Order within chaos: Harnessing Plasmodium falciparum var gene extreme polymorphism for malaria epidemiology

Marc-Antoine Guery, Antoine Claessens

PLOS Genetics: published February 25, 2021 | https://doi.org/10.1371/journal.pgen.1009344

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Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles

Kathryn A. Jewett, Ruth E. Thomas, Chi Q. Phan, Bernice Lin, Gillian Milstein, Selina Yu, Lisa F. Bettcher, Fausto Carnevale Neto, Danijel Djukovic, Daniel Raftery, Leo J. Pallanck, Marie Y. Davis

PLOS Genetics: published February 4, 2021 | https://doi.org/10.1371/journal.pgen.1008859

Opposing functions of the plant TOPLESS gene family during SNC1-mediated autoimmunity

Christopher M. Garner, Benjamin J. Spears, Jianbin Su, Leland J. Cseke, Samantha N. Smith, Conner J. Rogan, Walter Gassmann

PLOS Genetics: published February 23, 2021 | https://doi.org/10.1371/journal.pgen.1009026

Calcium ions trigger the exposure of phosphatidylserine on the surface of necrotic cells

Yoshitaka Furuta, Omar Pena-Ramos, Zao Li, Lucia Chiao, Zheng Zhou

PLOS Genetics: published February 11, 2021 | https://doi.org/10.1371/journal.pgen.1009066

Ancient and recent introgression shape the evolutionary history of pollinator adaptation and speciation in a model monkeyflower radiation (Mimulus section Erythranthe)

Thomas C. Nelson, Angela M. Stathos, Daniel D. Vanderpool, Findley R. Finseth, Yao-wu Yuan, Lila Fishman

PLOS Genetics: published February 22, 2021 | https://doi.org/10.1371/journal.pgen.1009095

Multiple sensors provide spatiotemporal oxygen regulation of gene expression in a Rhizobium-legume symbiosis

Paul J. Rutten, Harrison Steel, Graham A. Hood, Vinoy K. Ramachandran, Lucie McMurtry, Barney Geddes, Antonis Papachristodoulou, Philip S. Poole

PLOS Genetics: published February 4, 2021 | https://doi.org/10.1371/journal.pgen.1009099

The developmental genetic architecture of vocabulary skills during the first three years of life: Capturing emerging associations with later-life reading and cognition

Ellen Verhoef, Chin Yang Shapland, Simon E. Fisher, Philip S. Dale, Beate St Pourcain

PLOS Genetics: published February 12, 2021 | https://doi.org/10.1371/journal.pgen.1009144

yama, a mutant allele of Mov10l1, disrupts retrotransposon silencing and piRNA biogenesis

Yongjuan Guan, Scott Keeney, Devanshi Jain, P. Jeremy Wang

PLOS Genetics: published February 26, 2021 | https://doi.org/10.1371/journal.pgen.1009265

Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between continents

Gerry Tonkin-Hill, Shazia Ruybal-Pesántez, Kathryn E. Tiedje, Virginie Rougeron, Michael F. Duffy, Sedigheh Zakeri, Tepanata Pumpaibool, Pongchai Harnyuttanakorn, OraLee H. Branch, Lastenia Ruiz-Mesía, Thomas S. Rask, Franck Prugnolle, Anthony T. Papenfuss, Yao-ban Chan, Karen P. Day

PLOS Genetics: published February 25, 2021 | https://doi.org/10.1371/journal.pgen.1009269

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The impact of global and local Polynesian genetic ancestry on complex traits in Native Hawaiians

Hanxiao Sun, Meng Lin, Emily M. Russell, Ryan L. Minster, Tsz Fung Chan, Bryan L. Dinh, Take Naseri, Muagututi‘a Sefuiva Reupena, Annette Lum-Jones, the Samoan Obesity, Lifestyle, and Genetic Adaptations (OLaGA) Study Group, Iona Cheng, Lynne R. Wilkens, Loïc Le Marchand, Christopher A. Haiman, Charleston W. K. Chiang

PLOS Genetics: published February 11, 2021 | https://doi.org/10.1371/journal.pgen.1009273

Designing gene drives to limit spillover to non-target populations

Gili Greenbaum, Marcus W. Feldman, Noah A. Rosenberg, Jaehee Kim

PLOS Genetics: published February 25, 2021 | https://doi.org/10.1371/journal.pgen.1009278

