Yeast-based evolutionary modeling of androgen receptor mutations and natural selection

Haoran Zhang, Lu Zhang, Shaoyong Chen, Mingdong Yao, Zhenyi Ma, Yingjin Yuan

PLOS Genetics: published December 2, 2022 | https://doi.org/10.1371/journal.pgen.1010518

Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice

Lulu Kang, Jinghong Dai, Yufang Wang, Peiliang Shi, Yujie Zou, Jingwen Pei, Yaqiong Tian, Ji Zhang, Visarut Codey Buranasudja, Jingyu Chen, Hourong Cai, Xiang Gao, Zhaoyu Lin

PLOS Genetics: published December 2, 2022 | https://doi.org/10.1371/journal.pgen.1010515

LOF variants identifying candidate genes of laterality defects patients with congenital heart disease

Sijie Liu, Wei Wei, Pengcheng Wang, Chunjie Liu, Xuechao Jiang, Tingting Li, Fen Li, Yurong Wu, Sun Chen, Kun Sun, Rang Xu

PLOS Genetics: published December 2, 2022 | https://doi.org/10.1371/journal.pgen.1010530

Actin remodeling mediates ROS production and JNK activation to drive apoptosis-induced proliferation

Luchi Farrell, Aleix Puig-Barbe, Md. Iqramul Haque, Alla Amcheslavsky, Mengyuan Yu, Andreas Bergmann, Yun Fan

PLOS Genetics: published December 5, 2022 | https://doi.org/10.1371/journal.pgen.1010533

Genetic analysis of activin/inhibin β subunits in zebrafish development and reproduction

Cheng Zhao, Yue Zhai, Ruijing Geng, Kun Wu, Weiyi Song, Nana Ai, Wei Ge

PLOS Genetics: published December 5, 2022 | https://doi.org/10.1371/journal.pgen.1010523

Domestication and selection footprints in Persian walnuts (Juglans regia)

Xiang Luo, Huijuan Zhou, Da Cao, Feng Yan, Pengpeng Chen, Jiangtao Wang, Keith Woeste, Xin Chen, Zhangjun Fei, Hong An, Maria Malvolti, Kai Ma, Chaobin Liu, Aziz Ebrahimi, Chengkui Qiao, Hang Ye, Mengdi Li, Zhenhua Lu, Jiabao Xu, Shangying Cao, Peng Zhao

PLOS Genetics: published December 7, 2022 | https://doi.org/10.1371/journal.pgen.1010513

FgSnt1 of the Set3 HDAC complex plays a key role in mediating the regulation of histone acetylation by the cAMP-PKA pathway in Fusarium graminearum

Chen Gong, Daiying Xu, Daiyuan Sun, Jiangang Kang, Wei Wang, Jin-Rong Xu, Xue Zhang

PLOS Genetics: published December 7, 2022 | https://doi.org/10.1371/journal.pgen.1010510

Genetic variation in P-element dysgenic sterility is associated with double-strand break repair and alternative splicing of TE transcripts

Jyoti Lama, Satyam Srivastav, Sadia Tasnim, Donald Hubbard, Savana Hadjipanteli, Brittny R. Smith, Stuart J. Macdonald, Llewellyn Green, Erin S. Kelleher

PLOS Genetics: published December 7, 2022 | https://doi.org/10.1371/journal.pgen.1010080

S. pombe wtf drivers use dual transcriptional regulation and selective protein exclusion from spores to cause meiotic drive

Nicole L. Nuckolls, Ananya Nidamangala Srinivasa, Anthony C. Mok, Rachel M. Helston, María Angélica Bravo Núñez, Jeffrey J. Lange, Todd J. Gallagher, Chris W. Seidel, Sarah E. Zanders

PLOS Genetics: published December 7, 2022 | https://doi.org/10.1371/journal.pgen.1009847

Activation of ChvG-ChvI regulon by cell wall stress confers resistance to β-lactam antibiotics and initiates surface spreading in Agrobacterium tumefaciens

Michelle A. Williams, Jacob M. Bouchier, Amara K. Mason, Pamela J. B. Brown

PLOS Genetics: published December 8, 2022 | https://doi.org/10.1371/journal.pgen.1010274

