DIC (differential interference contrast) microscopy showing the radial growth of Aspergillus nidulans branches during initial stages of development on the surface of the medium. Image edited using Adobe Photoshop. The filamentous fungus A. nidulans needs to coordinate complex regulatory networks and the cross-talk between these pathways to appropriately sense and respond to environmental cues, such as carbon source availability. Subsequently, intracellular signalling events are activated which are coordinated by different protein kinase pathways to regulate carbon source metabolism. Carbon catabolite repression ensures utilisation of the energetically most favourable carbon source glucose whilst repressing the utilisation of alternative carbon sources. See de Assis et al.
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Image Credit: Leandro José de Assis
Editorial
Genomic imprinting: An epigenetic regulatory system
PLOS Genetics: published August 6, 2020 | https://doi.org/10.1371/journal.pgen.1008970
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Viewpoints
How many familial relationship testing results could be wrong?
PLOS Genetics: published August 13, 2020 | https://doi.org/10.1371/journal.pgen.1008929
Reviews
Long noncoding RNA functionality in imprinted domain regulation
PLOS Genetics: published August 6, 2020 | https://doi.org/10.1371/journal.pgen.1008930
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The roles of replication-transcription conflict in mutagenesis and evolution of genome organization
PLOS Genetics: published August 27, 2020 | https://doi.org/10.1371/journal.pgen.1008987
Research Articles
A human-specific VNTR in the TRIB3 promoter causes gene expression variation between individuals
PLOS Genetics: published August 3, 2020 | https://doi.org/10.1371/journal.pgen.1008981
DAnkrd49 and Bdbt act via Casein kinase Iε to regulate planar polarity in Drosophila
PLOS Genetics: published August 4, 2020 | https://doi.org/10.1371/journal.pgen.1008820
Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR proteins
PLOS Genetics: published August 4, 2020 | https://doi.org/10.1371/journal.pgen.1008975
Haspin kinase modulates nuclear architecture and Polycomb-dependent gene silencing
PLOS Genetics: published August 4, 2020 | https://doi.org/10.1371/journal.pgen.1008962
Mapping gene flow between ancient hominins through demography-aware inference of the ancestral recombination graph
PLOS Genetics: published August 6, 2020 | https://doi.org/10.1371/journal.pgen.1008895
Replication of the Salmonella Genomic Island 1 (SGI1) triggered by helper IncC conjugative plasmids promotes incompatibility and plasmid loss
PLOS Genetics: published August 6, 2020 | https://doi.org/10.1371/journal.pgen.1008965
A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein
PLOS Genetics: published August 6, 2020 | https://doi.org/10.1371/journal.pgen.1008941
Drosophila miR-87 promotes dendrite regeneration by targeting the transcriptional repressor Tramtrack69
PLOS Genetics: published August 7, 2020 | https://doi.org/10.1371/journal.pgen.1008942
Mutation of CFAP57, a protein required for the asymmetric targeting of a subset of inner dynein arms in Chlamydomonas, causes primary ciliary dyskinesia
PLOS Genetics: published August 7, 2020 | https://doi.org/10.1371/journal.pgen.1008691
Immediate activation of chemosensory neuron gene expression by bacterial metabolites is selectively induced by distinct cyclic GMP-dependent pathways in Caenorhabditis elegans
PLOS Genetics: published August 10, 2020 | https://doi.org/10.1371/journal.pgen.1008505
THOC1 deficiency leads to late-onset nonsyndromic hearing loss through p53-mediated hair cell apoptosis
PLOS Genetics: published August 10, 2020 | https://doi.org/10.1371/journal.pgen.1008953
Nitrogen coordinated import and export of arginine across the yeast vacuolar membrane
PLOS Genetics: published August 10, 2020 | https://doi.org/10.1371/journal.pgen.1008966
Gα/GSA-1 works upstream of PKA/KIN-1 to regulate calcium signaling and contractility in the Caenorhabditis elegans spermatheca
PLOS Genetics: published August 10, 2020 | https://doi.org/10.1371/journal.pgen.1008644
Disruption of the ERLIN–TM6SF2–APOB complex destabilizes APOB and contributes to non-alcoholic fatty liver disease
PLOS Genetics: published August 10, 2020 | https://doi.org/10.1371/journal.pgen.1008955
Endogenization and excision of human herpesvirus 6 in human genomes
PLOS Genetics: published August 10, 2020 | https://doi.org/10.1371/journal.pgen.1008915
Mushroom body subsets encode CREB2-dependent water-reward long-term memory in Drosophila
PLOS Genetics: published August 11, 2020 | https://doi.org/10.1371/journal.pgen.1008963
Cfap97d1 is important for flagellar axoneme maintenance and male mouse fertility
PLOS Genetics: published August 12, 2020 | https://doi.org/10.1371/journal.pgen.1008954