ATF3 downmodulates its new targets IFI6 and IFI27 to suppress the growth and migration of tongue squamous cell carcinoma cells

Lin Xu, Tingjian Zu, Tao Li, Min Li, Jun Mi, Fuxiang Bai, Guanyi Liu, Jie Wen, Hui Li, Cord Brakebusch, Xuxia Wang, Xunwei Wu

PLOS Genetics: published February 4, 2021 | https://doi.org/10.1371/journal.pgen.1009283

IgH 3’ regulatory region increases ectopic class switch recombination

Sandrine Le Noir, Amélie Bonaud, Bastien Hervé, Audrey Baylet, François Boyer, Sandrine Lecardeur, Zeliha Oruc, Christophe Sirac, Michel Cogné

PLOS Genetics: published February 8, 2021 | https://doi.org/10.1371/journal.pgen.1009288

Creating artificial human genomes using generative neural networks

Burak Yelmen, Aurélien Decelle, Linda Ongaro, Davide Marnetto, Corentin Tallec, Francesco Montinaro, Cyril Furtlehner, Luca Pagani, Flora Jay

PLOS Genetics: published February 4, 2021 | https://doi.org/10.1371/journal.pgen.1009303

Defects in the cytoplasmic assembly of axonemal dynein arms cause morphological abnormalities and dysmotility in sperm cells leading to male infertility

Isabella Aprea, Johanna Raidt, Inga Marlena Höben, Niki Tomas Loges, Tabea Nöthe-Menchen, Petra Pennekamp, Heike Olbrich, Thomas Kaiser, Luisa Biebach, Frank Tüttelmann, Judit Horvath, Maria Schubert, Claudia Krallmann, Sabine Kliesch, Heymut Omran

PLOS Genetics: published February 26, 2021 | https://doi.org/10.1371/journal.pgen.1009306

Genomic analyses of glycine decarboxylase neurogenic mutations yield a large-scale prediction model for prenatal disease

Joseph Farris, Md Suhail Alam, Arpitha Mysore Rajashekara, Kasturi Haldar

PLOS Genetics: published February 1, 2021 | https://doi.org/10.1371/journal.pgen.1009307

RAC1 controls progressive movement and competitiveness of mammalian spermatozoa

Alexandra Amaral, Bernhard G. Herrmann

PLOS Genetics: published February 4, 2021 | https://doi.org/10.1371/journal.pgen.1009308

Transcriptome-wide transmission disequilibrium analysis identifies novel risk genes for autism spectrum disorder

Kunling Huang, Yuchang Wu, Junha Shin, Ye Zheng, Alireza Fotuhi Siahpirani, Yupei Lin, Zheng Ni, Jiawen Chen, Jing You, Sunduz Keles, Daifeng Wang, Sushmita Roy, Qiongshi Lu

PLOS Genetics: published February 4, 2021 | https://doi.org/10.1371/journal.pgen.1009309

Vestigial mediates the effect of insulin signaling pathway on wing-morph switching in planthoppers

Jin-Li Zhang, Sheng-Jie Fu, Sun-Jie Chen, Hao-Hao Chen, Yi-Lai Liu, Xin-Yang Liu, Hai-Jun Xu

PLOS Genetics: published February 9, 2021 | https://doi.org/10.1371/journal.pgen.1009312

The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response

Zhe Zhang, Shuo Luo, Guilherme Oliveira Barbosa, Meirong Bai, Thomas B. Kornberg, Dengke K. Ma

PLOS Genetics: published February 1, 2021 | https://doi.org/10.1371/journal.pgen.1009317

Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis

Jonathan Lenz, Robert Liefke, Julianne Funk, Samuel Shoup, Andrea Nist, Thorsten Stiewe, Robert Schulz, Yumiko Tokusumi, Lea Albert, Hartmann Raifer, Klaus Förstemann, Olalla Vázquez, Tsuyoshi Tokusumi, Nancy Fossett, Alexander Brehm

PLOS Genetics: published February 18, 2021 | https://doi.org/10.1371/journal.pgen.1009318

Genetic loci associated with skin pigmentation in African Americans and their effects on vitamin D deficiency

Ken Batai, Zuxi Cui, Amit Arora, Ebony Shah-Williams, Wenndy Hernandez, Maria Ruden, Courtney M. P. Hollowell, Stanley E. Hooker, Madhavi Bathina, Adam B. Murphy, Carolina Bonilla, Rick A. Kittles

