Expanding human variation at PLOS Genetics

Gregory S. Barsh, Gregory P. Copenhaver, Hua Tang, Scott M. Williams

PLOS Genetics: published February 14, 2022 | https://doi.org/10.1371/journal.pgen.1010070

Soft selective sweeps: Addressing new definitions, evaluating competing models, and interpreting empirical outliers

Parul Johri, Wolfgang Stephan, Jeffrey D. Jensen

PLOS Genetics: published February 24, 2022 | https://doi.org/10.1371/journal.pgen.1010022

A transcriptome-based association study of growth, wood quality, and oleoresin traits in a slash pine breeding population

Xianyin Ding, Shu Diao, Qifu Luan, Harry X. Wu, Yini Zhang, Jingmin Jiang

PLOS Genetics: published February 2, 2022 | https://doi.org/10.1371/journal.pgen.1010017

Identification of potential functional variants and genes at 18q21.1 associated with the carcinogenesis of colorectal cancer

Xiaoqing Cheng, Fenglan Zhang, Jingwen Gong, Yige Li, Dan Zhou, Jing Wang, Eu Gene Vong, Ying Yuan, Maode Lai, Dandan Zhang

PLOS Genetics: published February 2, 2022 | https://doi.org/10.1371/journal.pgen.1010050

From musk to body odor: Decoding olfaction through genetic variation

Bingjie Li, Marissa L. Kamarck, Qianqian Peng, Fei-Ling Lim, Andreas Keller, Monique A. M. Smeets, Joel D. Mainland, Sijia Wang

PLOS Genetics: published February 3, 2022 | https://doi.org/10.1371/journal.pgen.1009564

MAPK-mediated transcription factor GATAd contributes to Cry1Ac resistance in diamondback moth by reducing PxmALP expression

Le Guo, Zhouqiang Cheng, Jianying Qin, Dan Sun, Shaoli Wang, Qingjun Wu, Neil Crickmore, Xuguo Zhou, Alejandra Bravo, Mario Soberón, Zhaojiang Guo, Youjun Zhang

PLOS Genetics: published February 3, 2022 | https://doi.org/10.1371/journal.pgen.1010037

Population genomics and geographic dispersal in Chagas disease vectors: Landscape drivers and evidence of possible adaptation to the domestic setting

Luis E. Hernandez-Castro, Anita G. Villacís, Arne Jacobs, Bachar Cheaib, Casey C. Day, Sofía Ocaña-Mayorga, Cesar A. Yumiseva, Antonella Bacigalupo, Björn Andersson, Louise Matthews, Erin L. Landguth, Jaime A. Costales, Martin S. Llewellyn, Mario J. Grijalva

PLOS Genetics: published February 4, 2022 | https://doi.org/10.1371/journal.pgen.1010019

Strategies for meiotic sex chromosome dynamics and telomeric elongation in Marsupials

Laia Marín-Gual, Laura González-Rodelas, Gala Pujol, Covadonga Vara, Marta Martín-Ruiz, Soledad Berríos, Raúl Fernández-Donoso, Andrew Pask, Marilyn B. Renfree, Jesús Page, Paul D. Waters, Aurora Ruiz-Herrera

PLOS Genetics: published February 7, 2022 | https://doi.org/10.1371/journal.pgen.1010040

Characterisation of the spectrum and genetic dependence of collateral mutations induced by translesion DNA synthesis

Ádám Póti, Bernadett Szikriszt, Judit Zsuzsanna Gervai, Dan Chen, Dávid Szüts

PLOS Genetics: published February 7, 2022 | https://doi.org/10.1371/journal.pgen.1010051

Heterochiasmy and the establishment of gsdf as a novel sex determining gene in Atlantic halibut

Rolf Brudvik Edvardsen, Ola Wallerman, Tomasz Furmanek, Lene Kleppe, Patric Jern, Andreas Wallberg, Erik Kjærner-Semb, Stig Mæhle, Sara Karolina Olausson, Elisabeth Sundström, Torstein Harboe, Ragnfrid Mangor-Jensen, Margareth Møgster, Prescilla Perrichon, Birgitta Norberg, Carl-Johan Rubin