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PLOS Genetics: published December 8, 2022 | https://doi.org/10.1371/journal.pgen.1010465

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Denisovan introgression has shaped the immune system of present-day Papuans

Davide M. Vespasiani, Guy S. Jacobs, Laura E. Cook, Nicolas Brucato, Matthew Leavesley, Christopher Kinipi, François-Xavier Ricaut, Murray P. Cox, Irene Gallego Romero

PLOS Genetics: published December 8, 2022 | https://doi.org/10.1371/journal.pgen.1010470

Disruption of the HIF-1 pathway in individuals with Ollier disease and Maffucci syndrome

Sarah R. Poll, Renan Martin, Elizabeth Wohler, Elizabeth S. Partan, Elizabeth Walek, Shaima Salman, Daniel Groepper, Lisa Kratz, Mirlene Cernach, Reynaldo Jesus-Garcia, Chad Haldeman-Englert, Yoon Jae Choi, Carol D. Morris, Bernard Cohen, Julie Hoover-Fong, David Valle, Gregg L. Semenza, Nara L. M. Sobreira

PLOS Genetics: published December 8, 2022 | https://doi.org/10.1371/journal.pgen.1010504

Homologous chromosomes are stably conjoined for Drosophila male meiosis I by SUM, a multimerized protein assembly with modules for DNA-binding and for separase-mediated dissociation co-opted from cohesin

Zeynep Kabakci, Heidi E. Reichle, Bianca Lemke, Dorota Rousova, Samir Gupta, Joe Weber, Alexander Schleiffer, John R. Weir, Christian F. Lehner

PLOS Genetics: published December 8, 2022 | https://doi.org/10.1371/journal.pgen.1010547

RAD18 opposes transcription-associated genome instability through FANCD2 recruitment

James P. Wells, Emily Yun-Chia Chang, Leticia Dinatto, Justin White, Stephanie Ryall, Peter C. Stirling

PLOS Genetics: published December 8, 2022 | https://doi.org/10.1371/journal.pgen.1010309

Identification of C. elegans ASNA-1 domains and tissue requirements that differentially influence platinum sensitivity and growth control

Dorota Raj, Agnieszka Podraza-Farhanieh, Pablo Gallego, Gautam Kao, Peter Naredi

PLOS Genetics: published December 8, 2022 | https://doi.org/10.1371/journal.pgen.1010538

Photoreception and transcriptomic response to light during early development of a teleost with a life cycle tightly controlled by seasonal changes in photoperiod

Mariann Eilertsen, David W. P. Dolan, Charlotte M. Bolton, Rita Karlsen, Wayne I. L. Davies, Rolf B. Edvardsen, Tomasz Furmanek, Harald Sveier, Herve Migaud, Jon Vidar Helvik

PLOS Genetics: published December 12, 2022 | https://doi.org/10.1371/journal.pgen.1010529

F-box receptor mediated control of substrate stability and subcellular location organizes cellular development of Aspergillus nidulans

Özlem Sarikaya Bayram, Özgür Bayram, Betim Karahoda, Cindy Meister, Anna M. Köhler, Sabine Thieme, Nadia Elramli, Dean Frawley, Jamie McGowan, David A. Fitzpatrick, Kerstin Schmitt, Leandro Jose de Assis, Oliver Valerius, Gustavo H. Goldman, Gerhard H. Braus

PLOS Genetics: published December 12, 2022 | https://doi.org/10.1371/journal.pgen.1010502

Rad51-mediated interhomolog recombination during budding yeast meiosis is promoted by the meiotic recombination checkpoint and the conserved Pif1 helicase

Andrew Ziesel, Qixuan Weng, Jasvinder S. Ahuja, Abhishek Bhattacharya, Raunak Dutta, Evan Cheng, G. Valentin Börner, Michael Lichten, Nancy M. Hollingsworth

PLOS Genetics: published December 12, 2022 | https://doi.org/10.1371/journal.pgen.1010407

Transcription factor binding process is the primary driver of noise in gene expression