PLOS Genetics: published February 18, 2021 | https://doi.org/10.1371/journal.pgen.1009319

Lhx6 regulates canonical Wnt signaling to control the fate of mesenchymal progenitor cells during mouse molar root patterning

Jinzhi He, Junjun Jing, Jifan Feng, Xia Han, Yuan Yuan, Tingwei Guo, Fei Pei, Yuanyuan Ma, Courtney Cho, Thach-Vu Ho, Yang Chai

PLOS Genetics: published February 17, 2021 | https://doi.org/10.1371/journal.pgen.1009320

Actionable pharmacogenetic variants in Hong Kong Chinese exome sequencing data and projected prescription impact in the Hong Kong population

Mullin Ho Chung Yu, Marcus Chun Yin Chan, Claudia Ching Yan Chung, Andrew Wang Tat Li, Chara Yin Wa Yip, Christopher Chun Yu Mak, Jeffrey Fong Ting Chau, Mianne Lee, Jasmine Lee Fong Fung, Mandy Ho Yin Tsang, Joshua Chun Ki Chan, Wilfred Hing Sang Wong, Jing Yang, William Chun Ming Chui, Patrick Ho Yu Chung, Wanling Yang, So Lun Lee, Godfrey Chi Fung Chan, Paul Kwong Hang Tam, Yu Lung Lau, Clara Sze Man Tang, Kit San Yeung, Brian Hon Yin Chung

PLOS Genetics: published February 18, 2021 | https://doi.org/10.1371/journal.pgen.1009323

Fruitless decommissions regulatory elements to implement cell-type-specific neuronal masculinization

Margarita V. Brovkina, Rachel Duffié, Abbigayl E. C. Burtis, E. Josephine Clowney

PLOS Genetics: published February 18, 2021 | https://doi.org/10.1371/journal.pgen.1009338

Aberrant binding of mutant HSP47 affects posttranslational modification of type I collagen and leads to osteogenesis imperfecta

Delfien Syx, Yoshihiro Ishikawa, Jan Gebauer, Sergei P. Boudko, Brecht Guillemyn, Tim Van Damme, Sanne D’hondt, Sofie Symoens, Sheela Nampoothiri, Douglas B. Gould, Ulrich Baumann, Hans Peter Bächinger, Fransiska Malfait

PLOS Genetics: published February 1, 2021 | https://doi.org/10.1371/journal.pgen.1009339

The Species-Specific Acquisition and Diversification of a K1-like Family of Killer Toxins in Budding Yeasts of the Saccharomycotina

Lance R. Fredericks, Mark D. Lee, Angela M. Crabtree, Josephine M. Boyer, Emily A. Kizer, Nathan T. Taggart, Cooper R. Roslund, Samuel S. Hunter, Courtney B. Kennedy, Cody G. Willmore, Nova M. Tebbe, Jade S. Harris, Sarah N. Brocke, Paul A. Rowley

PLOS Genetics: published February 4, 2021 | https://doi.org/10.1371/journal.pgen.1009341

Four families of folate-independent methionine synthases

Morgan N. Price, Adam M. Deutschbauer, Adam P. Arkin

PLOS Genetics: published February 3, 2021 | https://doi.org/10.1371/journal.pgen.1009342

Increased dopaminergic neurotransmission results in ethanol dependent sedative behaviors in Caenorhabditis elegans

Pratima Pandey, Anuradha Singh, Harjot Kaur, Anindya Ghosh-Roy, Kavita Babu

PLOS Genetics: published February 1, 2021 | https://doi.org/10.1371/journal.pgen.1009346

Acetyltransferase Enok regulates transposon silencing and piRNA cluster transcription

Shih-Ying Tsai, Fu Huang

PLOS Genetics: published February 1, 2021 | https://doi.org/10.1371/journal.pgen.1009349

Oscillating and stable genome topologies underlie hepatic physiological rhythms during the circadian cycle

Jérôme Mermet, Jake Yeung, Felix Naef

PLOS Genetics: published February 1, 2021 | https://doi.org/10.1371/journal.pgen.1009350

Interdependent recruitment of CYC8/TUP1 and the transcriptional activator XYR1 at target promoters is required for induced cellulase gene expression in Trichoderma reesei

Lei Wang, Weixin Zhang, Yanli Cao, Fanglin Zheng, Guolei Zhao, Xinxing Lv, Xiangfeng Meng, Weifeng Liu

