The good, the bad, and the ugly: Evolutionary and pathological aspects of gene dosage alterations

M. Felicia Basilicata, Claudia Isabelle Keller Valsecchi

PLOS Genetics: published December 9, 2021 | https://doi.org/10.1371/journal.pgen.1009906

MLL1 is required for maintenance of intestinal stem cells

Neha Goveas, Claudia Waskow, Kathrin Arndt, Julian Heuberger, Qinyu Zhang, Dimitra Alexopoulou, Andreas Dahl, Walter Birchmeier, Konstantinos Anastassiadis, A. Francis Stewart, Andrea Kranz

PLOS Genetics: published December 3, 2021 | https://doi.org/10.1371/journal.pgen.1009250

bfc, a novel serpent co-factor for the expression of croquemort, regulates efferocytosis in Drosophila melanogaster

Qian Zheng, Ning Gao, Qiling Sun, Xiaowen Li, Yanzhe Wang, Hui Xiao

PLOS Genetics: published December 3, 2021 | https://doi.org/10.1371/journal.pgen.1009947

What makes a histone variant a variant: Changing H2A to become H2A.Z

Hilary T. Brewis, Alice Y. Wang, Aline Gaub, Justine J. Lau, Peter C. Stirling, Michael S. Kobor

PLOS Genetics: published December 6, 2021 | https://doi.org/10.1371/journal.pgen.1009950

MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cells

Manuel Albanese, Yen-Fu Adam Chen, Corinna Hüls, Kathrin Gärtner, Takanobu Tagawa, Ernesto Mejias-Perez, Oliver T. Keppler, Christine Göbel, Reinhard Zeidler, Mikhail Shein, Anne K. Schütz, Wolfgang Hammerschmidt

PLOS Genetics: published December 6, 2021 | https://doi.org/10.1371/journal.pgen.1009951

Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α

Naotaka Ochi, Mai Nakamura, Rina Nagata, Naoki Wakasa, Ryosuke Nakano, Tatsushi Igaki

PLOS Genetics: published December 6, 2021 | https://doi.org/10.1371/journal.pgen.1009958

A secretory phospholipase D hydrolyzes phosphatidylcholine to suppress rice heading time

Li Qu, Yu-Jia Chu, Wen-Hui Lin, Hong-Wei Xue

PLOS Genetics: published December 8, 2021 | https://doi.org/10.1371/journal.pgen.1009905

RB depletion is required for the continuous growth of tumors initiated by loss of RB

Alex Doan, Julia Arand, Diana Gong, Alexandros P. Drainas, Yan Ting Shue, Myung Chang Lee, Shuyuan Zhang, David M. Walter, Andrea C. Chaikovsky, David M. Feldser, Hannes Vogel, Lukas E. Dow, Jan M. Skotheim, Julien Sage

PLOS Genetics: published December 8, 2021 | https://doi.org/10.1371/journal.pgen.1009941

Germ cells commit somatic stem cells to differentiation following priming by PI3K/Tor activity in the Drosophila testis

Alice C. Yuen, Kenzo-Hugo Hillion, Ruoxu Wang, Marc Amoyel

PLOS Genetics: published December 13, 2021 | https://doi.org/10.1371/journal.pgen.1009609

Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration

Pooja Flora, Meng-Yen Li, Phillip M. Galbo Jr., Maider Astorkia, Deyou Zheng, Elena Ezhkova

PLOS Genetics: published December 14, 2021 | https://doi.org/10.1371/journal.pgen.1009948

TM2D genes regulate Notch signaling and neuronal function in Drosophila

Jose L. Salazar, Sheng-An Yang, Yong Qi Lin, David Li-Kroeger, Paul C. Marcogliese, Samantha L. Deal, G. Gregory Neely, Shinya Yamamoto

PLOS Genetics: published December 14, 2021 | https://doi.org/10.1371/journal.pgen.1009962

ENAP1 retrains seed germination via H3K9 acetylation mediated positive feedback regulation of ABI5

Bo Zhao, Likai Wang, Zhengyao Shao, Kevin Chin, Daveraj Chakravarty, Hong Qiao

PLOS Genetics: published December 15, 2021 | https://doi.org/10.1371/journal.pgen.1009955

Mutations in a barley cytochrome P450 gene enhances pathogen induced programmed cell death and cutin layer instability