Lavisha Parab, Sampriti Pal, Riddhiman Dhar

PLOS Genetics: published December 12, 2022 | https://doi.org/10.1371/journal.pgen.1010535

Rapid molecular diversification and homogenization of clustered major ampullate silk genes in Argiope garden spiders

Richard H. Baker, André Corvelo, Cheryl Y. Hayashi

PLOS Genetics: published December 12, 2022 | https://doi.org/10.1371/journal.pgen.1010537

Inferring selection effects in SARS-CoV-2 with Bayesian Viral Allele Selection

Martin Jankowiak, Fritz H. Obermeyer, Jacob E. Lemieux

PLOS Genetics: published December 12, 2022 | https://doi.org/10.1371/journal.pgen.1010540

A role for brassinosteroid signalling in decision-making processes in the Arabidopsis seedling

Nils Kalbfuß, Alexander Strohmayr, Marcel Kegel, Lien Le, Friederike Grosse-Holz, Barbara Brunschweiger, Katharina Stöckl, Christian Wiese, Carina Franke, Caroline Schiestl, Sophia Prem, Shuyao Sha, Katrin Franz-Oberdorf, Juliane Hafermann, Marc Thiemé, Eva Facher, Wojciech Palubicki, Cordelia Bolle, Farhah F. Assaad

PLOS Genetics: published December 12, 2022 | https://doi.org/10.1371/journal.pgen.1010541

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PARP1 recruits DNA translocases to restrain DNA replication and facilitate DNA repair

Yen-Chih Ho, Chen-Syun Ku, Siang-Sheng Tsai, Jia-Lin Shiu, Yi-Zhen Jiang, Hui Emmanuela Miriam, Han-Wen Zhang, Yen-Tzu Chen, Wen-Tai Chiu, Song-Bin Chang, Che-Hung Shen, Kyungjae Myung, Peter Chi, Hungjiun Liaw

PLOS Genetics: published December 13, 2022 | https://doi.org/10.1371/journal.pgen.1010545

Two distinct lipid transporters together regulate invasive filamentous growth in the human fungal pathogen Candida albicans

Miguel A. Basante-Bedoya, Stéphanie Bogliolo, Rocio Garcia-Rodas, Oscar Zaragoza, Robert A. Arkowitz, Martine Bassilana

PLOS Genetics: published December 14, 2022 | https://doi.org/10.1371/journal.pgen.1010549

Mating system and speciation I: Accumulation of genetic incompatibilities in allopatry

Lucas Marie-Orleach, Christian Brochmann, Sylvain Glémin

PLOS Genetics: published December 15, 2022 | https://doi.org/10.1371/journal.pgen.1010353

Loss of growth differentiation factor 9 causes an arrest of early folliculogenesis in zebrafish–A novel insight into its action mechanism

Weiting Chen, Yue Zhai, Bo Zhu, Kun Wu, Yuqin Fan, Xianqing Zhou, Lin Liu, Wei Ge

PLOS Genetics: published December 15, 2022 | https://doi.org/10.1371/journal.pgen.1010318

Distinct signaling signatures drive compensatory proliferation via S-phase acceleration

Carlo Crucianelli, Janhvi Jaiswal, Ananthakrishnan Vijayakumar Maya, Liyne Nogay, Andrea Cosolo, Isabelle Grass, Anne-Kathrin Classen

PLOS Genetics: published December 15, 2022 | https://doi.org/10.1371/journal.pgen.1010516

Tup1 is critical for transcriptional repression in Quiescence in S. cerevisiae

Thomas B. Bailey, Phaedra A. Whitty, Eric U. Selker, Jeffrey. N. McKnight, Laura E. McKnight

PLOS Genetics: published December 21, 2022 | https://doi.org/10.1371/journal.pgen.1010559

The PilT retraction ATPase promotes both extension and retraction of the MSHA type IVa pilus in Vibrio cholerae

Hannah Q. Hughes, Nicholas D. Christman, Triana N. Dalia, Courtney K. Ellison, Ankur B. Dalia

PLOS Genetics: published December 21, 2022 | https://doi.org/10.1371/journal.pgen.1010561