PLOS Genetics: published February 19, 2021 | https://doi.org/10.1371/journal.pgen.1009351

Steroid hormone ecdysone deficiency stimulates preparation for photoperiodic reproductive diapause

Shuang Guo, Zhong Tian, Qing-Wen Wu, Kirst King-Jones, Wen Liu, Fen Zhu, Xiao-Ping Wang

PLOS Genetics: published February 2, 2021 | https://doi.org/10.1371/journal.pgen.1009352

Fitness landscape of a dynamic RNA structure

Valerie W. C. Soo, Jacob B. Swadling, Andre J. Faure, Tobias Warnecke

PLOS Genetics: published February 1, 2021 | https://doi.org/10.1371/journal.pgen.1009353

Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells

Andrey A. Parkhitko, Arashdeep Singh, Sharon Hsieh, Yanhui Hu, Richard Binari, Christopher J. Lord, Sridhar Hannenhalli, Colm J. Ryan, Norbert Perrimon

PLOS Genetics: published February 16, 2021 | https://doi.org/10.1371/journal.pgen.1009354

Regulation of ddb2 expression in blind cavefish and zebrafish reveals plasticity in the control of sunlight-induced DNA damage repair

Haiyu Zhao, Hongxiang Li, Juan Du, Giuseppe Di Mauro, Sebastian Lungu-Mitea, Nathalie Geyer, Daniela Vallone, Cristiano Bertolucci, Nicholas S. Foulkes

PLOS Genetics: published February 5, 2021 | https://doi.org/10.1371/journal.pgen.1009356

LZP is required for hepatic triacylglycerol transportation through maintaining apolipoprotein B stability

Jiao-Xiang Wu, Kun-Yan He, Zhuang-Zhuang Zhang, Yu-Lan Qu, Xian-Bin Su, Yi Shi, Na Wang, Lan Wang, Ze-Guang Han

PLOS Genetics: published February 16, 2021 | https://doi.org/10.1371/journal.pgen.1009357

α-synuclein impairs autophagosome maturation through abnormal actin stabilization

Souvarish Sarkar, Abby L. Olsen, Katja Sygnecka, Kelly M. Lohr, Mel B. Feany

PLOS Genetics: published February 8, 2021 | https://doi.org/10.1371/journal.pgen.1009359

CRMP/UNC-33 organizes microtubule bundles for KIF5-mediated mitochondrial distribution to axon

Ying-Chun Chen, Hao-Ru Huang, Chia-Hao Hsu, Chan-Yen Ou

PLOS Genetics: published February 11, 2021 | https://doi.org/10.1371/journal.pgen.1009360

Systemic and local effect of the Drosophila headcase gene and its role in stress protection of Adult Progenitor Cells

Panagiotis Giannios, Jordi Casanova

PLOS Genetics: published February 8, 2021 | https://doi.org/10.1371/journal.pgen.1009362

Hippocampal transcriptome-wide association study and neurobiological pathway analysis for Alzheimer’s disease

Nana Liu, Jiayuan Xu, Huaigui Liu, Shijie Zhang, Miaoxin Li, Yao Zhou, Wen Qin, Mulin Jun Li, Chunshui Yu, for the Alzheimer’s disease Neuroimaging Initiative

PLOS Genetics: published February 25, 2021 | https://doi.org/10.1371/journal.pgen.1009363

Low immunogenicity of common cancer hot spot mutations resulting in false immunogenic selection signals

Arne Claeys, Tom Luijts, Kathleen Marchal, Jimmy Van den Eynden

PLOS Genetics: published February 8, 2021 | https://doi.org/10.1371/journal.pgen.1009368

Hybrid seed incompatibility in Capsella is connected to chromatin condensation defects in the endosperm

Katarzyna Dziasek, Lauriane Simon, Clément Lafon-Placette, Benjamin Laenen, Cecilia Wärdig, Juan Santos-González, Tanja Slotte, Claudia Köhler

PLOS Genetics: published February 11, 2021 | https://doi.org/10.1371/journal.pgen.1009370

Homeodomain protein Six4 prevents the generation of supernumerary Drosophila type II neuroblasts and premature differentiation of intermediate neural progenitors

Rui Chen, Yanjun Hou, Marisa Connell, Sijun Zhu

PLOS Genetics: published February 8, 2021 | https://doi.org/10.1371/journal.pgen.1009371

Detection of hard and soft selective sweeps from Drosophila melanogaster population genomic data