PLOS Genetics: published February 8, 2022 | https://doi.org/10.1371/journal.pgen.1010011

Ribosomal DNA promoter recognition is determined in vivo by cooperation between UBTF1 and SL1 and is compromised in the UBTF-E210K neuroregression syndrome

Michel G. Tremblay, Dany S. Sibai, Melissa Valère, Jean-Clément Mars, Frédéric Lessard, Roderick T. Hori, Mohammad Moshahid Khan, Victor Y. Stefanovsky, Mark S. LeDoux, Tom Moss

PLOS Genetics: published February 9, 2022 | https://doi.org/10.1371/journal.pgen.1009644

DBT affects sleep in both circadian and non-circadian neurons

Jialin Wang, Jin-Yuan Fan, Zhangwu Zhao, Stephane Dissel, Jeffrey Price

PLOS Genetics: published February 9, 2022 | https://doi.org/10.1371/journal.pgen.1010035

Multi-insecticide resistant malaria vectors in the field remain susceptible to malathion, despite the presence of Ace1 point mutations

Nadja C. Wipf, Wandrille Duchemin, France-Paraudie A. Kouadio, Behi K. Fodjo, Christabelle G. Sadia, Chouaïbou S. Mouhamadou, Laura Vavassori, Pascal Mäser, Konstantinos Mavridis, John Vontas, Pie Müller

PLOS Genetics: published February 10, 2022 | https://doi.org/10.1371/journal.pgen.1009963

Genomic legacy of migration in endangered caribou

Maria Cavedon, Bridgett vonHoldt, Mark Hebblewhite, Troy Hegel, Elizabeth Heppenheimer, Dave Hervieux, Stefano Mariani, Helen Schwantje, Robin Steenweg, Jessica Theoret, Megan Watters, Marco Musiani

PLOS Genetics: published February 10, 2022 | https://doi.org/10.1371/journal.pgen.1009974

Circadian control of heparan sulfate levels times phagocytosis of amyloid beta aggregates

Gretchen T. Clark, Yanlei Yu, Cooper A. Urban, Guo Fu, Chunyu Wang, Fuming Zhang, Robert J. Linhardt, Jennifer M. Hurley

PLOS Genetics: published February 10, 2022 | https://doi.org/10.1371/journal.pgen.1009994

A genetic screen in C. elegans reveals roles for KIN17 and PRCC in maintaining 5’ splice site identity

Jessie M. N. G. L. Suzuki, Kenneth Osterhoudt, Catiana H. Cartwright-Acar, Destiny R. Gomez, Sol Katzman, Alan M. Zahler

PLOS Genetics: published February 10, 2022 | https://doi.org/10.1371/journal.pgen.1010028

Planktonic sea urchin larvae change their swimming direction in response to strong photoirradiation

Shunsuke Yaguchi, Yuri Taniguchi, Haruka Suzuki, Mai Kamata, Junko Yaguchi

PLOS Genetics: published February 10, 2022 | https://doi.org/10.1371/journal.pgen.1010033

Predictors of genomic differentiation within a hybrid taxon

Angélica Cuevas, Fabrice Eroukhmanoff, Mark Ravinet, Glenn-Peter Sætre, Anna Runemark

PLOS Genetics: published February 11, 2022 | https://doi.org/10.1371/journal.pgen.1010027

Genetic dissection of novel myopathy models reveals a role of CapZα and Leiomodin 3 during myofibril elongation

Joachim Berger, Silke Berger, Yu Shan G. Mok, Mei Li, Hakan Tarakci, Peter D. Currie

PLOS Genetics: published February 11, 2022 | https://doi.org/10.1371/journal.pgen.1010066

Mitochondrial fusion regulates proliferation and differentiation in the type II neuroblast lineage in Drosophila

Dnyanesh Dubal, Prachiti Moghe, Rahul Kumar Verma, Bhavin Uttekar, Richa Rikhy

PLOS Genetics: published February 14, 2022 | https://doi.org/10.1371/journal.pgen.1010055

