
PLOS Genetics: published May 10, 2024 | https://doi.org/10.1371/journal.pgen.1011273
A novel method for multiple phenotype association studies based on genotype and phenotype network
PLOS Genetics: published May 10, 2024 | https://doi.org/10.1371/journal.pgen.1011245
The Hog1 MAPK substrate governs Candida glabrata-epithelial cell adhesion via the histone H2A variant
PLOS Genetics: published May 14, 2024 | https://doi.org/10.1371/journal.pgen.1011281
A role for the C. elegans Argonaute protein CSR-1 in small nuclear RNA 3’ processing
PLOS Genetics: published May 14, 2024 | https://doi.org/10.1371/journal.pgen.1011284
Human disease-causing mutations result in loss of leiomodin 2 through nonsense-mediated mRNA decay
PLOS Genetics: published May 15, 2024 | https://doi.org/10.1371/journal.pgen.1011279
Two distinct regulatory systems control pulcherrimin biosynthesis in Bacillus subtilis
PLOS Genetics: published May 16, 2024 | https://doi.org/10.1371/journal.pgen.1011283
Modelling daisy quorum drive: A short-term bridge across engineered fitness valleys
PLOS Genetics: published May 16, 2024 | https://doi.org/10.1371/journal.pgen.1011262
RNA polymerase II-mediated rDNA transcription mediates rDNA copy number expansion in Drosophila
PLOS Genetics: published May 17, 2024 | https://doi.org/10.1371/journal.pgen.1011136
Queuosine biosynthetic enzyme, QueE moonlights as a cell division regulator
PLOS Genetics: published May 20, 2024 | https://doi.org/10.1371/journal.pgen.1011287
Cryptococcus neoformans Slu7 ensures nuclear positioning during mitotic progression through RNA splicing
PLOS Genetics: published May 20, 2024 | https://doi.org/10.1371/journal.pgen.1011272
Structured and disordered regions of Ataxin-2 contribute differently to the specificity and efficiency of mRNP granule formation
PLOS Genetics: published May 20, 2024 | https://doi.org/10.1371/journal.pgen.1011251
Bridging the gap between the evolutionary dynamics and the molecular mechanisms of meiosis: A model based exploration of the PRDM9 intra-genomic Red Queen
PLOS Genetics: published May 20, 2024 | https://doi.org/10.1371/journal.pgen.1011274
Red and far-red light improve the antagonistic ability of Trichoderma guizhouense against phytopathogenic fungi by promoting phytochrome-dependent aerial hyphal growth
PLOS Genetics: published May 20, 2024 | https://doi.org/10.1371/journal.pgen.1011282
Physical interactions between specifically regulated subpopulations of the MCM and RNR complexes prevent genetic instability
PLOS Genetics: published May 22, 2024 | https://doi.org/10.1371/journal.pgen.1011148
Transcription decouples estrogen-dependent changes in enhancer-promoter contact frequencies and spatial proximity
PLOS Genetics: published May 23, 2024 | https://doi.org/10.1371/journal.pgen.1011277
Simultaneous estimation of genotype error and uncalled deletion rates in whole genome sequence data
PLOS Genetics: published May 24, 2024 | https://doi.org/10.1371/journal.pgen.1011297
The distribution of fitness effects during adaptive walks using a simple genetic network
PLOS Genetics: published May 24, 2024 | https://doi.org/10.1371/journal.pgen.1011289
Clock-dependent chromatin accessibility rhythms regulate circadian transcription
PLOS Genetics: published May 28, 2024 | https://doi.org/10.1371/journal.pgen.1011278
miR-34a is a tumor suppressor in zebrafish and its expression levels impact metabolism, hematopoiesis and DNA damage
PLOS Genetics: published May 28, 2024 | https://doi.org/10.1371/journal.pgen.1011290
Her2 amplification, Rel-A, and Bach1 can influence APOBEC3A expression in breast cancer cells
PLOS Genetics: published May 28, 2024 | https://doi.org/10.1371/journal.pgen.1011293
Paramutation at the maize pl1 locus is associated with RdDM activity at distal tandem repeats
PLOS Genetics: published May 30, 2024 | https://doi.org/10.1371/journal.pgen.1011296
Single-cell and single-nucleus RNA-sequencing from paired normal-adenocarcinoma lung samples provide both common and discordant biological insights
PLOS Genetics: published May 30, 2024 | https://doi.org/10.1371/journal.pgen.1011301
Adaptations to nitrogen availability drive ecological divergence of chemosynthetic symbionts
PLOS Genetics: published May 31, 2024 | https://doi.org/10.1371/journal.pgen.1011295
Correction
Correction: Kinesin-2 transports Orco into the olfactory cilium of Drosophila melanogaster at specific developmental stages
PLOS Genetics: published May 31, 2024 | https://doi.org/10.1371/journal.pgen.1011305
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Retractions
Retraction: miR-3607-3p suppresses non-small cell lung cancer (NSCLC) by targeting TGFBR1 and CCNE2
PLOS Genetics: published May 7, 2024 | https://doi.org/10.1371/journal.pgen.1011270
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Retraction: DNA methylation-mediated repression of exosomal miR-652-5p expression promotes oesophageal squamous cell carcinoma aggressiveness by targeting PARG and VEGF pathways
PLOS Genetics: published May 7, 2024 | https://doi.org/10.1371/journal.pgen.1011269