Nandita R. Garud, Philipp W. Messer, Dmitri A. Petrov

PLOS Genetics: published February 26, 2021 | https://doi.org/10.1371/journal.pgen.1009373

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PLOS Genetics: published February 9, 2021 | https://doi.org/10.1371/journal.pgen.1009375

Histone modification dynamics at H3K27 are associated with altered transcription of in planta induced genes in Magnaporthe oryzae

Wei Zhang, Jun Huang, David E. Cook

PLOS Genetics: published February 3, 2021 | https://doi.org/10.1371/journal.pgen.1009376

RanBP2/Nup358 enhances miRNA activity by sumoylating Argonautes

Qingtang Shen, Yifan E. Wang, Mathew Truong, Kohila Mahadevan, Jingze J. Wu, Hui Zhang, Jiawei Li, Harrison W. Smith, Craig A. Smibert, Alexander F. Palazzo

PLOS Genetics: published February 18, 2021 | https://doi.org/10.1371/journal.pgen.1009378

IAA3-mediated repression of PIF proteins coordinates light and auxin signaling in Arabidopsis

Yulin Xi, Yan Yang, Jie Yang, Xing Zhang, Yajie Pan, Hongwei Guo

PLOS Genetics: published February 18, 2021 | https://doi.org/10.1371/journal.pgen.1009384

Split versions of Cleave and Rescue selfish genetic elements for measured self limiting gene drive

Georg Oberhofer, Tobin Ivy, Bruce A. Hay

PLOS Genetics: published February 18, 2021 | https://doi.org/10.1371/journal.pgen.1009385

Genomic rearrangements generate hypervariable mini-chromosomes in host-specific isolates of the blast fungus

Thorsten Langner, Adeline Harant, Luis B. Gomez-Luciano, Ram K. Shrestha, Angus Malmgren, Sergio M. Latorre, Hernán A. Burbano, Joe Win, Sophien Kamoun

PLOS Genetics: published February 16, 2021 | https://doi.org/10.1371/journal.pgen.1009386

Intermedilysin cytolytic activity depends on heparan sulfates and membrane composition

Gediminas Drabavicius, Dirk Daelemans

PLOS Genetics: published February 12, 2021 | https://doi.org/10.1371/journal.pgen.1009387

Zebrafish Ski7 tunes RNA levels during the oocyte-to-embryo transition

Luis Enrique Cabrera-Quio, Alexander Schleiffer, Karl Mechtler, Andrea Pauli

PLOS Genetics: published February 18, 2021 | https://doi.org/10.1371/journal.pgen.1009390

A novel role for Dun1 in the regulation of origin firing upon hyper-acetylation of H3K56

Lihi Gershon, Martin Kupiec

PLOS Genetics: published February 18, 2021 | https://doi.org/10.1371/journal.pgen.1009391

RNA-binding protein syncrip regulates starvation-induced hyperactivity in adult Drosophila

Wanhao Chi, Wei Liu, Wenqin Fu, Shengqian Xia, Ellie S. Heckscher, Xiaoxi Zhuang

PLOS Genetics: published February 22, 2021 | https://doi.org/10.1371/journal.pgen.1009396

Molecular parallelisms between pigmentation in the avian iris and the integument of ectothermic vertebrates

Pedro Andrade, Małgorzata A. Gazda, Pedro M. Araújo, Sandra Afonso, Jacob. A. Rasmussen, Cristiana I. Marques, Ricardo J. Lopes, M. Thomas P. Gilbert., Miguel Carneiro

PLOS Genetics: published February 23, 2021 | https://doi.org/10.1371/journal.pgen.1009404

Power analysis of transcriptome-wide association study: Implications for practical protocol choice

Chen Cao, Bowei Ding, Qing Li, Devin Kwok, Jingjing Wu, Quan Long

PLOS Genetics: published February 26, 2021 | https://doi.org/10.1371/journal.pgen.1009405

Correction: Demographic history shaped geographical patterns of deleterious mutation load in a broadly distributed Pacific Salmon

Quentin Rougemont, Jean-Sébastien Moore, Thibault Leroy, Eric Normandeau, Eric B. Rondeau, Ruth E. Withler, Donald M. Van Doornik, Penelope A. Crane, Kerry A. Naish, John Carlos Garza, Terry D. Beacham, Ben F. Koop, Louis Bernatchez

PLOS Genetics: published February 18, 2021 | https://doi.org/10.1371/journal.pgen.1009397

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