TOR complex 2 contributes to regulation of gene expression via inhibiting Gcn5 recruitment to subtelomeric and DNA replication stress genes

Adiel Cohen, Emese Pataki, Martin Kupiec, Ronit Weisman

PLOS Genetics: published February 14, 2022 | https://doi.org/10.1371/journal.pgen.1010061

An ancient haplotype containing antimicrobial peptide gene variants is associated with severe fungal skin disease in Persian cats

Alexandra N. Myers, Sara D. Lawhon, Alison B. Diesel, Charles W. Bradley, Aline Rodrigues Hoffmann, William J. Murphy, 99 Lives Cat Genome Consortium

PLOS Genetics: published February 14, 2022 | https://doi.org/10.1371/journal.pgen.1010062

Post-insemination selection dominates pre-insemination selection in driving rapid evolution of male competitive ability

Katja R. Kasimatis, Megan J. Moerdyk-Schauwecker, Ruben Lancaster, Alexander Smith, John H. Willis, Patrick C. Phillips

PLOS Genetics: published February 14, 2022 | https://doi.org/10.1371/journal.pgen.1010063

Interactions between mobile genetic elements: An anti-phage gene in an integrative and conjugative element protects host cells from predation by a temperate bacteriophage

Christopher M. Johnson, M. Michael Harden, Alan D. Grossman

PLOS Genetics: published February 14, 2022 | https://doi.org/10.1371/journal.pgen.1010065

MxB inhibits long interspersed element type 1 retrotransposition

Yu Huang, Fengwen Xu, Shan Mei, Xiaoman Liu, Fei Zhao, Liang Wei, Zhangling Fan, Yamei Hu, Liming Wang, Bin Ai, Shan Cen, Chen Liang, Fei Guo

PLOS Genetics: published February 16, 2022 | https://doi.org/10.1371/journal.pgen.1010034

The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly

Kehan Bao, Chun-Min Shan, Xiao Chen, Gulzhan Raiymbek, Jeremy G. Monroe, Yimeng Fang, Takenori Toda, Kristin S. Koutmou, Kaushik Ragunathan, Chao Lu, Luke E. Berchowitz, Songtao Jia

PLOS Genetics: published February 16, 2022 | https://doi.org/10.1371/journal.pgen.1010049

Viral protein instability enhances host-range evolvability

Hannah M. Strobel, Elijah K. Horwitz, Justin R. Meyer

PLOS Genetics: published February 17, 2022 | https://doi.org/10.1371/journal.pgen.1010030

Indian genetic heritage in Southeast Asian populations

Piya Changmai, Kitipong Jaisamut, Jatupol Kampuansai, Wibhu Kutanan, N. Ezgi Altınışık, Olga Flegontova, Angkhana Inta, Eren Yüncü, Worrawit Boonthai, Horolma Pamjav, David Reich, Pavel Flegontov

PLOS Genetics: published February 17, 2022 | https://doi.org/10.1371/journal.pgen.1010036

Considerations for homology-based DNA repair in mosquitoes: Impact of sequence heterology and donor template source

Joshua Xin De Ang, Katherine Nevard, Rebekah Ireland, Deepak-Kumar Purusothaman, Sebald A. N. Verkuijl, Lewis Shackleford, Estela Gonzalez, Michelle A. E. Anderson, Luke Alphey

PLOS Genetics: published February 18, 2022 | https://doi.org/10.1371/journal.pgen.1010060

In rice splice variants that restore the reading frame after frameshifting indel introduction are common, often induced by the indels and sometimes lead to organism-level rescue

Yanxiao Jia, Chao Qin, Milton Brian Traw, Xiaonan Chen, Ying He, Jing Kai, Sihai Yang, Long Wang, Laurence D. Hurst

PLOS Genetics: published February 18, 2022 | https://doi.org/10.1371/journal.pgen.1010071

Histone demethylase IBM1-mediated meiocyte gene expression ensures meiotic chromosome synapsis and recombination