Gazala Ameen, Shyam Solanki, Lauren Sager-Bittara, Jonathan Richards, Prabin Tamang, Timothy L. Friesen, Robert S. Brueggeman

PLOS Genetics: published December 16, 2021 | https://doi.org/10.1371/journal.pgen.1009473

Sequencing of Argonaute-bound microRNA/mRNA hybrids reveals regulation of the unfolded protein response by microRNA-320a

Christopher J. Fields, Lu Li, Nicholas M. Hiers, Tianqi Li, Peike Sheng, Taha Huda, Jixiu Shan, Lauren Gay, Tongjun Gu, Jiang Bian, Michael S. Kilberg, Rolf Renne, Mingyi Xie

PLOS Genetics: published December 16, 2021 | https://doi.org/10.1371/journal.pgen.1009934

Choline Transporter regulates olfactory habituation via a neuronal triad of excitatory, inhibitory and mushroom body neurons

Runa Hamid, Hitesh Sonaram Sant, Mrunal Nagaraj Kulkarni

PLOS Genetics: published December 16, 2021 | https://doi.org/10.1371/journal.pgen.1009938

Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status

Paul F. Langton, Michael E. Baumgartner, Remi Logeay, Eugenia Piddini

PLOS Genetics: published December 16, 2021 | https://doi.org/10.1371/journal.pgen.1009946

Distinguishing gene flow between malaria parasite populations

Tyler S. Brown, Olufunmilayo Arogbokun, Caroline O. Buckee, Hsiao-Han Chang

PLOS Genetics: published December 20, 2021 | https://doi.org/10.1371/journal.pgen.1009335

Domestication reshaped the genetic basis of inbreeding depression in a maize landrace compared to its wild relative, teosinte

Luis Fernando Samayoa, Bode A. Olukolu, Chin Jian Yang, Qiuyue Chen, Markus G. Stetter, Alessandra M. York, Jose de Jesus Sanchez-Gonzalez, Jeffrey C. Glaubitz, Peter J. Bradbury, Maria Cinta Romay, Qi Sun, Jinliang Yang, Jeffrey Ross-Ibarra, Edward S. Buckler, John F. Doebley, James B. Holland

PLOS Genetics: published December 20, 2021 | https://doi.org/10.1371/journal.pgen.1009797

tRNA biogenesis and specific aminoacyl-tRNA synthetases regulate senescence stability under the control of mTOR

Jordan Guillon, Hugo Coquelet, Géraldine Leman, Bertrand Toutain, Coralie Petit, Cécile Henry, Alice Boissard, Catherine Guette, Olivier Coqueret

PLOS Genetics: published December 20, 2021 | https://doi.org/10.1371/journal.pgen.1009953

HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly

Deepika Sharma, Anthony J. Mirando, Abigail Leinroth, Jason T. Long, Courtney M. Karner, Matthew J. Hilton

PLOS Genetics: published December 20, 2021 | https://doi.org/10.1371/journal.pgen.1009982

RNA-driven JAZF1-SUZ12 gene fusion in human endometrial stromal cells

Sachin Kumar Gupta, Jocelyn Duen-Ya Jea, Laising Yen

PLOS Genetics: published December 20, 2021 | https://doi.org/10.1371/journal.pgen.1009985

The rarA gene as part of an expanded RecFOR recombination pathway: Negative epistasis and synthetic lethality with ruvB, recG, and recQ

Kanika Jain, Elizabeth A. Wood, Michael M. Cox

PLOS Genetics: published December 22, 2021 | https://doi.org/10.1371/journal.pgen.1009972

Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth

Emily C. A. Goodall, Georgia L. Isom, Jessica L. Rooke, Karthik Pullela, Christopher Icke, Zihao Yang, Gabriela Boelter, Alun Jones, Isabel Warner, Rochelle Da Costa, Bing Zhang, James Rae, Wee Boon Tan, Matthias Winkle, Antoine Delhaye, Eva Heinz, Jean-Francois Collet, Adam F. Cunningham, Mark A. Blaskovich, Robert G. Parton, Jeff A. Cole, Manuel Banzhaf, Shu-Sin Chng, Waldemar Vollmer, Jack A. Bryant, Ian R. Henderson

