Mixed methods

David J. Balding, Gregory S. Barsh, Gregory P. Copenhaver, Chengqi Yi

PLOS Genetics: published July 15, 2020 | https://doi.org/10.1371/journal.pgen.1008950

Predicting longevity responses to dietary restriction: A stepping stone toward precision geroscience

Maria C. Perez-Matos, William B. Mair

PLOS Genetics: published July 9, 2020 | https://doi.org/10.1371/journal.pgen.1008833

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Not too long, not too short: Goldilocks principle of eye size

Rachel W. Kuchtey

PLOS Genetics: published July 15, 2020 | https://doi.org/10.1371/journal.pgen.1008914

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A FAS solution to a DEAD case

Alexandra Gruss

PLOS Genetics: published July 30, 2020 | https://doi.org/10.1371/journal.pgen.1008842

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Double-edged sword: The evolutionary consequences of the epigenetic silencing of transposable elements

Jae Young Choi, Yuh Chwen G. Lee

PLOS Genetics: published July 16, 2020 | https://doi.org/10.1371/journal.pgen.1008872

Advances and challenges in genetic technologies to produce single-sex litters

Charlotte Douglas, James M. A. Turner

PLOS Genetics: published July 23, 2020 | https://doi.org/10.1371/journal.pgen.1008898

Conditional knockout of RAD51-related genes in Leishmania major reveals a critical role for homologous recombination during genome replication

Jeziel D. Damasceno, João Reis-Cunha, Kathryn Crouch, Dario Beraldi, Craig Lapsley, Luiz R. O. Tosi, Daniella Bartholomeu, Richard McCulloch

PLOS Genetics: published July 1, 2020 | https://doi.org/10.1371/journal.pgen.1008828

Brassinosteroids regulate root meristem development by mediating BIN2-UPB1 module in Arabidopsis

Taotao Li, Wei Lei, Ruiyuan He, Xiaoya Tang, Jifu Han, Lijuan Zou, Yanhai Yin, Honghui Lin, Dawei Zhang

PLOS Genetics: published July 1, 2020 | https://doi.org/10.1371/journal.pgen.1008883

Repression of tick microRNA-133 induces organic anion transporting polypeptide expression critical for Anaplasma phagocytophilum survival in the vector and transmission to the vertebrate host

Ellango Ramasamy, Vikas Taank, John F Anderson, Hameeda Sultana, Girish Neelakanta

PLOS Genetics: published July 2, 2020 | https://doi.org/10.1371/journal.pgen.1008856

Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits

Andrew D. Bretherick, Oriol Canela-Xandri, Peter K. Joshi, David W. Clark, Konrad Rawlik, Thibaud S. Boutin, Yanni Zeng, Carmen Amador, Pau Navarro, Igor Rudan, Alan F. Wright, Harry Campbell, Veronique Vitart, Caroline Hayward, James F. Wilson, Albert Tenesa, Chris P. Ponting, J. Kenneth Baillie, Chris Haley

PLOS Genetics: published July 6, 2020 | https://doi.org/10.1371/journal.pgen.1008785

Genome wide distribution of G-quadruplexes and their impact on gene expression in malaria parasites

Elodie Gazanion, Laurent Lacroix, Patrizia Alberti, Pratima Gurung, Sharon Wein, Mingpan Cheng, Jean-Louis Mergny, Ana Rita Gomes, Jose-Juan Lopez-Rubio

PLOS Genetics: published July 6, 2020 | https://doi.org/10.1371/journal.pgen.1008917

The membrane protein ANKH is crucial for bone mechanical performance by mediating cellular export of citrate and ATP

Flora Szeri, Stefan Lundkvist, Sylvia Donnelly, Udo F. H. Engelke, Kyu Rhee, Charlene J. Williams, John P. Sundberg, Ron A. Wevers, Ryan E. Tomlinson, Robert S. Jansen, Koen van de Wetering

PLOS Genetics: published July 8, 2020 | https://doi.org/10.1371/journal.pgen.1008884

An expanded cell wall damage signaling network is comprised of the transcription factors Rlm1 and Sko1 in Candida albicans

Marienela Y. Heredia, Mélanie A. C. Ikeh, Deepika Gunasekaran, Karen A. Conrad, Sviatlana Filimonava, Dawn H. Marotta, Clarissa J. Nobile, Jason M. Rauceo