Chengpeng He, Zhiyu Chen, Yiyong Zhao, Yue Yu, Hongkuan Wang, Cong Wang, Gregory P. Copenhaver, Ji Qi, Yingxiang Wang

PLOS Genetics: published February 22, 2022 | https://doi.org/10.1371/journal.pgen.1010041

Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development

Judith Habicher, Gaurav K. Varshney, Laura Waldmann, Daniel Snitting, Amin Allalou, Hanqing Zhang, Abdurrahman Ghanem, Caroline Öhman Mägi, Tabea Dierker, Lena Kjellén, Shawn M. Burgess, Johan Ledin

PLOS Genetics: published February 22, 2022 | https://doi.org/10.1371/journal.pgen.1010067

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Targeting EDEM protects against ER stress and improves development and survival in C. elegans

Simona Ghenea, Marioara Chiritoiu, Robi Tacutu, Antonio Miranda-Vizuete, Stefana Maria Petrescu

PLOS Genetics: published February 22, 2022 | https://doi.org/10.1371/journal.pgen.1010069

Lrh1 can help reprogram sexual cell fate and is required for Sertoli cell development and spermatogenesis in the mouse testis

Kellie S. Agrimson, Anna Minkina, Danielle Sadowski, Andrew Wheeler, Mark W. Murphy, Micah D. Gearhart, Vivian J. Bardwell, David Zarkower

PLOS Genetics: published February 22, 2022 | https://doi.org/10.1371/journal.pgen.1010088

The widespread nature of Pack-TYPE transposons reveals their importance for plant genome evolution

Jack S. Gisby, Marco Catoni

PLOS Genetics: published February 24, 2022 | https://doi.org/10.1371/journal.pgen.1010078

FXS causing missense mutations disrupt FMRP granule formation, dynamics, and function

Emily L. Starke, Keelan Zius, Scott A. Barbee

PLOS Genetics: published February 24, 2022 | https://doi.org/10.1371/journal.pgen.1010084

CaSWC4 regulates the immunity-thermotolerance tradeoff by recruiting CabZIP63/CaWRKY40 to target genes and activating chromatin in pepper

Weiwei Cai, Sheng Yang, Ruijie Wu, Yutong Zheng, Shicong He, Lei Shen, Deyi Guan, Shuilin He

PLOS Genetics: published February 28, 2022 | https://doi.org/10.1371/journal.pgen.1010023

Nervous system-wide analysis of Hox regulation of terminal neuronal fate specification in Caenorhabditis elegans

Chaogu Zheng, Ho Ming Terence Lee, Kenneth Pham

PLOS Genetics: published February 28, 2022 | https://doi.org/10.1371/journal.pgen.1010092

Absence of YhdP, TamB, and YdbH leads to defects in glycerophospholipid transport and cell morphology in Gram-negative bacteria

Martin V. Douglass, Amanda B. McLean, M. Stephen Trent

PLOS Genetics: published February 28, 2022 | https://doi.org/10.1371/journal.pgen.1010096

Separable roles for RNAi in regulation of transposable elements and viability in the fission yeast Schizosaccharomyces japonicus

Elliott Chapman, Francesca Taglini, Elizabeth H. Bayne

PLOS Genetics: published February 28, 2022 | https://doi.org/10.1371/journal.pgen.1010100

Correction: Bacterial recognition by PGRP-SA and downstream signalling by Toll/DIF sustain commensal gut bacteria in Drosophila

Shivohum Bahuguna, Magda Atilano, Marcus Glittenberg, Dohun Lee, Srishti Arora, Lihui Wang, Jun Zhou, Siamak Redhai, Michael Boutros, Petros Ligoxygakis

PLOS Genetics: published February 23, 2022 | https://doi.org/10.1371/journal.pgen.1010082

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Retraction: Pleiotropic role of Drosophila phosphoribosyl pyrophosphate synthetase in autophagy and lysosome homeostasis

Keemo Delos Santos, Minhee Kim, Christine Yergeau, Steve Jean, Nam-Sung Moon

PLOS Genetics: published February 4, 2022 | https://doi.org/10.1371/journal.pgen.1010048

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