A subset of broadly responsive Type III taste cells contribute to the detection of bitter, sweet and umami stimuli
PLOS Genetics: published August 13, 2020 | https://doi.org/10.1371/journal.pgen.1008925
Transcriptional regulators of the Golli/myelin basic protein locus integrate additive and stealth activities
PLOS Genetics: published August 13, 2020 | https://doi.org/10.1371/journal.pgen.1008752
Cryptic genetic variation enhances primate L1 retrotransposon survival by enlarging the functional coiled coil sequence space of ORF1p
PLOS Genetics: published August 14, 2020 | https://doi.org/10.1371/journal.pgen.1008991
Quorum sensing sets the stage for the establishment and vertical transmission of Sodalis praecaptivus in tsetse flies
PLOS Genetics: published August 14, 2020 | https://doi.org/10.1371/journal.pgen.1008992
On the cross-population generalizability of gene expression prediction models
PLOS Genetics: published August 14, 2020 | https://doi.org/10.1371/journal.pgen.1008927
Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis
PLOS Genetics: published August 17, 2020 | https://doi.org/10.1371/journal.pgen.1008906
Systematic identification of functional SNPs interrupting 3’UTR polyadenylation signals
PLOS Genetics: published August 17, 2020 | https://doi.org/10.1371/journal.pgen.1008977
Polo kinase recruitment via the constitutive centromere-associated network at the kinetochore elevates centromeric RNA
PLOS Genetics: published August 18, 2020 | https://doi.org/10.1371/journal.pgen.1008990
Phospho-regulation of the Shugoshin - Condensin interaction at the centromere in budding yeast
PLOS Genetics: published August 18, 2020 | https://doi.org/10.1371/journal.pgen.1008569
Drosophila Myc restores immune homeostasis of Imd pathway via activating miR-277 to inhibit imd/Tab2
PLOS Genetics: published August 18, 2020 | https://doi.org/10.1371/journal.pgen.1008989
Paired Box 9 (PAX9), the RNA polymerase II transcription factor, regulates human ribosome biogenesis and craniofacial development
PLOS Genetics: published August 19, 2020 | https://doi.org/10.1371/journal.pgen.1008967
Conditional antagonism in co-cultures of Pseudomonas aeruginosa and Candida albicans: An intersection of ethanol and phosphate signaling distilled from dual-seq transcriptomics
PLOS Genetics: published August 19, 2020 | https://doi.org/10.1371/journal.pgen.1008783
A general framework for functionally informed set-based analysis: Application to a large-scale colorectal cancer study
PLOS Genetics: published August 24, 2020 | https://doi.org/10.1371/journal.pgen.1008947
Pan-genomic open reading frames: A potential supplement of single nucleotide polymorphisms in estimation of heritability and genomic prediction
PLOS Genetics: published August 24, 2020 | https://doi.org/10.1371/journal.pgen.1008995
Gluconeogenesis and PEPCK are critical components of healthy aging and dietary restriction life extension
PLOS Genetics: published August 25, 2020 | https://doi.org/10.1371/journal.pgen.1008982
Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequences
PLOS Genetics: published August 25, 2020 | https://doi.org/10.1371/journal.pgen.1008893
Functional information from clinically-derived drug resistant forms of the Candida glabrata Pdr1 transcription factor
PLOS Genetics: published August 25, 2020 | https://doi.org/10.1371/journal.pgen.1009005
The High Osmolarity Glycerol Mitogen-Activated Protein Kinase regulates glucose catabolite repression in filamentous fungi
PLOS Genetics: published August 25, 2020 | https://doi.org/10.1371/journal.pgen.1008996
Horizontal transmission and recombination maintain forever young bacterial symbiont genomes
PLOS Genetics: published August 25, 2020 | https://doi.org/10.1371/journal.pgen.1008935
Distinct and sequential re-replication barriers ensure precise genome duplication
PLOS Genetics: published August 25, 2020 | https://doi.org/10.1371/journal.pgen.1008988
Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae
PLOS Genetics: published August 26, 2020 | https://doi.org/10.1371/journal.pgen.1008745
Demographic history shaped geographical patterns of deleterious mutation load in a broadly distributed Pacific Salmon
PLOS Genetics: published August 26, 2020 | https://doi.org/10.1371/journal.pgen.1008348
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Learning the properties of adaptive regions with functional data analysis
PLOS Genetics: published August 27, 2020 | https://doi.org/10.1371/journal.pgen.1008896
Natural variation in a glucuronosyltransferase modulates propionate sensitivity in a C. elegans propionic acidemia model
PLOS Genetics: published August 28, 2020 | https://doi.org/10.1371/journal.pgen.1008984
Serotonergic modulation of visual neurons in Drosophila melanogaster
PLOS Genetics: published August 31, 2020 | https://doi.org/10.1371/journal.pgen.1009003
Opinion Piece
Costly Genes
PLOS Genetics: published August 20, 2020 | https://doi.org/10.1371/journal.pgen.1008889