PLOS Genetics: published December 23, 2021 | https://doi.org/10.1371/journal.pgen.1009586

Increasing calling accuracy, coverage, and read-depth in sequence data by the use of haplotype blocks

Torsten Pook, Adnane Nemri, Eric Gerardo Gonzalez Segovia, Daniel Valle Torres, Henner Simianer, Chris-Carolin Schoen

PLOS Genetics: published December 23, 2021 | https://doi.org/10.1371/journal.pgen.1009944

Integration of whole genome sequencing and transcriptomics reveals a complex picture of the reestablishment of insecticide resistance in the major malaria vector Anopheles coluzzii

Victoria A. Ingham, Jacob A. Tennessen, Eric R. Lucas, Sara Elg, Henrietta Carrington Yates, Jessica Carson, Wamdaogo Moussa Guelbeogo, N’Fale Sagnon, Grant L. Hughes, Eva Heinz, Daniel E. Neafsey, Hilary Ranson

PLOS Genetics: published December 23, 2021 | https://doi.org/10.1371/journal.pgen.1009970

Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1

Wenfeng Zhang, Chaoying Wu, Rui Ni, Qifen Yang, Lingfei Luo, Jianbo He

PLOS Genetics: published December 23, 2021 | https://doi.org/10.1371/journal.pgen.1009980

Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis

Jake J. Reske, Mike R. Wilson, Jeanne Holladay, Rebecca A. Siwicki, Hilary Skalski, Shannon Harkins, Marie Adams, John I. Risinger, Galen Hostetter, Ken Lin, Ronald L. Chandler

PLOS Genetics: published December 23, 2021 | https://doi.org/10.1371/journal.pgen.1009986

c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease

Abigail O. Smith, Julie A. Jonassen, Kenley M. Preval, Roger J. Davis, Gregory J. Pazour

PLOS Genetics: published December 28, 2021 | https://doi.org/10.1371/journal.pgen.1009711

Delta/Jagged-mediated Notch signaling induces the differentiation of agr2-positive epidermal mucous cells in zebrafish embryos

Yu-Fen Lu, Da-Wei Liu, I-Chen Li, Jamie Lin, Chien-Ming Wang, Kuo-Chang Chu, Hsiao-Hui Kuo, Che-Yi Lin, Ling-Huei Yih, Yun-Jin Jiang, Sheng-Ping L. Hwang

PLOS Genetics: published December 28, 2021 | https://doi.org/10.1371/journal.pgen.1009969

Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome

Brittany E. Jewell, An Xu, Dandan Zhu, Mo-Fan Huang, Linchao Lu, Mo Liu, Erica L. Underwood, Jun Hyoung Park, Huihui Fan, Julian A. Gingold, Ruoji Zhou, Jian Tu, Zijun Huo, Ying Liu, Weidong Jin, Yi-Hung Chen, Yitian Xu, Shu-Hsia Chen, Nino Rainusso, Nathaniel K. Berg, Danielle A. Bazer, Christopher Vellano, Philip Jones, Holger K. Eltzschig, Zhongming Zhao, Benny Abraham Kaipparettu, Ruiying Zhao, Lisa L. Wang, Dung-Fang Lee

PLOS Genetics: published December 29, 2021 | https://doi.org/10.1371/journal.pgen.1009971

Correction: Systemic Delivery of MicroRNA-101 Potently Inhibits Hepatocellular Carcinoma In Vivo by Repressing Multiple Targets

Fang Zheng, Yi-Ji Liao, Mu-Yan Cai, Tian-Hao Liu, Shu-Peng Chen, Pei-Hong Wu, Long Wu, Xiu-Wu Bian, Xin-Yuan Guan, Yi-Xin Zeng, Yun-Fei Yuan, Hsiang-Fu Kung, Dan Xie

PLOS Genetics: published December 8, 2021 | https://doi.org/10.1371/journal.pgen.1009960

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Correction: Local Transcriptional Control of YUCCA Regulates Auxin Promoted Root-Growth Inhibition in Response to Aluminium Stress in Arabidopsis

Guangchao Liu, Shan Gao, Huiyu Tian, Wenwen Wu, Hélène S. Robert, Zhaojun Ding

PLOS Genetics: published December 8, 2021 | https://doi.org/10.1371/journal.pgen.1009964

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