PLOS Genetics: published July 8, 2020 | https://doi.org/10.1371/journal.pgen.1008908

Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila

Kelly Jin, Kenneth A. Wilson, Jennifer N. Beck, Christopher S. Nelson, George W. Brownridge III, Benjamin R. Harrison, Danijel Djukovic, Daniel Raftery, Rachel B. Brem, Shiqing Yu, Mathias Drton, Ali Shojaie, Pankaj Kapahi, Daniel Promislow

PLOS Genetics: published July 9, 2020 | https://doi.org/10.1371/journal.pgen.1008835

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Impact of insertion sequences on convergent evolution of Shigella species

Jane Hawkey, Jonathan M. Monk, Helen Billman-Jacobe, Bernhard Palsson, Kathryn E. Holt

PLOS Genetics: published July 9, 2020 | https://doi.org/10.1371/journal.pgen.1008931

A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons

Derrick J. Morton, Binta Jalloh, Lily Kim, Isaac Kremsky, Rishi J. Nair, Khuong B. Nguyen, J. Christopher Rounds, Maria C. Sterrett, Brianna Brown, Thalia Le, Maya C. Karkare, Kathryn D. McGaughey, Shaoyi Sheng, Sara W. Leung, Milo B. Fasken, Kenneth H. Moberg, Anita H. Corbett

PLOS Genetics: published July 9, 2020 | https://doi.org/10.1371/journal.pgen.1008901

TaTLP1 interacts with TaPR1 to contribute to wheat defense responses to leaf rust fungus

Fei Wang, Shitao Yuan, Wenyue Wu, Yiqing Yang, Zhongchi Cui, Haiyan Wang, Daqun Liu

PLOS Genetics: published July 13, 2020 | https://doi.org/10.1371/journal.pgen.1008713

A non-canonical RNAi pathway controls virulence and genome stability in Mucorales

Carlos Pérez-Arques, María Isabel Navarro-Mendoza, Laura Murcia, Eusebio Navarro, Victoriano Garre, Francisco Esteban Nicolás

PLOS Genetics: published July 13, 2020 | https://doi.org/10.1371/journal.pgen.1008611

Epistatic interactions between PHOTOPERIOD1, CONSTANS1 and CONSTANS2 modulate the photoperiodic response in wheat

Lindsay M. Shaw, Chengxia Li, Daniel P. Woods, Maria A. Alvarez, Huiqiong Lin, Mei Y. Lau, Andrew Chen, Jorge Dubcovsky

PLOS Genetics: published July 13, 2020 | https://doi.org/10.1371/journal.pgen.1008812

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The beta-1, 4-N-acetylglucosaminidase 1 gene, selected by domestication and breeding, is involved in cocoon construction of Bombyx mori

Chunlin Li, Xiaoling Tong, Weidong Zuo, Hai Hu, Gao Xiong, Minjin Han, Rui Gao, Yue Luan, Kunpeng Lu, Tingting Gai, Zhonghuai Xiang, Cheng Lu, Fangyin Dai

PLOS Genetics: published July 15, 2020 | https://doi.org/10.1371/journal.pgen.1008907

A novel allele of ASY3 is associated with greater meiotic stability in autotetraploid Arabidopsis lyrata

Paul J. Seear, Martin G. France, Catherine L. Gregory, Darren Heavens, Roswitha Schmickl, Levi Yant, James D. Higgins

PLOS Genetics: published July 15, 2020 | https://doi.org/10.1371/journal.pgen.1008900

Unified inference of missense variant effects and gene constraints in the human genome

Yi-Fei Huang

PLOS Genetics: published July 15, 2020 | https://doi.org/10.1371/journal.pgen.1008922

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Resection and repair of a Cas9 double-strand break at CTG trinucleotide repeats induces local and extensive chromosomal deletions

Valentine Mosbach, David Viterbo, Stéphane Descorps-Declère, Lucie Poggi, Wilhelm Vaysse-Zinkhöfer, Guy-Franck Richard

PLOS Genetics: published July 16, 2020 | https://doi.org/10.1371/journal.pgen.1008924

Spontaneous mutations that confer resistance to 2-deoxyglucose act through Hxk2 and Snf1 pathways to regulate gene expression and HXT endocytosis