Mating disrupts morning anticipation in Drosophila melanogaster females

Sabrina Riva, Juan Ignacio Ispizua, María Trinidad Breide, Sofía Polcowñuk, José Ricardo Lobera, María Fernanda Ceriani, Sebastian Risau-Gusman, Diana Lorena Franco

PLOS Genetics: published December 22, 2022 | https://doi.org/10.1371/journal.pgen.1010258

Safeguarding Drosophila female germ cell identity depends on an H3K9me3 mini domain guided by a ZAD zinc finger protein

Laura Shapiro-Kulnane, Micah Selengut, Helen K. Salz

PLOS Genetics: published December 22, 2022 | https://doi.org/10.1371/journal.pgen.1010568

The circadian E3 ligase FBXL21 regulates myoblast differentiation and sarcomere architecture via MYOZ1 ubiquitination and NFAT signaling

Ji Ye Lim, Eunju Kim, Collin M. Douglas, Marvin Wirianto, Chorong Han, Kaori Ono, Sun Young Kim, Justin H. Ji, Celia K. Tran, Zheng Chen, Karyn A. Esser, Seung-Hee Yoo

PLOS Genetics: published December 27, 2022 | https://doi.org/10.1371/journal.pgen.1010574

Beneficial and detrimental genes in the cellular response to replication arrest

Luciane Schons-Fonseca, Milena D. Lazova, Janet L. Smith, Mary E. Anderson, Alan D. Grossman

PLOS Genetics: published December 27, 2022 | https://doi.org/10.1371/journal.pgen.1010564

Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis

Brea K. Hampton, Kenneth S. Plante, Alan C. Whitmore, Colton L. Linnertz, Emily A. Madden, Kelsey E. Noll, Samuel P. Boyson, Breantie Parotti, James G. Xenakis, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Mark T. Heise

PLOS Genetics: published December 27, 2022 | https://doi.org/10.1371/journal.pgen.1010548

Stress combined with loss of the Candida albicans SUMO protease Ulp2 triggers selection of aneuploidy via a two-step process

Marzia Rizzo, Natthapon Soisangwan, Samuel Vega-Estevez, Robert Jordan Price, Chloe Uyl, Elise Iracane, Matt Shaw, Jan Soetaert, Anna Selmecki, Alessia Buscaino

PLOS Genetics: published December 27, 2022 | https://doi.org/10.1371/journal.pgen.1010576

Gene drive designs for efficient and localisable population suppression using Y-linked editors

René Geci, Katie Willis, Austin Burt

PLOS Genetics: published December 27, 2022 | https://doi.org/10.1371/journal.pgen.1010550

Leveraging pleiotropy to discover and interpret GWAS results for sleep-associated traits

Sung Chun, Sebastian Akle, Athanasios Teodosiadis, Brian E. Cade, Heming Wang, Tamar Sofer, Daniel S. Evans, Katie L. Stone, Sina A. Gharib, Sutapa Mukherjee, Lyle J. Palmer, David Hillman, Jerome I. Rotter, Craig L. Hanis, John A. Stamatoyannopoulos, Susan Redline, Chris Cotsapas, Shamil R. Sunyaev

PLOS Genetics: published December 27, 2022 | https://doi.org/10.1371/journal.pgen.1010557

Tracking N- and C-termini of C. elegans polycystin-1 reveals their distinct targeting requirements and functions in cilia and extracellular vesicles

Jonathon D. Walsh, Juan Wang, Molly DeHart, Inna A. Nikonorova, Jagan Srinivasan, Maureen M. Barr

PLOS Genetics: published December 27, 2022 | https://doi.org/10.1371/journal.pgen.1010560

Retraction: Molecular predictors of brain metastasis-related microRNAs in lung adenocarcinoma

The PLOS Genetics Editors

PLOS Genetics: published December 16, 2022 | https://doi.org/10.1371/journal.pgen.1010552

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Expression of Concern: Complexin in ivermectin resistance in body lice

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PLOS Genetics: published December 13, 2022 | https://doi.org/10.1371/journal.pgen.1010531

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