Samantha R. Soncini, Dakshayini G. Chandrashekarappa, David A. Augustine, Kenny P. Callahan, Allyson F. O’Donnell, Martin C. Schmidt

PLOS Genetics: published July 16, 2020 | https://doi.org/10.1371/journal.pgen.1008484

Maize adaptation across temperate climates was obtained via expression of two florigen genes

Sara Castelletti, Aude Coupel-Ledru, Italo Granato, Carine Palaffre, Llorenç Cabrera-Bosquet, Chiara Tonelli, Stéphane D. Nicolas, François Tardieu, Claude Welcker, Lucio Conti

PLOS Genetics: published July 16, 2020 | https://doi.org/10.1371/journal.pgen.1008882

Protein-Protein interactions uncover candidate ‘core genes’ within omnigenic disease networks

Abhirami Ratnakumar, Nils Weinhold, Jessica C. Mar, Nadeem Riaz

PLOS Genetics: published July 17, 2020 | https://doi.org/10.1371/journal.pgen.1008903

CRL4^Cdt2 ubiquitin ligase regulates Dna2 and Rad16 (XPF) nucleases by targeting Pxd1 for degradation

Jia-Min Zhang, Jin-Xin Zheng, Yue-He Ding, Xiao-Ran Zhang, Fang Suo, Jing-Yi Ren, Meng-Qiu Dong, Li-Lin Du

PLOS Genetics: published July 21, 2020 | https://doi.org/10.1371/journal.pgen.1008933

Developmental loss of neurofibromin across distributed neuronal circuits drives excessive grooming in Drosophila

Lanikea B. King, Tamara Boto, Valentina Botero, Ari M. Aviles, Breanna M. Jomsky, Chevara Joseph, James A. Walker, Seth M. Tomchik

PLOS Genetics: published July 22, 2020 | https://doi.org/10.1371/journal.pgen.1008920

The Paramecium histone chaperone Spt16-1 is required for Pgm endonuclease function in programmed genome rearrangements

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PLOS Genetics: published July 23, 2020 | https://doi.org/10.1371/journal.pgen.1008949

IgaA negatively regulates the Rcs Phosphorelay via contact with the RcsD Phosphotransfer Protein

Erin A. Wall, Nadim Majdalani, Susan Gottesman

PLOS Genetics: published July 27, 2020 | https://doi.org/10.1371/journal.pgen.1008610

The evolution and functional divergence of the histone H2B family in plants

Danhua Jiang, Michael Borg, Zdravko J. Lorković, Sean A. Montgomery, Akihisa Osakabe, Ramesh Yelagandula, Elin Axelsson, Frédéric Berger

PLOS Genetics: published July 27, 2020 | https://doi.org/10.1371/journal.pgen.1008964

The DEAD-box RNA helicase CshA is required for fatty acid homeostasis in Staphylococcus aureus

Vanessa Khemici, Julien Prados, Bianca Petrignani, Benjamin Di Nolfi, Elodie Bergé, Caroline Manzano, Caroline Giraud, Patrick Linder

PLOS Genetics: published July 30, 2020 | https://doi.org/10.1371/journal.pgen.1008779

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PCH-2 collaborates with CMT-1 to proofread meiotic homolog interactions

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PLOS Genetics: published July 30, 2020 | https://doi.org/10.1371/journal.pgen.1008904

Introns mediate post-transcriptional enhancement of nuclear gene expression in the green microalga Chlamydomonas reinhardtii

Thomas Baier, Nick Jacobebbinghaus, Alexander Einhaus, Kyle J. Lauersen, Olaf Kruse

PLOS Genetics: published July 30, 2020 | https://doi.org/10.1371/journal.pgen.1008944

RCC1L (WBSCR16) isoforms coordinate mitochondrial ribosome assembly through their interaction with GTPases

Aurelio Reyes, Paola Favia, Sara Vidoni, Vittoria Petruzzella, Massimo Zeviani

PLOS Genetics: published July 31, 2020 | https://doi.org/10.1371/journal.pgen.1008923

Holocentric chromosomes

Mauro Mandrioli, Gian Carlo Manicardi

PLOS Genetics: published July 30, 2020 | https://doi.org/10.1371/journal.pgen.1008918